메뉴 건너뛰기




Volumn 22, Issue 4, 2012, Pages 229-235

A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy

Author keywords

adverse drug reaction; myelosuppression; pancreatic cancer; single nucleotide polymorphism

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; GEMCITABINE;

EID: 84859101072     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32834e9eba     Document Type: Article
Times cited : (20)

References (33)
  • 1
    • 0030867348 scopus 로고    scopus 로고
    • Safety profile of gemcitabine a novel anticancer agent, in non-small cell lung cancer
    • DOI 10.1097/00001813-199707000-00005
    • Cortes-Funes H, Martin C, Abratt R, Lund B. Safety profile ofgemcitabine, a novel anticancer agent, in non-small cell lung cancer. Anticancer Drugs 1997; 8:582-587. (Pubitemid 27373437)
    • (1997) Anti-Cancer Drugs , vol.8 , Issue.6 , pp. 582-587
    • Cortes-Funes, H.1    Martin, C.2    Abratt, R.3    Lund, B.4
  • 2
    • 0033635935 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin inthe treatment of advanced or metastatic pancreatic cancer
    • Heinemann V, Wilke H, Mergenthaler HG, Clemens M, Konig H, Illiger HJ, et al. Gemcitabine and cisplatin inthe treatment of advanced or metastatic pancreatic cancer. Ann Oncol 2000; 11:1399-1403.
    • (2000) Ann Oncol , vol.11 , pp. 1399-1403
    • Heinemann, V.1    Wilke, H.2    Mergenthaler, H.G.3    Clemens, M.4    Konig, H.5    Illiger, H.J.6
  • 3
    • 55149114668 scopus 로고    scopus 로고
    • Prognostic factors inJapanese patients with advanced pancreatic cancer treated with single-agent gemcitabine as first-line therapy
    • Tanaka T, Ikeda M, Okusaka T, Ueno H, Morizane C, Hagihara A, et al. Prognostic factors inJapanese patients with advanced pancreatic cancer treated with single-agent gemcitabine as first-line therapy. Jpn J Clin Oncol 2008; 38:755-761.
    • (2008) Jpn J Clin Oncol , vol.38 , pp. 755-761
    • Tanaka, T.1    Ikeda, M.2    Okusaka, T.3    Ueno, H.4    Morizane, C.5    Hagihara, A.6
  • 4
    • 65949103437 scopus 로고    scopus 로고
    • Palliative chemotherapy for patients with recurrent hepatocellular carcinoma after liver transplantation
    • Lee JO, Kim DY, Lim JH, Seo MD, Yi HG, Oh DY, et al. Palliative chemotherapy for patients with recurrent hepatocellular carcinoma after liver transplantation. J Gastroenterol Hepatol 2009; 24:800-805.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 800-805
    • Lee, J.O.1    Kim, D.Y.2    Lim, J.H.3    Seo, M.D.4    Yi, H.G.5    Oh, D.Y.6
  • 5
    • 0033520708 scopus 로고    scopus 로고
    • Gemcitabine transport inxenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters
    • Mackey JR, Yao SY, Smith KM, Karpinski E, Baldwin SA, Cass CE, et al. Gemcitabine transport inxenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. J Natl Cancer Inst 1999; 91:1876-1881.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1876-1881
    • Mackey, J.R.1    Yao, S.Y.2    Smith, K.M.3    Karpinski, E.4    Baldwin, S.A.5    Cass, C.E.6
  • 6
    • 0035951808 scopus 로고    scopus 로고
    • +-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)
    • +-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J Biol Chem 2001; 276:2914-2927.
    • (2001) J Biol Chem , vol.276 , pp. 2914-2927
    • Ritzel, M.W.1    Ng, A.M.2    Yao, S.Y.3    Graham, K.4    Loewen, S.K.5    Smith, K.M.6
  • 7
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey JR, Mani RS, Selner M, Mowles D, Young JD, Belt JA, et al. Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res 1998; 58:4349-4357. (Pubitemid 28450036)
    • (1998) Cancer Research , vol.58 , Issue.19 , pp. 4349-4357
