The clinicopathological significance of REIC expression in colorectal carcinomas

Histology and Histopathology

Volumn 27, Issue 6, 2012, Pages 735-743

  Wang, Wei ^a   Zhu, Wan ^a   Xu, Xiao Yan ^a   Nie, Xiao Cui ^a   Yang, Xue ^a   Xing, Ya Nan ^a   Yu, Miao ^a   Liu, Yun Peng ^a   Takano, Yasuo ^b   Zheng, Hua Chuan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b KANAGAWA CANCER CENTER   (Japan)

Author keywords

Carcinogenesis; Colorectal carcinoma; Prognosis; Progression; Reic

Indexed keywords

DKK3 PROTEIN, HUMAN; SIGNAL PEPTIDE; TUMOR MARKER;

ADENOCARCINOMA; ADENOMA; ARTICLE; CANCER STAGING; CELL STRAIN HCT116; CELL STRAIN HT29; COLORECTAL TUMOR; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; METABOLISM; MORTALITY; MULTIVARIATE ANALYSIS; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RISK FACTOR; TISSUE MICROARRAY; WESTERN BLOTTING;

ADENOCARCINOMA; ADENOMA; BLOTTING, WESTERN; COLORECTAL NEOPLASMS; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIER ESTIMATE; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REAL-TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RISK FACTORS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84859304138     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Abarzua F., Sakaguchi M., Takaishi M., Nasu Y., Kurose K., Ebara S., Miyazaki M., Namba M., Kumon H. and Huh N.H (2005). Adenovirus-mediated overexpression of REIC/Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-Jun-NH2-kinase. Cancer Res. 65, 9617-9622.
2. Abarzua F., Sakaguchi M., Tanimoto R., Sonegawa H., Li D.W., Edamura K., Kobayashi T., Watanabe M., Kashiwakura Y., Kaku H., Saika T., Nakamura K., Nasu Y., Kumon H. and Huh N.H. (2007). Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3. Int. J. Mol. Med. 20, 37-43.
3. Abarzua F., Kashiwakura Y., Takaoka M., Watanabe M., Ochiai K., Sakaguchi M., Iwawaki T., Tanimoto R., Nasu Y., Huh N.H. and Kumon H. (2008). An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis. Biochem. Biophys. Res. Commun. 375, 614-618.
4. Amit S., Hatzubai A., Birman Y., Andersen J.S., Ben-Shushan E., Mann M., Ben-Neriah Y. and Alkalay I. (2002). Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev. 16, 1066-1076.
5. American Cancer Society (2005). Colorectal cancer facts and figures. American Cancer Society, 2005 edition.
6. Ding Z., Qian Y.B., Zhu LX. and Xiong Q.R. (2009). Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma. World J. Gastroenterol. 15, 2595-2601.
7. Edamura K., Nasu Y., Takaishi M., Kobayashi T., Abarzua F., Sakaguchi M., Kashiwakura Y., Ebara S., Saika T., Watanabe M., Huh N.H. and Kumon H. (2007). Adenovirus-mediated REIC/Dkk-3 gene transfer inhibits tumor growth and metastasis in an orthotopic prostate cancer model. Cancer Gene Ther. 14, 765-772.
8. Fong D., Hermann M., Untergasser G., Pirkebner D., Draxl A., Heitz M., Moser P., Margreiter R., Hengster P. and Amberger A. (2009). Dkk-3 expression in the tumor endothelium: a novel prognostic marker of pancreatic adenocarcinomas. Cancer Sci. 100, 1414-1420.
9. Hamilton S.R. and Aaltonen L.A. (2000). WHO classification of tumors: pathology and genetics of tumors of the digestive system. IARC press, lyon.
10. Hsieh S.Y., Hsieh P.S., Chiu C.T. and Chen W.Y. (2004). Dickkopf- 3/REIC functions as a suppressor gene of tumor growth. Oncogene 23, 9183-9189.
11. Katase N., Gunduz M., Beder L., Gunduz E., Lefeuvre M., Hatipoglu OF., Borkosky S.S., Tamamura R., Tominaga S., Yamanaka N., Shimizu K., Nagai N. and Nagatsuka H. (2008). Deletion at Dickkopf (dkk)-3 locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas. Oncol. Res. 17, 273-282.
12. Kobayashi K., Ouchida M., Tsuji T., Hanafusa H., Miyazaki M., Namba M., Shimizu N. and Shimizu K. (2002). Reduced expression of the REIC/Dkk-3 gene by promoter-hypermethylation in human tumor cells. Gene 282, 151-158.
13. Kumada T., Tsuneyama K., Hatta H., Ishizawa S. and Takano Y. (2004). Improved 1-h rapid immunostaining method using intermittent microwave irradiation: practicability based on 5 years application in Toyama Medical and Pharmaceutical University Hospital. Mod. Pathol. 17, 1141 -1149.
14. Kurose K., Sakaguchi M., Nasu Y., Ebara S., Kaku H., Kariyama R., Arao Y., Miyazaki M., Tsushima T., Namba M., Kumon H. and Huh N.H. (2004). Decreased expression of REIC/Dkk-3 in human renal clear cell carcinoma. J. Urol. 171, 1314-1318.
15. Lee E.J., Jo M., Rho S.B., Park K, Yoo Y.N., Park J., Chae M., Zhang W. and Lee J.H. (2009). Dkk3, downregulated in cervical cancer, functions as a negative regulator of beta-catenin, Int. J. Cancer 124, 287-97.
