Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 11, 2008, Pages 5932-5938

  Martínez Mayorga, Karina ^a   Medina Franco, Jose L ^a   Giulianotti, Marc A ^a   Pinilla, Clemencia ^a   Dooley, Colette T ^a   Appel, Jon R ^a   Houghten, Richard A ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Mixture based combinatorial libraries; Molecular similarity; Multi fusion similarity maps; Opioid receptor ligands; Structure activity relationships

Indexed keywords

BENZYL DERIVATIVE; GUANIDINE DERIVATIVE; KAPPA OPIATE RECEPTOR; OPIATE;

ARTICLE; COMBINATORIAL LIBRARY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTATIONAL BIOLOGY; GUANIDINE; NUCLEIC ACID CONFORMATION; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; THERMODYNAMICS;

EID: 44449163419     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.061     Document Type: Article

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