Interleukin-1 receptor mediates the interplay between CD4+ T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjögren's syndrome

Laboratory Investigation

Volumn 92, Issue 4, 2012, Pages 556-570

  Chen, Ying Ting ^a   Lazarev, Stanislav ^a   Bahrami, Ahmad F ^a   Noble, Lisa B ^a   Chen, Feeling Y T ^a   Zhou, Delu ^a   Gallup, Marianne ^a   Yadav, Mahesh ^a   McNamara, Nancy A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

autoimmunity; IL 1R1; lacrimal exocrinopathy; ocular surface mucosa; Sj gren's syndrome; squamous metaplasia

Indexed keywords

INTERLEUKIN 1 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; KERATINIZATION; LACRIMAL GLAND; LYMPHOCYTIC INFILTRATION; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SJOEGREN SYNDROME; SQUAMOUS CELL METAPLASIA;

EID: 84859356898     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.189     Document Type: Article

References (46)

1. Nelson JD, Wright JC. Conjunctival goblet cell densities in ocular surface disease. Arch Ophthalmol 1984;102:1049-1051. (Pubitemid 14083489)
2. Nishida K, Yamanishi K, Yamada K, et al. Epithelial hyperproliferation and transglutaminase 1 gene expression in Stevens-Johnson syndrome conjunctiva. Am J Pathol 1999;154:331-336. (Pubitemid 29094083)
3. Tseng SC. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology 1985;92:728-733. (Pubitemid 15059999)
4. Pflugfelder SC, Tseng SC, Sanabria O, et al. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea 1998;17:38-56. (Pubitemid 28047008)
5. Research in dry eye. Report of the research subcommittee of the international dry eye WorkShop (2007). Ocul Surf 2007;5:179-193.
6. Adamson 3rd TC, Fox RI, Frisman DM, et al. Immunohistologic analysis of lymphoid infiltrates in primary Sjögren's syndrome using monoclonal antibodies. J Immunol 1983;130:203-208. (Pubitemid 13172654)
7. Skopouli FN, Fox PC, Galanopoulou V, et al. T cell subpopulations in the labial minor salivary gland histopathologic lesion of Sjögren's syndrome. J Rheumatol 1991;18:210-214.
8. El Annan J, Chauhan SK, Ecoiffier T, et al. Characterization of effector T cells in dry eye disease. Invest Ophthalmol Vis Sci 2009;50: 3802-3807.
9. Niederkorn JY, Stern ME, Pflugfelder SC, et al. Desiccating stress induces T cell-mediated Sjögren's syndrome-like lacrimal keratoconjunctivitis. J Immunol 2006;176:3950-3957. (Pubitemid 44264372)
10. Siemasko KF, Gao J, Calder VL, et al. In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation. Invest Ophthalmol Vis Sci 2008;49:5434-5440.
11. Zheng X, de Paiva CS, Li DQ, et al. Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci 2010;51:3083-3091.
12. Chauhan SK, El Annan J, Ecoiffier T, et al. Autoimmunity in dry eye is due to resistance of Th17 to treg suppression. J Immunol 2009;182: 1247-1252.
13. De Paiva CS, Villarreal AL, Corrales RM, et al. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci 2007;48:2553-2560. (Pubitemid 351261205)
14. Chen YT, Li S, Nikulina K, et al. Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye. Mol Vis 2009;15:563-576.
15. Chen YT, Nikulina K, Lazarev S, et al. Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndrome. Am J Pathol 2010;177:1333-1343.
16. Eller MS, Yaar M, Ostrom K, et al. A role for interleukin-1 in epidermal differentiation: regulation by expression of functional versus decoy receptors. J Cell Sci 1995;108(Part 8):2741-2746.
17. Solomon A, Dursun D, Liu Z, et al. Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci 2001;42:2283-2292. (Pubitemid 32848857)
18. Fabre EJ, Bureau J, Pouliquen Y, et al. Binding sites for human interleukin 1 alpha, gamma interferon and tumor necrosis factor on cultured fibroblasts of normal cornea and keratoconus. Curr Eye Res 1991;10:585-592.
19. Rosenbaum JT, Planck ST, Huang XN, et al. Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. Invest Ophthalmol Vis Sci 1995;36:2151-2155.
20. Li S, Gallup M, Chen YT, et al. Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. Invest Ophthalmol Vis Sci 2010;51:2466-2475.
21. Deknuydt F, Bioley G, Valmori D, et al. IL-1beta and IL-2 convert human treg into T(H)17 cells. Clin Immunol 2009;131:298-307.
