Eradication of H. pylori did not improve abnormal sonic hedgehog expression in the high risk group for gastric cancer

Digestive Diseases and Sciences

Volumn 57, Issue 3, 2012, Pages 643-649

  Shiotani, Akiko ^a   Murao, Takahisa ^a   Uedo, Noriya ^b   Iishi, Hiroyasu ^b   Yamanaka, Yoshiyuki ^a   Kamada, Tomoari ^a   Kusunoki, Hiroaki ^a   Inoue, Kazuhiko ^a   Haruma, Ken ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

Author keywords

Gastric cancer; Intestinal metaplasia; Methylation; MUC5AC

Indexed keywords

AMOXICILLIN; BONE MORPHOGENETIC PROTEIN 4; CLARITHROMYCIN; LANSOPRAZOLE; MESSENGER RNA; METRONIDAZOLE; MUCIN 5AC; OMEPRAZOLE; PROTEIN PATCHED; RABEPRAZOLE; SONIC HEDGEHOG PROTEIN; BMP4 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; GLI1 PROTEIN, HUMAN; MUC5AC PROTEIN, HUMAN; PATCHED RECEPTORS; SHH PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

AGED; ARTICLE; CANCER PATIENT; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CONTROL; DOWNSTREAM PROCESSING; EARLY CANCER; ENDOSCOPIC SUBMUCOSAL DISSECTION; ENDOSCOPIC SURGERY; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; MALE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; QUANTITATIVE ANALYSIS; STOMACH BIOPSY; STOMACH CANCER; STOMACH GLAND; ATROPHIC GASTRITIS; BIOPSY; CASE CONTROL STUDY; DNA METHYLATION; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; RISK FACTOR; STOMACH MUCOSA; STOMACH TUMOR;

AGED; BIOPSY; BONE MORPHOGENETIC PROTEIN 4; CASE-CONTROL STUDIES; DNA METHYLATION; FEMALE; GASTRIC MUCOSA; GASTRITIS, ATROPHIC; GENETIC PREDISPOSITION TO DISEASE; HEDGEHOG PROTEINS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; MUCIN 5AC; PHENOTYPE; PROMOTER REGIONS, GENETIC; RECEPTORS, CELL SURFACE; RISK FACTORS; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 84859481705     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-011-1916-3     Document Type: Article

References (29)

1. Hammerschmidt M, Brook A, McMahon AP. The world according to hedgehog. Trends Genet. 1997;13:14-21. (Pubitemid 27062504)
2. Bitgood MJ, McMahon AP. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. 1995;172:126-138.
3. Echelard Y, Epstein DJ, St-Jacques B, Shen L, et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993;75: 1417-1430. (Pubitemid 24021915)
4. van den Brink GR, Hardwick JC, Nielsen C, Xu C, et al. Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut. 2002;51:628-633. (Pubitemid 35216847)
5. Oldak M, Grzela T, Lazarczyk M, Malejczyk J, Skopinski P. Clinical aspects of disrupted hedgehog signaling (review). Int J Mol Med. 2001;8:445-452.
6. Jacob J, Briscoe J. Gli proteins and the control of spinal-cord patterning. EMBO Rep. 2003;4:761-765. (Pubitemid 37063183)
7. Faller G, Kirchner T. Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia. Virchows Arch. 2005; 446:1-9. (Pubitemid 40179149)
8. van den Brink GR, Hardwick JC, Tytgat GN, Brink MA, et al. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology. 2001;121:317-328. (Pubitemid 32729379)
9. Fukaya M, Isohata N, Ohta H, Aoyagi K, et al. Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology. 2006;131:14-29. (Pubitemid 44015761)
10. Nitsche H, Ramamoorthy S, Sareban M, Pausawasdi N, Todisco A. Functional role of bone morphogenetic protein-4 in isolated canine parietal cells. Am J Physiol Gastrointest Liver Physiol. 2007;293:G607-G614. (Pubitemid 47435387)
11. Phillips RW, Frierson HF Jr., Moskaluk CA. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol. 2003;27:1442-1447. (Pubitemid 37315196)
12. Silberg DG, Sullivan J, Kang E, Swain GP, et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology. 2002;122:689-696. (Pubitemid 34173821)
13. Shiotani A, Uedo N, Iishi H, Tatsuta M, et al. Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia. Int J Cancer. 2007;121:1182-1189. (Pubitemid 47293783)
14. Shiotani A, Kamada T, Yamanaka Y, Manabe N, et al. Sonic hedgehog and CDX2 expression in the stomach. J Gastroenterol Hepatol. 2008;23:S161-S166.
15. Shiotani A, Iishi H, Uedo N, Ishiguro S, et al. Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer. Am J Gastroenterol. 2005;100:581-587. (Pubitemid 40487556)
16. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature. 2003;422: 313-317. (Pubitemid 36378358)
17. Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, et al. Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003;425:846-851. (Pubitemid 37351469)
18. Lee SY, Han HS, Lee KY, Hwang TS, et al. Sonic hedgehog expression in gastric cancer and gastric adenoma. Oncol Rep. 2007;17:1051-1055.
19. Fu X, Yang X, Li J, Tian X, Cai J, Zhang Y. Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers. Pathology. 2010;42:553-559.
20. Silver A, Sengupta N, Propper D, Wilson P, et al. A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers. Int J Cancer. 2011. (Epub ahead of print ). doi:10.1002/ijc.26104.
21. Wang LH, Choi YL, Hua XY, Shin YK, et al. Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions. Mod Pathol. 2006;19:675-683.
22. Maekita T, Nakazawa K, Mihara M, Nakajima T, et al. High levels of aberrant DNA methylation in Helicobacter pyloriinfected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res. 2006;12:989-995. (Pubitemid 43259882)
23. Graham DY, Shiotani A. The time to eradicate gastric cancer is now. Gut. 2005;54:735-738. (Pubitemid 40732080)
24. Mutoh H, Hayakawa H, Sashikawa M, Sakamoto H, Sugano K. Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation. BiochemJ. 2010;427:423-434.
25. Shiotani A, Haruma K, Uedo N, Iishi H, et al. Histological risk markers for non-cardia early gastric cancer: pattern of mucin expression and gastric cancer. Virchows Arch. 2006;449:652-659. (Pubitemid 44832636)
26. Shiotani A, Iishi H, Uedo N, Kumamoto M, et al. Histologic and serum risk markers for noncardia early gastric cancer. Int J Cancer. 2005;115:463-469. (Pubitemid 40663752)
27. Kato M, Asaka M, Ono S, Nakagawa M, et al. Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection. J Gastroenterol. 2007;42:16-20. (Pubitemid 46140358)
28. Wong BC, Lam SK, WongWM,Chen JS, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA. 2004;291:187-194. (Pubitemid 38082812)
29. Graham DY, Uemura N. Natural history of gastric cancer after Helicobacter pylori eradication in Japan: after endoscopic resection, after treatment of the general population, and naturally. Helicobacter. 2006;11:139-143. (Pubitemid 43736546)