A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase C modulator: Implications for radiosensitization and EBV-targeted therapy

Clinical Cancer Research

Volumn 6, Issue 4, 2000, Pages 1452-1458

  Chung, Yih Lin ^a,b,c   Lee, Yan Hwa Wu ^b   Yen, Sang Hue ^a,b   Chi, Kwan Hwa ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c KOO FOUNDATION SUN YAT SEN CANCER CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLBUTYRIC ACID DERIVATIVE; GANCICLOVIR; PROTEIN KINASE C; THYMIDINE KINASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DAUDI CELL; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOSIS INHIBITION; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; RADIOSENSITIVITY;

ANTIVIRAL AGENTS; CELL DIVISION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; EPSTEIN-BARR VIRUS INFECTIONS; GANCICLOVIR; HERPESVIRUS 4, HUMAN; HL-60 CELLS; HUMANS; NASOPHARYNGEAL NEOPLASMS; PHENYLBUTYRATES; PROTEIN KINASE C; RADIATION-SENSITIZING AGENTS; TELOMERASE; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

EID: 0034088092     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Van Hassent, C. A., and Gibb, A. G. Nasopharyngeal Carcinoma. Hong Kong: The Chinese University Press, 1991.
2. Samid, D., Shack, S., and Sherman, L. T. Phenylacetate: a novel nontoxic inducer of tumor cell differentiation. Cancer Res., 52: 1988-1992, 1992.
3. Samid, D., Yeh, A., and Prasanna, P. Induction of erythroid differentiation and fetal hemoglobin production in human leukemia cells treated with phenylacetate. Blood, 80: 1576-1581, 1992.
4. Cinatl, J. J., Cinatl, J., Mainke, M., Weibflog, A., Rabenau, H., Kornhuber, B., and Doerr, H. W. In vitro differentiation of human neuroblastoma cells induced by sodium phenylacetate. Cancer Lett., 70: 41-48, 1993.
5. Cinatl, J. J., Herneiz, P., Rabenau, H., Novak, M., Benda, R., Gumbel, H., Kornhuber, B., and Doerr, H-W. Induction of myogenic differentiation in a human rhabdomyosarcoma cell line by phenylacetate. Cancer Lett., 78: 41-48, 1994.
6. Sidel, N., Wada, R., Han, G., Chang, B., Shack, S., Moore, T., and Samid, D. Phenylacetate synergizes with retinoic acid in inducing the differentiation of human neuroblastoma cells. Int. J. Cancer, 60: 507-514, 1995.
7. Ferrandina, G., Melichar, B., Loercher, A., Verschraegen, C. F., Kudelka, A. P., Edwards, C. L., Scambia, G., Kavanagh, J. J., Abbruzzese, J. L., and Freedman, R. S. Growth inhibitory effects of sodium phenylacetate (NSC3039) on ovarian carcinoma cells in vitro. Cancer Res., 57: 4309-4315, 1997.
8. Pineau, T., Hudgins, W. R., Liu, L., Chen, L. C., Sher, T., Gonzalez, F. J., and Samid, D. Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs. Biochem. Pharmacol., 52: 659-667, 1996.
9. Waf1/Cip1 during growth arrest of human breast carcinoma MCF-7 cells by phenylacetate. Cell Growth Differ., 7: 1609-1615, 1996.
10. Danesi, R., Nardini, D., Basolo, F., Del Tacca, M., Samid, D., and Myers, C. E. Phenylacetate inhibits protein isoprenylation and growth of the androgen-independent LNCaP prostate cancer cells transfected with the T24 Ha-ras oncogene. Mol. Pharmacol., 49: 972-979, 1996.
11. Adam, L., Creptin, M., Savin, C., and Israel, L. Sodium phenylacetate induces growth inhibition and Bcl-2 down-regulation and apoptosis in MCF7ras cells in vitro and in nude mice. Cancer Res., 55: 5156-5160, 1995.
12. Liu, L., Hudgins, W. R., Miller, A. C., Chen, L. C., and Samid, D. Transcriptional up-regulation of TGF-α by phenylacetate and phenylbutyrate is associated with differentiation of human melanoma cells. Cytokine, 7: 449-456, 1995.
13. Shack, S., Chen, L. C., Miller, A. C., Danesi, R., and Samid, D. Increased susceptibility of ras-transformed cells to phenylacetate is associated with inhibition of p21ras isoprenylation and phenotypic reversion. Int. J. Cancer, 63: 124-129, 1995.
14. Piscitelli, S. C., Thibault, A., Figg, W. D., Tompkins, A., Headlee, D., Liebennan, R., Samid, D., and Myers, C. E. Disposition of phenylbutyrate and its metabolites, phenylacetate and phenylacetylglutamine. J. Clin. Pharmacol., 35: 368-373, 1995.
15. Dover, G. J., Brusilow, S., and Charache, S. Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate. Blood, 84: 339-343, 1994.
16. Olivieri, N. F., Rees, D. C., Cinder, G. D., Thein, S. L., Brittenham, G. M., Waye, J. S., and Weatherall, D. J. Treatment of thalassemia major with phenylbutyrate and hydroxyurea. Lancet, 350: 491-492, 1997.
17. Rubenstein, R. C., and Zeitlin, P. L. A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in 8F508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function. Am. J. Respir. Crit. Care Med., 157: 484-490, 1998.
