-
1
-
-
0015311426
-
Anti-angiogenesis: new concept for therapy of solid tumors
-
Folkman J, (1972) Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 175: 409-416.
-
(1972)
Ann Surg
, vol.175
, pp. 409-416
-
-
Folkman, J.1
-
2
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P, Jain RK, (2000) Angiogenesis in cancer and other diseases. Nature 407: 249-257.
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
3
-
-
0034796595
-
Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
-
Jain RK, (2001) Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy. Nature Medicine 7: 987-989.
-
(2001)
Nature Medicine
, vol.7
, pp. 987-989
-
-
Jain, R.K.1
-
4
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N, Kerbel RS, (2005) Angiogenesis as a therapeutic target. Nature 438: 967-974.
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
5
-
-
0032053823
-
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy
-
Brown JM, Giaccia AJ, (1998) The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Research 58: 1408-1416.
-
(1998)
Cancer Research
, vol.58
, pp. 1408-1416
-
-
Brown, J.M.1
Giaccia, A.J.2
-
6
-
-
0033405294
-
The hypoxic cell: A target for selective cancer therapy - Eighteenth Bruce F. Cain Memorial Award lecture
-
Brown JM, (1999) The hypoxic cell: A target for selective cancer therapy- Eighteenth Bruce F. Cain Memorial Award lecture. Cancer Research 59: 5863-5870.
-
(1999)
Cancer Research
, vol.59
, pp. 5863-5870
-
-
Brown, J.M.1
-
7
-
-
2942590732
-
Exploiting tumour hypoxia in cancer treatment
-
Brown JM, William WR, (2004) Exploiting tumour hypoxia in cancer treatment. Nature Reviews Cancer 4: 437-447.
-
(2004)
Nature Reviews Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
William, W.R.2
-
8
-
-
11844254414
-
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
-
Jain RK, (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307: 58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
9
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, et al. (2004) Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6: 553-563.
-
(2004)
Cancer Cell
, vol.6
, pp. 553-563
-
-
Winkler, F.1
Kozin, S.V.2
Tong, R.T.3
Chae, S.S.4
Booth, M.F.5
-
10
-
-
35748970483
-
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
-
Fukumura D, Jain RK, (2007) Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvasc Res 74: 72-84.
-
(2007)
Microvasc Res
, vol.74
, pp. 72-84
-
-
Fukumura, D.1
Jain, R.K.2
-
11
-
-
34250660932
-
Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization
-
Dings RP, Loren M, Heun H, McNiel E, Griffioen AW, et al. (2007) Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization. Clin Cancer Res 13: 3395-3402.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3395-3402
-
-
Dings, R.P.1
Loren, M.2
Heun, H.3
McNiel, E.4
Griffioen, A.W.5
-
12
-
-
34047260282
-
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model
-
Jain RK, Tong RT, Munn LL, (2007) Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res 67: 2729-2735.
-
(2007)
Cancer Res
, vol.67
, pp. 2729-2735
-
-
Jain, R.K.1
Tong, R.T.2
Munn, L.L.3
-
13
-
-
77949553030
-
Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation
-
McGee MC, Hamner JB, Williams RF, Rosati SF, Sims TL, et al. (2010) Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation. Int J Radiat Oncol Biol Phys 76: 1537-1545.
-
(2010)
Int J Radiat Oncol Biol Phys
, vol.76
, pp. 1537-1545
-
-
McGee, M.C.1
Hamner, J.B.2
Williams, R.F.3
Rosati, S.F.4
Sims, T.L.5
-
14
-
-
77954699789
-
Angiopoietin-2 Interferes with Anti-VEGFR2-Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas
-
Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, et al. (2010) Angiopoietin-2 Interferes with Anti-VEGFR2-Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas. Clinical Cancer Research 16: 3618-3627.
