Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine

Neuropharmacology

Volumn 62, Issue 7, 2012, Pages 2251-2260

  Hirakawa, Ryoko ^a   El Bizri, Nesrine ^a   Shryock, John C ^a   Belardinelli, Luiz ^a   Rajamani, Sridharan ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

Dorsal root ganglion; Neuropathic pain; Sodium channel; Tetrodotoxin

Indexed keywords

RANOLAZINE; SODIUM CHANNEL; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MEMBRANE STEADY POTENTIAL; NERVE CELL; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SODIUM CURRENT; SPINAL GANGLION; STEADY STATE;

EID: 84859103408     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.01.021     Document Type: Article

References (35)

1. C. Antzelevitch, L. Belardinelli, A.C. Zygmunt, A. Burashnikov, J.M. Di Diego, J.M. Fish, J.M. Cordeiro, and G. Thomas Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties Circulation 110 2004 904 910 (Pubitemid 39136212)
2. S.C. Benn, M. Costigan, S. Tate, M. Fitzgerald, and C.J. Woolf Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons J. Neurosci. 21 2001 6077 6085 (Pubitemid 32737741)
3. B.K. Beyreuther, J. Freitag, C. Heers, N. Krebsfanger, U. Scharfenecker, and T. Stohr Lacosamide: a review of preclinical properties CNS Drug Rev. 13 2007 21 42 (Pubitemid 46697839)
4. J.A. Black, S. Liu, M. Tanaka, T.R. Cummins, and S.G. Waxman Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain Pain 108 2004 237 247 (Pubitemid 38353046)
5. N.T. Blair, and B.P. Bean Role of tetrodotoxin-resistant Na+ current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons J. Neurosci. 23 2003 10338 10350 (Pubitemid 37444611)
6. D.B. Carr, M. Day, A.R. Cantrell, J. Held, T. Scheuer, W.A. Catterall, and D.J. Surmeier Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticity Neuron 39 2003 793 806 (Pubitemid 37088091)
7. G.P. Casey, J.S. Roberts, D. Paul, I. Diamond, and H.J. Gould 3rd Ranolazine attenuation of CFA-induced mechanical hyperalgesia Pain Med. 11 2010 119 126
8. J.J. Cox, F. Reimann, A.K. Nicholas, G. Thornton, E. Roberts, K. Springell, G. Karbani, H. Jafri, J. Mannan, Y. Raashid, L. Al-Gazali, H. Hamamy, E.M. Valente, S. Gorman, R. Williams, D.P. McHale, J.N. Wood, F.M. Gribble, and C.G. Woods An SCN9A channelopathy causes congenital inability to experience pain Nature 444 2006 894 898 (Pubitemid 46024997)
9. T.R. Cummins, F. Aglieco, M. Renganathan, R.I. Herzog, S.D. Dib-Hajj, and S.G. Waxman Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons J. Neurosci. 21 2001 5952 5961 (Pubitemid 32737728)
10. S.D. Dib-Hajj, J.A. Black, and S.G. Waxman Voltage-gated sodium channels: therapeutic targets for pain Pain Med. 10 2009 1260 1269
11. J.P. Drenth, R.H. te Morsche, G. Guillet, A. Taieb, R.L. Kirby, and J.B. Jansen SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels J. Invest. Dermatol. 124 2005 1333 1338 (Pubitemid 40847424)
12. v1.4 sodium channels and paramyotonia congenita mutants Channels (Austin) 5 2011 161 172
13. A.C. Errington, T. Stohr, C. Heers, and G. Lees The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels Mol. Pharmacol. 73 2008 157 169 (Pubitemid 350294207)
14. M. Estacion, S.G. Waxman, and S.D. Dib-Hajj Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability Mol. Pain 6 2010 35
15. C.R. Fertleman, M.D. Baker, K.A. Parker, S. Moffatt, F.V. Elmslie, B. Abrahamsen, J. Ostman, N. Klugbauer, J.N. Wood, R.M. Gardiner, and M. Rees SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes Neuron 52 2006 767 774 (Pubitemid 44828442)
16. Y.P. Goldberg, J. MacFarlane, M.L. MacDonald, J. Thompson, M.P. Dube, M. Mattice, R. Fraser, C. Young, S. Hossain, T. Pape, B. Payne, C. Radomski, G. Donaldson, E. Ives, J. Cox, H.B. Younghusband, R. Green, A. Duff, E. Boltshauser, G.A. Grinspan, J.H. Dimon, B.G. Sibley, G. Andria, E. Toscano, J. Kerdraon, D. Bowsher, S.N. Pimstone, M.E. Samuels, R. Sherrington, and M.R. Hayden Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations Clin. Genet. 71 2007 311 319 (Pubitemid 46690905)
17. A.L. Goldin Evolution of voltage-gated Na(+) channels J. Exp. Biol. 205 2002 575 584
