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Volumn 93, Issue 7, 2004, Pages 1682-1691

Thiomers in noninvasive polypeptide delivery: In vitro and in vivo characterization of a polycarbophil-cysteine/glutathione gel formulation for human growth hormone

Author keywords

Glutathione; Human growth hormone (hGH); Noninvasive delivery system; Thiolated polymers

Indexed keywords

DEXTRAN; FLUORESCENT DYE; HUMAN GROWTH HORMONE; MONOMER; NOVEON; PENETRATION ENHANCING AGENT; POLYCARBOPHIL; POLYCARBOPHIL CYSTEINE; POLYCARBOPHIL GLUTATHIONE; THIOMER; UNCLASSIFIED DRUG;

EID: 3042684176     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20069     Document Type: Article
Times cited : (44)

References (33)
  • 1
    • 0035130249 scopus 로고    scopus 로고
    • The biopharmaceutical aspects of nasal mucoadhesive drug delivery
    • Ugwoke MI, Verbeke N, Kinget R. 2001. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J Pharm Pharmacol 53:3-21.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 3-21
    • Ugwoke, M.I.1    Verbeke, N.2    Kinget, R.3
  • 2
  • 3
    • 0035914224 scopus 로고    scopus 로고
    • Absorption of water-soluble compounds with different molecular weights and [Asul.7]-eel calcitonin from various mucosal administration sites
    • Yamamoto A, Iseki T, Ochi-Sugiyama M, Okada N, Fujita T, Muranishi S. 2001. Absorption of water-soluble compounds with different molecular weights and [Asul.7]-eel calcitonin from various mucosal administration sites. J Control Release 76:363-374.
    • (2001) J Control Release , vol.76 , pp. 363-374
    • Yamamoto, A.1    Iseki, T.2    Ochi-Sugiyama, M.3    Okada, N.4    Fujita, T.5    Muranishi, S.6
  • 4
    • 0035800249 scopus 로고    scopus 로고
    • Bioadhesive starch microspheres and absorption enhancing agents act synergistically to enhance the nasal absorption of polypeptides
    • Illum L, Fisher AN, Jabbal-Gill I, Davis SS. 2001. Bioadhesive starch microspheres and absorption enhancing agents act synergistically to enhance the nasal absorption of polypeptides. Int J Pharm 222:109-119.
    • (2001) Int J Pharm , vol.222 , pp. 109-119
    • Illum, L.1    Fisher, A.N.2    Jabbal-Gill, I.3    Davis, S.S.4
  • 5
    • 0037448409 scopus 로고    scopus 로고
    • Influence of multiple nasal administrations of bioadhesive powders on the insulin bioavailability
    • Callens C, Pringels E, Remon JP. 2003. Influence of multiple nasal administrations of bioadhesive powders on the insulin bioavailability. Int J Pharm 250:415-422.
    • (2003) Int J Pharm , vol.250 , pp. 415-422
    • Callens, C.1    Pringels, E.2    Remon, J.P.3
  • 6
    • 0035936973 scopus 로고    scopus 로고
    • Preparation of desmopressin-containing liposomes for intranasal delivery
    • Law SL, Huang KJ, Chou HY. 2001. Preparation of desmopressin-containing liposomes for intranasal delivery. J Control Release 70:375-382.
    • (2001) J Control Release , vol.70 , pp. 375-382
    • Law, S.L.1    Huang, K.J.2    Chou, H.Y.3
  • 7
    • 0029023871 scopus 로고
    • Combined use of 2-hydroxypropyl-cyclodextrin and a lipophilic absorption enhancer in nasal delivery of the LHRH agonist, buserelin acetate, in rats
    • Abe K, Irie T, Adachi H, Uekama K. 1995. Combined use of 2-hydroxypropyl-cyclodextrin and a lipophilic absorption enhancer in nasal delivery of the LHRH agonist, buserelin acetate, in rats. Int J Pharm 123:103-112.
    • (1995) Int J Pharm , vol.123 , pp. 103-112
    • Abe, K.1    Irie, T.2    Adachi, H.3    Uekama, K.4
  • 8
    • 0030576623 scopus 로고    scopus 로고
    • Nasal delivery of octreotide: Absorption enhancement by particulate carrier systems
    • Oechslein CR, Fricker G, Kissel T. 1996. Nasal delivery of octreotide: Absorption enhancement by particulate carrier systems. Int J Pharm 139:25-32.
    • (1996) Int J Pharm , vol.139 , pp. 25-32
    • Oechslein, C.R.1    Fricker, G.2    Kissel, T.3
  • 9
    • 0037459005 scopus 로고    scopus 로고
    • Nasal drug delivery: Possibilities, problems and solutions
    • Illum L. 2003. Nasal drug delivery: Possibilities, problems and solutions. J Control Release 87:187-198.
    • (2003) J Control Release , vol.87 , pp. 187-198
    • Illum, L.1
  • 10
    • 0026586445 scopus 로고
