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This retrospective study looks at the effectiveness of BAL fluid galactomannan (BAL-GM) in diagnosing IPA in 67 patients with hematopoietic stem cell transplantation, The sensitivity of BAL-GM in diagnosing proven or probable IPA was 73 and 67% (10/15) and specificity was 89 and 95%; positive and negative predictive values were 73 and 83%, and 89 and 87%, respectively. It was more sensitive than cytology, BAL fluid culture, transbronchial biopsy or serum galactomannan for diagnosing IPA
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Nguyen MH, Leather H, Clancy CJ, et al. Galactomannan testing in bronchoalveolar lavage fluid facilitates the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies and stem cell transplant recipients. Biol Blood Marrow Transplant 2011; 17:1043-1050. This retrospective study looks at the effectiveness of BAL fluid galactomannan (BAL-GM) in diagnosing IPA in 67 patients with hematopoietic stem cell transplantation, The sensitivity of BAL-GM in diagnosing proven or probable IPA was 73 and 67% (10/15) and specificity was 89 and 95%; positive and negative predictive values were 73 and 83%, and 89 and 87%, respectively. It was more sensitive than cytology, BAL fluid culture, transbronchial biopsy or serum galactomannan for diagnosing IPA.
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Ruhnke M, Böhme A, Buchheidt D, et al., Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Diagnosis of invasive fungal infections in hematology and oncology - guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol 2003; 82 (Suppl. 2):S141-S148. (Pubitemid 37265301)
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Lat A, Thompson GR. Update on the optimal use of voriconazole for invasive fungal infections. Infect Drug Resist 2011; 4:43-53. This comprehensive review on voriconazole deals with pharmacology and clinical outcomes data of while treating aspergillosis.
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Arthaus M. Prophylaxis and treatment of invasive aspergillosis with voriconazole, posaconazole and caspofungin: review of the literature. Eur J Med Res 2011; 16:145-152. This review article deals with current state of prophylaxis and treatment of invasive aspergillosis, taking into consideration availability of newer antifungal agents posaconazole and caspofungin.
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Derouin, F.5
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Styczynski J, Reusser P, Einsele H, et al. Management of hSV, VZV and EBV infections in patients with hematological malignancies and after SCT: guidelines from the Second European Conference on Infections in Leukemia. Second European Conference on Infections in Leukemia. Bone Marrow Transplant 2009; 43:757-770.
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This retrospective study describes the clinical outcomes of HSCT recipients who received adjunctive CMV-IVIG for probable or proven CMV disease. Analysis suggests that the factors associated with mortality are the need for intubation and earlier onset of CMV disease after HSCT. Treatment with CMV-IVIG appears to be well tolerated in HSCT recipients
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Alexander BT, Hladnik LM, Augustin KM, et al. Use of cytomegalovirus intravenous immune globulin for the adjunctive treatment of cytomegalovirus in hematopoietic stem cell transplant recipients. Pharmacotherapy 2010; 30:554-561. This retrospective study describes the clinical outcomes of HSCT recipients who received adjunctive CMV-IVIG for probable or proven CMV disease. Analysis suggests that the factors associated with mortality are the need for intubation and earlier onset of CMV disease after HSCT. Treatment with CMV-IVIG appears to be well tolerated in HSCT recipients.
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Ljungman P, de la Camara R, Cordonnier C, et al. Management of cMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT. European Conference on Infections in Leukemia. Bone Marrow Transplant 2008; 42:227-240.