    • Mackey, J.R.1    Mani, R.S.2    Selner, M.3    Mowles, D.4    Young, J.D.5    Belt, J.A.6    Crawford, C.R.7    Cass, C.E.8
  • 8
    • 0242552804 scopus 로고    scopus 로고
    • Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
    • DOI 10.1016/j.pharmthera.2003.07.001
    • Van Rompay AR, Johansson M, Karlsson A. Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases. Pharmacol Ther 2003; 100:119-139. (Pubitemid 37377909)
    • (2003) Pharmacology and Therapeutics , vol.100 , Issue.2 , pp. 119-139
    • Van Rompay, A.R.1    Johansson, M.2    Karlsson, A.3
  • 10
    • 0029584109 scopus 로고
    • Preclinical characteristics ofgemcitabine
    • Plunkett W, Huang P, Gandhi V. Preclinical characteristics ofgemcitabine. Anticancer Drugs 1995; 6 (Suppl 6):7-13.
    • (1995) Anticancer Drugs , vol.6 , Issue.SUPPL. 6 , pp. 7-13
    • Plunkett, W.1    Huang, P.2    Gandhi, V.3
  • 11
    • 34447137381 scopus 로고    scopus 로고
    • An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients
    • Rha SY, Jeung HC, Choi YH, Yang WI, Yoo JH, Kim BS, et al. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. Oncologist 2007; 12:622-630.
    • (2007) Oncologist , vol.12 , pp. 622-630
    • Rha, S.Y.1    Jeung, H.C.2    Choi, Y.H.3    Yang, W.I.4    Yoo, J.H.5    Kim, B.S.6
  • 13
    • 78449305536 scopus 로고    scopus 로고
    • Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer
    • Tanaka M, Javle M, Dong X, Eng C, Abbruzzese JL, Li D. Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. Cancer 2010; 116:5325-5335.
    • (2010) Cancer , vol.116 , pp. 5325-5335
    • Tanaka, M.1    Javle, M.2    Dong, X.3    Eng, C.4    Abbruzzese, J.L.5    Li, D.6
  • 14
    • 65549094094 scopus 로고    scopus 로고
    • Phase IIstudies of gemcitabine and cisplatin in heavily and minimally pretreated metastatic breast cancer
    • Chew HK, Doroshow JH, Frankel P, Margolin KA, Somlo G, Lenz HJ, et al. Phase IIstudies of gemcitabine and cisplatin in heavily and minimally pretreated metastatic breast cancer. J Clin Oncol 2009; 27:2163-2169.
    • (2009) J Clin Oncol , vol.27 , pp. 2163-2169
    • Chew, H.K.1    Doroshow, J.H.2    Frankel, P.3    Margolin, K.A.4    Somlo, G.5    Lenz, H.J.6
  • 17
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • International HapMap Consortium
    • International HapMap Consortium. The International HapMap Project. Nature 2003; 426:789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 18
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B 1995; 57:289-300.
    • (1995) J R Stat Soc B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 20
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • DOI 10.1093/bioinformatics/bth457
    • Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265. (Pubitemid 40202029)
    • (2005) Bioinformatics , vol.21 , Issue.2 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 21
    • 0032428332 scopus 로고    scopus 로고
    • Death associated proteins (DAPs): From gene identification to the analysis of their apoptotic and tumor suppressive functions
    • Levy-Strumpf N, Kimchi A. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. Oncogene 1998; 17:3331-3340. (Pubitemid 29043985)
    • (1998) Oncogene , vol.17 , Issue.25 , pp. 3331-3340
    • Levy-Strumpf, N.1    Kimchi, A.2
  • 22
    • 0032540501 scopus 로고    scopus 로고
    • DAP genes: Novel apoptotic genes isolated by a functional approach to gene cloning
    • DOI 10.1016/S0304-419X(98)00002-X, PII S0304419X9800002X
    • Kimchi A. DAP genes: novel apoptotic genes isolated by a functional approach to gene cloning. Biochim Biophys Acta 1998; 1377:F13-F33. (Pubitemid 28207051)
