Monitoring of systemic exposure to plant protection products and DNA damage in orchard workers

Toxicology Letters

Volumn 210, Issue 2, 2012, Pages 182-188

  Kasiotis, Konstantinos M ^a   Kyriakopoulou, Katerina ^a   Emmanouil, Christina ^a   Tsantila, Nektaria ^a   Liesivuori, Jyrki ^b   Souki, Helen ^c   Manakis, Sotiris ^d   Machera, Kyriaki ^a  

^a BENAKI PHYTOPATHOLOGICAL INSTITUTE   (Greece)

^b UNIVERSITY OF TURKU   (Finland)

^c Agrinion General Hospital   (Greece)

^d Agricultural Cooperatives Union of Agrinio   (Greece)

Author keywords

Biomonitoring; Comet assay; DNA damage; GC MS MS; Pesticides

Indexed keywords

CAPTAN; CHLORPYRIFOS; CIPERMETHRIN; DELTAMETHRIN; MYCLOBUTANIL; PESTICIDE; PLANT PROTECTION PRODUCT; PROPARGITE; UNCLASSIFIED DRUG;

ADULT; AGED; AGRICULTURAL WORKER; ARTICLE; BIOLOGICAL MONITORING; COMET ASSAY; CONTROLLED STUDY; CROPPING SYSTEM; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; GAS CHROMATOGRAPHY; HUMAN; MALE; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; ORCHARD; PLANT PRODUCT; PLUM; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ADULT; AGED; AGRICULTURE; COMET ASSAY; DNA DAMAGE; ENVIRONMENTAL MONITORING; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PESTICIDE RESIDUES; PESTICIDES; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

PRUNUS DOMESTICA;

EID: 84859158913     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.10.020     Document Type: Article

References (49)

