Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4 + T cells and γδ T cells

Journal of Immunology

Volumn 188, Issue 7, 2012, Pages 3107-3115

  Lukens, John R ^a   Barr, Maggie J ^a   Chaplin, David D ^b   Chi, Hongbo ^a   Kanneganti, Thirumala Devi ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 23; MYELOID DIFFERENTIATION FACTOR 88; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ALPHA BETA T LYMPHOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL LINEAGE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GAMMA DELTA T LYMPHOCYTE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SYNTHESIS REGULATION; T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INFLAMMASOMES; INTERLEUKIN-1BETA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, INTERLEUKIN-1; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTE SUBSETS;

EID: 84859381897     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103308     Document Type: Article

References (29)

1. Chu, C. Q., S. Wittmer, and D. K. Dalton. 2000. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J. Exp. Med. 192: 123-128. (Pubitemid 30470813)
2. Haak, S., A. L. Croxford, K. Kreymborg, F. L. Heppner, S. Pouly, B. Becher, and A. Waisman. 2009. IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 119: 61-69.
3. Codarri, L., G. Gyülvészi, V. Tosevski, L. Hesske, A. Fontana, L. Magnenat, T. Suter, and B. Becher. 2011. RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 12: 560-567.
4. El-Behi, M., B. Ciric, H. Dai, Y. Yan, M. Cullimore, F. Safavi, G. X. Zhang, B. N. Dittel, and A. Rostami. 2011. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol. 12: 568-575.
5. Kroenke, M. A., S. W. Chensue, and B. M. Segal. 2010. EAE mediated by a non- IFN-γ/non-IL-17 pathway. Eur. J. Immunol. 40: 2340-2348.
6. Ponomarev, E. D., L. P. Shriver, K. Maresz, J. Pedras-Vasconcelos, D. Verthelyi, and B. N. Dittel. 2007. GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. J. Immunol. 178: 39-48. (Pubitemid 46039660)
7. Dinarello, C. A. 2011. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117: 3720-3732.
8. Lukens, J. R., V. D. Dixit, and T. D. Kanneganti. 2011. Inflammasome activation in obesity-related inflammatory diseases and autoimmunity. Discov. Med. 12: 65-74.
9. Shaw, P. J., M. F. McDermott, and T. D. Kanneganti. 2011. Inflammasomes and autoimmunity. Trends Mol. Med. 17: 57-64.
10. Shaw, P. J., J. R. Lukens, S. Burns, H. Chi, M. A. McGargill, and T. D. Kanneganti. 2010. Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. J. Immunol. 184: 4610-4614.
11. Shornick, L. P., P. De Togni, S. Mariathasan, J. Goellner, J. Strauss-Schoenberger, R. W. Karr, T. A. Ferguson, and D. D. Chaplin. 1996. Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone. J. Exp. Med. 183: 1427-1436. (Pubitemid 26134286)
12. Furlan, R., G. Martino, F. Galbiati, P. L. Poliani, S. Smiroldo, A. Bergami, G. Desina, G. Comi, R. Flavell, M. S. Su, and L. Adorini. 1999. Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J. Immunol. 163: 2403-2409. (Pubitemid 29399158)
13. Gris, D., Z. Ye, H. A. Iocca, H. Wen, R. R. Craven, P. Gris, M. Huang, M. Schneider, S. D. Miller, and J. P. Ting. 2010. NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J. Immunol. 185: 974-981.
14. Lalor, S. J., L. S. Dungan, C. E. Sutton, S. A. Basdeo, J. M. Fletcher, and K. H. Mills. 2011. Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity. J. Immunol. 186: 5738-5748.
15. Sutton, C., C. Brereton, B. Keogh, K. H. Mills, and E. C. Lavelle. 2006. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203: 1685-1691. (Pubitemid 44036274)
16. Chung, Y., S. H. Chang, G. J. Martinez, X. O. Yang, R. Nurieva, H. S. Kang, L. Ma, S. S. Watowich, A. M. Jetten, Q. Tian, and C. Dong. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30: 576-587.
17. McCandless, E. E., M. Budde, J. R. Lees, D. Dorsey, E. Lyng, and R. S. Klein. 2009. IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis. J. Immunol. 183: 613-620.
18. Cua, D. J., and C. M. Tato. 2010. Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 10: 479-489.
19. Ben-Sasson, S. Z., S. Caucheteux, M. Crank, J. Hu-Li, and W. E. Paul. 2011. IL-1 acts on T cells to enhance the magnitude of in vivo immune responses. Cytokine 56: 122-125.
20. Nakanishi, K., T. Yoshimoto, H. Tsutsui, and H. Okamura. 2001. Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19: 423-474. (Pubitemid 32368042)
21. Kufer, T. A., and P. J. Sansonetti. 2011. NLR functions beyond pathogen recognition. Nat. Immunol. 12: 121-128.
22. Zhou, S., E. A. Kurt-Jones, A. M. Cerny, M. Chan, R. T. Bronson, and R. W. Finberg. 2009. MyD88 intrinsically regulates CD4 T-cell responses. J. Virol. 83: 1625-1634.
23. Rahman, A. H., W. Cui, D. F. Larosa, D. K. Taylor, J. Zhang, D. R. Goldstein, E. J. Wherry, S. M. Kaech, and L. A. Turka. 2008. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J. Immunol. 181: 3804-3810.
24. LaRosa, D. F., J. S. Stumhofer, A. E. Gelman, A. H. Rahman, D. K. Taylor, C. A. Hunter, and L. A. Turka. 2008. T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc. Natl. Acad. Sci. USA 105: 3855-3860. (Pubitemid 351723489)
25. Khameneh, H. J., S. A. Isa, L. Min, F. W. Nih, and C. Ruedl. 2011. GM-CSF signalling boosts dramatically IL-1 production. PLoS ONE 6: e23025.
26. Kayagaki, N., S. Warming, M. Lamkanfi, L. Vande Walle, S. Louie, J. Dong, K. Newton, Y. Qu, J. Liu, S. Heldens, et al. 2011. Non-canonical inflammasome activation targets caspase-11. Nature 479: 117-121.
27. Hayday, A. C. 2009. Gammadelta T cells and the lymphoid stress-surveillance response. Immunity 31: 184-196.
28. Sutton, C. E., S. J. Lalor, C. M. Sweeney, C. F. Brereton, E. C. Lavelle, and K. H. Mills. 2009. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31: 331-341.
29. Kebir, H., I. Ifergan, J. I. Alvarez, M. Bernard, J. Poirier, N. Arbour, P. Duquette, and A. Prat. 2009. Preferential recruitment of interferon-gamma- expressing TH17 cells in multiple sclerosis. Ann. Neurol. 66: 390-402.