    • (1998) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1377 , Issue.2
    • Kimchi, A.1
  • 23
    • 0036279152 scopus 로고    scopus 로고
    • Overexpression of translocation-associated fusion genes of FGFR1, MYC, NPM1, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis
    • Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, et al. Overexpression oftranslocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis. Haematologica 2002; 87:569-577. (Pubitemid 34640638)
    • (2002) Haematologica , vol.87 , Issue.6 , pp. 569-577
    • Larramendy, M.L.1    Niini, T.2    Elonen, E.3    Nagy, B.4    Ollila, J.5    Vihinen, M.6    Knuutila, S.7
  • 25
    • 77951047269 scopus 로고    scopus 로고
    • Establishment and characterization ofmultidrug-resistant gastric cancer cell lines
    • Zhang X, Yashiro M, Qiu H, Nishii T, Matsuzaki T, Hirakawa K. Establishment and characterization ofmultidrug-resistant gastric cancer cell lines. Anticancer Res 2010; 30:915-921.
    • (2010) Anticancer Res , vol.30 , pp. 915-921
    • Zhang, X.1    Yashiro, M.2    Qiu, H.3    Nishii, T.4    Matsuzaki, T.5    Hirakawa, K.6
  • 26
    • 0001074646 scopus 로고    scopus 로고
    • Subtypes of the type 4 cAMP phosphodiesterases: Structure, regulation and selective inhibition
    • DOI 10.1016/0165-6147(96)10035-3
    • Muller T, Engels P, Fozard JR. Subtypes ofthe type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition. Trends Pharmacol Sci 1996; 17:294-298. (Pubitemid 26261894)
    • (1996) Trends in Pharmacological Sciences , vol.17 , Issue.8 , pp. 294-298
    • Muller, T.1    Engels, P.2    Fozard, J.R.3
  • 28
    • 34249329914 scopus 로고    scopus 로고
    • Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification
    • DOI 10.1158/0008-5472.CAN-06-4495
    • Tooker P, Yen WC, Ng SC, Negro-Vilar A, Hermann TW. Bexarotene (LGD1069, Targretin), aselective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. Cancer Res 2007; 67:4425-4433. (Pubitemid 46815092)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4425-4433
    • Tooker, P.1    Yen, W.-C.2    Ng, S.-C.3    Negro-Vilar, A.4    Hermann, T.W.5
  • 30
    • 74949112149 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms ofgemcitabine metabolic genes and pancreatic cancer survival and drug toxicity
    • Okazaki T, Javle M, Tanaka M, Abbruzzese JL, Li D. Single nucleotide polymorphisms ofgemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. Clin Cancer Res 2010; 16:320-329.
    • (2010) Clin Cancer Res , vol.16 , pp. 320-329
    • Okazaki, T.1    Javle, M.2    Tanaka, M.3    Abbruzzese, J.L.4    Li, D.5
  • 32
    • 57649112390 scopus 로고    scopus 로고
    • Distribution ofgemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients
    • Soo RA, Wang LZ, Ng SS, Chong PY, Yong WP, Lee SC, et al. Distribution ofgemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients. Lung Cancer 2009; 63:121-127.
    • (2009) Lung Cancer , vol.63 , pp. 121-127
    • Soo, R.A.1    Wang, L.Z.2    Ng, S.S.3    Chong, P.Y.4    Yong, W.P.5    Lee, S.C.6
  • 33
    • 62549146215 scopus 로고    scopus 로고
    • Homozygous CDA*3 is amajor cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
    • Ueno H, Kaniwa N, Okusaka T, Ikeda M, Morizane C, Kondo S, et al. Homozygous CDA*3 is amajor cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients. Br J Cancer 2009; 100:870-873.
    • (2009) Br J Cancer , vol.100 , pp. 870-873
    • Ueno, H.1    Kaniwa, N.2    Okusaka, T.3    Ikeda, M.4    Morizane, C.5    Kondo, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.