    • Drug metabolism in the nasal mucosa
    • Sarkar MA. 1992. Drug metabolism in the nasal mucosa. Pharm Res 9:1-9.
    • (1992) Pharm Res , vol.9 , pp. 1-9
    • Sarkar, M.A.1
  • 11
    • 0033776833 scopus 로고    scopus 로고
    • In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil
    • Clausen AE, Bernkop-Schnürch A. 2000. In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil. J Pharm Sci 89:1253-1261.
    • (2000) J Pharm Sci , vol.89 , pp. 1253-1261
    • Clausen, A.E.1    Bernkop-Schnürch, A.2
  • 12
    • 0033955625 scopus 로고    scopus 로고
    • Synthesis and characterisation of mucoadhesive thiolated polymers
    • Bernkop-Schnürch A, Steininger S. 2000. Synthesis and characterisation of mucoadhesive thiolated polymers. Int J Pharm 194:239-247.
    • (2000) Int J Pharm , vol.194 , pp. 239-247
    • Bernkop-Schnürch, A.1    Steininger, S.2
  • 13
    • 0035157888 scopus 로고    scopus 로고
    • Thiolation of polycarbophil enhances its inhibition of soluble and intestinal brush border membrane bound aminopeptidase N
    • Bernkop-Schnürch A, Zarti H, Walker GF. 2001. Thiolation of polycarbophil enhances its inhibition of soluble and intestinal brush border membrane bound aminopeptidase N. J Pharm Sci 90:1907-1914.
    • (2001) J Pharm Sci , vol.90 , pp. 1907-1914
    • Bernkop-Schnürch, A.1    Zarti, H.2    Walker, G.F.3
  • 14
    • 0036001390 scopus 로고    scopus 로고
    • The role of glutathione in the permeation enhancing effect of thiolated polymers
    • Clausen AE, Kast CE, Bernkop-Schnürch A. 2002. The role of glutathione in the permeation enhancing effect of thiolated polymers. Pharm Res 19:602-608.
    • (2002) Pharm Res , vol.19 , pp. 602-608
    • Clausen, A.E.1    Kast, C.E.2    Bernkop-Schnürch, A.3
  • 15
    • 0141518595 scopus 로고    scopus 로고
    • Systemic peptide delivery via the stomach: In vivo evaluation of an oral dosage form for salmon calcitonin
    • Guggi D, Krauland AH, Bernkop-Schnürch A. 2003. Systemic peptide delivery via the stomach: In vivo evaluation of an oral dosage form for salmon calcitonin. J Control Release 92:125-135.
    • (2003) J Control Release , vol.92 , pp. 125-135
    • Guggi, D.1    Krauland, A.H.2    Bernkop-Schnürch, A.3
  • 16
    • 0038015493 scopus 로고    scopus 로고
    • Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil
    • Kast CE, Guggi D, Langoth N, Bernkop-Schnürch A. 2002. Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil. Pharm Res 20:931-936.
    • (2002) Pharm Res , vol.20 , pp. 931-936
    • Kast, C.E.1    Guggi, D.2    Langoth, N.3    Bernkop-Schnürch, A.4
  • 17
    • 0033020555 scopus 로고    scopus 로고
    • Polymers with thiol groups: A new generation of mucoadhesive polymers?
    • Bernkop-Schnürch A, Schwarz V, Steininger S. 1999. Polymers with thiol groups: A new generation of mucoadhesive polymers? Pharm Res 16:876-881.
    • (1999) Pharm Res , vol.16 , pp. 876-881
    • Bernkop-Schnürch, A.1    Schwarz, V.2    Steininger, S.3
  • 18
    • 0038402606 scopus 로고    scopus 로고
    • Mucoadhesive ocular insert based on thiolated poly(acrylic acid): Development and in vivo evaluation in humans
    • Hornof M, Weyenberg W, Ludwig A, Bernkop-Schnürch A. 2003. Mucoadhesive ocular insert based on thiolated poly(acrylic acid): Development and in vivo evaluation in humans. J Control Release 89:419-428.
    • (2003) J Control Release , vol.89 , pp. 419-428
    • Hornof, M.1    Weyenberg, W.2    Ludwig, A.3    Bernkop-Schnürch, A.4
  • 20
    • 0035030213 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit
    • Venn RM, Bryant A, Hall GM, Grounds RM. 2001. Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit. Br J Anaesth 86:650-656.
    • (2001) Br J Anaesth , vol.86 , pp. 650-656
    • Venn, R.M.1    Bryant, A.2    Hall, G.M.3    Grounds, R.M.4
  • 21
    • 0002086622 scopus 로고
    • Physical chemical analysis of percutaneous absorption process from creams and ointments
    • Higuchi T. 1960. Physical chemical analysis of percutaneous absorption process from creams and ointments. J Soc Cosmet Chem 11:85-97.
    • (1960) J Soc Cosmet Chem , vol.11 , pp. 85-97
    • Higuchi, T.1
  • 22
    • 0025076267 scopus 로고
    • The effect of sodium tauro-24,25-dihydrofusidate on the nasal absorption of human growth hormone in three animal models
