Partial protective effect of CCR5-Delta 32 heterozygosity in a cohort of heterosexual Italian HIV-1 exposed uninfected individuals

AIDS Research and Therapy

Volumn 3, Issue 1, 2006, Pages

  Trecarichi, Enrico M ^a   Tumbarello, Mario ^a   de Gaetano Donati, Katleen ^a   Tamburrini, Enrica ^a   Cauda, Roberto ^a   Brahe, Christina ^a   Tiziano, Francesco D ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR5;

ADULT; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROSEXUALITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION SENSITIVITY; ITALY; MALE; OPEN READING FRAME; PRIORITY JOURNAL; PROTECTION; SEQUENCE ANALYSIS; SEXUAL INTERCOURSE; STATISTICAL SIGNIFICANCE; VIRUS RESISTANCE;

EID: 33749646458     PISSN: 17426405     EISSN: None     Source Type: Journal    
DOI: 10.1186/1742-6405-3-22     Document Type: Article

References (17)

1. O'Brien SI. Nelson GW: Human genes that limit AIDS. Nat Genet 2004, 36(6):565-74. Review
2. Hogan CM, Hammer SM: Host determinants in HIV infection and disease. Part 2: genetic factors and implications for antiretroviral therapeutics. Ann Intern Med 134(10):978-96. 2001 May 15. Review
3. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, MacDonald ME, Stuhlmann H, Koup RA, Landau NR: Homozygous defect in HIV-I coreceptor accounts for resistance of some multiply-exposed individuals to HIV-I infection. Cell 86(3):367-77. 1996 Aug 9
4. Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SP, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, O'Brien SJ: Genetic restriction of HIV-I infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 273(5283):1856-62. 1996 Sep 27
5. Huang Y, Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T, Kang S, Ceradini D, Jin Z, Yazdanbakhsh K, Kunstman K, Erickson D, Dragon E, Landau NR,. Phair J, Ho DD, Koup RA. The role of a mutant CCRS allele in HIV-I transmission and disease progression. Nat Med 1996, 2(11):1240-3.
6. Tchilian EZ, Wallace DL, Dawes R, Imami N, Burton C, Gotch F, Beverley PC: A point mutation in CD45 may be associated with an increased risk of HIV-I infection. AIDS. 15(14):1892-4. 2001 Sep 28. Erratum in: AIDS 2001 Nov 9;15(16):2210
7. Tchilian EZ, Wallace DL, Imami N, Liao HX, Burton C, Gotch F, Martinson J, Haynes BF, Beverley PC: The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans. J Immunol 166(10):6144-8. 2001 May 15
8. Lucotte G, Mercier G: Distribution of the CCR5 gene 32-bp deletion in Europe. J Acquir Immune Defic Syndr Hum Retrovirol 19(2):174-7. 1998 Oct 1
9. Zamarchi R, Indraccolo S, Minuzzo S, Coppola V, Gringeri A, Santagostino E, Vicenzi E, De Silvestro G, Biagiotti R, Baldassarre C, Chieco-Bianchi L, Amadori A: Frequency of a mutated CCR-5 allele (delta32) among Italian healthy donors and individuals at risk of parenteral HIV infection. AIDS Res Hum Retroviruses 15(4):337-44. 1999 Mar 1
10. Diaz FJ, Vega JA, Patino PJ, Bedoya G, Nagles J, Villegas C, Vesga R, Rugeles MT: Frequency of CCR5 delta-32 mutation in human immunodeficiency virus (HIV)-seropositive and HIV-exposed seronegative individuals and in general population of Medellin, Colombia. Mem Inst Oswaldo Cruz 2000, 95(2):237-42.
11. Lockett SF, Alonso A, Wyld R, Martin MP, Robertson JR, Gore SM, Leen CL, Brettle RP, Yirrell DL, Carrington M, Brown AJ: Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission. J Infect Dis 1999, 180(3):614-21.
12. Liu H, Hwangbo Y. Holte S, Lee J, Wang C, Kaupp N, Zhu H, Celum C, Corey L, McElrath MJ, Zhu T: Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-I. J Infect Dis 190(6):1055-8. 2004 Sep 15. Epub 2004 Aug 02
13. Rugeles MT, Solano F, Diaz FJ, Bedoya VI, Patino PJ: Molecular characterization of the CCR 5 gene in seronegative individuals exposed to human immunodeficiency virus (HIV). J Clin Virol 2002, 23(3):161-9.
14. Hoffman TL, MacGregor RR, Burger H, Mick R, Doms RW, Collman RG: CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type I infection status. J Infect Dis 1997, 176(4):1093-6.
15. Philpott S. Weiser B, Tarwater P, Vermund SH, Kleeberger CA, Gange SJ, Anastos K, Cohen M, Greenblatt RM, Kovacs A, Minkoff H, Young MA, Miotti P, Dupuis M, Chen CH, Burger H: CC chemokine receptor 5 genotype and susceptibility to transmission of human immunodeficiency virus type I in women. J Infect Dis 187(4):569-75. 2003 Feb 15. Epub 2003 Jan 29
16. Marmor M, Sheppard HW, Donnell D, Bozeman S, Celum C, Buchbinder S, Koblin B, Seage GR 3rd, HIV Network for Prevention Trials Vaccine Preparedness Protocol Team: Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection. J Acquir Immune Defic Syndr 27(5):472-81. 2001 Aug 15
17. Agrawal L, Lu X, Qingwen J, VanHorn-Ali Z, Nicolescu IV, McDermott DH, Murphy PM, Alkhatib G: Role for CCR5Delta32 protein in resistance to R5, R5X4, and X4 human immunodeficiency virus type I in primary CD4+ cells. J Virol 2004, 78(5):2277-87.