16. Mühlmann G., Untergasser G., Zitt M., Zitt M., Maier H., Mikuz G., Kronberger I.E., Haffner M.C., Gunsilius E. and Ofner D. (2010). Immunohistochemically detectable dickkopf-3 expression in tumor vessels predicts survival in gastric cancer. Virchows Arch. 456, 635-646.
17. Nozaki I., Tsuji T., Iijima O., Ohmura Y., Andou A., Miyazaki M., Shimizu N. and Namba M. (2011). Reduced expression of REIC/Dkk-3 gene in non-small cell lung cancer. Int. J. Oncol. 19, 117-121.
18. Qin S.Y., Liu Z.M., Jiang H.X., Ge L.Y., Tao L., Tang G.D. and Nie H.M. (2006). Detection of reduced mRNA expression of REIC/Dkk-3 gene in human primary hepatocellular carcinoma. Zhonghua Gan Zang Bing Za Zhi. 14, 775-776.
19. Sato H., Suzuki H., Toyota M., Nojima M., Maruyama R., Sasaki S., Takagi H., Sogabe Y., Sasaki Y., Idogawa M., Sonoda T., Mori M., Imai K., Tokino T. and Shinomura Y. (2007). Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. Carcinogenesis. 28, 2459-66.
20. Sobin L.H. and Wittekind C.H. (2000). TNM Classification of Malignant Tumours. 6th edition, John Wiley & Sons. Hoboken, New Jersey, USA
21. Tanimoto R., Abarzua F., Sakaguchi M., Takaishi M., Nasu Y., Kumon H. and Huh N.H. (2007). REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer. Int. J. Mol. Med. 19, 363-368.
22. Tanimoto R., Sakaguchi M., Abarzua F., Kataoka K., Kurose K., Murata H., Nasu Y., Kumon H. and Huh N.H. (2010). Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to genetherapeutic overexpression of REIC/Dkk-3. Int. J. Cancer 126, 1562-1569.
23. Tsuji T., Miyazaki M., Sakaguchi M., Inoue Y. and Namba M. (2000). A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. Biochem. Biophys. Res. Commun. 268, 20-24.
24. Tsuji T., Nozaki I., Miyazaki M., Sakaguchi M., Pu H., Hamazaki Y., Iijima O. and Namba M. (2001). Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas. Biochem. Biophys. Res. Commun. 289, 257-263.
25. Untergasser G., Steurer M., Zimmermann M., Hermann M., Kern J., Amberger A., Gastl G. and Gunsilius E. (2008). The Dickkopfhomolog 3 is expressed in tumor endothelial cells and supports capillary formation. Int. J. Cancer 122, 1539-47.
26. Urakami S., Shiina H., Enokida H., Kawakami T., Kawamoto K., Hirata H., Tanaka Y., Kikuno N., Nakagawa M., Igawa M. and Dahiya R. (2006). Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. Clin. Cancer Res. 12, 2109-2116.
27. Veeck J., Wild P.J., Fuchs T., Schüffler P.J., Hartmann A., Knüchel R. and Dahl E. (2009). Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. BMC Cancer 9, 217.
28. Xing Y.N., Yang X., Xu X.Y., Zheng Y., Xu H.M., Takano Y., Zheng H.C.(2011)The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression. Hum. Pathol. 42, 25-35.
29. Yang B., Du Z., Gao Y.T., Lou C., Zhang S.G., Bai T., Wang Y.J. and Song W.Q. (2010). Methylation of Dickkopf-3 as a prognostic factor in cirrhosis-related hepatocellular carcinoma. World J. Gastroenterol. 16, 755-763.
30. Yoshida D., Kono S., Moore M.A., Toyomura K., Nagano J., Mizoue T., Mibu R., Tanaka M., Kakeji Y., Maehara Y., Okamura T., Ikejiri K., Futami K., Yasunami Y., Maekawa T., Takenaka K., Ichimiya H. and Imaizumi N. (2007). Colorectal polypectomy and risk of colorectal cancer by subsite: the Fukuoka Colorectal Cancer study. Jpn. J. Clin. Oncol. 37, 597-602.
31. Yue W., Sun Q., Dacic S., Landreneau R.J., Siegfried J.M., Yu J. and Zhang L. (2008). Downregulation of Dkk3 activates betacatenin/ TCF-4 signaling in lung cancer, Carcinogenesis 29, 84-92.
32. Yu J., Tao Q., Cheng Y.Y., Lee K.Y., Ng S.S., Cheung K.F., Tian L., Rha S.Y., Neumann U., Röcken C., Ebert M.P., Chan F.K. and Sung J.J. (2009). Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer. Cancer 115, 49-60.
33. Zheng H.C., Sun J.M., Wei Z.L., Yang X.F., Zhang Y.C. and Xin Y. (2003). Expression of Fas ligand and caspase-3 contributes to formation of immune escape in gastric cancer. World J. Gastroenterol. 9, 1415-1420.
34. Zheng H.C., Xia P., Xu X.Y., Takahashi H. and Takano Y. (2011). The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas. Hum. Pathol. 42, 424-433.
35. Zitt M., Untergasser G., Amberger A., Moser P., Stadlmann S., Zitt M., Müller H.M., Mühlmann G., Perathoner A., Margreiter R., Gunsilius E. and Ofner D. (2008). Dickkopf-3 as a new potential marker for neoangiogenesis in colorectal cancer: expression in cancer tissue and adjacent non-cancerous tissue. Dis. Markers 24, 101-109.