Non-glycosylated BMP-2 can induce ectopic bone formation at lower concentrations compared to glycosylated BMP-2

Journal of Controlled Release

Volumn 159, Issue 1, 2012, Pages 69-77

  Van De Watering, F C J ^a   Van Den Beucken, J J J P ^a   Van Der Woning, S P ^b   Briest, A ^c   Eek, A ^a   Qureshi, H ^d   Winnubst, L ^d   Boerman, O C ^a   Jansen, J A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c OSSACUR AG   (Germany)

^d UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Bone substitute material; Growth factor release; In vivo response; rhBMP 2

Indexed keywords

BACTERIAL EXPRESSION SYSTEMS; BIOLOGICAL PERFORMANCE; BONE FORMATION; BONE SUBSTITUTES; ECTOPIC BONES; GLYCOSYLATED; GROWTH FACTOR; GROWTH FACTOR RELEASE; IMPLANTATION MODELS; IN VIVO RESPONSE; IN-VITRO; MAMMALIAN CELLS; MORPHOGENIC; RHBMP-2;

BIOACTIVITY; BIOLOGICAL MATERIALS; CALCIUM PHOSPHATE; MAMMALS; PEPTIDES; RECOMBINANT PROTEINS;

BONE;

CALCIUM PHOSPHATE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT GLYCOSYLATED BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT NON GLYCOSYLATED BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BONE PROSTHESIS; BONE REGENERATION; BONE TRANSPLANTATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; GLYCOSYLATION; IN VITRO STUDY; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; RAT;

ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 2; BONE SUBSTITUTES; CALCIUM PHOSPHATES; CELL LINE; GLYCOSYLATION; MALE; MICE; OSTEOGENESIS; PROSTHESES AND IMPLANTS; RATS; RATS, WISTAR;

EID: 84859484390     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.12.041     Document Type: Article

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