메뉴 건너뛰기




Volumn 153, Issue 4, 2012, Pages 1806-1816

Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; FIBROBLAST GROWTH FACTOR 23; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; OXYGENASE;

EID: 84859385905     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1831     Document Type: Article
Times cited : (44)

References (51)
  • 1
    • 20444418706 scopus 로고    scopus 로고
    • MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression
    • DOI 10.1016/j.cbpa.2005.04.004, PII S1367593105000578, Combinatorial Chemistry
    • Johnson GL, Dohlman HG, Graves LM 2005 MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression. Curr Opin Chem Biol 9:325-331 (Pubitemid 40804557)
    • (2005) Current Opinion in Chemical Biology , vol.9 , Issue.3 , pp. 325-331
    • Johnson, G.L.1    Dohlman, H.G.2    Graves, L.M.3
  • 7
    • 34547803312 scopus 로고    scopus 로고
    • Rickets due to hereditary abnormalities of vitamin D synthesis or action
    • Glorieux FH, Pettifor JM, Juppner H, eds. San Diego: Academic Press
    • Portale AA, Miller WL 2003 Rickets due to hereditary abnormalities of vitamin D synthesis or action. In: Glorieux FH, Pettifor JM, Juppner H, eds. Pediatric bone. San Diego: Academic Press; 583-598
    • (2003) Pediatric Bone , pp. 583-598
    • Portale, A.A.1    Miller, W.L.2
  • 8
    • 0942279588 scopus 로고    scopus 로고
    • Renal Phosphate Wasting Disorders: Clinical Features and Pathogenesis
    • DOI 10.1053/j.semnephrol.2003.08.016
    • Brame LA, White KE, Econs MJ 2004 Renal phosphate wasting disorders: clinical features and pathogenesis. Semin Nephrol 24:39-47 (Pubitemid 38141843)
    • (2004) Seminars in Nephrology , vol.24 , Issue.1 , pp. 39-47
    • Brame, L.A.1    White, K.E.2    Econs, M.J.3
  • 11
    • 0032893855 scopus 로고    scopus 로고
    • X-linked hypophosphataemia: A homologous disorder in humans and mice
    • DOI 10.1093/ndt/14.2.333
    • Tenenhouse HS 1999 X-linked hypophosphataemia: a homologous disorder in humans and mice. Nephrol Dial Transplant 14:333-341 (Pubitemid 29062787)
    • (1999) Nephrology Dialysis Transplantation , vol.14 , Issue.2 , pp. 333-341
    • Tenenhouse, H.S.1
  • 12
  • 19
    • 0018961064 scopus 로고
    • Abnormal vitamin D metabolism in the X-linked hypophosphatemic mouse
    • Meyer Jr RA, Gray RW, Meyer MH 1980 Abnormal vitamin D metabolism in the X-linked hypophosphatemic mouse. Endocrinology 107:1577-1581 (Pubitemid 10029756)
    • (1980) Endocrinology , vol.107 , Issue.5 , pp. 1577-1581
    • Meyer Jr., R.A.1    Cray, R.W.2    Meyer, M.H.3
  • 20
    • 0019434180 scopus 로고
    • Serum 1,25-dihydroxyvitamin D concentration in hypophosphatemic vitamin D-resistant rickets
    • Delvin EE, Glorieux FH 1981 Serum 1,25-dihydroxyvitamin D concentrations in hypophosphatemic vitamin D-resistant rickets. Calcif Tissue Int 33:173-175 (Pubitemid 11100010)
    • (1981) Calcified Tissue International , vol.33 , Issue.2 , pp. 173-175
    • Delvin, E.E.1    Glorieux, F.H.2
  • 21
    • 9644303231 scopus 로고    scopus 로고
    • Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    • DOI 10.1016/j.matbio.2004.09.007, PII S0945053X04001155
    • Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, Jüppner H, Lanske B 2004 Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol 23:421-432 (Pubitemid 39576657)
    • (2004) Matrix Biology , vol.23 , Issue.7 , pp. 421-432
    • Sitara, D.1    Razzaque, M.S.2    Hesse, M.3    Yoganathan, S.4    Taguchi, T.5    Erben, R.G.6    Juppner, H.7    Lanske, B.8
  • 22
    • 33847095086 scopus 로고    scopus 로고
    • Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration
    • DOI 10.1007/s00280-006-0323-5
    • Brown AP, Carlson TC, Loi CM, Graziano MJ 2007 Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration. Cancer Chemother Pharmacol 59:671-679 (Pubitemid 46295133)
    • (2007) Cancer Chemotherapy and Pharmacology , vol.59 , Issue.5 , pp. 671-679
    • Brown, A.P.1    Carlson, T.C.G.2    Loi, C.-M.3    Graziano, M.J.4
  • 24
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases - The major drug targets of the twenty-first century?
