메뉴 건너뛰기




Volumn 18, Issue 4, 2010, Pages 303-312

Nasal delivery of antisense oligonucleotides: In vitro evaluation of a thiomer/glutathione microparticulate delivery system

Author keywords

Drug delivery system; Microparticles; Mucoadhesion; Permeation enhancement; Phosphorothioate antisense oligonucleotides; Polycarbophil cysteine; Thiomer

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GLUTATHIONE; PENETRATION ENHANCING AGENT; PHOSPHOROTHIOATE ANTISENSE OLIGONUCLEOTIDE; POLYCARBOPHIL CYSTEINE; UNCLASSIFIED DRUG;

EID: 77951095329     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/10611860903450031     Document Type: Article
Times cited : (14)

References (38)
  • 1
    • 0030271959 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Towards clinical trials
    • Agrawal S. (1996). Antisense oligonucleotides: towards clinical trials. Trends Biotechnol, 14: 376-387.
    • (1996) Trends Biotechnol , vol.14 , pp. 376-387
    • Agrawal, S.1
  • 2
    • 59649096203 scopus 로고    scopus 로고
    • Preparation of preformed porous PLGA microparticles and antisense oligonucleotides loading
    • Ahmed AR, Bodmeier R. (2009). Preparation of preformed porous PLGA microparticles and antisense oligonucleotides loading. Eur J Pharm Biopharm, 71: 264-270.
    • (2009) Eur J Pharm Biopharm , vol.71 , pp. 264-270
    • Ahmed, A.R.1    Bodmeier, R.2
  • 3
    • 0032472305 scopus 로고    scopus 로고
    • Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: Synthesis and evaluation of different chitosan-EDTA conjugates
    • Bernkop-Schnürch A, Krajicek ME. (1998). Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates. J Control Release, 50: 215-223.
    • (1998) J Control Release , vol.50 , pp. 215-223
    • Bernkop-Schnürch, A.1    Krajicek, M.E.2
  • 4
    • 0033020555 scopus 로고    scopus 로고
    • Polymers with thiol groups: A new generation of mucoadhesive polymers?
    • DOI 10.1023/A:1018830204170
    • Bernkop-Schnürch A, Schwarz V, Steininger S. (1999). Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm Res, 16: 876-881. (Pubitemid 29284199)
    • (1999) Pharmaceutical Research , vol.16 , Issue.6 , pp. 876-881
    • Bernkop-Schnurch, A.1    Schwarz, V.2    Steininger, S.3
  • 5
    • 0033955625 scopus 로고    scopus 로고
    • Synthesis and characterisation of mucoadhesive thiolated polymers
    • Bernkop-Schnürch A, Steininger S. (2000a). Synthesis and characterisation of mucoadhesive thiolated polymers. Int J Pharm, 194: 239-247.
    • (2000) Int J Pharm , vol.194 , pp. 239-247
    • Bernkop-Schnürch, A.1    Steininger, S.2
  • 6
    • 0034600188 scopus 로고    scopus 로고
    • Development of controlled drug release systems based on thiolated polymers
    • Bernkop-Schnürch A, Scholler S, Biebel RG. (2000b). Development of controlled drug release systems based on thiolated polymers. J Control Release, 66: 39-48.
    • (2000) J Control Release , vol.66 , pp. 39-48
    • Bernkop-Schnürch, A.1    Scholler, S.2    Biebel, R.G.3
  • 7
    • 0035157888 scopus 로고    scopus 로고
    • Thiolation of polycarbophil enhances its inhibition of intestinal brush border membrane bound aminopeptidase N
    • Bernkop-Schnürch A, Zarti H, Walker GF. (2001). Thiolation of polycarbophil enhances its inhibition of intestinal brush border membrane bound aminopeptidase N. J Pharm Sci, 90: 1907-1914.
    • (2001) J Pharm Sci , vol.90 , pp. 1907-1914
    • Bernkop-Schnürch, A.1    Zarti, H.2    Walker, G.F.3
  • 8
    • 0242321144 scopus 로고    scopus 로고
    • Preparation and in vitro characterization of poly(acrylic acid)-cysteine microparticles
    • Bernkop-Schnürch A, Egger C, Elhassan Imam M, Krauland AH. (2003). Preparation and in vitro characterization of poly(acrylic acid)-cysteine microparticles. J Control Release, 93: 29-38.
    • (2003) J Control Release , vol.93 , pp. 29-38
