Effect of CCR5-δ32 heterozygosity on HIV-1 susceptibility: A meta-analysis

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Liu, SiJie ^a   Kong, ChuiJin ^a   Wu, Jie ^a   Ying, Hao ^a   Zhu, HuanZhang ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

AFRICAN; ARTICLE; BASE PAIRING; CAUCASIAN; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; ETHNICITY; FEMALE; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; LATINA; MALE; MONGOLOID; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SAMPLE SIZE; SENSITIVITY ANALYSIS; GENE DELETION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; META ANALYSIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HIV INFECTIONS; HIV-1; HUMANS; MALE; POLYMORPHISM, GENETIC; RECEPTORS, CCR5; SEQUENCE DELETION;

EID: 84859297386     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035020     Document Type: Article

References (41)

1. Kaur G, Mehra N, (2009) Genetic determinants of HIV-1 infection and progression to AIDS: susceptibility to HIV infection. Tissue Antigens; 73: 289-301.
2. O'Brien SJ, Moore JP, (2000) The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol Rev; 177: 99-111.
3. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, et al. (1996) Homozygous defects in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell: 86: 367-77.
4. Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, et al. (1996) Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science: 273: 1856-62.
5. Hütter G, Nowak D, Mossner M, Ganepola S, Müssiq A, et al. (2009) Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med; 360: 692-8.
6. Allers K, Hütter G, Hofmann J, Loddenkemper C, Rieger K, et al. (2011) Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood; 117: 2791-9.
7. Contopoulos-Ioannidis DG, O'Brien TR, Goedert JJ, Rosenberg PS, Ioannidis JP, (2003) Effect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: a meta-analysis. J Acquir Immune Defic Syndr; 32: 70-6.
8. Oh DY, Jessen H, Kücherer C, Neumann K, Oh N, et al. (2008) CCR5D32 Genotypes in a German HIV-1 Seroconverter Cohort and Report of HIV-1 Infection in a CCR5D32 Homozygous Individual. PLoS One; 3: e2747.
9. Hladik F, Liu H, Speelmon E, Livingston-Rosanoff D, Wilson S, et al. (2005) Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism-2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. J Virol; 79: 11677-84.
10. Papa A, Papadimitriou E, Adwan G, Clewley JP, Malissiovas N, et al. (2000) HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks. FEMS Immunol Med Microbiol; 28: 87-9.
11. Trecarichi EM, Tumbarello M, de Gaetano Donati K, Tamburrini E, Cauda R, et al. (2006) Partial protective effect of CCR5-Delta 32 heterozygosity in a cohort of heterosexual Italian HIV-1 exposed uninfected individuals. AIDS Res Ther; 3: 22.
12. Philpott S, Weiser B, Tarwater P, Vermund SH, Kleeberger CA, et al. (2003) CC chemokine receptor 5 genotype and susceptibility to transmission of human immunodeficiency virus type 1 in women. J Infect Dis; 187: 569-75.
13. Grimaldi R, Shindo N, Acosta AX, Dourado I, Brites C, et al. (2002) Prevalence of the CCR5Delta32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection. Hum Genet; 111: 102-4.
14. Pasi KJ, Sabin CA, Jenkins PV, Devereux HL, Ononye C, et al. (2000) The effects of the 32-bp CCR-5 deletion on HIV transmission and HIV disease progression in individuals with haemophilia. Br J Haematol; 111: 136-142.
15. Marmor M, Sheppard HW, Donnell D, Bozeman S, Celum C, et al. (2001) Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection. J Acquir Immune Defic Synd; 27: 472-81.
16. Tan XH, Zhang JY, Di CH, Hu AR, Yang L, et al. (2010) Distribution of CCR5-Delta32, CCR5m303A, CCR2-64I and SDF1-3'A in HIV-1 infected and uninfected high-risk Uighurs in Xinjiang, China. Infect Genet Evol; 10: 268-72.
17. Battiloro E, Andreoni M, Parisi SG, Mura MS, Sotgiu G, et al. (2000) Distribution of the CCR5 delta32 allele in Italian HIV type 1-infected and normal individuals. AIDS Res Hum Retroviruses; 16: 181-2.