    • Baldwin PA, Klingbeil CK, Grimm CJ, Longenecker JP. 1990. The effect of sodium tauro-24,25-dihydrofusidate on the nasal absorption of human growth hormone in three animal models. Pharm Res 7:547-552.
    • (1990) Pharm Res , vol.7 , pp. 547-552
    • Baldwin, P.A.1    Klingbeil, C.K.2    Grimm, C.J.3    Longenecker, J.P.4
  • 23
    • 0028577536 scopus 로고
    • Epithelial transport and bioavailability of intranasally administered human growth hormone formulated with the absorption enhancers didecanoyl-L-alpha-phosphatidylcholine and alpha-cyclodextrin in rabbits
    • Agerholm C, Bastholm L, Johansen PB, Nielsen MH, Elling F. 1994. Epithelial transport and bioavailability of intranasally administered human growth hormone formulated with the absorption enhancers didecanoyl-L-alpha- phosphatidylcholine and alpha-cyclodextrin in rabbits. J Pharm Sci 83:1706-1711.
    • (1994) J Pharm Sci , vol.83 , pp. 1706-1711
    • Agerholm, C.1    Bastholm, L.2    Johansen, P.B.3    Nielsen, M.H.4    Elling, F.5
  • 25
    • 0037202213 scopus 로고    scopus 로고
    • Evaluation of drug release from gels on pig nasal mucosa in a horizontal Ussing chamber
    • Osth K, Paulsson M, Bjork E, Edsman K. 2002. Evaluation of drug release from gels on pig nasal mucosa in a horizontal Ussing chamber. J Control Release 83:377-388.
    • (2002) J Control Release , vol.83 , pp. 377-388
    • Osth, K.1    Paulsson, M.2    Bjork, E.3    Edsman, K.4
  • 26
    • 0035066209 scopus 로고    scopus 로고
    • In vitro evaluation of matrix tablets based on thiolated polycarbophil
    • Clausen AE, Bernkop-Schnürch A. 2001. In vitro evaluation of matrix tablets based on thiolated polycarbophil. Pharm Ind 63:312-317.
    • (2001) Pharm Ind , vol.63 , pp. 312-317
    • Clausen, A.E.1    Bernkop-Schnürch, A.2
  • 27
    • 0036229558 scopus 로고    scopus 로고
    • Thiolated polymers: Self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion
    • Marschütz MK, Bernkop-Schnürch A. 2002. Thiolated polymers: Self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion. Eur J Pharm Sci 15:387-394.
    • (2002) Eur J Pharm Sci , vol.15 , pp. 387-394
    • Marschütz, M.K.1    Bernkop-Schnürch, A.2
  • 28
    • 0042140521 scopus 로고    scopus 로고
    • Thiolated polymers: Evidence for the formation of disulphide bonds with mucus glycoproteins
    • Leitner VM, Walker GF, Bernkop-Schnürch A. 2003. Thiolated polymers: Evidence for the formation of disulphide bonds with mucus glycoproteins. Eur J Pharm Biopharm 56:207-214.
    • (2003) Eur J Pharm Biopharm , vol.56 , pp. 207-214
    • Leitner, V.M.1    Walker, G.F.2    Bernkop-Schnürch, A.3
  • 29
    • 0034750031 scopus 로고    scopus 로고
    • Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity
    • Tannenbaum GS, Choi HK, Gurd W, Waxman DJ. 2001. Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity. Endocrinology 142:4599-4606.
    • (2001) Endocrinology , vol.142 , pp. 4599-4606
    • Tannenbaum, G.S.1    Choi, H.K.2    Gurd, W.3    Waxman, D.J.4
  • 30
    • 0032528453 scopus 로고    scopus 로고
    • Nasal absorption kinetics of human growth hormone enhanced by acylcarnitines in rats
    • Kagatani S, Inaba N, Fukui M, Sonobe T. 1998. Nasal absorption kinetics of human growth hormone enhanced by acylcarnitines in rats. Int J Pharm 169:245-253.
    • (1998) Int J Pharm , vol.169 , pp. 245-253
    • Kagatani, S.1    Inaba, N.2    Fukui, M.3    Sonobe, T.4
  • 31
    • 0028032731 scopus 로고
    • An investigation of the effect of anaesthetics on the nasal absorption of insulin in rats
    • Mayor S, Illum L. 1994. An investigation of the effect of anaesthetics on the nasal absorption of insulin in rats. Proc Int Symp Control Release Bioact Mater 21:334-335.
    • (1994) Proc Int Symp Control Release Bioact Mater , vol.21 , pp. 334-335
    • Mayor, S.1    Illum, L.2
  • 33
    • 0029760056 scopus 로고    scopus 로고
    • Nasal delivery. The use of animal models to predict performance in man
    • Illum L. 1996. Nasal delivery. The use of animal models to predict performance in man. J Drug Target 3:427-442.
    • (1996) J Drug Target , vol.3 , pp. 427-442
    • Illum, L.1


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