Lebecetin, a potent antiplatelet C-type lectin from Macrovipera lebetina venom

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1651, Issue 1-2, 2003, Pages 30-40

  Sarray, Sameh ^a   Srairi, Najet ^a   Hatmi, Mohamed ^b   Luis, Jose ^c   Louzir, Hechmi ^a   Regaya, Imed ^a   Slema, Hmida ^d   Marvaldi, Jacques ^c   El Ayeb, Mohamed ^a   Marrakchi, Naziha ^a,e  

^a PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^b INSERM   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d Ctr Natl de Transfusion Sanguine   (Tunisia)

^e UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

Author keywords

Anti aggregating protein; C type lectin like venom protein; Glycoprotein Ib antagonist; Macrovipera lebetina

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; AMINO ACID; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; FLUORESCEIN ISOTHIOCYANATE; FORMALDEHYDE; GLYCOPROTEIN IB; LEBECETIN; LECTIN; PROTEIN ANTIBODY; PROTEIN SUBUNIT; SEPHADEX; SNAKE VENOM; THROMBIN; THROMBOXANE A2 DERIVATIVE; UNCLASSIFIED DRUG; LEBECETIN PROTEIN, MACROVIPERA LEBETINA; VIPER VENOM;

AGGLUTINATION TEST; AMINO TERMINAL SEQUENCE; ANALYTICAL EQUIPMENT; ARTICLE; BINDING KINETICS; CONCENTRATION RESPONSE; DRUG POTENCY; FLOW CYTOMETRY; GEL FILTRATION; HUMAN; HUMAN CELL; ION EXCHANGE CHROMATOGRAPHY; MACROVIPERA LEBETINA; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PURIFICATION; SEQUENCE HOMOLOGY; SNAKE; THROMBOCYTE AGGREGATION INHIBITION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; FEMALE; GENETICS; ISOLATION AND PURIFICATION; MALE; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SEQUENCE ALIGNMENT; THROMBOCYTE; THROMBOCYTE AGGREGATION;

MACROVIPERA; MACROVIPERA LEBETINA;

AMINO ACID SEQUENCE; ANIMALS; BLOOD PLATELETS; CROTALID VENOMS; FEMALE; HUMANS; LECTINS, C-TYPE; MALE; MOLECULAR SEQUENCE DATA; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN SUBUNITS; SEQUENCE ALIGNMENT; THROMBIN; VIPER VENOMS; VIPERIDAE;

EID: 0642311167     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-9639(03)00232-2     Document Type: Article

References (38)