22. Matsuki T, Nakae S, Sudo K, et al. Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis. Int Immunol 2006;18:399-407. (Pubitemid 43160152)
23. Sutton C, Brereton C, Keogh B, et al. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006;203:1685-1691. (Pubitemid 44036274)
24. Ben-Sasson SZ, Hu-Li J, Quiel J, et al. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci USA 2009;106:7119-7124.
25. Li S, Nikulina K, DeVoss J, et al. Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. Invest Ophthalmol Vis Sci 2008;49:34-41.
26. Chen YT, Li W, Hayashida Y, et al. Human amniotic epithelial cells as novel feeder layers for promoting ex vivo expansion of limbal epithelial progenitor cells. Stem Cells 2007;25:1995-2005. (Pubitemid 47258177)
27. Devoss JJ, Shum AK, Johannes KP, et al. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol 2008;181:4072-4079.
28. Reksten TR, Jonsson MV, Szyszko EA, et al. Cytokine and autoantibody profiling related to histopathological features in primary Sjögren's syndrome. Rheumatology (Oxford) 2009;48:1102-1106.
29. Arend WP, Malyak M, Guthridge CJ, et al. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 1998;16:27-55. (Pubitemid 28183358)
30. van Exel E, Eikelenboom P, Comijs H, et al. Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. Arch Gen Psychiatry 2009;66:1263-1270.
31. Curtsinger JM, Mescher MF. Inflammatory cytokines as a third signal for T cell activation. Curr Opin Immunol 2010;22:333-340.
32. Kawasaki S, Kawamoto S, Yokoi N, et al. Up-regulated gene expression in the conjunctival epithelium of patients with Sjögren's syndrome. Exp Eye Res 2003;77:17-26. (Pubitemid 36776270)
33. Byeseda SE, Burns AR, Dieffenbaugher S, et al. ICAM-1 is necessary for epithelial recruitment of gammadelta T cells and efficient corneal wound healing. Am J Pathol 2009;175:571-579.
34. Chen WS, Lin KC, Chen CH, et al. Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjögren's syndrome. J Rheumatol 2009;36:989-996.
35. Gao J, Morgan G, Tieu D, et al. ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjögren's syndrome-like MRL/lpr mice. Exp Eye Res 2004;78: 823-835. (Pubitemid 38252959)
36. Nakamura T, Nishida K, Dota A, et al. Elevated expression of transglutaminase 1 and keratinization-related proteins in conjunctiva in severe ocular surface disease. Invest Ophthalmol Vis Sci 2001;42: 549-556. (Pubitemid 32206891)
37. Zhang X, Chen W, De Paiva CS, et al. Interferon-{gamma} exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci 2011;52:6279-6285.
38. Zhang X, Chen W, De Paiva CS, et al. Desiccating stress induces CD4(+) T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-gamma. Am J Pathol 2011;179:1807-1814.
39. Schaumburg CS, Siemasko KF, De Paiva CS, et al. Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol 2011;187:3653-3662.
40. Chen YT, Lazarev S, Gallup M, et al. Interleukin-1 is a determinant for ocular mucin alteration in autoimmune regulator-mediated keratinizing squamous metaplasia. ARVO Meet Abstr 2010;51:1561.
41. Chen YY, Wang HH, Antonioli DA, et al. Significance of acid-mucin-positive nongoblet columnar cells in the distal esophagus and gastroesophageal junction. Hum Pathol 1999;30:1488-1495. (Pubitemid 30032926)
42. Pflugfelder SC, Huang AJ, Feuer W, et al. Conjunctival cytologic features of primary Sjögren's syndrome. Ophthalmology 1990;97:985-991. (Pubitemid 20251125)
43. Ishida Y, Kondo T, Kimura A, et al. Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway. J Immunol 2006;176:5598-5606.
44. Li DQ, Tseng SC. Differential regulation of keratinocyte growth factor and hepatocyte growth factor/scatter factor by different cytokines in human corneal and limbal fibroblasts. J Cell Physiol 1997;172:361-372. (Pubitemid 27376202)
45. Ishida Y, Kondo T, Kimura A, et al. Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway. J Immunol 2006;176:5598-5606.
46. Moore JE, McMullen TC, Campbell IL, et al. The inflammatory milieu associated with conjunctivalized cornea and its alteration with IL-1 RA gene therapy. Invest Ophthalmol Vis Sci 2002;43:2905-2915. (Pubitemid 34977039)