Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells

Journal of Hazardous Materials

Volumn 182, Issue 1-3, 2010, Pages 649-655

  Hsu, Hsin Fen ^a   Tsou, Tsui Chun ^a   Chao, How Ran ^b   Kuo, Ya Ting ^a   Tsai, Feng Yuan ^a   Yeh, Szu Ching ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Adipocytes; Adipogenesis; Glucose uptake; Insulin resistance; TCDD

Indexed keywords

3T3-L1 ADIPOCYTES; ADIPOCYTES; ADIPOGENESIS; ADIPOGENIC; ADIPOSE TISSUE; ARYL HYDROCARBON RECEPTOR; CCAAT/ENHANCER-BINDING PROTEINS; CELL METABOLISM; GLUCOSE TRANSPORTERS; GLUCOSE UPTAKE; IN-VITRO; INHIBITORY EFFECT; INSULIN RESISTANCE; ISOPROTERENOL; MARKER GENES; OIL DROPLETS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; TETRACHLORODIBENZO P DIOXINS; TYPE II;

CYTOLOGY; DROP FORMATION; ENZYME INHIBITION; ENZYMES; GENE EXPRESSION; GLYCEROL; HYDROCARBONS; INSULIN; METABOLISM;

GLUCOSE;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; CCAAT ENHANCER BINDING PROTEIN ALPHA; DIOXIN; GLUCOSE TRANSPORTER 4; GLYCEROL; INSULIN; ISOPRENALINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

CHEMICAL COMPOUND; CYTOLOGY; DIABETES; GLUCOSE; METABOLISM; TCDD;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL METABOLISM; CELL STRAIN 3T3; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; IN VITRO STUDY; INSULIN RESISTANCE; LIPID METABOLISM; LIPOLYSIS; MOUSE; NONHUMAN;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; DNA PRIMERS; GLUCOSE; INSULIN; ISOPROTERENOL; MICE; RECEPTORS, ARYL HYDROCARBON; TETRACHLORODIBENZODIOXIN;

EID: 77955561314     PISSN: 03043894     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2010.06.081     Document Type: Article

References (43)