    • Bernkop-Schnürch, A.1    Egger, C.2    Elhassan Imam, M.3    Krauland, A.H.4
  • 9
    • 33745105965 scopus 로고    scopus 로고
    • In vitro evaluation of the potential of thiomers for the nasal administration of Leu-enkephalin
    • Bernkop-Schnürch A, Obermair K, Greimel A, Palmberger TF. (2006). In vitro evaluation of the potential of thiomers for the nasal administration of Leu-enkephalin. Amino Acids, 30: 417-423.
    • (2006) Amino Acids , vol.30 , pp. 417-423
    • Bernkop-Schnürch, A.1    Obermair, K.2    Greimel, A.3    Palmberger, T.F.4
  • 10
    • 0035140601 scopus 로고    scopus 로고
    • Enhanced nasal retention of hydrophobically modified polyelectrolytes
    • Bromberg LE. (2001). Enhanced nasal retention of hydrophobically modified polyelectrolytes. J Pharm Pharmacol, 53: 109-114.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 109-114
    • Bromberg, L.E.1
  • 12
    • 0033776833 scopus 로고    scopus 로고
    • In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil
    • Clausen AE, Bernkop-Schnürch A. (2000). In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil. J Pharm Sci, 89: 1253-1261.
    • (2000) J Pharm Sci , vol.89 , pp. 1253-1261
    • Clausen, A.E.1    Bernkop-Schnürch, A.2
  • 13
    • 77951132948 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide) microspheres for the controlled release of oligonucleotide/polyethylenimine complexes
    • De Rosa G, Quaglia F, La Rotonda MI, Appel M, Alphandary H, Fattal E. (2002). Poly(lactide-co-glycolide) microspheres for the controlled release of oligonucleotide/polyethylenimine complexes. Int J Pharm, 254: 98-193
    • (2002) Int J Pharm , vol.254 , pp. 98-193
    • De Rosa, G.1    Quaglia, F.2    La Rotonda, M.I.3    Appel, M.4    Alphandary, H.5    Fattal, E.6
  • 14
    • 0026671198 scopus 로고
    • Principle and investigation of the bioadhesion mechanism of solid dosage forms
    • Duchêne D, Ponchel G. (1992). Principle and investigation of the bioadhesion mechanism of solid dosage forms. Biomaterials, 13: 709-714.
    • (1992) Biomaterials , vol.13 , pp. 709-714
    • Duchêne, D.1    Ponchel, G.2
  • 15
    • 49749177569 scopus 로고
    • A colorimetric method for determining low concentrations of mercaptans
    • Ellman GL. (1958). A colorimetric method for determining low concentrations of mercaptans. Arch Biochem Biophys, 74: 443-450.
    • (1958) Arch Biochem Biophys , vol.74 , pp. 443-450
    • Ellman, G.L.1
  • 16
    • 0000065457 scopus 로고
    • Significance of the pH of nasal secretions in situ
    • Fabricant ND. (1941). Significance of the pH of nasal secretions in situ. Arch Otolaryngol, 34: 150-153.
    • (1941) Arch Otolaryngol , vol.34 , pp. 150-153
    • Fabricant, N.D.1
  • 17
    • 68549104191 scopus 로고    scopus 로고
    • Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA
    • Fattal E, Barratt G. (2009). Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA. Br J Pharmacol, 157: 179-194.
    • (2009) Br J Pharmacol , vol.157 , pp. 179-194
    • Fattal, E.1    Barratt, G.2
  • 18
    • 34247129541 scopus 로고    scopus 로고
    • In vitro culture of porcine respiratory nasal mucosa explants for studying the interaction of porcine viruses with the respiratory tract
    • Glorieux S, Van den Broeck W, van der Meulen KM, Van Reeth K, Favoreel HW, Nauwynck HJ. (2007). In vitro culture of porcine respiratory nasal mucosa explants for studying the interaction of porcine viruses with the respiratory tract. J Virol Methods, 142: 105-112.
    • (2007) J Virol Methods , vol.142 , pp. 105-112
    • Glorieux, S.1    Van Den Broeck, W.2    Van Der Meulen, K.M.3    Van Reeth, K.4    Favoreel, H.W.5    Nauwynck, H.J.6
  • 19
    • 0035850241 scopus 로고    scopus 로고
    • Characterization of complexes of an antisense oligonucleotide with protamine and poly-L-lysine salts
