A novel peroxy radical based oxidative stressing system for ranking the oxidizability of drug substances

Journal of Pharmaceutical Sciences

Volumn 95, Issue 9, 2006, Pages 2014-2028

  Harmon, Paul A ^a   Kosuda, Kathryn ^a,b   Nelson, Eric ^a   Mowery, Mark ^a,c   Reed, Robert A ^a,d  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Patheon Pharmacueticals Inc   (United States)

^d XenoPort Inc   (United States)

Author keywords

Chemical stability; Forced degradation; HPLC; Oxidation; Peroxy radical; Preformulation

Indexed keywords

ALKADIENE; BENZOIC ACID; BENZYL ALCOHOL; COLECALCIFEROL; CUMENE; FERRIC CHLORIDE; FERROUS ION; HYDROPEROXIDE; PEROXY RADICAL; POLYSORBATE 80; SOLUBILIZER;

ARTICLE; CHEMICAL STRUCTURE; DRUG ELIMINATION; DRUG OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION;

EID: 33748929319     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20668     Document Type: Article

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