18. Díaz FJ, Vega JA, Patiño PJ, Bedoya G, Nagles J, et al. (2000) Frequency of CCR5 delta-32 mutation in human immunodeficiency virus (HIV)-seropositive and HIV-exposed seronegative individuals and in general population of Medellin, Colombia. Mem Inst Oswaldo Cruz; 95: 237-42.
19. Lockett SF, Alonso A, Wyld R, Martin MP, Robertson JR, et al. (1999) Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission. J Infect Dis; 180: 14-21.
20. Liu H, Hwangbo Y, Holte S, Lee J, Wang C, et al. (2004) Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1. J Infect Dis; 190: 055-8.
21. Wang FS, Hong WG, Cao Y, Liu MX, Jin L, et al. (2003) Population survey of CCR5 delta32, CCR5 m303, CCR2b 64I, and SDF1 3'A allele frequencies in indigenous Chinese healthy individuals, and in HIV-1-infected and HIV-1-uninfected individuals in HIV-1 risk groups. J Acquir Immune Defic Syndr; 32: 24-30.
22. Takacova M, Nogova P, Habekova M, Staneková D, (2008) Prevalence of a 32 bp deletion in the gene for human immunodeficiency virus 1 co-receptor ccr5 in slovak population. Acta Virol; 52: 61-4.
23. Veloso S, Olona M, García F, Domingo P, Alonso-Villaverde C, et al. (2010) Effect of TNF-alpha genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards. BMC Med Genet; 11: 3.
24. Downer MV, Hodge T, Smith DK, Qari SH, Schuman P, et al. (2002) Regional variation in CCR5-Delta32 gene distribution among women from the US HIV Epidemiology Research Study (HERS). Genes Immun; 3: 95-8.
25. Tang H, Guo SX, Zhao RL, Zhang JY, Tan XH, (2010) Research on the Polymorphism of HIV Infection-Related Gene CCR5-Delta32 in HIV Highly-Infected Uygur Population in Yili Prefecture of Xinjiang Uygur Autonomous Region. Journal of Shihezi University{Natural Science); 28: 98-201.
26. Li GH, Wei FL, He Y, Sun F, Zhou ZQ, et al. (2003) Impact of the polymorphisms of CCR5, CCR2 and SDF1 on HIV??1 heterosexual transmission. Chin J Microbiol Immunol, 23: 65-9.
27. Paz-y-Mino C, Morillo SA, Celi AP, Witte AP, Tania, (2005) CCR5delta32, CCR2-64I, and SDF1-3'A polymorphisms related to resistance to HIV-1 infection and disease in the Ecuadorian population. Hum Biol; 77: 21-6.
28. Deng XL, Hong KX, Chen JP, Ruan YH, Xu MY, et al. (2004) Genetic polymorphism of human immunodeficiency virus coreceptor CCR5-Delta32 and CCR2-64I alleles in Chinese Yi Ethnic group in Sichuan. Chin J Epidemiol; 25: 050-3.
29. Cochran WG, (1954) The combination of estimates from different experiments. Biometrics; 10: 9.
30. Mantel N, Haenszel W, (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Nat Cancer Inst; 22: 19-48.
31. Dersimonian R, Larid N, (1986) Mata-analysis in clinical trials. Control Clin Trials; 7: 77-88.
32. Egger M, Davey Smith G, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ; 315: 29-34.
33. Begg CB, Mazumdar M, (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics; 50: 088-100.
34. Ioannidis JP, Rosenberg PS, Goedert JJ, Ashton LJ, Benfield TL, et al. (2001) Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. Ann Intern Med; 135: 82-95.
35. Wu L, Paxton WA, Kassam N, Ruffing N, Rottman JB, et al. (1997) CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J Exp Med; 85: 681-91.
36. de Roda Husman AM, Blaak H, Brouwer M, Schuitemaker H, (1999) CC chemokine receptor 5 cell-surface expression in relation to CC chemokine receptor 5 genotype and the clinical course of HIV-1 infection. J Immunol; 163: 597-603.
37. Schuitemaker H, Kootstra NA, de Goede RE, de Wolf F, Miedema F, et al. (1991) Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture[J]. J Virol, 65: 356-63.
38. O'Brien SJ, Nelson GW, (2004) Human genes that limit AIDS. Nat Genet; 36: 565-74.
39. Ghaffari G, Tuttle DL, Briggs D, Burkhardt BR, Bhatt D, et al. (2005) Complex determinants in human immunodeficiency virus type 1 envelope gp120 mediate CXCR4-dependent infection of macrophages. J. Virol; 79: 13250-61.
40. Isaacman-Beck J, Hermann EA, Yi Y, Ratcliffe SJ, Mulenga J, et al. (2009) Heterosexual transmission of human immunodeficiency virus type 1 subtype C: Macrophage tropism, alternative coreceptor use, and the molecular anatomy of CCR5 utilization. J Virol; 83: 8208-20.
41. Schuitemaker H, van 't Wout AB, Lusso P, (2009) Clinical significance of HIV-1 coreceptor usage. J Transl Med; Suppl 1: S5.