-
(2010)
Clinical Cancer Research
, vol.16
, pp. 3618-3627
-
-
Chae, S.S.1
Kamoun, W.S.2
Farrar, C.T.3
Kirkpatrick, N.D.4
Niemeyer, E.5
-
15
-
-
70350456094
-
Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature
-
Hedlund EM, Hosaka K, Zhong Z, Cao R, Cao Y, (2009) Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature. Proc Natl Acad Sci U S A 106: 17505-17510.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 17505-17510
-
-
Hedlund, E.M.1
Hosaka, K.2
Zhong, Z.3
Cao, R.4
Cao, Y.5
-
16
-
-
68349137598
-
Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy
-
Cerniglia GJ, Pore N, Tsai JH, Schultz S, Mick R, et al. (2009) Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PLoS One 4: e6539.
-
(2009)
PLoS One
, vol.4
-
-
Cerniglia, G.J.1
Pore, N.2
Tsai, J.H.3
Schultz, S.4
Mick, R.5
-
17
-
-
79952103326
-
Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: combined analyses of NPC-9901 and NPC-9902 Trials
-
Lee AW, Tung SY, Ngan RK, Chappell R, Chua DT, et al. (2011) Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: combined analyses of NPC-9901 and NPC-9902 Trials. European Journal of Cancer 47: 656-666.
-
(2011)
European Journal of Cancer
, vol.47
, pp. 656-666
-
-
Lee, A.W.1
Tung, S.Y.2
Ngan, R.K.3
Chappell, R.4
Chua, D.T.5
-
18
-
-
79954437256
-
ZD6474, a small molecule tyrosine kinase inhibitor, potentiates the anti-tumor and anti-metastasis effects of radiation for human nasopharyngeal carcinoma
-
Yang S, Wu J, Zuo Y, Tan L, Jia H, et al. (2010) ZD6474, a small molecule tyrosine kinase inhibitor, potentiates the anti-tumor and anti-metastasis effects of radiation for human nasopharyngeal carcinoma. Curr Cancer Drug Targets 10: 611-622.
-
(2010)
Curr Cancer Drug Targets
, vol.10
, pp. 611-622
-
-
Yang, S.1
Wu, J.2
Zuo, Y.3
Tan, L.4
Jia, H.5
-
19
-
-
0031454617
-
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, et al. (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88: 277-285.
-
(1997)
Cell
, vol.88
, pp. 277-285
-
-
O'Reilly, M.S.1
Boehm, T.2
Shing, Y.3
Fukai, N.4
Vasios, G.5
-
20
-
-
34547106834
-
Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells
-
Ling Y, Yang Y, Lu N, You QD, Wang S, et al. (2007) Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells. Biochem Biophys Res Commun 361: 79-84.
-
(2007)
Biochem Biophys Res Commun
, vol.361
, pp. 79-84
-
-
Ling, Y.1
Yang, Y.2
Lu, N.3
You, Q.D.4
Wang, S.5
-
21
-
-
27644476564
-
Results of phase III trial of rh-endostatin (YH-16) in advanced non-small cell lung cancer (NSCLC) patients
-
Sun Y, Wang J, Liu Y, Song X, Zhang Y, et al. (2005) Results of phase III trial of rh-endostatin (YH-16) in advanced non-small cell lung cancer (NSCLC) patients. J Clin Oncol 23: 654S.
-
(2005)
J Clin Oncol
, vol.23
-
-
Sun, Y.1
Wang, J.2
Liu, Y.3
Song, X.4
Zhang, Y.5
-
22
-
-
0020546128
-
Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma
-
Sizhong Z, Xiukung G, Yi Z, (1983) Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma. Int J Cancer 31: 587-590.
-
(1983)
Int J Cancer
, vol.31
, pp. 587-590
-
-
Sizhong, Z.1
Xiukung, G.2
Yi, Z.3
-
23
-
-
33745685884
-
Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells
-
Song LB, Zeng MS, Liao WT, Zhang L, Mo HY, et al. (2006) Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res 66: 6225-6232.
