Alsophinase, a new P-III metalloproteinase with α-fibrinogenolytic and hemorrhagic activity from the venom of the rear-fanged Puerto Rican Racer Alsophis portoricensis (Serpentes: Dipsadidae)

Biochimie

Volumn 94, Issue 5, 2012, Pages 1189-1198

  Weldon, Caroline L ^a   MacKessy, Stephen P ^a  

^a UNIVERSITY OF NORTHERN COLORADO   (United States)

Author keywords

Bond specificity; Colubrid; Inhibitor; Mass spectrometry; Toxin

Indexed keywords

1,10 PHENANTHROLINE; ADAM PROTEIN; ALANINE; FIBRINOGEN; INSULIN; LEUCINE; METALLOPROTEINASE; POLYPEPTIDE; PROTEIN ALSOPHINASE; SNAKE VENOM; UNCLASSIFIED DRUG;

ALSOPHIS PORTORICENSIS; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BIOCATALYSIS; BLEEDING; CONTROLLED STUDY; ENZYME ISOLATION; FIBRINOGENOLYSIS; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; ION EXCHANGE CHROMATOGRAPHY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OXIDATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN PURIFICATION; PUERTO RICO; SNAKE;

AMINO ACID SEQUENCE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FIBRINOGEN; HEMORRHAGE; METALLOPROTEASES; MICE; MOLECULAR SEQUENCE DATA; PHENANTHROLINES; SEQUENCE HOMOLOGY, AMINO ACID; SNAKE VENOMS; SNAKES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ALSOPHIS; ALSOPHIS PORTORICENSIS; COLUBRIDAE; MUS; PHILODRYAS OLFERSII; SERPENTES; VIPERIDAE;

EID: 84859422460     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.02.006     Document Type: Article

References (58)

