Distinct control of MyD88 adapter-dependent and Akt kinase-regulated responses by the interleukin (IL)-1RI co-receptor, TILRR

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 12348-12352

  Zhang, Xiao ^a   Pino, Gemma Montagut ^a   Shephard, Freya ^a   Kiss Toth, Endre ^a   Qwarnstrom, Eva E ^a,b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; PROTEINS;

ADAPTER PROTEINS; ALANINE-SCANNING MUTAGENESIS; CELL SURVIVAL; HELICAL STRUCTURES; INFLAMMATORY GENES; INFLAMMATORY RESPONSE; SECONDARY STRUCTURE PREDICTION; SELECTIVE AMPLIFICATION;

CHEMICAL ACTIVATION;

CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR TYPE I; MUTANT PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE B; REGULATOR PROTEIN; SCLEROPROTEIN; TOLL LIKE AND INTERLEUKIN 1 RECEPTOR REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; INDUCED MUTATION; INFLAMMATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION;

EID: 84859495961     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C111.321711     Document Type: Article

References (23)

1. Akira, S., and Takeda, K. (2004) Toll-like receptor signaling. Nat. Rev. Immunol. 4, 499-511
2. O'Neill, L. A., and Bowie, A. G. (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signaling. Nat. Rev. immunol. 7, 353-364 (Pubitemid 46674493)
3. Wang, K. Z., Wara-Aswapati, N., Boch, J. A., Yoshida, Y., Hu, C. D., Galson, D. L., and Auron, P. E. (2006) TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src. J. Cell Sci. 119, 1579-1591 (Pubitemid 43732984)
4. Barkett, M., and Gilmore, T. D. (1999) Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 18, 6910-6924
5. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D. R., Aebersold, R., Siderovski, D. P., Penninger, J. M., and Kroemer, G. (1999) Molecular characterization of mitochondrial apoptosis- inducing factor. Nature 397, 441-446
6. Wang, W., Prince, C. Z., Mou, Y., and Pollman, M. J. (2002) Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/ MAPK activation: resistance to Fas ligand-induced apoptosis. J. Biol. Chem. 277, 21723-21729 (Pubitemid 34952323)
7. Gay, N. J., and Keith, F. J. (1991) Drosophila Toll and IL-1 receptor. Nature 351, 355-356
8. Davis, C. N., Mann, E., Behrens, M. M., Gaidarova, S., Rebek, M., Rebek, J., Jr., and Bartfai, T. (2006) MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics. Proc. Natl. Acad. Sci. U.S.A. 103, 2953-2958
9. McGregor, L., Makela, V., Darling, S. M., Vrontou, S., Chalepakis, G., Roberts, C., Smart, N., Rutland, P., Prescott, N., Hopkins, J., Bentley, E., Shaw, A., Roberts, E., Mueller, R., Jadeja, S., Philip, N., Nelson, J., Francannet, C., Perez-Aytes, A., Megarbane, A., Kerr, B., Wainwright, B., Woolf, A. S., Winter, R. M., and Scambler, P. J. (2003) Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein. Nat. Genet. 34, 203-208 (Pubitemid 36666933)
10. Zhang, X., Shephard, F., Kim, H. B., Palmer, I. R., McHarg, S., Fowler, G. J., O'Neill, L. A., Kiss-Toth, E., and Qwarnstrom, E. E. (2010) TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-≲καππα∀B. J. Biol. Chem. 285, 7222-7232
11. Slack, J. L., Schooley, K., Bonnert, T. P., Mitcham, J. L., Qwarnstrom, E. E., Sims, J. E., and Dower, S. K. (2000) Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. J. Biol. Chem. 275, 4670-4678 (Pubitemid 30108853)
12. Yang, L., Ross, K., and Qwarnstrom, E. E. (2003) RelA control of IκBαphosphorylation: a positive feedback loop for high affinity NF-κB complexes. J. Biol. Chem. 278, 30881-30888 (Pubitemid 36994599)
13. Garnier, J., Gibrat, J. F., and Robson, B. (1996) GOR method for predicting protein secondary structure from amino acid sequence. Methods Enzymol. 266, 540-553
14. Garnier, J., Osguthorpe, D. J., and Robson, B. (1978) Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J. Mol. Biol. 120, 97-120 (Pubitemid 8312913)
15. Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J. L., and Tong, L. (2000) Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408, 111-115
16. Motshwene, P. G., Moncrieffe, M. C., Grossmann, J. G., Kao, C., Ayaluru, M., Sandercock, A. M., Robinson, C. V., Latz, E., and Gay, N. J. (2009) An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. J. Biol. Chem. 284, 25404-25411
17. Lin, S. C., Lo, Y. C., and Wu, H. (2010) Helical assembly in the MyD88- IRAK4-IRAK2 complex in TLR/IL-1R signaling. Nature 465, 885-890
18. Gay, N. J., Gangloff, M., and O'Neill, L. A. (2011) What the Myddosome structure tells us about the initiation of innate immunity. Trends Immunol. 32, 104-109
19. Burow, M. E., Weldon, C. B., Melnik, L. I., Duong, B. N., Collins-Burow, B. M., Beckman, B. S., and McLachlan, J. A. (2000) PI3-K/AKT regulation of NF-κB signaling events in suppression of TNF-induced apoptosis. Biochem. Biophys. Res. Commun. 271, 342-345 (Pubitemid 30444728)
20. Gustin, J. A., Ozes, O. N., Akca, H., Pincheira, R., Mayo, L. D., Li, Q., Guzman, J. R., Korgaonkar, C. K., and Donner, D. B. (2004) Cell type-specific expression of the IκB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-κB activation. J. Biol. Chem. 279, 1615-1620 (Pubitemid 38084426)
21. Lewis, K. A., Gray, P. C., Blount, A. L., MacConell, L. A., Wiater, E., Bilezikjian, L. M., and Vale, W. (2000) β-Glycan binds inhibin and can mediate functional antagonism of activin signaling. Nature 404, 411-414 (Pubitemid 30164345)
22. MacDonald, B. T., Yokota, C., Tamai, K., Zeng, X., and He, X. (2008) Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6. J. Biol. Chem. 283, 16115-16123
23. Monje, P. V., Athauda, G., and Wood, P. M. (2008) Protein kinase A-mediated gating of neuregulin-dependent ErbB2-ErbB3 activation underlies the synergistic action of cAMP on Schwann cell proliferation. J. Biol. Chem. 283, 34087-34100