In vitro Generation of Functional Insulin-producing Cells from Lipoaspirated Human Adipose Tissue-derived Stem Cells

Archives of Medical Research

Volumn 43, Issue 1, 2012, Pages 83-88

  Mohamad Buang, Mohamad Lizan ^a   Seng, Heng Kien ^b   Chung, Lee Han ^a   Saim, Aminuddin Bin ^a,c   Idrus, Ruszymah Bt Hj ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA MEDICAL CENTER   (Malaysia)

^b Petaling Jaya   (Malaysia)

^c Ampang Puteri Specialist Hospital Malaysia   (Malaysia)

Author keywords

Adipose tissue derived stem cells; Diabetes mellitus; Glucose challenge test; Insulin producing cells; Tissue engineering

Indexed keywords

ACTIVIN A; DITHIZONE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HUMAN INSULIN; NICOTINAMIDE;

ABDOMINAL FAT; ADIPOSE TISSUE CELL; ADULT; ARTICLE; CELL DIFFERENTIATION; CELL SELECTION; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INSULIN RELEASE; LIPOSUCTION; MICROSCOPY; PANCREAS ISLET BETA CELL; PROVOCATION TEST; STEM CELL; TRANSMISSION ELECTRON MICROSCOPY;

ABDOMINAL FAT; ADULT STEM CELLS; AVIAN PROTEINS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; CULTURE MEDIA; CYTOKINES; GLUCOSE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INSULIN; ISLETS OF LANGERHANS; SECRETORY VESICLES; TISSUE ENGINEERING;

EID: 84859222130     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2012.01.012     Document Type: Article

References (32)

1. National Diabetes Fact Sheet: General Information and National Estimates on Diabetes in the United States 2003, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA.
2. Sustained effect of intensive treatment of type 1diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA 2003, 290:2159-2167. Epidemiology of Diabetes Interventions and Complications Research Group.
3. Shapiro A.M., Lakey J.R., Rajotte R.V., et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000, 343:230-238.
4. Ryan E.A., Paty B.W., Shapiro A.M., et al. Five year follow-up after clinical islet transplantation. Diabetes 2005, 54:2060.
5. Bajada S., Mazakova I., Richardson J.B., et al. Updates on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med 2008, 2:169-183.
6. Mazlyzam A.L., Aminuddin B.S., Ruszymah B.H.I., et al. Reconstruction of living bilayer human skin equivalent utilizing human fibrin as a scaffold. Burns 2007, 33:355-363.
7. Ramiya V.K., Maraist M., Cornelius J.G., et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 2000, 6:278-282.
8. Sapir T., Shternhall K., Meivar-Levy I., et al. Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human embryonic cells. Proc Natl Acad Sci USA 2005, 102:7964-7969.
9. Oh S.H., Muzzonigro T.M., Bae S.H., et al. Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes. Lab Invest 2004, 84:607-617.
10. Yoshida S., Ishikawa F., Shimoda S., et al. Human cord blood-derived cells generate insulin-producing cells in vivo. Stem Cells 2005, 23:1409-1416.
11. Kang H., Kim J., Kim K.S., et al. Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice. J Stem Cells Express 2009, 27:199-2008.
12. Zuk P.A. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cells 2002, 13:4279-4295.
13. Chua K.H. Lipoaspirate stem cell for cartilage engineering. Med J Malaysia 2008, 63(suppl A):4.
14. Hamid A.A., Ruszymah B.H.I., Chua K.H., et al. Differential gene expression of human adipose-derived stem cells in osteogenic induction. Med J Malaysia 2008, 63(suppl A):9-10.
15. Hamid A.A., Ruszymah B.H.I., Chua K.H., et al. Characterisation of human adipose-derived stem cells and expression of its chondrogenic genes during induction of cartilage differentiation. Clinics 2011, 30.
16. Lin C.S., Xin Z.C., Deng C.H., et al. Defining adipose-derived stem cell in tissue and in culture. Histol Histopathol 2010, 15:805.
17. Moore J.H., Kolaczynski J.W., Morales L.M., et al. Viability of fat obtained by syringe suction lipectomy: effects of local anesthesia with lidocaine. Aesthetic Plast Surg 1995, 19:335-339.
18. Lalikos J.F., Li Y.Q., Roth T.P., et al. Biochemical assessment of cellular damage after adipocyte harvest. J Surg Res 1997, 70:95-100.
19. Timper K., Seboek D., Eberhardt M., et al. Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin and glucagon expressing cells. J Biochem Biophys Res Commun 2006, 341:1135-1140.
20. Billon N., Caetano M., Dani M. Developmental origin of adipocytes: new insights into a pending question. Biol Cell 2008, 100:563-575.
21. Pittenger M.F., Mosca J.D., McIntosh K.R. Human mesenchymal stem cells: progenitor cells for cartilage, bone, fat and stroma. Curr Top Microbiol Immunol 2000, 251:3-11.
22. Peptan I.A., Hong L., Mao J.J. Comparison of osteogenic potentials of visceral and subcutaneous adipose-derived cells of rabbits. Plast Reconstr Surg 2006, 117:1462-1470.
23. Edlund H. Pancreatic organogenesis: developmental mechanisms and implications for therapy. Nat Rev Genet 2002, 3:524-532.
24. Bonner-Weir S., Deery D., Weir G.C., et al. Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes 1989, 38:49-53.
25. Jonas J.C., Sharma A., Weir G.C., et al. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 1999, 274:14112-14121.
26. Otonkoski T., Beattie G.M., Hayek A., et al. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest 1993, 92:1459-1466.
27. Demeterco C., Beattie G.M., Dib S.A., et al. A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth. J Clin Endocrinol Metab 2000, 85:3892-3897.
28. Hui H., Wright C., Perfetti R. Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 2001, 50:785-796.
29. Clark S.A., Borland K.M., Sherman S.D., et al. Staining and in vitro toxicity of dithizone with canine, porcine, and bovine islets. Cell Transplant 1994, 3:299-306.
30. Michael S. Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates. Proc Natl Acad Sci 1993, 90:1781-1785.
31. Hu Y.H., Wu D.Q., Zhang A., et al. Secretory function of human insulin-producing cells in vivo. Hepatobiliary Pancreat Dis Int 2009, 8:255-258.
32. Safford K.M., Hiock K.C., Safford S.D., et al. Neurogenic differentiation of murine and human adipose-derived stromal cells. Biochem Biophys Res Commun 2002, 294:371-379.