1. Niewiarowski S., McLane M.A., Kloczewiak M., Stewart G.J. Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors. Semin. Hematol. 31:1994;289-300.
2. McLane M.A., Marcinkiewicz C., Vijay-Kumar S., Wierzbicka-Patynowski I., Niewiarowski S. Viper venom disintegrin and related molecules. Proc. Soc. Exp. Biol. Med. 219:1998;109-119.
3. Marcinkiewicz C., Rosenthal L.A., Mosser D.M., Kunicki T.J., Niewiarowski S. Immunological characterization of eristostatin and echistatin binding sites on alpha IIb beta 3 and alpha v beta 3 integrins. Biochem. J. 317:1996;817-825.
4. Marcinkiewicz C., Calvete J.J., Marcinkiewicz M.M., Raida M., Vijay-Kumar S., Huang Z., Lobb R.R., Niewiarowski S. EC3, a novel heterodimeric disintegrin from Echis carinatus venom, inhibits alpha4 and alpha5 in an RGD-independent manner. J. Biol. Chem. 274:1999;12468-12473.
5. Marcinkiewicz C., Calvete J.J., Vijay-Kumar S., Marcinkiewicz M.M., Raida M., Shick P., Lobb R.R., Niewiarowski S. Structural and functional characterization of EMF10, a heterodimeric disintegrin from Eristocophis macmahoni venom that selectively inhibits alpha 5 beta 1 integrins. Biochemistry. 38:1999;13302-13309.
6. Fujimura Y., Titani K., Usami Y., Suzuki M., Oyama R., Matsui T., Fukui H., Sugimoto M., Ruggeri Z.M. Isolation and characterization of two structurally and functionally distinct from botrocetin, the platelet co agglutinin from the venom of Bothrops jararaca. Biochemistry. 30:1991;1957-1964.
7. Read M.S., Smith S.V., Lamb M.A., Brinkhous K.M. Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor. Blood. 74:1989;1031-1035.
8. Peng M., Emig F.A., Mao A., Lu W., Kirby E.P., Niewiarowski S., Kowalska M.A. Interaction of echicetin with a high affinity thrombin-binding site on platelet glycoprotein GPIb. Thromb. Haemost. 74:1995;954-957.
9. Peng M., Lu W., Beviglia L., Niewiarowski S., Kirby E.P. A snake venom protein that inhibits binding of von Willebrand Factor and alboaggregins to platelet glycoprotein Ib. Blood. 81:1993;2321-2328.
10. Peng M., Lu W., Kirby E.P. Alboaggregins-B: a new platelet agonist that binds to platelet membrane glycoprotein Ib. Biochemistry. 30:1991;11529-11536.
11. Peng M., Lu W., Kirby E.P. Characterization of three alboaggregins purified from Trimeresurus albolabris venom. Thromb. Haemost. 67:1992;702-707.
12. Yeh C.H., Wang W.C., Hsieh T.T., Huang T.F. Agkicetin, a snake venom-derived glycoprotein Ib antagonist, disrupts von Willebrand factor-endothelial cell interaction and inhibits angiogenesis. J. Biol. Chem. 275:2000;18615-18618.
13. Taniuchi Y., Kawasaki T., Fujimura Y., Suzuki M., Titani K., Sakai K., Kaku S., Hisamichi N., Satoh V., Takenaka T., Handa M., Swai Y. Flavocetin-A and -B, two high molecular mass glycoprotein Ib binding proteins with high affinity purified from Trimeresurus flavoridis venom, inhibit platelet aggregation at high shear stress. Biochim. Biophys. Acta. 1244:1995;331-338.
14. Kawasaki T., Taniuchi Y., Hisamichi N., Fujimura Y., Suzuki M., Titani K., Kaku S., Satoh N., Takenaka T., Handa M., Swai Y. Tokaracetin, a new platelet antagonist that binds to platelet glycoprotein Ib and inhibits von Willebrand factor-dependent shear-induced platelet aggregation. Biochem. J. 308:1995;947-953.
15. Marcinkiewicz C., Lobb R.R., Marcinkiewicz M.M., Daniel J.L., Bryan Smith J., Dangelmair C., Weinreb P.H., Beacham D.A., Niewiarowski S. Isolation and characterization of EM16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the α2β1 integrin. Biochemistry. 39:2000;9859-9867.
16. Drickamer K., Taylor M.E. Biology of animal lectins. Annu. Rev. Cell Biol. 9:1993;237-264.
17. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 277:1970;680-685.
18. Dubois M., Gilles K.A., Hamilton J.K., Rebers P.A., Smith F. Colorimetric method for determination of sugars and related substances. Anal. Chem. 1956;350-356.
19. Song P.L., Xin P. A lectin-like peptide isolated from the venom of the Chinese spider Selenocosmia huwena. Toxicon. 33:1995;875-882.
