Release of mitochondrial apoptogenic factors and cell death are mediated by CK2 and NADPH oxidase

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 4, 2012, Pages 720-730

  Kim, Gab Seok ^a   Jung, Joo Eun ^a   Narasimhan, Purnima ^a   Sakata, Hiroyuki ^a   Yoshioka, Hideyuki ^a   Song, Yun Seon ^a   Okami, Nobuya ^a   Chan, Pak H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Casein kinase 2; middle cerebral artery occlusion; NADPH oxidase; NOX2; reactive oxygen species

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; APOPTOSIS INDUCING FACTOR; CASEIN KINASE 2ALPHA; CASEIN KINASE 2BETA; CASEIN KINASE II; CINNAMIC ACID DERIVATIVE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; GLYCOPROTEIN GP 91; HISTONE H2AX; POLY(ADENOSINE DIPHOSPHATE RIBOSE); REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DNA DAMAGE; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME RELEASE; KNOCKOUT MOUSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; REPERFUSION; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; APOPTOSIS INDUCING FACTOR; BRAIN INFARCTION; CASEIN KINASE II; CELL DEATH; CELLS, CULTURED; CINNAMATES; CYTOCHROMES C; DEOXYGUANINE NUCLEOTIDES; DNA DAMAGE; ENZYME ACTIVATION; FEMALE; HISTONES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; NADPH OXIDASE; NERVE TISSUE PROTEINS; PHOSPHORYLATION; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

EID: 84859428789     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.176     Document Type: Article

References (34)