    • González Ferreiro M, Tillman L, Hardee G, Bodmeier R. (2001). Characterization of complexes of an antisense oligonucleotide with protamine and poly-L-lysine salts. J Control Release, 73: 381-390.
    • (2001) J Control Release , vol.73 , pp. 381-390
    • González Ferreiro, M.1    Tillman, L.2    Hardee, G.3    Bodmeier, R.4
  • 20
    • 0036288129 scopus 로고    scopus 로고
    • Alginate/poly-L-lysine microparticles for the intestinal delivery of antisense oligonucleotides
    • DOI 10.1023/A:1016188312399
    • González Ferreiro M, Tillman LG, Hardee G, Bodmeier R. (2002). Alginate/poly-L-lysine microparticles for the intestinal delivery of antisense oligonucleotides. Pharm Res, 19: 755-764. (Pubitemid 34686733)
    • (2002) Pharmaceutical Research , vol.19 , Issue.6 , pp. 755-764
    • Gonzalez Ferreiro, M.1    Tillman, L.G.2    Hardee, G.3    Bodmeier, R.4
  • 22
    • 0026802436 scopus 로고
    • The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region
    • Gum JR Jr, Hicks JW, Toribara NW, Rothe EM, Lagace RE, Kim YS. (1992). The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region. J Biol Chem, 267: 21375-21383.
    • (1992) J Biol Chem , vol.267 , pp. 21375-21383
    • Gum Jr., J.R.1    Hicks, J.W.2    Toribara, N.W.3    Rothe, E.M.4    Lagace, R.E.5    Kim, Y.S.6
  • 23
    • 0015731657 scopus 로고
    • A sensitive method for localization of disulfide containing peptides in column effluents
    • Habeeb AF. (1973). A sensitive method for localization of disulfide containing peptides in column effluents. Anal Biochem, 56: 60-65.
    • (1973) Anal Biochem , vol.56 , pp. 60-65
    • Habeeb, A.F.1
  • 24
    • 1842486782 scopus 로고    scopus 로고
    • Development and characterization of mucoadhesive microspheres bearing salbutamol for nasal delivery
    • Jain SK, Chourasia MK, Jain AK, Jain RK, Shrivastava AK. (2004). Development and characterization of mucoadhesive microspheres bearing salbutamol for nasal delivery. Drug Deliv, 11: 113-122.
    • (2004) Drug Deliv , vol.11 , pp. 113-122
    • Jain, S.K.1    Chourasia, M.K.2    Jain, A.K.3    Jain, R.K.4    Shrivastava, A.K.5
  • 25
    • 34447528700 scopus 로고    scopus 로고
    • Mucoadhesive multivesicular liposomes as an effective carrier for transmucosal insulin delivery
    • Jain AK, Chalasani KB, Khar RK, Ahmed FJ, Diwan PV. (2007). Mucoadhesive multivesicular liposomes as an effective carrier for transmucosal insulin delivery. J Drug Target, 15: 417-427.
    • (2007) J Drug Target , vol.15 , pp. 417-427
    • Jain, A.K.1    Chalasani, K.B.2    Khar, R.K.3    Ahmed, F.J.4    Diwan, P.V.5
  • 26
    • 0043212012 scopus 로고    scopus 로고
    • Polymeric microspheres for drug delivery to the oral cavity: An in vitro evaluation of mucoadhesive potential
    • Kockisch S, Rees GD, Young SA, Tsibouklis J, Smart JD. (2003). Polymeric microspheres for drug delivery to the oral cavity: an in vitro evaluation of mucoadhesive potential. J Pharm Sci, 92: 1614-1623.
    • (2003) J Pharm Sci , vol.92 , pp. 1614-1623
    • Kockisch, S.1    Rees, G.D.2    Young, S.A.3    Tsibouklis, J.4    Smart, J.D.5
  • 27
    • 1442286264 scopus 로고    scopus 로고
    • Thiomers: Development and in vitro evaluation of a peroral microparticulate peptide delivery system
    • DOI 10.1016/j.ejpb.2003.09.011
    • Krauland AH, Bernkop-Schnürch A. (2004). Thiomers: development and in vitro evaluation of a peroral microparticulate peptide delivery system. Eur J Pharm Biopharm, 57: 181-187. (Pubitemid 38283693)
    • (2004) European Journal of Pharmaceutics and Biopharmaceutics , vol.57 , Issue.2 , pp. 181-187
    • Krauland, A.H.1    Bernkop-Schnurch, A.2
  • 28
    • 0042140521 scopus 로고    scopus 로고
    • Thiolated polymers: Evidence for the formation of disulphide bonds with mucus glycoproteins
    • Leitner VM, Walker GF, Bernkop-Schnürch A. (2003). Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins. Eur J Pharm Biopharm, 56: 207-214.
