Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression

Biochemical and Biophysical Research Communications

Volumn 392, Issue 1, 2010, Pages 63-66

  Song, Kwang Hoon ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

ApoA5; Apolipoprotein; Gene expression; Nur77; Orphan nuclear receptor

Indexed keywords

APOLIPOPROTEIN A5; NUCLEAR RECEPTOR NUR77;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIPOPROTEIN METABOLISM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION;

APOLIPOPROTEINS A; BASE SEQUENCE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; RNA, MESSENGER;

EID: 74849136419     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.168     Document Type: Article

References (26)

1. Giguere V. Orphan nuclear receptors: from gene to function. Endocr. Rev. 20 (1999) 689-725
2. Wang Z., Benoit G., Liu J., Prasad S., Aarnisalo P., Liu X., Xu H., Walker N.P., and Perlmann T. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 423 (2003) 555-560
3. Cheng L.E., Chan F.K., Cado D., and Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 16 (1997) 1865-1875
4. Wilson T.E., Fahrner T.J., Johnston M., and Milbrandt J. Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252 (1991) 1296-1300
5. Yeo M.G., Yoo Y.G., Choi H.S., Pak Y.K., and Lee M.O. Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells. Mol. Endocrinol. 19 (2005) 950-963
6. Nakai A., Kartha S., Sakurai A., Toback F.G., and DeGroot L.J. A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. Mol. Endocrinol. 4 (1990) 1438-1443
7. Pei L., Waki H., Vaitheesvaran B., Wilpitz D.C., Kurland I.J., and Tontonoz P. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat. Med. 12 (2006) 1048-1055
8. Pols T.W., Ottenhoff R., Vos M., Levels J.H., Quax P.H., Meijers J.C., Pannekoek H., Groen A.K., and de Vries C.J. Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity. Biochem. Biophys. Res. Commun. 366 (2008) 910-916
9. Breslow J.L. Apolipoprotein genetic variation and human disease. Physiol. Rev. 68 (1988) 85-132
10. Ribalta J., Vallve J.C., Girona J., and Masana L. Apolipoprotein and apolipoprotein receptor genes. Blood lipids and disease. Curr. Opin. Clin. Nutr. Metab. Care 6 (2003) 177-187
11. van der Vliet H.N., Sammels M.G., Leegwater A.C., Levels J.H., Reitsma P.H., Boers W., and Chamuleau R.A. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J. Biol. Chem. 276 (2001) 44512-44520
12. Pennacchio L.A., Olivier M., Hubacek J.A., Cohen J.C., Cox D.R., Fruchart J.C., Krauss R.M., and Rubin E.M. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science 294 (2001) 169-173
13. Fruchart-Najib J., Bauge E., Niculescu L.S., Pham T., Thomas B., Rommens C., Majd Z., Brewer B., Pennacchio L.A., and Fruchart J.C. Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem. Biophys. Res. Commun. 319 (2004) 397-404
14. van der Vliet H.N., Schaap F.G., Levels J.H., Ottenhoff R., Looije N., Wesseling J.G., Groen A.K., and Chamuleau R.A. Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice. Biochem. Biophys. Res. Commun. 295 (2002) 1156-1159
15. Vu-Dac N., Gervois P., Jakel H., Nowak M., Bauge E., Dehondt H., Staels B., Pennacchio L.A., Rubin E.M., Fruchart-Najib J., and Fruchart J.C. Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators. J. Biol. Chem. 278 (2003) 17982-17985
16. Prieur X., Coste H., and Rodriguez J.C. The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element. J. Biol. Chem. 278 (2003) 25468-25480
17. Genoux A., Dehondt H., Helleboid-Chapman A., Duhem C., Hum D.W., Martin G., Pennacchio L.A., Staels B., Fruchart-Najib J., and Fruchart J.C. Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 1186-1192
18. Prieur X., Schaap F.G., Coste H., and Rodriguez J.C. Hepatocyte nuclear factor-4alpha regulates the human apolipoprotein AV gene: identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-gamma coactivator-1alpha, AMP-activated protein kinase, and mitogen-activated protein kinase pathway. Mol. Endocrinol. 19 (2005) 3107-3125
19. Prieur X., Huby T., Coste H., Schaap F.G., Chapman M.J., and Rodriguez J.C. Thyroid hormone regulates the hypotriglyceridemic gene APOA5. J. Biol. Chem. 280 (2005) 27533-27543
20. Jakel H., Nowak M., Moitrot E., Dehondt H., Hum D.W., Pennacchio L.A., Fruchart-Najib J., and Fruchart J.C. The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c. J. Biol. Chem. 279 (2004) 45462-45469
21. Song K.H., Park Y.Y., Kee H.J., Hong C.Y., Lee Y.S., Ahn S.W., Kim H.J., Lee K., Kook H., Lee I.K., and Choi H.S. Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2. J. Biol. Chem. 281 (2006) 15605-15614
22. Song K.H., Li T., and Chiang J.Y. A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. J. Biol. Chem. 281 (2006) 10081-10088
23. Song K.H., Ellis E., Strom S., and Chiang J.Y. Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes. Hepatology 46 (2007) 1993-2002
24. Venteclef N., Haroniti A., Tousaint J.J., Talianidis I., and Delerive P. Regulation of anti-atherogenic apolipoprotein M gene expression by the orphan nuclear receptor LRH-1. J. Biol. Chem. 283 (2008) 3694-3701
25. Scearce L.M., Laz T.M., Hazel T.G., Lau L.F., and Taub R. RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. J. Biol. Chem. 268 (1993) 8855-8861
26. Prieur X., Lesnik P., Moreau M., Rodriguez J.C., Doucet C., Chapman M.J., and Huby T. Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha. Implications for the study of pharmaceutical modifiers of hypertriglyceridemia in mice. Biochim. Biophys. Acta 1791 (2009) 764-771