20. Li Y.S., Liu K.F., Wang Q.C. Mechanism of action of the platelet function inhibitor from Vipera russelli siamensis snake venom. Toxicon. 24:1986;875-883.
21. Ardlie N.G., Perry D.W., Packham M.A., Mustard J.F. Adenosine diphosphate induced platelet aggregation in suspensions of washed rabbit platelet. Proc. Soc. Exp. Biol. Med. 13:1970;1021-1023.
22. Born G.V.R., Cross M.J. The aggregation of blood platelets. J. Physiol. 168:1963;178-195.
23. Holmsen H., Storm E., Day H.J. Determination of ATP and ADP in blood platelets: a modification of the firefly luciferase assay for plasma. Anal. Biochem. 46:1972;489-501.
24. Kirby E.P., Mills D.C.B. The interaction of bovine factor VIII with human platelets. J. Clin. Invest. 56:1975;491-502.
25. Liu C.Z., Wang Y.W., Shen M.C., Huang T.F. Analysis of human platelet glycoprotein IIb-IIIa by fluorescein isothiocyanate-conjugated disintegrins with flow cytometry. Thromb. Haemost. 39:1994;1915-1923.
26. Chen Y.L., Tsai I.H. Functional and sequence characterization of coagulation factor X-binding protein from the venom of Echis carinatus leucogaster. Biochemistry. 35:1996;5264-5271.
27. Leduc M., Bon C. Cloning of subunits of convulxin, a collagen-like platelet aggregating protein from Crotalus durissus terrificus venom. Biochem. J. 333:1998;389-393.
28. Komori Y., Nikai T., Tohkai T., Sugihara H. Primary structure and biological activity of snake venom lectin (APL) from Agkistrodon p. piscivorus (Eastern cottonmouth). Toxicon. 37:1999;1053-1064.
29. Barbouche R., Marrakchi N., Mansuelle P., Krifi M., Fenouillet E., Rochat H., El Ayeb M. Novel anti-platelet aggregation polypeptides from Vipera lebetina venom: isolation and characterization. FEBS Lett. 392:1996;6-10.
30. Barbouche R., Marrakchi N., Mabrouk K., Krifi M., Van Rietschoten J., Fenouillet E., El Ayeb M., Rochat H. Anti-platelet activity of the peptides composing the lebetin 1 family, a new cl of inhibitors of platelet aggregation. Toxicon. 36:1998;1939-1947.
31. Peng M., Holt J.C., Niewiarowski S. Isolation, characterization and amino acid sequence of echicetin beta subunit, a specific inhibitor of von Willebrand factor and thrombin interaction with glycoprotein Ib. Biochem. Biophys. Res. Commun. 205:1994;68-72.
32. Polgar J., Magnenat E.M., Peitsch M.C., Wells T.N.C., Saqi M.S.A., Clemetson K.J. Amino acid sequence of the alpha subunit and computer modelling of the alpha and beta subunits of echicetin from the venom of Echis carinatus (saw-scaled viper). Biochem. J. 323:1997;533-537.
33. Kowalska M.A., Tan L., Holt J.C., Peng M., Karczewski J., Calvete J.J., Niewiarowski S. Alboaggregins A and B. Structure and interaction with human platelets. Thromb. Haemost. 79:1998;609-613.
34. Usami Y., Fujimura Y., Suzuki M., Ozeki Y., Nishio K., Fukui H., Titani K. Primary structure of two chain botrocetin, a von Willebrand factor modulator purified from the venom of Bothrops jararaca. Proc. Natl. Acad. Sci. U. S. A. 90:1993;928-932.
35. Cheng X., Qian Y., Liu Q., Li B.X., Zhang M., Liu J. Purification, characterization, and cDNA cloning of a new fibrinogenolytic venom protein, Agkisacutacin, from Agkistrodon acutus venom. Biochem. Biophys. Res. Commun. 265:1999;530-535.
36. Calvete J.J. Platelet integrin GPIIb/IIIa structure-function correlations. An update and lessons from other integrins. Proc. Soc. Exp. Biol. Med. 222:1999;29-38.
37. Kawasaki T., Fujimura Y., Usami Y., Suzuki M., Miura S., Sakurai Y., Makita K., Taniuchi Y., Hirano K., Titani K. Complete amino acid sequence and identification of the platelet glycoprotein Ib-binding site of jararaca GPIb-BP, a snake venom protein isolated from Bothrops jararaca. J. Biol. Chem. 271:1996;10635-10639.
38. Chung C.H., Au L.C., Huang T.F. Molecular cloning and sequence analysis of aggretin, a collagen-like platelet aggregation inducer. Biochem. Biophys. Res. Commun. 263:1999;723-727.