1. Alvarado D., Yañez L., Montero R. Organochlorine pesticides mixture exposure assessment and DNA damage in mother-child pairs in agricultural community in San Luis Potosi, Mexico. Toxicol. Lett. 2009, 189S:S208.
2. Araoud M., Douki W., Najjar M.F., Kenani A. Simple analytical method for determination of pesticide residues in human serum by liquid chromatography tandem mass spectrometry. J. Environ. Sci. Health B 2010, 45:242-248.
3. Aronson K.J., Wilson J.W., Hamel M., Diarsvitri W., Fan W., Woolcott C., Heaton J.P., Nickel J.C., Macneily A., Morales A. Plasma organochlorine levels and prostate cancer risk. J. Expo. Sci. Environ. Epidemiol. 2010, 20:434-445.
4. Atherton K.M., Williams F.M., Egea Gonzalez F.J., Glass R., Rushton S., Blain P.G., Mutch E. DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure. Biomarkers 2009, 14:443-451.
5. Berthet A., Bouchard M., Schupfer P., Vernez D., Danuser B., Hyunh C.K. Liquid chromatography-tandem mass spectrometry (LC/APCI-MS/MS) methods for the quantification of captan and folpet phthalimide metabolites in human plasma and urine. Anal. Bioanal. Chem. 2011, 399:2243-2255.
6. Bhalli J.A., Ali T., Asi M.R., Khalid Z.M., Ceppi M., Khan Q.M. DNA damage in Pakistani agricultural workers exposed to mixture of pesticides. Environ. Mol. Mutagen. 2009, 50:37-45.
7. Castillo-Cadena J., Tenorio-Vieyra L.E., Quintana-Carabia A.I., Garcia-Fabila M.M., Juan E.R., Madrigal-Bujaidar E. Determination of DNA damage in floriculturists exposed to mixtures of pesticides. J. Biomed. Biotechnol. 2006, 2006:97896-97900.
8. Cole L.M., Ruzo L.O., Wood E.J., Casida J.E. Pyrethroid metabolism - comparative fate in rats of tralomethrin, tralocythrin, deltamethrin, and (1r,alpha-S)-cis-cypermethrin. J. Agric. Food Chem. 1982, 30:631-636.
9. Commission E. Review Report for the Active Substance Acetamiprid. SANCO/1392/2001 2004.
10. Cypermethrin. Available from: http://www.inchem.org/documents/pims/chemical/pim163.htm.
11. Deltamethrin. Available from: http://npic.orst.edu/factsheets/Deltatech.pdf.
12. Duez P., Dehon G., Kumps A., Dubois J. Statistics of the Comet assay: a key to discriminate between genotoxic effects. Mutagenesis 2003, 18:159-166.
13. Ennaceur S., Driss M.R. Serum organochlorine pesticide and polychlorinated biphenyl levels measured in delivering women from different locations in Tunisia. Int. J. Environ. Anal. Chem. 2010, 90:821-828.
14. Faust F., Kassie F., Knasmuller S., Boedecker R.H., Mann M., Mersch-Sundermann V. The use of the alkaline comet assay with lymphocytes in human biomonitoring studies. Mutat. Res. 2004, 566:209-229.
15. Garaj-Vrhovac V., Zeljezic D. Assessment of genome damage in a population of Croatian workers employed in pesticide production by chromosomal aberration analysis, micronucleus assay and Comet assay. J. Appl. Toxicol. 2002, 22:249-255.
16. Goñi F., López R., Etxeandia A., Millán E., Amiano P. High throughput method for the determination of organochlorine pesticides and polychlorinated biphenyls in human serum. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2007, 852:15-21.
17. Holland N.T., Smith M.T., Eskenazi B., Bastaki M. Biological sample collection and processing for molecular epidemiological studies. Mutat. Res. 2003, 543:217-234.
18. Kasiotis K.M., Souki H., Carageorgiou H., Machera K. Determination of dimethoate and omethoate in human serum samples. Risk assessment for the operator. Int. J. Environ. Anal. Chem. 2011, 91:876-883.
19. Kasiotis K.M., Souki H., Tsakirakis A.N., Carageorgiou H., Theotokatos S.A., Haroutounian S.A., Machera K. Headspace solid phase micro extraction gas chromatographic determination of fenthion in human serum. Int. J. Mol. Sci. 2008, 9:906-913.
20. Lam T.H., Zhu C.Q., Jiang C.Q. Lymphocyte DNA damage in elevator manufacturing workers in Guangzhou, China. Mutat. Res. 2002, 515:147-157.
21. Lebailly P., Vigreux C., Lechevrel C., Ledemeney D., Godard T., Sichel F., LeTalaer J.Y., Henry-Amar M., Gauduchon P. DNA damage in mononuclear leukocytes of farmers measured using the alkaline comet assay: modifications of DNA damage levels after a one-day field spraying period with selected pesticides. Cancer Epidemiol. Biomarkers Prev. 1998, 7:929-940.
22. Lovell D.P., Thomas G., Dubow R. Issues related to the experimental design and subsequent statistical analysis of in vivo and in vitro comet studies. Teratog. Carcinog. Mutagen. 1999, 19:109-119.
23. Maluf S.W., Erdtmann B. Follow-up study of the genetic damage in lymphocytes of pharmacists and nurses handling antineoplastic drugs evaluated by cytokinesis-block micronuclei analysis and single cell gel electrophoresis assay. Mutat. Res. 2000, 471:21-27.
