Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation

Biochemical Journal

Volumn 427, Issue 3, 2010, Pages 423-434

  Mutoh, Hiroyuki ^a   Hayakawa, Hiroko ^a   Sashikawa, Miho ^a   Sakamoto, Hirotsugu ^a   Sugano, Kentaro ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Caudal type homeobox 2 (Cdx2); Intestinal metaplastic mucosa; Sonic Hedgehog (Shh); Stomach; Transgenic mouse

Indexed keywords

GASTRIC CARCINOMA; GASTRIC MUCOSA; HELICOBACTER PYLORI; HYPERMETHYLATION; MRNA LEVEL; SONIC HEDGEHOGS; TATA BOX; TRANSGENIC MICE; WILD TYPES;

CELL CULTURE;

TRANSCRIPTION;

MESSENGER RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR CDX2; CDX2 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; SHH PROTEIN, MOUSE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTESTINE METAPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; STOMACH CARCINOMA; STOMACH MUCOSA; TATA BOX; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; GEL MOBILITY SHIFT ASSAY; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH; STOMACH TUMOR; TUMOR CELL LINE;

ERINACEIDAE; HELICOBACTER PYLORI; MUS; MUS MUSCULUS;

ANIMALS; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINAL MUCOSA; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STOMACH; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 77951235508     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091177     Document Type: Article

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