An investigation of the influence of process and formulation variables on mechanical properties of high shear granules using design of experiment

International Journal of Pharmaceutics

Volumn 427, Issue 2, 2012, Pages 328-336

  Mangwandi, Chirangano ^a   Adams, Michael J ^b   Hounslow, Michael J ^a   Salman, Agba D ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Elastoplastic ratio; Experimental design; Granulation; Packing coefficient; Strength

Indexed keywords

CAFFEINE; HYDROXYPROPYLCELLULOSE; LACTOSE; STARCH;

ARTICLE; CONCENTRATION (PARAMETERS); DRUG FORMULATION; DRUG GRANULATION; DRUG GRANULE; EXPERIMENTAL DESIGN; IMPELLER; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROCESS DESIGN; SHEAR FLOW; TABLET COMPRESSION; TABLET PROPERTY; TABLET STRENGTH; VELOCITY;

ALGORITHMS; ANALYSIS OF VARIANCE; CAFFEINE; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DESICCATION; EQUIPMENT DESIGN; EXCIPIENTS; HARDNESS; LACTOSE; MECHANICAL PROCESSES; MODELS, STATISTICAL; PARTICLE SIZE; POWDERS; REGRESSION ANALYSIS; SHEAR STRENGTH; STARCH; TECHNOLOGY, PHARMACEUTICAL;

EID: 84859104969     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.02.029     Document Type: Article

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