Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors

Human Pathology

Volumn 38, Issue 10, 2007, Pages 1516-1525

  Massi, Daniela ^a   Marconi, Chiara ^a   Franchi, Alessandro ^a   Bianchini, Francesca ^a   Paglierani, Milena ^a   Ketabchi, Sheyda ^a   Miracco, Clelia ^b   Santucci, Marco ^a   Calorini, Lido ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Arginase; Arginine metabolism; Inducible nitric oxide synthase; Melanoma; Tumor associated macrophages

Indexed keywords

ARGINASE; ARGININE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE;

ADULT; ADVANCED CANCER; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER LOCALIZATION; CANCER STAGING; CLINICAL PROTOCOL; COCULTURE; EXPERIMENTAL MELANOMA; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA B16; PROTEIN EXPRESSION; PROTEIN METABOLISM; SKIN CANCER; SKIN CARCINOGENESIS; SKIN DEFECT; TISSUE SECTION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ARGINASE; ARGININE; CELL LINE, TUMOR; FEMALE; HUMANS; MACROPHAGES; MALE; MELANOMA; MICE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE II; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; RNA, MESSENGER; SKIN NEOPLASMS;

EID: 34548697727     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2007.02.018     Document Type: Article

References (35)

1. Liotta L.A., and Kohn E.C. The microenvironment of the tumour-host interface. Nature 411 (2001) 375-379
2. Fidler I.J. The organ microenvironment and cancer metastasis. Differentiation 70 (2002) 498-505
3. Hsu M.Y., Meier F., and Herlyn M. Melanoma development and progression: a conspiracy between tumor and host. Differentiation 70 (2002) 522-536
4. van Kempen L.C., Ruiter D.J., van Muijen G.N., and Coussens L.M. The tumor microenvironment: a critical determinant of neoplastic evolution. Eur J Cell Biol 82 (2003) 539-548
5. Mantovani A., Bottazzi B., Colotta F., Sozzani S., and Ruco L. The origin and function of tumor-associated macrophages. Immunol Today 13 (1992) 265-270
6. Nesbit M., Schaider H., Miller T.H., and Herlyn M. Low-level monocyte chemoattractant protein-1 stimulation of monocytes leads to tumor formation in nontumorigenic melanoma cells. J Immunol 166 (2001) 6483-6490
7. Bingle L., Brown N.J., and Lewis C.E. The role of tumour-associated macrophages in tumour progression: implication for new anticancer therapies. J Pathol 196 (2002) 254-265
8. Mantovani A., Allavena P., and Sica A. Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression. Eur J Cancer 40 (2004) 1660-1667
9. Stout R.D., Jiang C., Matta B., Tietzel I., Watkins S.K., and Suttles J. Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J Immunol 175 (2005) 342-349
10. Bröcker E.B., Zwadlo G., Suter L., Brune M., and Sorg C. Infiltration of primary and metastatic melanomas with macrophages of the 25F9-positive phenotype. Cancer Immunol Immunother 25 (1987) 81-86
11. Mills C.D., Shearer J., Evans R., and Caldwell M.D. Macrophage arginine metabolism and the inhibition or stimulation of cancer. J Immunol 149 (1992) 2709-2714
12. Boutard V., Havouis R., Fouqueray B., Philippe C., Moulinoux J.P., and Baud L. Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity. J Immunol 155 (1995) 2077-2084
13. Auvinen M., Paasinen A., Andersson L.C., and Holtta E. Ornithine decarboxylase activity is critical for cell transformation. Nature 360 (1992) 355-358
14. Chang C.I., Liao J.C., and Kuo L. Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. Cancer Res 61 (2001) 1100-1106
15. Bröcker E.B., Zwadlo G., Holzmann B., Macher E., and Sorg C. Inflammatory cell infiltrates in human melanoma at different stages of tumor progression. Int J Cancer 41 (1988) 562-567
16. Ono M., Torisu H., Fukushi J., Nishie A., and Kuwano M. Biological implications of macrophage infiltration in human tumor angiogenesis. Cancer Chemother Pharmacol 43 (1999) S69-S71
17. Torisu H., Ono M., Kiryu H., et al. Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNF-α and IL-1α. Int J Cancer 85 (2000) 182-188
18. Varney M.L., Johansson S.L., and Singh R.K. Tumour-associated macrophage infiltration, neovascularization and aggressiveness in malignant melanoma: role of monocyte chemotactic protein-1 and vascular endothelial growth factor-A. Melanoma Res 15 (2005) 417-425
19. Piras F., Colombari R., Minerba L., et al. The predictive value of CD8, CD4, CD68, and human leukocyte antigen-D-related cells in the prognosis of cutaneous malignant melanoma with vertical growth phase. Cancer 104 (2005) 1246-1254
20. Gattoni-Celli S., Calorini L., Simile M.M., and Ferrone S. Modulation by MHC class I antigens of the biology of melanoma cells. Non immunological mechanism. Melanoma Res 3 (1993) 285-289
21. Chen T.R. In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Exp Cell Res 104 (1977) 255-262
22. Cecconi O., Calorini L., Mannini A., Mugnai G., and Ruggieri S. Enhancement of lung-colonizing potential of murine tumor cell lines co-cultivated with activated macrophages. Clin Exp Metastasis 15 (1997) 94-101
23. Calorini L., Bianchini F., Mannini A., Mugnai G., and Ruggieri S. Enhancement of nitric oxide release in mouse inflammatory macrophages co-cultivated with tumor cells of a different origin. Clin Exp Metastasis 22 (2005) 413-419
24. Aggarwal B.B., and Mehta K. The determination and regulation of nitric oxide production from macrophages lipopolysaccharides, cytokines, and retinoids. Methods Enzymol 269 (1996) 166-171
25. Stuher D.J., and Marletta M.A. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A 82 (1985) 7738-7742
26. Adams D.O., and Hamilton T.A. Molecular basis of macrophage activation: diversity and its origins. In: Lewis C.E., and Mc Gee J.O.'D. (Eds). The natural immune system: the macrophages (1992), Oxford University Press, Oxford 75-114
27. Gordon S. Alternative activation of macrophages. Nat Rev 3 (2003) 23-35
28. Massi D., Franchi A., Sardi I., et al. Inducible nitric oxide synthase expression in benign and malignant melanocytic lesions. J Pathol 194 (2001) 194-200
29. Makitie T., Summanen P., Tarkkanen A., and Kivela T. Tumor-infiltrating macrophages (CD68(+) cells) and prognosis in malignant uveal melanoma. Invest Ophthalmol Vis Sci 42 (2001) 1414-1421
30. Toivonen P., Makitie T., Kujala E., and Kivela T. Microcirculation and tumor-infiltrating macrophages in choroidal and ciliary body melanoma and corresponding metastases. Invest Ophthalmol Vis Sci 45 (2004) 1-6
31. Lewis C., and Murdoch C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol 167 (2005) 627-635
32. Park K.G., Heys S.D., Harris C.I., et al. Arginine metabolism in benign and malignant disease of breast and colon: evidence for possible inhibition of tumor-infiltrating macrophages. Nutrition 7 (1991) 185-188
33. Nicotera P., Bonfoco E., and Brune B. Mechanisms for nitric oxide-induced cell death: involvement of apoptosis. Adv Neuroimmunol 5 (1997) 411-420
34. Dimmeler S., Haendler J., Nehls M., and Zeiher A.M. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J Exp Med 185 (1997) 601-607
35. Joshi M., Strandhoy J., and White W.L. Nitric oxide synthase activity is up-regulated in melanoma cell lines: a potential mechanism for metastases formation. Melanoma Res 6 (1996) 121-126