1. L.G. Jia, K. Shimokawa, J.B. Bjarnason, and J.W. Fox Snake venom metalloproteinases: structure, function and relationship to the ADAMs family of proteins Toxicon 34 1996 1269 1276
2. J.B. Bjarnason, and J.W. Fox Snake venom metalloendopeptidases: reprolysins Methods Enzymol. 248 1995 345 368
3. J.W. Fox, and S.M.T. Serrano Snake venom metalloproteinases S.P. Mackessy, Handbook of Venoms and Toxins of Reptiles 2009 CRC Press Boca Raton, FL 95 113
4. J.M. Gutiérrez, M. Romero, J. Nunez, F. Chavez, G. Borkow, and M. Ovadia Skeletal muscle necrosis and regeneration after injection of BaH1, a hemorrhagic metalloproteinase isolated from the venom of the snake Bothrops asper (Terciopelo) Exp. Mol. Pathol. 62 1995 28 41
5. A. Rucavado, B. Lomonte, M. Ovadia, and J.M. Gutiérrez Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom Exp. Mol. Pathol. 63 1995 186 199
6. A. Franceschi, A. Rucavado, N. Mora, and J.M. Gutiérrez Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper Toxicon 38 2000 63 77
7. E.N. Baramova, J.D. Shannon, J.B. Bjarnason, and J.W. Fox Degradation of extracellular matrix proteins by hemorrhagic metalloproteinases Arch. Biochem. Biophys. 275 1989 63 71
8. J.B. Bjarnason, and J.W. Fox Hemorrhagic metalloproteinases from snake venoms Pharmacol. Ther. 62 1994 325 372
9. J.M. Gutiérrez, A. Rucavado, T. Escalante, and C. Diaz Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanism involved in microvessel damage Toxicon 45 2005 997 1011
10. J.M. Gutiérrez, and A. Rucavado Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage Biochime 82 2000 841 850
11. S.P. Mackessy Venom composition in rattlesnakes: trends and biological significance W.K. Hayes, K.R. Beaman, M.D. Cardwell, S.P. Bush, The Biology of Rattlesnakes 2008 Loma Linda University Press Loma Linda, CA 495 510
12. M.T. Assakura, A.P. Reichl, and F.R. Mandlebaum Isolation and characterization of five fibrin(ogen)olytic enzymes from the venom of Philodryas olfersii (green snake) Toxicon 32 1994 819 831
13. R.E. Hill, and S.P. Mackessy Characterization of venom (Duvernoy's secretion) from twelve species of colubrid snakes with partial sequence of four venom proteins Toxicon 38 2000 1663 1687
14. A.S. Kamiguti, R.D. Theakston, N. Sherman, and J.W. Fox Mass spectrophotometric evidence for P-III/P-IV metalloproteinases in the venom of the Boomslang (Dispholidus typus) Toxicon 38 2000 1613 1620
15. S.P. Mackessy Biochemistry and pharmacology of colubrid snake venoms J. Toxicol. - Toxin Rev. 21 2002 43 83
16. K. Komori, M. Konishi, Y. Maruta, M. Toriba, A. Sakai, A. Matsuda, T. Hori, M. Nakatani, N. Minamino, and T. Akizawa Characterization of a novel metalloproteinase in Duvernoy's gland of Rhabdophis tigrinus tigrinus J. Toxicol. Sci. 31 2006 157 168
17. M.E. Peichoto, P. Teibler, S.P. Mackessy, L. Leiva, O. Acosta, L.R.C. Gonalves, A.M. Tanaka-Azevedo, and M.L. Santoro Purification and biological activities of patagonfibrase, an α-fibrinogenase from Philodryas patagoniensis snake venom Biochim. Biophys. Acta 1770 2007 810 819
18. J. Durban, P. Juárez, Y. Angulo, B. Lomonte, M. Flores-Diaz, A. Alape-Girón, M. Sasa, L. Sanz, J.M. Gutiérrez, J. Dopazo, A. Conesa, and J.J. Calvete Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing BMC Genomics 12 2011 259 274
19. D.R. Rokyta, K.P. Wray, A.R. Lemmon, E. Moriarty Lemmon, and S.B. Caudle A high-throughput venom-gland transcriptome for the Eastern Diamondback Rattlesnake (Crotalus adamanteus) and evidence for pervasive positive selection across toxin classes Toxicon 57 2011 657 671
20. L. Sanz, H.L. Gibbs, S.P. Mackessy, and J.J. Calvete Venom proteomes of closely related Sistrurus rattlesnakes with divergent diets J. Proteome Res. 5 2006 2098 2112
21. B. Zhang, Q. Liu, W. Yin, X. Zhang, Y. Huang, Y. Luo, P. Qiu, X. Su, J. Yu, S. Hu, and G. Yan Transcriptome analysis of Deinagkistrodon acutus venomous gland focusing on cellular structure and functional aspects using expressed sequence tags BMC Genomics 7 2006 152 162
22. J.M. Gutiérrez Snakebite envenomations in Central America S.P. Mackessy, Handbook of Venoms and Toxins of Reptiles 2009 CRC Press Boca Raton, FL 491 507
23. J.M. Gutiérrez, D. Williams, H.W. Fan, and D.A. Warrell Snakebite envenoming from a global perspective: towards an integrated approach Toxicon 56 2010 1223 1235
24. T. Escalante, A. Rucavado, J.W. Fox, and J.M. Gutiérrez Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases J. Proteomics 74 2011 1781 1794
25. C. Baldo, C. Jamora, N. Yamanouye, T.M. Zorn, and A.M. Moura-da-Silva Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis PLoS Negl. Trop. Dis. 4 2010 e727 10.1371/journal.pntd.0000727
26. T.S. Kang, D. Georgieva, N. Genov, M.T. Murakami, M. Sinha, R.P. Kumar, P. Kaur, S. Kumar, S. Dey, S. Sharma, A. Vrielink, C. Betzel, S. Takeda, R.K. Arni, T.P. Singh, and R.M. Kini Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis FEBS J. 278 2011 4544 4576
27. S. Takeda, H. Takeya, and S. Iwanaga Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM/ADAMTS family proteins Biochim. Biophys. Acta 1824 2011 164 176 10.1016/j.bbapap.2011.04.009
28. Q. Zhou, R.P. Sherwin, C. Parrish, V. Richters, S.G. Groshen, D. Tsao-Wei, and F.S. Markland Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression Breast Cancer Res. Treat. 61 2000 249 260