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25
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Iademarco, M.F.10
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Ruoss, S.13
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Wallace Jr., R.J.15
Winthrop, K.16
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26
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Dharnidharka VR, Agodoa LY, Abbott KC. Risk factors for hospitalization for bacterial or viral infection in renal transplant recipients - an analysis of USRDS data. Am J Transplant 2007; 7:653-661. (Pubitemid 46376457)
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27
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28
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A retrospective study was performed to identify risk factors for PCP in kidney transplant recipients and to define parameters for use in clinical prophylaxis guidelines. It revealed that chemoprophylaxis in the first 6 months for all renal transplant patients - and during the first year after transplantation for patients greater than 55 years of age or those treated for rejection - would result in very low PCP incidence and optimal avoidance of TMP-SMX toxicity
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De Boer MG, Kroon FP, le Cessie S, et al. Risk factors for Pneumocystis jirovecii pneumonia in kidney transplant recipients and appraisal of strategies for selective use of chemoprophylaxis. Transpl Infect Dis 2011; 13:559-569. A retrospective study was performed to identify risk factors for PCP in kidney transplant recipients and to define parameters for use in clinical prophylaxis guidelines. It revealed that chemoprophylaxis in the first 6 months for all renal transplant patients - and during the first year after transplantation for patients greater than 55 years of age or those treated for rejection - would result in very low PCP incidence and optimal avoidance of TMP-SMX toxicity.
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De Boer, M.G.1
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This prospective study evaluated the possible association between infection and immunosuppression regimens in 1398 renal transplant recipients. The study concluded that the use of sirolimus as maintenance therapy in kidney recipients is associated with a low rate of CMV infection and with a higher risk of surgical site infection
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Fortun J, Martin-Davila P, Pascual J, et al. Immunosuppressive therapy and infection after kidney transplantation. Transpl Infect Dis 2010; 12:397-405. This prospective study evaluated the possible association between infection and immunosuppression regimens in 1398 renal transplant recipients. The study concluded that the use of sirolimus as maintenance therapy in kidney recipients is associated with a low rate of CMV infection and with a higher risk of surgical site infection.
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TRANSNET prospectively surveyed and identified 1208 invasive fungal infections among 1063 organ transplant recipients. The most common were candidiasis, aspergillosis, and cryptococcosis, median time to onset being 103, 184, and 575 days, respectively
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Pappas PG, Alexander BD, Andes DR, et al. Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis 2010; 50:1101-1111. TRANSNET prospectively surveyed and identified 1208 invasive fungal infections among 1063 organ transplant recipients. The most common were candidiasis, aspergillosis, and cryptococcosis, median time to onset being 103, 184, and 575 days, respectively.
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Gasink LB, Blumberg EA. Bacterial and mycobacterial pneumonia in transplant recipients. Clin Chest Med 2005; 26:647-659. (Pubitemid 41563264)
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This prospective study involving 604 heart transplant recipients suggests that nearly half of the patients experience a significant infection during the first year after transplantation. Early onset infections occur in the ICUs and are caused by nosocomial organisms; late-onset infections are of more varied etiology and preferentially affect the skin and genitourinary tract
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Sánchez-Lázaro IJ, Almenar L, Blanes M. Timing, etiology, and location of first infection in first year after heart transplantation. Transplant Proc 2010; 42:3017-3019. This prospective study involving 604 heart transplant recipients suggests that nearly half of the patients experience a significant infection during the first year after transplantation. Early onset infections occur in the ICUs and are caused by nosocomial organisms; late-onset infections are of more varied etiology and preferentially affect the skin and genitourinary tract.
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Refaat M, McNamara D, Teuteberg J. Successful cidofovir treatment in an adult heart transplant recipient with severe adenovirus pneumonia. J Heart Lung Transplant 2008; 27:699-700.
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This retrospective study involving 4925 solid-organ transplantation recipients concludes that the incidence of TB in transplant recipients is much higher than the overall background incidence in the USA; non-Caucasian and renal transplant recipients are at higher risk likely because of latent disease
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Lopez de Castilla D, Schluger NW. Tuberculosis following solid organ transplantation. Transpl Infect Dis 2010; 12:106-112. This retrospective study involving 4925 solid-organ transplantation recipients concludes that the incidence of TB in transplant recipients is much higher than the overall background incidence in the USA; non-Caucasian and renal transplant recipients are at higher risk likely because of latent disease.
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