    • Cohen P 2002 Protein kinases - the major drug targets of the twenty-first century? Nat Rev Drug Discov 1:309-315 (Pubitemid 37361447)
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.4 , pp. 309-315
    • Cohen, P.1
  • 25
    • 36049037977 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1α-hydroxylase expression in vitro
    • DOI 10.1152/ajprenal.00463.2006
    • Perwad F, Zhang MY, Tenenhouse HS, Portale AA 2007 Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1α-hydroxylase expression in vitro. Am J Physiol Renal Physiol 293:F1577-F1583 (Pubitemid 350085994)
    • (2007) American Journal of Physiology - Renal Physiology , vol.293 , Issue.5
    • Perwad, F.1    Zhang, M.Y.H.2    Tenenhouse, H.S.3    Portale, A.A.4
  • 26
    • 0036155775 scopus 로고    scopus 로고
    • Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1α-hydroxylase gene expression in the proximal renal tubule
    • DOI 10.1210/en.143.2.587
    • Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL, Portale AA 2002 Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1α-hydroxylase gene expression in the proximal renal tubule. Endocrinology 143:587-595 (Pubitemid 34107213)
    • (2002) Endocrinology , vol.143 , Issue.2 , pp. 587-595
    • Zhang, M.Y.H.1    Wang, X.2    Wang, J.T.3    Compagnone, N.A.4    Mellon, S.H.5    Olson, J.L.6    Tenenhouse, H.S.7    Miller, W.L.8    Portale, A.A.9
  • 27
    • 34250745769 scopus 로고    scopus 로고
    • Isolation of renal proximal tubular brush-border membranes
    • DOI 10.1038/nprot.2007.156, PII NPROT.2007.156
    • Biber J, Stieger B, Stange G, Murer H 2007 Isolation of renal proximal tubular brush-border membranes. Nat Protoc 2:1356-1359 (Pubitemid 46952317)
    • (2007) Nature Protocols , vol.2 , Issue.6 , pp. 1356-1359
    • Biber, J.1    Stieger, B.2    Stange, G.3    Murer, H.4
  • 28
    • 55749104922 scopus 로고    scopus 로고
    • The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development
    • Chang W, Tu C, Chen TH, Bikle D, Shoback D 2008 The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal 1:ra1
    • (2008) Sci Signal , vol.1
    • Chang, W.1    Tu, C.2    Chen, T.H.3    Bikle, D.4    Shoback, D.5
  • 29
    • 12344262661 scopus 로고    scopus 로고
    • Skeletal overexpression of gremlin impairs bone formation and causes osteopenia
    • DOI 10.1210/en.2004-0766
    • Gazzerro E, Pereira RC, Jorgetti V, Olson S, Economides AN, Canalis E 2005 Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology 146:655-665 (Pubitemid 40129821)
    • (2005) Endocrinology , vol.146 , Issue.2 , pp. 655-665
    • Gazzerro, E.1    Pereira, R.C.2    Jorgetti, V.3    Olson, S.4    Economides, A.N.5    Canalis, E.6
  • 31
    • 0032482367 scopus 로고    scopus 로고
    • Stress-induced immediate-early gene, egr-1, involves activation of p38/JNK1
    • Lim CP, Jain N, Cao X 1998 Stress-induced immediate-early gene, egr-1, involves activation of p38/JNK1. Oncogene 16:2915-2926 (Pubitemid 28383276)
    • (1998) Oncogene , vol.16 , Issue.22 , pp. 2915-2926
    • Lim, C.P.1    Jain, N.2    Cao, X.3
  • 32
    • 0035469890 scopus 로고    scopus 로고
    • Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor α expression by inducing Elk-1 phosphorylation and Egr-1 expression
    • Guha M, O'Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, Stern D, Mackman N 2001 Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor α expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood 98:1429-1439
    • (2001) Blood , vol.98 , pp. 1429-1439
    • Guha, M.1    O'Connell, M.A.2    Pawlinski, R.3    Hollis, A.4    McGovern, P.5    Yan, S.F.6    Stern, D.7    Mackman, N.8
  • 33
    • 3042634460 scopus 로고    scopus 로고
    • Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis
    • DOI 10.1210/en.2003-1768
    • Larsson T, Marsell R, Schipani E, Ohlsson C, Ljunggren O, Tenenhouse HS, Jüppner H, Jonsson KB 2004 Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia and disturbed phosphate homeostasis. Endocrinology 145:3087-3094 (Pubitemid 38829975)
    • (2004) Endocrinology , vol.145 , Issue.7 , pp. 3087-3094
    • Larsson, T.1    Marsell, R.2    Schipani, E.3    Ohlsson, C.4    Ljunggren, O.5    Tenenhouse, H.S.6    Juppner, H.7    Jonsson, K.B.8
  • 35
    • 0026736322 scopus 로고
    • Effect of dietary phosphate deprivation and supplementation of recipient mice on bone formation by transplanted cells from normal and X-linked hypophosphatemic mice
