Thiolated polycarbophil as an adjuvant for permeation enhancement in nasal delivery of antisense oligonucleotides

Journal of Pharmaceutical Sciences

Volumn 99, Issue 3, 2010, Pages 1427-1439

  Vetter, A ^a   Martien, R ^b   Bernkop Schnurch A ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b GADJAH MADA UNIVERSITY   (Indonesia)

Author keywords

Cell culture; Drug delivery system; HPLC; Nasal absorption; Permeation enhancement; Phosphorothioate antisense oligonucleotides; Polycarbophil cysteine; Polymer biodegradation; Thiomer; Tight junction

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYSTEINE; DEOXYRIBONUCLEASE I; GLUTATHIONE; NOVEON; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; POLYCARBOPHIL; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CHROMATOGRAPHY; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY TEST; DIFFUSION CHAMBER; DRUG STABILITY; ENZYMATIC ASSAY; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; EPITHELIUM CELL; HISTOLOGY; HUMAN; HUMAN CELL; INCUBATION TIME; NOSE CAVITY; NOSE MUCOSA; NOSE POLYP; RESPIRATORY TRACT MUCOSA;

EID: 76649110178     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21887     Document Type: Article

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