1. Ames BN (1989) Endogenous oxidative DNA damage, aging, and cancer. Free Radic Res Commun 7:121-8 (Pubitemid 19281959)
2. Andrabi SA, Kim NS, Yu S-W, Wang H, Koh DW, Sasaki M, Klaus JA, Otsuka T, Zhang Z, Koehler RC, Hurn PD, Poirier GG, Dawson VL, Dawson TM (2006) Poly(ADPribose) (PAR) polymer is a death signal. Proc Natl Acad Sci USA 103:18308-13 (Pubitemid 44871654)
3. Breusing N, Grune T (2008) Regulation of proteasomemediated protein degradation during oxidative stress and aging. Biol Chem 389:203-9 (Pubitemid 351329027)
4. Chan PH (2005) Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke. Ann NY Acad Sci 1042:203-9 (Pubitemid 40967640)
5. Chan PH, Epstein CJ, Kinouchi H, Kamii H, Chen SF, Carlson E, Gafni J, Yang G, Reola L (1996) Neuroprotective role of CuZn-superoxide dismutase in ischemic brain damage. Adv Neurol 71:271-80
6. Cregan SP, Fortin A, MacLaurin JG, Callaghan SM, Cecconi F, Yu S-W, Dawson TM, Dawson VL, Park DS, Kroemer G, Slack RS (2002) Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol 158:507-17 (Pubitemid 34851709)
7. Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellechia M, Blomgren K, Plesnila N (2005) Apoptosisinducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci 25:10262-72 (Pubitemid 41636223)
8. Epstein CJ, Avraham KB, Lovett M, Smith S, Elroy-Stein O, Rotman G, Bry C, Groner Y (1987) Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc Natl Acad Sci USA 84:8044-8
9. Esposito E, Cuzzocrea S (2009) Superoxide, NO, peroxynitrite and PARP in circulatory shock and inflammation. Front Biosci 14:263-96
10. Fujimura M, Morita-Fujimura Y, Murakami K, Kawase M, Chan PH (1998) Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 18:1239-47 (Pubitemid 28509838)
11. Giulivi C, Pacifici RE, Davies KJA (1994) Exposure of hydrophobic moieties promotes the selective degradation of hydrogen peroxide-modified hemoglobin by the multicatalytic proteinase complex, proteasome. Arch Biochem Biophys 311:329-41 (Pubitemid 24220152)
12. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R,Wahlgren N, Toni D (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359:1317-29
13. Jung JE, Kim GS, Chen H, Maier CM, Narasimhan P, Song YS, Niizuma K, Katsu M, Okami N, Yoshioka H, Sakata H, Goeders CE, Chan PH (2010) Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol Neurobiol 41:172-9
14. Jung JE, Kim GS, Narasimhan P, Song YS, Chan PH (2009) Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia. J Neurosci 29:7003-14
15. Jung T, Bader N, Grune T (2007) Oxidized proteins: intracellular distribution and recognition by the proteasome. Arch Biochem Biophys 462:231-7 (Pubitemid 46856318)
16. Kang H, Jung J-W, Kim MK, Chung JH (2009) CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One 4:e6611
17. Kim GS, Jung JE, Niizuma K, Chan PH (2009) CK2 is a novel negative regulator of NADPH oxidase and a neuroprotectant in mice after cerebral ischemia. J Neurosci 29:14779-89
18. Kirkland RA, Franklin JL (2001) Evidence for redox regulation of cytochrome c release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition. J Neurosci 21:1949-63 (Pubitemid 32221379)
19. Kitazawa M, Wagner JR, Kirby ML, Anantharam V, Kanthasamy AG (2002) Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. J Pharmacol Exp Ther 302:26-35 (Pubitemid 34680417)
20. Kondo K, Obitsu S, Ohta S, Matsunami K, Otsuka H, Teshima R (2010) Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by a-tocopherol and MEK inhibition. J Biol Chem 285:13079-91
21. Moskowitz MA, Lo EH, Iadecola C (2010) The science of stroke: mechanisms in search of treatments. Neuron 67:181-98
22. Murakami K, Kondo T, Kawase M, Li Y, Sato S, Chen SF, Chan PH (1998) Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 18:205-13 (Pubitemid 28046782)
23. Narasimhan P, Fujimura M, Noshita N, Chan PH (2003) Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia. Mol Brain Res 113:28-36 (Pubitemid 36579063)
24. Rajamohan SB, Pillai VB, Gupta M, Sundaresan NR, Birukov KG, Samant S, Hottiger MO, Gupta MP (2009) SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol 29:4116-29
25. Sugawara T, Fujimura M, Morita-Fujimura Y, Kawase M, Chan PH (1999) Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia. J Neurosci 19:RC39
26. Suh SW, Hamby AM, Gum ET, Shin BS, Won SJ, Sheline CT, Chan PH, Swanson RA (2008) Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death. J Cereb Blood Flow Metab 28:1697-706
27. Suzuki K (2009) Anti-oxidants for therapeutic use: why are only a few drugs in clinical use? Adv Drug Deliv Rev 61:287-9
28. Wang Y, Dawson VL, Dawson TM (2009) Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol 218:193-202
29. Wang Y, Kim NS, Haince J-F, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM (2011) Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal 4:ra20
30. Won MH, Kang T-C, Jeon G-S, Lee J-C, Kim D-Y, Choi E-M, Lee KH, Choi CD, Chung M-H, Cho SS (1999) Immunohistochemical detection of oxidative DNA damage induced by ischemia-reperfusion insults in gerbil hippocampus in vivo. Brain Res 836:70-8 (Pubitemid 29354472)
31. Yu S-W, Andrabi SA,Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL (2006) Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci USA 103:18314-9 (Pubitemid 44871655)
32. Yu S-W, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL (2002) Mediation of poly(ADP-ribose) polymerase-1- dependent cell death by apoptosis-inducing factor. Science 297:259-63 (Pubitemid 34761289)
33. Yu S-W, Wang Y, Frydenlund DS, Ottersen OP, Dawson VL, Dawson TM (2009) Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release. ASN Neuro 1:275-81
34. Zhang Y, Zhang X, Park TS, Gidday JM (2005) Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation. J Cereb Blood Flow Metab 25:868-77 (Pubitemid 40905614)