    • (2003) Eur J Pharm Biopharm , vol.56 , pp. 207-214
    • Leitner, V.M.1    Walker, G.F.2    Bernkop-Schnürch, A.3
  • 29
    • 7444254865 scopus 로고    scopus 로고
    • Nasal delivery of human growth hormone: In vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system
    • Leitner VM, Guggi D, Krauland AH, Bernkop-Schnürch A. (2004). Nasal delivery of human growth hormone: in vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system. J Control Release, 100: 87-95.
    • (2004) J Control Release , vol.100 , pp. 87-95
    • Leitner, V.M.1    Guggi, D.2    Krauland, A.H.3    Bernkop-Schnürch, A.4
  • 30
    • 0027233057 scopus 로고
    • An investigation into the role of water movement and mucus gel dehydration in mucoadhesion
    • Mortazavi SA, Smart JD. (1993). An investigation into the role of water movement and mucus gel dehydration in mucoadhesion. J Control Release, 25: 197-203.
    • (1993) J Control Release , vol.25 , pp. 197-203
    • Mortazavi, S.A.1    Smart, J.D.2
  • 31
    • 0031950147 scopus 로고    scopus 로고
    • Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): Comparison with other delivery routes
    • Nicklin Bayley PL, Giddings J, Craig SJ, Cummins LL, Hastewell JG, Phillips JA. (1998). Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): comparison with other delivery routes. Pharm Res, 15(4): 583-591.
    • (1998) Pharm Res , vol.15 , Issue.4 , pp. 583-591
    • Nicklin Bayley, P.L.1    Giddings, J.2    Craig, S.J.3    Cummins, L.L.4    Hastewell, J.G.5    Phillips, J.A.6
  • 32
    • 0024352077 scopus 로고
    • A novel in situ method to test polymers and coated microparticles for bioadhesion
    • Ranga Rao KV, Buri P. (1989). A novel in situ method to test polymers and coated microparticles for bioadhesion. Int J Pharm, 52: 265-270.
    • (1989) Int J Pharm , vol.52 , pp. 265-270
    • Ranga Rao, K.V.1    Buri, P.2
  • 33
    • 0034023237 scopus 로고    scopus 로고
    • Validation of excised bovine nasal mucosa as in vitro model to study drug transport and metabolic pathways in nasal epithelium
    • Schmidt MC, Simmen D, Hilbe M, Boderke P, Ditzinger G, Sandow J, Lang S, Rubas W, Merkle HP. (2000). Validation of excised bovine nasal mucosa as in vitro model to study drug transport and metabolic pathways in nasal epithelium. J Pharm Sci, 89: 396-407.
    • (2000) J Pharm Sci , vol.89 , pp. 396-407
    • Schmidt, M.C.1    Simmen, D.2    Hilbe, M.3    Boderke, P.4    Ditzinger, G.5    Sandow, J.6    Lang, S.7    Rubas, W.8    Merkle, H.P.9
  • 34
    • 0027376439 scopus 로고
    • Antisense oligonucleotides as therapeutic agents-is the bullet really magical?
    • Stein CA, Cheng YC. (1993). Antisense oligonucleotides as therapeutic agents-is the bullet really magical? Science, 261: 1004-1012.
    • (1993) Science , vol.261 , pp. 1004-1012
    • Stein, C.A.1    Cheng, Y.C.2
  • 36
    • 0033568723 scopus 로고    scopus 로고
    • Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite
    • Takakura K, Beckman JS, MacMillan-Crow LA, Crow JP. (1999). Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite. Arch Biochem Biophys, 369: 197-207.
    • (1999) Arch Biochem Biophys , vol.369 , pp. 197-207
    • Takakura, K.1    Beckman, J.S.2    MacMillan-Crow, L.A.3    Crow, J.P.4
  • 37
    • 0025914835 scopus 로고
    • Double-labelling technique in the evaluation of nasal mucoadhesion of disodium cromoglycate microspheres
    • Vidgren P, Vidgren M, Vainio P, Nuutinen J, Paronen P. (1991). Double-labelling technique in the evaluation of nasal mucoadhesion of disodium cromoglycate microspheres. Int J Pharm, 73: 131-136.
    • (1991) Int J Pharm , vol.73 , pp. 131-136
    • Vidgren, P.1    Vidgren, M.2    Vainio, P.3    Nuutinen, J.4    Paronen, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.