Identification of benzoylisoquinolines as potential anti-Chagas agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 8, 2012, Pages 2587-2594

  Byler, Kendall G ^a   Brito Arias, Marco ^b   Marquez Navarro, Adrian ^b   Nogueda Torres, Benjamin ^b   Torres Bustillos, Luis G ^b   Martínez Mayorga, Karina ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Benzoyl isoquinolones; Chemical space; Structural similarity; Trypanosoma cruzi

Indexed keywords

3 BENZOYL 4 HYDROXYISOQUINOLIN 1(2H)ONE; 3 BENZOYLISOQUINOLINE DERIVATIVE; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; ISOQUINOLINE DERIVATIVE; MOLECULAR SCAFFOLD; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA BASE; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; IN VITRO STUDY; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRINCIPAL COMPONENT ANALYSIS; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

CHAGAS DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOQUINOLINES; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PRINCIPAL COMPONENT ANALYSIS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA CRUZI;

PROTOZOA; TRYPANOSOMA CRUZI;

EID: 84859423617     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.046     Document Type: Article

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