18. H.J. Gould 3rd, C. Garrett, R.R. Donahue, D. Paul, I. Diamond, and B.K. Taylor Ranolazine attenuates behavioral signs of neuropathic pain Behav. Pharmacol. 2009
19. S.B. Hoyt, C. London, H. Ok, E. Gonzalez, J.L. Duffy, C. Abbadie, B. Dean, J.P. Felix, M.L. Garcia, N. Jochnowitz, B.V. Karanam, X. Li, K.A. Lyons, E. McGowan, D.E. Macintyre, W.J. Martin, B.T. Priest, M.M. Smith, R. Tschirret-Guth, V.A. Warren, B.S. Williams, G.J. Kaczorowski, and W.H. Parsons Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain Bioorg. Med. Chem. Lett. 17 2007 6172 6177 (Pubitemid 47552831)
20. M.F. Jarvis, P. Honore, C.C. Shieh, M. Chapman, S. Joshi, X.F. Zhang, M. Kort, W. Carroll, B. Marron, R. Atkinson, J. Thomas, D. Liu, M. Krambis, Y. Liu, S. McGaraughty, K. Chu, R. Roeloffs, C. Zhong, J.P. Mikusa, G. Hernandez, D. Gauvin, C. Wade, C. Zhu, M. Pai, M. Scanio, L. Shi, I. Drizin, R. Gregg, M. Matulenko, A. Hakeem, M. Gross, M. Johnson, K. Marsh, P.K. Wagoner, J.P. Sullivan, C.R. Faltynek, and D.S. Krafte A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat Proc. Natl. Acad. Sci. U. S. A. 104 2007 8520 8525 (Pubitemid 47175520)
21. K.M. Kahlig, I. Lepist, K. Leung, S. Rajamani, and A.L. George Jr. Ranolazine selectively blocks persistent current evoked by epilepsy-associated Na(V) 1.1 mutations Br. J. Pharmacol. 161 2010 1414 1426
22. C.H. Kim, Y. Oh, J.M. Chung, and K. Chung The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation Brain Res. Mol. Brain Res. 95 2001 153 161 (Pubitemid 33000374)
23. Y.I. Kim, H.S. Na, S.H. Kim, H.C. Han, Y.W. Yoon, B. Sung, H.J. Nam, S.L. Shin, and S.K. Hong Cell type-specific changes of the membrane properties of peripherally-axotomized dorsal root ganglion neurons in a rat model of neuropathic pain Neuroscience 86 1998 301 309 (Pubitemid 28270875)
24. M.J. Lee, H.S. Yu, S.T. Hsieh, D.A. Stephenson, C.J. Lu, and C.C. Yang Characterization of a familial case with primary erythromelalgia from Taiwan J. Neurol. 254 2007 210 214 (Pubitemid 46356054)
25. M. Mantegazza, G. Curia, G. Biagini, D.S. Ragsdale, and M. Avoli Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders Lancet Neurol. 9 2010 413 424
26. D.A. Morrow, B.M. Scirica, E. Karwatowska-Prokopczuk, S.A. Murphy, A. Budaj, S. Varshavsky, A.A. Wolff, A. Skene, C.H. McCabe, and E. Braunwald Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial JAMA 297 2007 1775 1783 (Pubitemid 46658646)
27. A.K. Persson, J.A. Black, A. Gasser, T. Fischer, and S.G. Waxman Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals Mol. Pain 6 2010 84
28. S. Rajamani, J.C. Shryock, and L. Belardinelli Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine Channels (Austin) 2 2008 449 460
29. M.L. Roy, and T. Narahashi Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons J. Neurosci. 12 1992 2104 2111
30. A.M. Rush, M.E. Brau, A.A. Elliott, and J.R. Elliott Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia J. Physiol. 511 Pt 3 1998 771 789 (Pubitemid 28456906)
31. A. Toib, V. Lyakhov, and S. Marom Interaction between duration of activity and time course of recovery from slow inactivation in mammalian brain Na+ channels J. Neurosci. 18 1998 1893 1903 (Pubitemid 28103097)
32. J.J. Toledo-Aral, B.L. Moss, Z.J. He, A.G. Koszowski, T. Whisenand, S.R. Levinson, J.J. Wolf, I. Silos-Santiago, S. Halegoua, and G. Mandel Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons Proc. Natl. Acad. Sci. U. S. A. 94 1997 1527 1532 (Pubitemid 27087885)
33. P.K. Tripathi, L. Trujillo, C.A. Cardenas, C.G. Cardenas, A.J. de Armendi, and R.S. Scroggs Analysis of the variation in use-dependent inactivation of high-threshold tetrodotoxin-resistant sodium currents recorded from rat sensory neurons Neuroscience 143 2006 923 938 (Pubitemid 44827520)
34. G.K. Wang, J. Calderon, and S.Y. Wang State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine Mol. Pharmacol. 73 2008 940 948 (Pubitemid 351397898)
35. S.G. Waxman, J.D. Kocsis, and J.A. Black Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy J. Neurophysiol. 72 1994 466 470 (Pubitemid 24233666)