An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis

Biochemical and Biophysical Research Communications

Volumn 375, Issue 4, 2008, Pages 614-618

  Abarzua, Fernando ^a   Kashiwakura, Yuji ^a   Takaoka, Munenori ^a   Watanabe, Masami ^a   Ochiai, Kazuhiko ^a   Sakaguchi, Masakiyo ^a   Iwawaki, Takao ^b   Tanimoto, Ryuta ^a   Nasu, Yasutomo ^a   Huh, Nam ho ^a   Kumon, Hiromi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Japan Science and Technology Agency   (Japan)

Author keywords

Cationic biodegradable polymer; ER stress; Gene therapy; REIC Dkk 3; Truncation form

Indexed keywords

AMINO ACID; DKK3 PROTEIN; DNA; POLYMER; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DKK3 GENE; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NONVIRAL GENE THERAPY; PLASMID; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; GENE THERAPY; GENES, TUMOR SUPPRESSOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; POLYMERS; PROSTATIC NEOPLASMS; SEQUENCE DELETION; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 51449117648     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.08.079     Document Type: Article

References (16)

1. Mao B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., and Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 (2001) 321-325
2. Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 25 (2006) 7469-7481
3. Tsuji T., Miyazaki M., Sakaguchi M., Inoue Y., and Namba M. A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. Biochem. Biophys. Res. Commun. 268 (2000) 20-24
4. Tsuji T., Nozaki I., Miyazaki M., Sakaguchi M., Pu H., Hamazaki Y., Iijima O., and Namba M. Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas. Biochem. Biophys. Res. Commun. 289 (2001) 257-263
5. 2-kinase. Cancer Res. 65 (2005) 9617-9622
6. Y. Kashiwakura, K. Ochiai, M. Watanabe, F. Abarzua, M. Sakaguchi, M. Takaoka, R. Tanimoto, Y. Nasu, N-h. Huh, H. Kumon, Down-regulation of inhibition of differentiation-1 via activation of ATF3 and Smad regulates REIC/dickkopf-3-induced apoptosis, Cancer Res., in press.
7. Bernard L., Babajko S., Binoux M., and Ricort J.M. The amino-terminal region of insulin-like growth factor binding protein-3, (1-95)IGFBP-3, induces apoptosis of MCF-7 breast carcinoma cells. Biochem. Biophys. Res. Commun. 293 (2002) 55-60
8. Djordjevic J.T., Bieri S., Smith R., and Kroon P.A. A deletion in the first cysteine-rich repeat of the low-density-lipoprotein receptor leads to the formation of multiple misfolded isomers. Eur. J. Biochem. 239 (1996) 214-219
9. Kodama K., Katayama Y., Shoji Y., and Nakashima H. The features and shortcomings for gene delivery of current non-viral carriers. Curr. Med. Chem. 13 (2006) 2155-2161
10. Luten J., van Nostrum C.F., De Smedt S.C., and Hennink W.E. Biodegradable polymers as non-viral carriers for plasmid DNA delivery. J. Control. Release 126 (2008) 97-110
11. Kashiwakura Y., Katoh Y., Tamayose K., Konishi H., Takaya N., Yuhara S., Yamada M., Sugimoto K., and Daida H. Isolation of bone marrow stromal cell-derived smooth muscle cells by a human SM22alpha promoter: in vitro differentiation of putative smooth muscle progenitor cells of bone marrow. Circulation 107 (2003) 2078-2081
12. Iwawaki T., Arai R., Kohno K., and Miura M. A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat. Med. 10 (2004) 98-102
13. Kim R., Emi M., Tanabe K., and Murakami S. Role of the unfolded protein response in cell death. Apoptosis 11 (2006) 5-13
14. Koumenis C. ER stress, hypoxia tolerance and tumor progression. Curr. Mol. Med. 6 (2006) 55-69
15. Moenner M., Pluquet O., Bouchecareilh M., and Chevet E. Integrated endoplasmic reticulum stress responses in cancer. Cancer Res. 67 (2007) 10631-10634
16. Abarzua F., Sakaguchi M., Tanimoto R., Sonegawa H., Li D.W., Edamura K., Kobayashi T., Watanabe M., Kashiwakura Y., Kaku H., Saika T., Nakamura K., Nasu Y., Kumon H., and Huh N.-H. Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3. Int. J. Mol. Med. 20 (2007) 37-43