Powder functionality test: A methodology for rheological and mechanical characterization

Pharmaceutical Development and Technology

Volumn 10, Issue 2, 2005, Pages 327-338

  Viana, Marylène ^a   Ribet, Jérome ^a   Rodriguez, Fernand ^a   Chulia, Dominique ^a  

^a UNIVERSITY OF LIMOGES   (France)

Author keywords

Celluloses; Characterization; Energetic analysis of compression; Excipients; Functionality; Powders

Indexed keywords

EXCIPIENT; MICROCRYSTALLINE CELLULOSE;

ARTICLE; COMPRESSION; DENSITY; DRUG FORMULATION; ENERGY YIELD; FLOW KINETICS; MATERIALS TESTING; PARTICLE SIZE; POLYMERIZATION; POROSITY; POWDER; PRIORITY JOURNAL; TECHNIQUE;

ALGORITHMS; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DRUG COMPOUNDING; POROSITY; POWDERS; RHEOLOGY; TENSILE STRENGTH;

EID: 18744376589     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-200054481     Document Type: Article

References (20)

1. Reynier, J.P.; Andrieu, V.; Piccerelle, P. Regulatory perpectives on excipients affecting the development and the approval of medicinal products. Eur. J. Pharm. Sci. 2003, 17 (Suppl. 1), S4-S5.
2. Gabaude, C.M.D.; Gautier, J.-C.; Saudemon, P.; Chulia, D. Validation of a new pertinent packing coefficient to estimate flow properties of pharmav ceutical powders at a very early development stage, by comparison with mercury intrusion and classical flowability methods. J. Mater. Sci. 2001, 36, 1763-1773.
3. Viana, M.; Gabaude-Renou, C.M.D.; Pontier, C.; Chulia, D. The packing coefficient: a suitable parameter to assess the flow properties of powders. Kona 2001, 19, 85-93.
4. Pontier, C. Les phosphates de calcium apathiques en compression. De la chimie aux qualités d'usage. Ph.D. Thesis; Chatenay-Malabry: Paris XI, 2001.
5. Pontier, C.; Viana, M.; Champion, E.; Bernache-Assolant, D.; Chulia, D. Energetic yields in apatitic calcium phosphate compression: influence of the Ca/P molar ratio. Polym. Int. 2003, 52, 625-628.
6. Heckel, R.W. Density-pressure relationships in powder compaction. Trans. Metall. Soc. AIME 1961, 221, 671-675.
7. Gabaude, C.M.D.; Guillot, M.; Gautier, J.-C.; Saudemon, P.; Chulia, D. Effects of true density, compacted mass, compression speed, and punch deformation on the mean yield pressure. J. Pharm. Sci. 1999, 88 (7), 725-730.
8. Procopio, A.T.; Zavaliangos, A.; Cunningham, J.C. Analysis of the diametral compression test and the applicability to plastically deforming materials. J. Mater. Sci. 2003, 38, 3629-3639.
9. Cunningham, J.C.; Sinka, I.C.; Zavaliangos, A. Analysis of tablet compaction. I. Characterization of mechanical behavior of powder and powder/tooling friction. J. Pharm. Sci. 2004, 93 (8), 2022-2039.
10. Fell, J.T.; Newton, J.-M. Determination of tablet strength by the diametral-compression test. J. Pharm. Sci. 1970, 59 (5), 688-691.
11. Gabaude, C. De la poudre au comprimé: une stratégie de caractérisation pour un développement rationnel. Ph.D. Thesis, 1999, Limoges.
12. Pontier, C.; Champion, E.; Viani M.; Chulia, D.; Bernache-Assolant, D. Use of cycles of compression to characterize powder behavior - application to apatitic calcium phosphates. J. Eur. Ceram. Soc. 2002, 22 (8), 171-182.
13. Pontier, C.; Viana, M.; Champion, E.; Chulia, D. Apatitic calcium phosphates used in compression: rationalization of the end-use properties. Powder Technol. 2003, 130, 436-441.
14. Doelker, E.; Gurny, R.; Schurz, J.; Janosi, A.; Matin, N. Degrees of crystallinity and polymerization of modified cellulose powders for direct tabletting. Powder Technol. 1987, 52, 207-213.
15. Landin, M.; Martinez-pachero, R.; Geinez-Amoza, J.L.; Souto, C.; Concheiro, A.; Rowe, R.C. Effect of batch variation and source of pulp on the properties of macrocrystalline cellulose. Int. J. Pharm. 1993, 91, 133-141.
16. European Pharmacopoeia, 4th Ed.; European Council Editions: Strasbourg, 2004.
17. AVICEL, FMC BioPolymer, Technical Document.
18. ELCEMA, Degussa AG, Technical Document.
19. Détermination de l'indice de viscosité limite de la cellulose en solution diluée, NFT 12-005 norm.
20. Viana, M.; Jouannin, P.; Pontier, C.; Chulia, D. About pycnometric density measurements. Talanta 2002, 57, 583-593.