-
(2006)
Cancer Res
, vol.66
, pp. 6225-6232
-
-
Song, L.B.1
Zeng, M.S.2
Liao, W.T.3
Zhang, L.4
Mo, H.Y.5
-
24
-
-
0034088092
-
A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase C modulator: Implications for radiosensitization and EBV-targeted therapy
-
Chung YL, Lee YHW, Yen SH, Chi KH, (2000) A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase C modulator: Implications for radiosensitization and EBV-targeted therapy. Clinical Cancer Research 6: 1452-1458.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 1452-1458
-
-
Chung, Y.L.1
Lee, Y.H.W.2
Yen, S.H.3
Chi, K.H.4
-
25
-
-
77951192102
-
Stem-like cancer cells are inducible by increasing genomic instability in cancer cells
-
Liang Y, Zhong Z, Huang Y, Deng W, Cao J, et al. (2010) Stem-like cancer cells are inducible by increasing genomic instability in cancer cells. Journal of Biological Chemistry 285: 4931-4940.
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 4931-4940
-
-
Liang, Y.1
Zhong, Z.2
Huang, Y.3
Deng, W.4
Cao, J.5
-
26
-
-
34948905351
-
Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
-
Nissen LJ, Cao R, Hedlund EM, Wang Z, Zhao X, et al. (2007) Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest 117: 2766-2777.
-
(2007)
J Clin Invest
, vol.117
, pp. 2766-2777
-
-
Nissen, L.J.1
Cao, R.2
Hedlund, E.M.3
Wang, Z.4
Zhao, X.5
-
27
-
-
5444266254
-
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
-
Cao R, Bjorndahl MA, Religa P, Clasper S, Garvin S, et al. (2004) PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell 6: 333-345.
-
(2004)
Cancer Cell
, vol.6
, pp. 333-345
-
-
Cao, R.1
Bjorndahl, M.A.2
Religa, P.3
Clasper, S.4
Garvin, S.5
-
28
-
-
57149137027
-
Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu(+) tumors
-
Hardee M, Eapen R, Rabbani Z, Dreher M, Marks J, et al. (2009) Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu(+) tumors. Cancer Chemotherapy and Pharmacology 63: 219-228.
-
(2009)
Cancer Chemotherapy and Pharmacology
, vol.63
, pp. 219-228
-
-
Hardee, M.1
Eapen, R.2
Rabbani, Z.3
Dreher, M.4
Marks, J.5
-
29
-
-
40949141801
-
Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide
-
Zhou QY, Guo P, Gallo JM, (2008) Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clinical Cancer Research 14: 1540-1549.
-
(2008)
Clinical Cancer Research
, vol.14
, pp. 1540-1549
-
-
Zhou, Q.Y.1
Guo, P.2
Gallo, J.M.3
-
30
-
-
72949117051
-
TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model
-
Ohta M, Kawabata T, Yamamoto M, Tanaka T, Kikuchi H, et al. (2009) TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model. Surg Today 39: 1046-1053.
-
(2009)
Surg Today
, vol.39
, pp. 1046-1053
-
-
Ohta, M.1
Kawabata, T.2
Yamamoto, M.3
Tanaka, T.4
Kikuchi, H.5
-
31
-
-
38949178751
-
Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model
-
Taguchi E, Nakamura K, Miura T, Shibuya M, Isoe T, (2008) Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. Cancer Sci 99: 623-630.
-
(2008)
Cancer Sci
, vol.99
, pp. 623-630
-
-
Taguchi, E.1
Nakamura, K.2
Miura, T.3
Shibuya, M.4
Isoe, T.5
-
32
-
-
84859493167
-
-
Normalization of tumor vasculature and microenvironment - A potential mechanism of action of antiangiogenic therapies; Teicher BA, Ellis LM, Teicher BA, Ellis LM: Humana Press Inc
-
Jain RK, Batchelor TT, Duda DG, Willett CG, (2008) pp. 261-276 Normalization of tumor vasculature and microenvironment- A potential mechanism of action of antiangiogenic therapies; Teicher BA, Ellis LM, Teicher BA, Ellis LM: Humana Press Inc.
-
(2008)
, pp. 261-276
-
-
Jain, R.K.1
Batchelor, T.T.2
Duda, D.G.3
Willett, C.G.4
-
33
-
-
70449428715
-
Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
-
Maione F, Molla F, Meda C, Latini R, Zentilin L, et al. (2009) Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest 119: 3356-3372.