24. Mariscal-Arcas M., Lopez-Martinez C., Granada A., Olea N., Lorenzo-Tovar M.L., Olea-Serrano F. Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet. Food Chem. Toxicol. 2010, 48:1311-1315.
25. Moller P., Knudsen L.E., Loft S., Wallin H. The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol. Biomarkers Prev. 2000, 9:1005-1015.
26. Moretti M., Villarini M., Scassellati-Sforzolini G., Pasquini R. Pesticide-induced primary DNA damage in peripheral blood leukocytes of farm workers evaluated by the computerized 'comet' assay. Biomarkers 2000, 5:192-204.
27. Myclobutanil. Available from: http://whqlibdoc.who.int/hq/1993/WHO_PCS_93.34_(myclobutanil).pdf.
28. Nardelli V., dell'Oro D., Palermo C., Centonze D. Multi-residue method for the determination of organochlorine pesticides in fish feed based on a cleanup approach followed by gas chromatography-triple quadrupole tandem mass spectrometry. J. Chromatogr. A 2010, 1217:4996-5003.
29. Niessen W.M. Group-specific fragmentation of pesticides and related compounds in liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2010, 1217:4061-4070.
30. Palus J., Dziubaltowska E., Rydzynski K. DNA damage detected by the comet assay in the white blood cells of workers in a wooden furniture plant. Mutat. Res. 1999, 444:61-74.
31. Pastor S., Creus A., Parron T., Cebulska-Wasilewska A., Siffel C., Piperakis S., Marcos R. Biomonitoring of four European populations occupationally exposed to pesticides: use of micronuclei as biomarkers. Mutagenesis 2003, 18:249-258.
32. Piperakis S.M., Kontogianni K., Karanastasi G., Iakovidou-Kritsi Z., Cebulska-Wasilewska A., Piperakis M.M. Investigation of the genotoxic effect of pesticides on greenhouse workers' lymphocytes. Environ. Mol. Mutagen. 2009, 50:121-126.
33. Piperakis S.M., Kontogianni K., Piperakis M.M., Tsilimigaki S. Effects of pesticides on occupationally exposed humans. Sci. World J. 2006, 6:1211-1220.
34. Piperakis S.M., Kontogianni K., Siffel C., Piperakis M.M. Measuring the effects of pesticides on occupationally exposed humans with the comet assay. Environ. Toxicol. 2006, 21:355-359.
35. Pitarque M., Vaglenov A., Nosko M., Hirvonen A., Norppa H., Creus A., Marcos R. Evaluation of DNA damage by the Comet assay in shoe workers exposed to toluene and other organic solvents. Mutat. Res. 1999, 441:115-127.
36. Porta M., Gasull M., Puigdomènech E., Garí M., de Basea M.B., Guillèn M., López T., Bigas E., Pumarega J., Llebaria X., Grimalt J.O., Tresserras R. Distribution of blood concentrations of persistent organic pollutants in a representative sample of the population of Catalonia. Environ. Int. 2010, 36:655-664.
37. Propargite. Available from: http://www.cdpr.ca.gov/docs/risk/rcd/propargite.pdf.
38. Ruzo L.O., Cohen E., Capua S. Comparative metabolism of the pyrethroids bifenthrin and deltamethrin in the bulb mite Rhizoglyphus-Robini. J. Agric. Food Chem. 1988, 36:1040-1043.
39. Sawada N., Iwasaki M., Inoue M., Itoh H., Sasazuki S., Yamaji T., Shimazu T., Tsugane S. Plasma organochlorines and subsequent risk of prostate cancer in Japanese men: a nested case-control study. Environ. Health Perspect. 2010, 118:659-665.
40. Simoniello M.F., Kleinsorge E.C., Scagnetti J.A., Grigolato R.A., Poletta G.L., Carballo M.A. DNA damage in workers occupationally exposed to pesticide mixtures. J. Appl. Toxicol. 2008, 28:957-965.
41. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
42. Singh N.P., Stephens R.E., Schneider E.L. Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int. J. Radiat. Biol. 1994, 66:23-28.
43. Sunaga M., Yoshida M., Hara I. Metabolism and urinary excretion of chlorpyrifos in rats. Nippon Eiseigaku Zasshi 1989, 43:1124-1129.
44. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
45. Valverde M., Rojas E. Environmental and occupational biomonitoring using the Comet assay. Mutat. Res. 2009, 681:93-109.
46. Vlastos D., Stivaktakis P., Matthopoulos D.P. Pesticide exposure and genotoxicity correlations within a Greek farmers' group. Int. J. Environ. Anal. Chem. 2006, 86:215-223.
47. Walorczyk S. Development of a multi-residue screening method for the determination of pesticides in cereals and dry animal feed using gas chromatography-triple quadrupole tandem mass spectrometry. J. Chromatogr. A 2007, 1165:200-212.
48. Xu X., Dailey A.B., Talbott E.O., Ilacqua V.A., Kearney G., Asal N.R. Associations of serum concentrations of organochlorine pesticides with breast cancer and prostate cancer in U.S. adults. Environ. Health Perspect. 2010, 118:60-66.
49. Zhu C.Q., Lam T.H., Jiang C.Q., Wei B.X., Xu Q.R., Chen Y.H. Increased lymphocyte DNA strand breaks in rubber workers. Mutat. Res. 2000, 470:201-209.