18. Kemp, S., Wei, H. M., Lu, J. F., Braiterman, L. T., McGuinness, M. C., Moser, A. B., Watkins, P. A., and Smith, K. D. Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy. Nat. Med., 4: 1261-1268, 1998.
19. Prasanna, P., Shack, S., Wilson, V. L., and Samid, D. Clinical phenylacetate in chemoprevention: in vitro and in vivo suppression of 5-aza-2′-deoxycytidine-induced carcinogenesis. Clin. Cancer Res., 1: 865-871, 1995.
20. Warrell, R. P., He, L., Richon, V., Calleja, E., and Pandolfi, P. P. Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase. J. Natl. Cancer Inst., 90: 1621-1625, 1998.
21. Carducci, M. A., Nelson, J. B., Chan-Tack, K. M., Ayyagari, S. R., Sweatt, W. H., Campbell, P. A., Nelson, W. G., and Simons, J. W. Phenylbutyrate induces apoptosis human prostate cancer and is more potent than phenylacetate. Clin. Cancer Res., 2: 319-387, 1996.
22. Kakkawa, U., Takai, Y., Miyake, R., and Nishizuka, Y. Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J. Biol. Chem., 258: 11442-11445, 1987.
23. Nutter, L. M., Grill, S. P., Li, J. S., Tan, R. S., and Cheng, Y. C. Induction of virus enzymes by phorbol esters and n-butyrate in Epstein-Barr virus genome-carrying Raji cells. Cancer Res., 47: 4407-4412, 1987.
24. Contreras-Salazar, B., Ehlin-Henriksson, B., Klein, G., and Masucci, M. G. Up-regulation of the Epstein-Barr virus (EBV)-encoded membrane protein LMP in the Burkitt's lymphoma line Daudi after exposure to n-butyrate after EBV superinfection. J. Virol., 64: 5441-5447, 1990.
25. Ambinder, R. F., Robertson, K. D., Moore, S. M., and Yang, J. Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma. Semin. Cancer Biol., 7: 217-226, 1996.
26. Fuks, Z., Haimovitz-Friedman, A., and Kolesnick, R. N. The role of the sphingomyelin pathway and protein kinase C in radiation-induced cell kill. Important Adv. Oncol., 19-31: 1995.
27. Chmura, S. J., Mauceri, H. J., Advani, S., Heimann, R., Beckett, M. A., Nodzenski, E., Quintans, J., Kufe, D. W., and Weichselbaum, R. R. Decreasing the apoptotic threshold of tumor ceils through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res., 57: 4340-4347, 1997.
28. 2+, phospholid-dependent protein kinase associated with plasma membrane. Nature (Lond.), 301: 621-623, 1983.
29. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Washington DC), 266: 2011-2015, 1994.
30. Yamada, O., Takanashi, M., Ujihara, M., and Mizoguchi, H. Down-regulation of telomerase activity is an early event of cellular differentiation without apparent telomeric DNA change. Leuk. Res., 22: 711-717, 1998.
31. Abraham, C., Scaglione-Sewell, B., Skarosi, S. F., Qin, W., Bissonnette, M., and Brasitus, T. A. Protein kinase C α modulates growth and differentiation in CaCo-2 cells. Gastroenterology, 114: 503-509, 1998.
32. Verstovsek, G., Byrd, A., Frey, M. R., Petrelli, N. J., and Black, J. D. Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes. Gastroenterology, 115: 225-227, 1998.
33. Scaglione-Swell, B., Abraham, C., Bissonnette, M., Skarosi, S. F., Hart, J., Davidson, N. O., Wali, R. K., Davis, B. H., and Brasitus, T. A. Decreased PKC-α expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells. Cancer Res., 58: 1074-1081, 1998.
34. Isoda, H., Kitamoto, D., Shinmoto, H., Matsumura, M., and Nakahara, T. Microbial extracellular glycolipid induction of differentiation and inhibition of the protein kinase C activity of human promyelocytic leukemia cell line HL-60. Biosci. Biotechnol. Biochem., 61: 609-614, 1997.
35. Ku, W. C., Cheng, A. J., and Wang, T. C. Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture. Biochem. Biophys. Res. Commun., 241: 730-736, 1997.
36. Sharma, H. W., Sokoloski, J. A., Perez, J. R., Maltese, J. Y., Sartorelli, A. C., Stein, C. A., Nichols, G., Khaled, Z., Telang, N. T., and Narayanan, R. Differentiation of immortal cells inhibits telomerase activity. Proc. Natl. Acad. Sci. USA, 92: 12343-12346, 1995.
37. Miller, A. C., Whittaker, T., Thibault, A., and Samid, D. Modulation of radiation response of human tumour cells by the differentiation inducers, phenylacetate and phenylbutyrate. Int. J. Radiol. Biol., 72: 211-218, 1997.
38. Ozawa, T., Lu, R. M., Hu, L. J., Lamborn, K. R., Prados, M. D., and Deen, D. F. Radiopotentiation of human brain tumor cells by sodium phenylacetate. Cancer Lett., 38: A283, 1997.
39. Stewart, J. P., McGown, A. T., Prendiville, J., Pettit, G. R., Fox, B. W., and Arrand, J. R. Bryostain 1 induces productive Epstein-Barr virus replication in latently infected cells: implications for use in immunocompromised patients. Cancer Chemother. Pharmacol., 33: 89-91, 1993.
40. Mentzer, S. J., Fingeroth, J., Reilly, J. J., Perrine, S. P., and Faller, D. V. Arginine butyrate-induced susceptibility to ganciclovir in an Epstein-Barr virus associated lymphoma. Blood Cells Mol. Dis., 24: 114-123, 1998.