-
(2009)
J Clin Invest
, vol.119
, pp. 3356-3372
-
-
Maione, F.1
Molla, F.2
Meda, C.3
Latini, R.4
Zentilin, L.5
-
34
-
-
84857549551
-
Phase II study of chemoradiation plus bevacizumab (BV) for locally/regionally advanced nasopharyngeal carcinoma (NPC): Preliminary clinical results of RTOG 0615
-
Lee NY, Zhang QE, Garden AS, Kim JJ, Pfister DG, et al. (2011) Phase II study of chemoradiation plus bevacizumab (BV) for locally/regionally advanced nasopharyngeal carcinoma (NPC): Preliminary clinical results of RTOG 0615. 2011 ASCO Annual Meeting 29: 5516.
-
(2011)
2011 ASCO Annual Meeting
, vol.29
, pp. 5516
-
-
Lee, N.Y.1
Zhang, Q.E.2
Garden, A.S.3
Kim, J.J.4
Pfister, D.G.5
-
35
-
-
79957894276
-
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
-
Carmeliet P, Jain RK, (2011) Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 10: 417-427.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 417-427
-
-
Carmeliet, P.1
Jain, R.K.2
-
36
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
Dvorak HF, (2002) Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 20: 4368-4380.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
37
-
-
33749158265
-
PEDF: a potential molecular therapeutic target with multiple anti-cancer activities
-
Ek ET, Dass CR, Choong PF, (2006) PEDF: a potential molecular therapeutic target with multiple anti-cancer activities. Trends Mol Med 12: 497-502.
-
(2006)
Trends Mol Med
, vol.12
, pp. 497-502
-
-
Ek, E.T.1
Dass, C.R.2
Choong, P.F.3
-
38
-
-
0033538517
-
Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
-
Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, et al. (1999) Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285: 245-248.
-
(1999)
Science
, vol.285
, pp. 245-248
-
-
Dawson, D.W.1
Volpert, O.V.2
Gillis, P.3
Crawford, S.E.4
Xu, H.5
-
39
-
-
0037088694
-
Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5
-
Gao G, Li Y, Gee S, Dudley A, Fant J, et al. (2002) Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5. J Biol Chem 277: 9492-9497.
-
(2002)
J Biol Chem
, vol.277
, pp. 9492-9497
-
-
Gao, G.1
Li, Y.2
Gee, S.3
Dudley, A.4
Fant, J.5
-
40
-
-
33847195428
-
Matrix metalloproteinases and the regulation of tissue remodelling
-
Page-McCaw A, Ewald AJ, Werb Z, (2007) Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8: 221-233.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 221-233
-
-
Page-McCaw, A.1
Ewald, A.J.2
Werb, Z.3
-
41
-
-
77950931419
-
Matrix metalloproteinases: regulators of the tumor microenvironment
-
Kessenbrock K, Plaks V, Werb Z, (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141: 52-67.
-
(2010)
Cell
, vol.141
, pp. 52-67
-
-
Kessenbrock, K.1
Plaks, V.2
Werb, Z.3
-
42
-
-
67349222087
-
Endostar, a modified endostatin inhibits non small cell lung cancer cell in vitro invasion through osteopontin-related mechanism
-
Ni Q, Ji H, Zhao Z, Fan X, Xu C, (2009) Endostar, a modified endostatin inhibits non small cell lung cancer cell in vitro invasion through osteopontin-related mechanism. Eur J Pharmacol 614: 1-6.
-
(2009)
Eur J Pharmacol
, vol.614
, pp. 1-6
-
-
Ni, Q.1
Ji, H.2
Zhao, Z.3
Fan, X.4
Xu, C.5
-
43
-
-
50649083301
-
Endostar suppresses invasion through downregulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells
-
Lu N, Ling Y, Gao Y, Chen Y, Mu R, et al. (2008) Endostar suppresses invasion through downregulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells. Exp Biol Med (Maywood) 233: 1013-1020.
-
(2008)
Exp Biol Med (Maywood)
, vol.233
, pp. 1013-1020
-
-
Lu, N.1
Ling, Y.2
Gao, Y.3
Chen, Y.4
Mu, R.5
|