Hypotensive effect of Oxacom® containing a dinitrosyl iron complex with glutathione: Animal studies and clinical trials on healthy volunteers

Nitric Oxide - Biology and Chemistry

Volumn 26, Issue 3, 2012, Pages 148-156

  Chazov, Evgeny I ^a   Rodnenkov, Oleg V ^a   Zorin, Andrey V ^a   Lakomkin, Vladimir L ^a   Gramovich, Vladimir V ^a   Vyborov, Oleg N ^a   Dragnev, Anatoly G ^a   Timoshin, Alexander A ^a   Buryachkovskaya, Lyudmila I ^a   Abramov, Alexander A ^a   Massenko, Valery P ^a   Arzamastsev, Evgeny V ^a   Kapelko, Valery I ^a   Vanin, Anatoly F ^b  

^a N N BLOKHIN NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY   (Russian Federation)

^b SEMENOV INSTITUTE OF CHEMICAL PHYSICS   (Russian Federation)

Author keywords

Animals; Dinitrosyl iron complexes; Hypotension; Volunteers

Indexed keywords

ANTIHYPERTENSIVE AGENT; GLUTATHIONE; IRON COMPLEX; OXACOM; S NITROSOGLUTATHIONE; SODIUM NITRITE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; ANIMAL EXPERIMENT; ARTICLE; CLINICAL STUDY; CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; DRUG STABILITY; EVOKED RESPONSE; HEART OUTPUT; HEART RATE; HUMAN; HUMAN EXPERIMENT; INFORMATION PROCESSING; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

ADULT; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CARDIAC OUTPUT; EMBRYO, MAMMALIAN; FEMALE; FERROUS COMPOUNDS; GLUTATHIONE; HEMOSTASIS; HORMONES; HUMANS; MALE; PLATELET ADHESIVENESS; PREGNANCY; RATS; RATS, WISTAR; TOXICITY TESTS;

ANIMALIA; RATTUS;

EID: 84859104285     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2012.01.008     Document Type: Article

References (28)

