Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα)

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Crumbley, Christine ^a   Wang, Yongjun ^a   Banerjee, Subhashis ^a   Burris, Thomas P ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CITRATE SYNTHASE; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RORA PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CS GENE; DNA MICROARRAY; DNA RESPONSIVE ELEMENT; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME REGULATION; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INTERACTION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIPID METABOLISM; MARKER GENE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; RORA GENE; ANIMAL; BINDING SITE; C57BL MOUSE; CELL STRAIN HEPG2; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; LIVER; MALE; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

MUS;

ANIMALS; BASE SEQUENCE; BINDING SITES; CITRATE (SI)-SYNTHASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, NEUROLOGIC MUTANTS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; TRANSCRIPTION, GENETIC;

EID: 84859227398     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033804     Document Type: Article

References (27)

1. Kallen JA, Schlaeppi JM, Bitsch F, Geisse S, Geiser M, et al. (2002) X-ray structure of the hROR alpha LBD at 1.63 angstrom: Structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of ROR alpha. Structure 10: 1697-1707.
2. Kallen J, Schlaeppi JM, Bitsch F, Delhon I, Fournier B, (2004) Crystal structure of the human ROR alpha ligand binding domain in complex with cholesterol sulfate at 2.2 angstrom. Journal of Biological Chemistry 279: 14033-14038.
3. Wang Y, Kumar N, Crumbley C, Griffin PR, Burris TP, (2010) A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochim Biophys Acta 1801 917-923 pp. 917-923.
4. Wang Y, Kumar N, Solt LA, Richardson TI, Helvering LM, et al. (2010) Modulation of RORalpha and RORgamma activity by 7-oxygenated sterol ligands. Journal of Biological Chemistry 285: 5013-5025.
5. Wang YJ, Solt LA, Burris TP, (2010) Regulation of FGF21 Expression and Secretion by Retinoic Acid Receptor-related Orphan Receptor alpha. Journal of Biological Chemistry 285: 15668-15673.
6. Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, et al. (2011) Identification of SR3335 (ML-176): A Synthetic ROR alpha Selective Inverse Agonist. ACS Chemical Biology 6: 218-222.
7. Wang Y, Kumar N, Nuhant P, Cameron MD, Istrate MA, et al. (2010) Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORA and RORG. ACS Chemical Biology pp. 1029-1034.
8. Solt LA, Kumar N, Nuhant P, Wang YJ, Lauer JL, et al. (2011) Suppression of T(H)17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472: 491-494.
9. Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, et al. (2010) The benzenesulfonamide T0901317 is a novel ROR{alpha}/{gamma} Inverse Agonist. Molecular Pharmacology 77: 228-236.
10. Solt LA, Kojetin DJ, Burris TP, (2011) The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis. Future Medicinal Chemistry 3: 623-638.
11. VuDac N, Gervois P, Grotzinger T, DeVos P, Schoonjans K, et al. (1997) Transcriptional regulation of apolipoprotein A-I gene expression by the nuclear receptor ROR alpha. Journal of Biological Chemistry 272: 22401-22404.
12. Chen Y, Coulter S, Jetten AM, Goldstein JA, (2009) Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene. The Journal of pharmacology and experimental therapeutics 329: 192-201.
13. Wada T, Kang HS, Jetten AM, Xie W, (2008) The emerging role of nuclear receptor ROR alpha and its crosstalk with LXR in xeno- and endobiotic gene regulation. Experimental Biology and Medicine 233: 1191-1201.
14. Chopra AR, Louet JF, Saha P, An J, DeMayo F, et al. (2008) Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease. Science 322: 1395-1399.
15. Mamontova A, Seguret-Mace S, Esposito B, Chaniale C, Bouly M, et al. (1998) Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor ROR alpha. Circulation 98: 2738-2743.
16. Raspe E, Duez H, Gervois P, Fievet C, Fruchart JC, et al. (2001) Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor ROR alpha. Journal of Biological Chemistry 276: 2865-2871.
17. Lau P, Fitzsimmons RL, Raichur S, Wang SCM, Lechtken A, et al. (2008) The orphan nuclear receptor, ROR alpha, regulates gene expression that controls lipid metabolism- Staggerer (sg/sg) mice are resistant to diet-induced obesity. Journal of Biological Chemistry 283: 18411-18421.
18. Kraft CS, LeMoine CM, Lyons CN, Michaud D, Mueller CR, et al. (2006) Control of mitochondrial biogenesis during myogenesis. American journal of physiology Cell physiology 290: C1119-1127.
19. Crumbley C, Wang Y, Kojetin DJ, Burris TP, (2010) Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene. Journal of Biological Chemistry 285: 35386-35392.
20. Ovcharenko I, Nobrega MA, Loots GG, Stubbs L, (2004) ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes. Nucleic Acids Research 32: W280-W286.
21. Bass J, Takahashi JS, (2010) Circadian Integration of Metabolism and Energetics. Science 330: 1349-1354.
22. Green CB, Takahashi JS, Bass J, (2008) The meter of metabolism. Cell 134: 728-742.
23. Glatz JF, Baerwaldt CC, Veerkamp JH, Kempen HJ, (1984) Diurnal variation of cytosolic fatty acid-binding protein content and of palmitate oxidation in rat liver and heart. The Journal of biological chemistry 259: 4295-4300.
24. Jetten AM, (2009) Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal 7: e003.
25. Takeda Y, Kang HS, Angers M, Jetten AM, (2011) Retinoic acid-related orphan receptor gamma directly regulates neuronal PAS domain protein 2 transcription in vivo. Nucleic Acids Research 39: 4769-4782.
26. Burris TP, (2008) Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clock. Mol Endocrinol 22: 1509-1520.
27. Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, et al. (2004) A functional genomics strategy reveals rora as a component of the mammalian circadian clock. Neuron 43: 527-537.