Metastasis in melanoma xenografts is associated with tumor microvascular density rather than extent of hypoxia1

Neoplasia

Volumn 12, Issue 11, 2010, Pages 889-898

  Rofstad, Einar K ^a   Mathiesen, Berit ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 8; INTERLEUKIN 8 ANTIBODY; VASCULOTROPIN A; VASCULOTROPIN ANTIBODY;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PARAMETERS; CANCER CELL CULTURE; CARCINOGENICITY; CELL INVASION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; LUNG METASTASIS; MALE; MELANOMA; METASTASIS; MICROVASCULAR DENSITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

EID: 78449248084     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.10712     Document Type: Article

References (42)

1. Nowell PC (2002). Tumor progression: a brief historical perspective. Semin Cancer Biol 12, 261-266.
2. Vogelstein B and Kinzler KW (2004). Cancer genes and the pathways they control. Nat Med 10, 789-799.
3. Steeg PS (2006). Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 12, 895-904.
4. Brown JM and Giaccia AJ (1998). The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 58, 1408-1416.
5. Rofstad EK, Gaustad JV, Brurberg KG, Mathiesen B, Galappathi K, and Simonsen TG (2009). Radiocurability is associated with interstitial fluid pressure in human tumor xenografts. Neoplasia 11, 1243-1251.
6. Höckel M and Vaupel P (2001). Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93, 266-276.
7. Vaupel P and Mayer A (2007). Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 26, 225-239.
8. Rofstad EK (2000). Microenvironment-induced cancer metastasis. Int J Radiat Biol 76, 589-605.
9. Subarsky P and Hill RP (2003). The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 20, 237-250.
10. Huang CH, Yang WH, Chang SY, Tai SK, Tzeng CH, Kao JY, Wu KJ, and Yang MH (2009). Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis. Neoplasia 11, 1371-1382.
11. Bindra RS and Glazer PM (2005). Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis. Mutat Res 569, 75-85.
12. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, and Giaccia AJ (1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91.
13. Semenza GL (2010). Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29, 625-634.
14. Weidner N (1995). Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 147, 9-19.
15. Vermeulen PB, Gasparini G, Fox SB, Colpaert C, Marson LP, Gion M, Beliën JA, de Waal RM, van Mark E, Magnani E, et al. (2002). Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. Eur J Cancer 38, 1564-1579.
16. Geiger TR and Peeper DS (2009). Metastasis mechanisms. Biochim Biophys Acta 1796, 293-308.
17. Rofstad EK and Halsør EF (2002). Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8. Br J Cancer 86, 301-308.
18. Merighi S, Simioni C, Gessi S, Varani K, Mirandola P, Tabrizi MA, Baraldi PG, and Borea PA (2009). A2B and A3 adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin. Neoplasia 11, 1064-1073.
19. Gaustad JV, Simonsen TG, Brurberg KG, Huuse EM, and Rofstad EK (2009). Blood supply in melanoma xenografts is governed by the morphology of the supplying arteries. Neoplasia 11, 277-285.
20. Rofstad EK (1994). Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern. Br J Cancer 70, 804-812.
21. Rofstad EK, Ruud EBM, Mathiesen B, and Galappathi K (2010). Associations between radiocurability and interstitial fluid pressure in human tumor xenografts without hypoxic tissue. Clin Cancer Res 16, 936-945.
22. Rofstad EK, Mathiesen B, Kindem K, and Galappathi K (2006). Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res 66, 6699-6707.
23. Rofstad EK (1995). Metastatic behavior of human tumors in congenitally athymic nude mice: intrinsic properties of the tumor cells and host immune reactivity. Int J Cancer 63, 744-749.
24. Rofstad EK and Måseide K (1999). Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours. Int J Radiat Biol 75, 1377-1393.
25. Rofstad EK, Galappathi K, Mathiesen B, and Ruud EBM (2007). Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis. Clin Cancer Res 13, 1971-1978.
26. Srivastava A, Laidler P, Davies RP, Horgan K, and Hughes LE (1988). The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma: a quantitative histologic study. Am J Pathol 133, 419-423.
27. Denijn M and Ruiter DJ (1993). The possible role of angiogenesis in the metastatic potential of human melanoma. Clinicopathological aspects. Melanoma Res 3, 5-14.
28. Graham CH, Rivers J, Kerbel RS, Stankiewicz KS, and White WL (1994). Extent of vascularization as a prognostic indicator in thin (<0.76 mm) malignant melanomas. Am J Pathol 145, 510-514.
29. Moulder JE and Rockwell S (1984). Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 10, 695-712.
30. Fenton BM, Kiani MF, and Siemann DW (1995). Should direct measurements of tumor oxygenation relate to the radiobiological hypoxic fraction of a tumor? Int J Radiat Oncol Biol Phys 33, 365-373.
31. Bussink J, Kaanders JH, and van der Kogel AJ (2003). Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers. Radiother Oncol 67, 3-15.
32. Rofstad EK, Rasmussen H, Galappathi K, Mathiesen B, Nilsen K, and Graff BA (2002). Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor. Cancer Res 62, 1847-1853.
33. Rofstad EK, Gaustad JV, Egeland TAM, Mathiesen B, and Galappathi K (2010). Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination. Int J Cancer 127, 1535-1546.
34. Herlyn M (1990). Human melanoma: development and progression. Cancer Metastasis Rev 9, 101-112.
35. Marcoval J, Moreno A, Graells J, Vidal A, Escribà JM, Garcia-Ramírez M, and Fabra A (1997). Angiogenesis and malignant melanoma. Angiogenesis is related to the development of vertical (tumorigenic) growth phase. J Cutan Pathol 24, 212-218.
36. Erhard H, Rietveld FJ, van Altena MC, Brocker EB, Ruiter DJ, and de Waal RM (1997). Transition of horizontal to vertical growth phase melanoma is accompanied by induction of vascular endothelial growth factor expression and angiogenesis. Melanoma Res 7(suppl 2), s19-s26.
37. Höckel M, Schlenger K, Aral B, Mitze M, Schäffer U, and Vaupel P (1996). Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56, 4509-4515.
38. Brizel DM, Dodge RK, Clough RW, and Dewhirst MW (1999). Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 53, 113-117.
39. Nordsmark M, Alsner J, Keller J, Nielsen OS, Jensen OM, Horsman MR, and Overgaard J (2001). Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. Br J Cancer 84, 1070-1075.
40. Zhang L and Hill RP (2004). Hypoxia enhances metastatic efficiency by upregulating Mdm2 in KHT cells and increasing resistance to apoptosis. Cancer Res 64, 4180-4189.
41. Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JT, Jeffrey SS, and Giaccia AJ (2006). Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222-1226.
42. Rofstad EK, Sundfør K, Lyng H, and Tropé CG (2000). Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br J Cancer 83, 354-359.