29. S. Sarray, N. Srairi, J. Luis, J. Marvaldi, M. El Ayeb, and N. Marrakchi Lebecetin, a C-lectin protein from the venom of Macrovipera lebetina that inhibits platelet aggregation and adhesion of cancerous cells Haemostasis 31 2001 173 176
30. G. Murphy The ADAMs: signalling scissors in the tumour microenvironment Nat. Rev. Cancer 8 2008 929 941
31. S. Mochizuki, and Y. Okada ADAMs in cancer cell proliferation and progression Cancer Sci. 98 2007 621 628
32. A. Barun, G. Perry, R.W. Henderson, and R. Powell Alsophis portoricensis anegadae (Squamata: Colubridae): morphometric characteristics, activity patterns, and habitat use Copeia 2007 2007 93 100
33. C.L. Weldon, and S.P. Mackessy Biological and proteomic analysis of venom from the Puerto Rican Racer (Alsophis portoricensis: Dipsadidae) Toxicon 55 2010 558 569
34. G. Hegeman Enzymatic constitution of Alsophis saliva and its biological implications Brevioria 134 1961 1 8
35. R. Thomas, J.A. Prieto-Hernandez, The use of venom by the Puerto Rican snake, Alsophis portoricensis. Decimo Simposio de Recur sos Naturales, Departamento de Recursos Naturales, 1983 (1985), 13-22a.
36. S.P. Mackessy, N.M. Sixberry, W.H. Heyborne, and T. Fritts Venom of the brown treesnake, Boiga irregularis: ontogenetic shifts and taxa-specific toxicity Toxicon 47 2006 537 548
37. S.D. Aird, and N.J. da Silva Jr. Comparative enzymatic composition of Brazilian coral snake (Micrurus) venoms Comp. Biochem. Physiol. 99 1991 287 294
38. S.P. Mackessy Characterization of the major metalloprotease isolated from the venom of the Northern Pacific Rattlesnake, Crotalus viridis oreganus Toxicon 34 1996 277 1285
39. C. Ouyang, and T.F. Huang Alpha and beta-fibrinogenases from Trimeresurus gramineus snake venom Biochim. Biophys. Acta 571 1979 270 283
40. S.M. Munekiyo, and S.P. Mackessy Effects of temperature and storage conditions on the electrophoretic, toxic and enzymatic stability of venom components Comp. Biochem. Physiol. 119B 1998 119 127
41. B.M. Dunn Determination of protease mechanism R.J. Beynon, J.S. Bond, Proteolytic Enzymes: A Practical Approach 2001 Oxford University Press New York 77 104
42. T.J. Milne, G. Abbenante, J.D.A. Tyndall, J. Halliday, and R.J. Lewis Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily J. Biol. Chem. 278 2003 31105 31110
43. J.B. Bjarnason, and J.W. Fox Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox) Biochemistry 22 1983 3770 3778
44. B.G. Fry, H. Scheib, L. van der Weerd, B. Young, J. McNaughtan, S.F.R. Ramjan, N. Vidal, R.E. Poelmann, and J.A. Norman Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia) Mol. Cell. Proteomics 7 2008 215 246
45. F.S. Markland Snake venoms and the hemostatic system Toxicon 36 1998 1749 1800
46. S.P. Mackessy Kallikrein-like and thrombin-like proteases from the venom of juvenile Northern Pacific Rattlesnakes (Crotalus viridis oreganus) J. Nat. Toxins 2 1993 223 239
47. S.P. Mackessy Thrombin-like enzymes in snake venoms R.M. Kini, M.A. McLane, K. Clemetson, F.S. Markland, T. Morita, Toxins and Hemostasis: From Bench to Bedside 2010 Springer Science Dordrecht, NL 519 557
48. F.S. Markland Inventory of α- and β-fibrinogenases from snake venoms Thromb. Haemost. 65 1991 1277 1285
49. A.S. Kamiguti, J.R. Slupsky, M. Zuzel, and C.R. Hay Properties of fibrinogen cleaved by jararhagin, a metalloproteinase from the venom of Bothrops jararaca Thromb. Haemost. 72 1994 244 249
50. M.V. Mazzi, S. Marcussi, G.B. Carlos, R.G. Stabeli, J.J. Franco, F.K. Ticli, A.C. Cintra, S.C. Franca, A.M. Soares, and S.V. Sampaio A new hemorrhagic metalloproteinase from Bothrops jararacussu snake venom: isolation and biochemical characterization Toxicon 44 2004 215 223
51. J.W. Fox, R. Campbell, L. Beggerly, and J.B. Bjarnason Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom Eur. J. Biochem. 156 1986 65 72
52. A.P. Reichl, S.M. Serrano, C.A. Sampaio, and F.R. Mandelbaum Hydrolytic specificity of three basic proteinases isolated from the venom of Bothrops moojeni for the B-chain of oxidized insulin Toxicon 31 1993 1479 1482
53. M.E. Peichoto, O. Acosta, L. Leiva, P. Teibler, S. Marunak, and R. Ruiz Muscle and skin necrotizing and edema-forming activities of Duvernoy's gland secretion of the xenodontine colubrid Philodryas patagoniensis from the north-east of Argentina Toxicon 44 2004 589 596
54. O. Acosta de Perez, L. Leiva de Villa, M.E. Peichoto, S. Marunak, R. Ruiz, P. Teibler, C. Gay, and L. Rey Edematogenic and myotoxic activities of the Duvernoy's gland secretions of Philodryas olfersii from the north-east region of Argentina Biocell 27 2003 363 370
55. A.S. Kamiguti, R.D. Theakston, H. Desmond, and R.A. Hutton Systemic haemorrhage in rats induced by a haemorrhagic fraction from Bothrops jararaca venom Toxicon 29 1991 1097 1105
56. A.T. Ching, M.M. Rocha, A.F. Paes Leme, D.C. Pimenta, M.F. Furtado, S.M. Serrano, P.L. Ho, and I.L. Junqueira-de-Azevedo Some aspects of the venom proteome of the Colubridae snake Philodryas olfersii revealed from a Duvernoy's (venom) gland transcriptome FEBS Lett. 580 2006 4417 4422
57. M.E. Peichoto, A. Paes Leme, B. Pauletti, I. Correia Batista, S.P. Mackessy, O. Acosta, and M. Santoro Autolysis at the disintegrin domain of patagonfibrase, a metalloproteinase from Philodryas patagoniensis (Patagonia Green Racer; Dipsadidae) venom Biochim. Biophys. Acta - Proteins and Proteomics 1804 2010 1937 1942
58. S.P. Mackessy Venom ontogeny in the Pacific rattlesnake Crotalus viridis helleri and C. v. oreganus Copeia 1988 1988 92 101