1. Kulkarni P.S., Crespo J.G., Afonso C.A. Dioxins sources and current remediation technologies-a review. Environ. Int. 2008, 34:139-153.
2. Geyer H.J., Scheunert I., Rapp K., Gebefugi I., Steinberg C., Kettrup A. The relevance of fat content in toxicity of lipophilic chemicals to terrestrial animals with special reference to dieldrin and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ecotoxicol. Environ. Saf. 1993, 26:45-60.
3. Michalek J.E., Pirkle J.L., Caudill S.P., Tripathi R.C., Patterson D.G., Needham L.L. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up. J. Toxicol. Environ. Health 1996, 47:209-220.
4. EFSA, Dioxins: Methodologies and Principles for Setting Tolerable Intake Levels for Dioxins, Furans and Dioxin-like PCBs, European Food Safety Authority (EFSA), Brussels, Belgium, 2004.
5. Mullerova D., Kopecky J. White adipose tissue: storage and effector site for environmental pollutants. Physiol. Res. 2007, 56:375-381.
6. Walker A.E., Martin J.V. Lipid profiles in dioxin-exposed workers. Lancet 1979, 1:446-447.
7. Martin J.V. Lipid abnormalities in workers exposed to dioxin. Br. J. Ind. Med. 1984, 41:254-256.
8. Gasiewicz T.A., Neal R.A. 2,3,7,8-Tetrachlorodibenzo-p-dioxin tissue distribution, excretion, and effects on clinical chemical parameters in guinea pigs. Toxicol. Appl. Pharmacol. 1979, 51:329-339.
9. Brewster D.W., Matsumura F. TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig. Biochem. Biophys. Res. Commun. 1984, 122:810-817.
10. Neal R.A., Beatty P.W., Gasiewicz T.A. Studies of the mechanisms of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ann. N. Y. Acad. Sci. 1979, 320:204-213.
11. Gupta B.N., Vos J.G., Moore J.A., Zinkl J.G., Bullock B.C. Pathologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals. Environ. Health Perspect. 1973, 5:125-140.
12. McConnell E.E., Moore J.A., Dalgard D.W. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rhesus monkeys (Macaca mulatta) following a single oral dose. Toxicol. Appl. Pharmacol. 1978, 43:175-187.
13. Brodie A.E., Azarenko V.A., Hu C.Y. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibition of fat cell differentiation. Toxicol. Lett. 1996, 84:55-59.
14. Alexander D.L., Ganem L.G., Fernandez-Salguero P., Gonzalez F., Jefcoate C.R. Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis. J. Cell Sci. 1998, 111(Pt 22):3311-3322.
15. Green H., Kehinde O. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 1975, 5:19-27.
16. Tsou T.C., Yeh S.C., Tsai F.Y., Chang L.W. The protective role of intracellular GSH status in the arsenite-induced vascular endothelial dysfunction. Chem. Res. Toxicol. 2004, 17:208-217.
17. May J.S., Prince A.M., Lyle R.E., McGehee R.E. Antisense suppression of p107 inhibits 3T3-L1 adipocyte differentiation. Biochem. Biophys. Res. Commun. 2001, 283:837-842.
18. Paul D.S., Harmon A.W., Winston C.P., Patel Y.M. Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes. Biochem. J. 2003, 376:625-632.
19. Harmon A.W., Paul D.S., Patel Y.M. MEK inhibitors impair insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E758-766.
20. Juan C.C., Chang C.L., Lai Y.H., Ho L.T. Endothelin-1 induces lipolysis in 3T3-L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 2005, 288:E1146-1152.
21. Mimura J., Fujii-Kuriyama Y. Functional role of AhR in the expression of toxic effects by TCDD. Biochim. Biophys. Acta 2003, 1619:263-268.
22. Carmen G.Y., Victor S.M. Signalling mechanisms regulating lipolysis. Cell Signal. 2006, 18:401-408.
23. Langin D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol. Res. 2006, 53:482-491.
24. Rangwala S.M., Lazar M.A. Transcriptional control of adipogenesis. Annu. Rev. Nutr. 2000, 20:535-559.
25. Phillips M., Enan E., Liu P.C., Matsumura F. Inhibition of 3T3-L1 adipose differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Cell Sci. 1995, 108(Pt 1):395-402.
26. Cimafranca M.A., Hanlon P.R., Jefcoate C.R. TCDD administration after the pro-adipogenic differentiation stimulus inhibits PPARgamma through a MEK-dependent process but less effectively suppresses adipogenesis. Toxicol. Appl. Pharmacol. 2004, 196:156-168.
27. Shimba S., Todoroki K., Aoyagi T., Tezuka M. Depletion of arylhydrocarbon receptor during adipose differentiation in 3T3-L1 cells. Biochem. Biophys. Res. Commun. 1998, 249:131-137.
28. Shimba S., Hayashi M., Ohno T., Tezuka M. Transcriptional regulation of the AhR gene during adipose differentiation. Biol. Pharm. Bull. 2003, 26:1266-1271.
29. Gregoire F.M., Smas C.M., Sul H.S. Understanding adipocyte differentiation. Physiol. Rev. 1998, 78:783-809.
30. Rosen E.D., Spiegelman B.M. Molecular regulation of adipogenesis. Annu. Rev. Cell Dev. Biol. 2000, 16:145-171.
31. Henriksen G.L., Ketchum N.S., Michalek J.E., Swaby J.A. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. Epidemiology 1997, 8:252-258.
32. Bertazzi P.A., Bernucci I., Brambilla G., Consonni D., Pesatori A.C. The Seveso studies on early and long-term effects of dioxin exposure: a review. Environ. Health Perspect. 1998, 106(Suppl. 2):625-633.
33. Vena J., Boffetta P., Becher H., Benn T., Bueno-de-Mesquita H.B., Coggon D., Colin D., Flesch-Janys D., Green L., Kauppinen T., Littorin M., Lynge E., Mathews J.D., Neuberger M., Pearce N., Pesatori A.C., Saracci R., Steenland K., Kogevinas M. Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers. Environ. Health Perspect. 1998, 106(Suppl. 2):645-653.
34. Michalek J.E., Akhtar F.Z., Kiel J.L. Serum dioxin, insulin, fasting glucose, and sex hormone-binding globulin in veterans of Operation Ranch Hand. J. Clin. Endocrinol. Metab. 1999, 84:1540-1543.
35. Fujiyoshi P.T., Michalek J.E., Matsumura F. Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war. Environ. Health Perspect. 2006, 114:1677-1683.
36. Wang S.L., Tsai P.C., Yang C.Y., Leon Guo Y. Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort. Diabetes Care 2008, 31:1574-1579.
37. Chang J.W., Chen H.L., Su H.J., Liao P.C., Guo H.R., Lee C.C. Dioxin exposure and insulin resistance in Taiwanese living near a highly contaminated area. Epidemiology 2010, 21:56-61.
38. Liu P.C., Matsumura F. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the " adipose-type" and " brain-type" glucose transporters in mice. Mol. Pharmacol. 1995, 47:65-73.
39. Kurita H., Yoshioka W., Nishimura N., Kubota N., Kadowaki T., Tohyama C. Aryl hydrocarbon receptor-mediated effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on glucose-stimulated insulin secretion in mice. J. Appl. Toxicol. 2009, 29:689-694.
40. Olsen H., Enan E., Matsumura F. Regulation of glucose transport in the NIH 3T3 L1 preadipocyte cell line by TCDD. Environ. Health Perspect. 1994, 102:454-458.
41. Li W., Vogel C.F., Matsumura F. Studies on the cell treatment conditions to elicit lipolytic responses from 3T3-L1 adipocytes to TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Cell Biochem. 2007, 102:389-402.
42. Arner P. Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract. Res. Clin. Endocrinol. Metab. 2005, 19:471-482.
43. Kern P.A., Dicker-Brown A., Said S.T., Kennedy R., Fonseca V.A. The stimulation of tumor necrosis factor and inhibition of glucose transport and lipoprotein lipase in adipose cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Metabolism 2002, 51:65-68.