    • Ecarot B, Glorieux FH, Desbarats M, Travers R, Labelle L 1992 Effect of dietary phosphate deprivation and supplementation of recipient mice on bone formation by transplanted cells from normal and X-linked hypophosphatemic mice. J Bone Miner Res 7:523-530
    • (1992) J Bone Miner Res , vol.7 , pp. 523-530
    • Ecarot, B.1    Glorieux, F.H.2    Desbarats, M.3    Travers, R.4    Labelle, L.5
  • 36
    • 0020187970 scopus 로고
    • Healing of bone lesions with 1,25-dihydroxyvitamin D3 in the young X-linked hypophosphatemic male mouse
    • Marie PJ, Travers R, Glorieux FH 1982 Healing of bone lesions with 1,25-dihydroxyvitamin D3 in the young X-linked hypophosphatemic male mouse. Endocrinology 111:904-911
    • (1982) Endocrinology , vol.111 , pp. 904-911
    • Marie, P.J.1    Travers, R.2    Glorieux, F.H.3
  • 37
    • 0020028750 scopus 로고
    • Bone response to phosphate and vitamin D metabolites in the hypophosphatemic male mouse
    • Marie PJ, Travers R, Glorieux FH 1982 Bone response to phosphate and vitamin D metabolites in the hypophosphatemic male mouse. Calcif Tissue Int 34:158-164 (Pubitemid 12128643)
    • (1982) Calcified Tissue International , vol.34 , Issue.2 , pp. 158-164
    • Marie, P.J.1    Travers, R.2    Glorieux, F.H.3
  • 40
    • 58449088759 scopus 로고    scopus 로고
    • Regulation of phosphate transport in proximal tubules
    • Biber J, Hernando N, Forster I, Murer H 2008 Regulation of phosphate transport in proximal tubules. Pflugers Arch 18:77-84
    • (2008) Pflugers Arch , vol.18 , pp. 77-84
    • Biber, J.1    Hernando, N.2    Forster, I.3    Murer, H.4
  • 41
    • 0037008747 scopus 로고    scopus 로고
    • Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway
    • DOI 10.1074/jbc.M202527200
    • Yamashita T, Konishi M, Miyake A, Inui K, Itoh N 2002 Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway. J Biol Chem 277:28265-28270 (Pubitemid 34966781)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.31 , pp. 28265-28270
    • Yamashita, T.1    Konishi, M.2    Miyake, A.3    Inui, K.-I.4    Itoh, N.5
  • 43
    • 37149047561 scopus 로고    scopus 로고
    • Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice
    • DOI 10.1152/ajpendo.00396.2007
    • Liu S, Tang W, Zhou J, Vierthaler L, Quarles LD 2007 Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice. Am J Physiol Endocrinol Metab 293:E1636-E1644 (Pubitemid 350255114)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.293 , Issue.6
    • Liu, S.1    Tang, W.2    Zhou, J.3    Vierthaler, L.4    Quarles, L.D.5
  • 44
    • 79952161016 scopus 로고    scopus 로고
    • Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype
    • Li H, Martin A, David V, Quarles LD 2011 Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype. Am J Physiol Endocrinol Metab 300:E508-E517
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Li, H.1    Martin, A.2    David, V.3    Quarles, L.D.4
  • 46
    • 0036479315 scopus 로고    scopus 로고
    • Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype
    • DOI 10.1074/jbc.M107707200
    • Liu S, Guo R, Tu Q, Quarles LD 2002 Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype. J Biol Chem 277:3686-3697 (Pubitemid 34953243)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.5 , pp. 3686-3697
    • Liu, S.1    Guo, R.2    Tu, Q.3    Darryl, Q.L.4
  • 47
    • 20844431717 scopus 로고    scopus 로고
    • Overexpression of human PHEX under the human β-actin promoter does not fully rescue the Hyp mouse phenotype
    • DOI 10.1359/JBMR.050212
    • Erben RG, Mayer D, Weber K, Jonsson K, Jüppner H, Lanske B 2005 Overexpression of human PHEX under the human β-actin promoter does not fully rescue the Hyp mouse phenotype. J Bone Miner Res 20:1149-1160 (Pubitemid 40863802)
    • (2005) Journal of Bone and Mineral Research , vol.20 , Issue.7 , pp. 1149-1160
    • Erben, R.G.1    Mayer, D.2    Weber, K.3    Jonsson, K.4    Juppner, H.5    Lanske, B.6
  • 48
    • 12244263475 scopus 로고    scopus 로고
    • Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression
    • DOI 10.1210/me.2002-0113
    • Bai X, Miao D, Panda D, Grady S, McKee MD, Goltzman D, Karaplis AC 2002 Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression. Mol Endocrinol 16:2913-2925 (Pubitemid 36020666)
    • (2002) Molecular Endocrinology , vol.16 , Issue.12 , pp. 2913-2925
    • Bai, X.1    Miao, D.2    Panda, D.3    Grady, S.4    McKee, M.D.5    Goltzman, D.6    Karaplis, A.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.