1. V.L. Lakomkin, A.F. Vanin, A.A. Timoshin, V.I. Kapel'ko, and E.I. Chazov Long-lasting hypotensive action of stable preparation of dinitrosyl-iron complexes with thiol-containing ligands in conscious normotensive and hypertensive rats Nitric Oxide Biol. Chem. 16 2007 413 418
2. K.B. Shumaev, A.F. Vanin, V.L. Lakomkin, V.P. Mokh, L.I. Serebryakova, O.V. Tskitishvili, A.A. Timoshin, A.V. Maksimenko, O.I. Pisarenko, E.K. Ruuge, V.I. Kapel'ko, and E.I. Chazov Involvement of active oxygen forms in the modulation of the antihypertensive effect of iron dinitrosyl complexes Cardiological Vestnik (Rus.) 2 2007 31 37
3. V.L. Lakomkin, A.A. Timoshin, Ts.R. Orlova, S.A. Gubkina, A.N. Storozhilova, T.E. Gvozdik, A.B. Dobrovol'sky, E.K. Ruuge, A.F. Vanin, V.I. Kapel'ko, B.A. Lapin, and E.I. Chazov Effect of the nitric oxide donor dinitrosyl iron complex with glutathione on circulation in rats, rabbit and monkey Kardiologiya (Rus.) 49 2009 53 60
4. A.F. Vanin, A.P. Poltorakov, V.D. Mikoyan, L.N. Kubrina, and D.S. Burbaev Polynuclear water-soluble dinitrosyl iron complexes with cysteine or glutathione ligands: electron paramagnetic resonance and optical studies Nitric Oxide Biol. Chem. 23 2010 136 149
5. A.F. Vanin, V.P. Mokh, V.A. Serezhenkov, and E.I. Chazov Vasorelaxing activity of stable powder preparations of dinitrosyl iron complexes with cysteine or glutathione Nitric Oxide Biol. Chem. 16 2007 322 330
6. A. Mülsch, P. Mordvintcev, A.F. Vanin, and R. Busse The potent vasodilating activity and guanylyl cyclase activating dinitrosyl-iron(II) complex is stored in a protein-bound form in vascular tissue and is released by thiols FEBS Lett. 294 1991 252 256
7. Y.P. Vedernikov, P.I. Mordvintcev, I.V. Malenkova, and A.F. Vanin Similarity between the vasorelaxing activity of dinitrosyl iron complexes and endothelium-derived relaxing factor Eur. J. Pharmcol. 211 1992 313 317
8. A.F. Vanin, I.V. Malenkova, and V.A. Serezhenkov Iron catalyzes both decomposition and synthesis of S-nitrosothiols: optical and electron paramagnetic resonance studies Nitric Oxide Biol. Chem. 1 1997 191 203
9. S. Constanzo, S. Menage, R. Purello, R.P. Bonomo, and M. Fontecave Re-examination of the formation of dinitrosyl-iron complexes during reaction of S-nitrosothiols with Fe(II) Inorg. Chem. Acta 318 2001 1 7
10. M. Lo Bello, M. Nuccetelli, A.M. Caccuri, L. Stella, M.W. Parker, J. Rossjohn, W. McKinstry, A.F. Mozzi, G. Federici, F. Polici, J.Z. Pedersen, and G. Ricci Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme J. Biol. Chem. 276 2001 42138 42145
11. A.F. Vanin, V.I. Lozinsky, V.I. Kapel'ko, Polymeric composition for designing a stabilized form of dinitrosyl-iron complex and the method of this complex form synthesis. Russian Patent Application, No. 2291880 from 01.12.2005 to 01.12.2025.
12. R.U. Khabriev (Ed.), Handbook on Experimental (Preclinical) Studies of New Substances. Moscow, 2005, p. 827 (in Russian).
13. A.F. Vanin, V.A. Serezhenkov, V.D. Mikoyan, and M.V. Genkin The 2.03 signal as an indicator of dinitrosyl-iron complexes with thiol-containing ligands Nitric Oxide Biol. Chem. 2 1998 224 234
14. A.F. Vanin Dinitrosyl iron complexes with thiolate ligands: physico-chemistry, biochemistry and physiology Nitric Oxide Biol. Chem. 21 2009 1 13
15. L.J. Ignarro Nitric Oxide: Biology and Pharmacology 2000 1st Academic Press San Diego
16. A.F. Vanin, and V.Ja. Varich Nitrosyl non-heme iron complexes in animal tissues Studia Biophys. 86 1981 175 185
17. K.B. Shumaev, A.A. Gubkin, V.A. Serezhenkov, I.I. Lobysheva, O.V. Kosmachevskaya, E.K. Ruuge, V.Z. Lankin, A.F. Topunov, and A.F. Vanin Interaction of reactive oxygen and nitrogen species with albumin- and methemoglobin-bound dinitrosyl-iron complexes Nitric Oxide Biol. Chem. 18 2007 37 46
18. R.M. Pluta, E.H. Oldfield, K.D. Bakhtian, A.R. Fathi, R.K. Smith, H.L. DeVroom, M. Nahavandi, S. Woo, W.D. Figg, and R.L. Lonser Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers Plos ONE 6 2011 e14504
19. K. Cosby, K.S. Patovi, J.H. Crawford, R.H. Patel, C.D. Reiter, S. Martyr, B.K. Yang, M.A. Waclawiw, G. Zalos, X. Xu, K.T. Huang, H. Shields, D.B. Kim-Shapiro, A.N. Shechter, R.O. Cannon, and M.T. Gladwin Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation Nat. Med. 9 2003 1498 1505
20. D. Jourd'heuil, F.L. Jourd'heuil, and M. Feelisch Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide J. Biol. Chem. 278 2003 15720 15726
21. Z. Huang, S. Shiva, D. Kim-Shapiro, R. Patel, L. Ringwood, C. Irby, K. Huang, C. Ho, N. Hogg, A. Shechter, and M. Gladwin Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control J. Clin. Invest. 115 2005 2099 2107
22. P.I. Mordvintcev, V.G. Rudneva, A.F. Vanin, L.L. Shimkevich, and B.I. Khodorov The inhibitory effect of low-molecular dinitrosyl iron complexes on platelet aggregation Biokhimiya (Rus.) 51 1986 1851 1857
23. V.A. Kuznetsov, P.I. Mordvintcev, E.K. Dank, V.A. Yurkiv, and A.F. Vanin Low-molecular and protein-bound dinitrosyl iron complexes as inhibitors of platelet aggregation Voprosy Med. Khimii (Rus.) 5 1988 43 46
24. R.H. Zhou, and W.H. Frishman The antiplatelet effects of nitrates: is it of clinical significance in patients with cardiovascular diseases? Cardiol. Rev. 18 2010 198 203
25. C.A. Bosworth, J.C. Toledo, J.W. Zmijewski, Q. Li, and J.R. Lancaster Dinitrosyliron complexes and the mechanism(s) of cellular protein nitrosothiol formation from nitric oxide Proc. Natl. Acad. Sci. USA 106 2009 4671 4676
26. N.Ja. Giliano, L.V. Konevega, L.A. Noskin, V.A. Serezhenkov, A.P. Poltorakov, and A.F. Vanin Dinitrosyl iron complexes with thiol-containing ligands and apoptosis: studies with HeLa cell culture Nitric Oxide Biol. Chem. 24 2011 151 159
27. H. Ding, and B. Demple Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator Proc. Natl. Acad. Sci. USA 97 2000 5146 5150
28. J.C. Crack, L.J. Smith, M.T.R. Stapleton, J. Peck, N.J. Walmough, M.J. Buttner, R.S. Buxton, J. Green, V.S. Oganesyan, A.J. Thomson, and N.E. Le Brun Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster in WhiB-like proteins J. Am. Chem. Soc. 133 2011 1112 1121