메뉴 건너뛰기




Volumn 231, Issue 1, 2012, Pages 92-96

Antioxidant administration prevents memory impairment in an animal model of maple syrup urine disease

Author keywords

Antioxidants; Cognitive impairment; Inborn errors of metabolism; Maple syrup urine disease; SHIRPA

Indexed keywords

ACETYLCYSTEINE; BRANCHED CHAIN AMINO ACID; DEFEROXAMINE; ISOLEUCINE; LEUCINE; SODIUM CHLORIDE; VALINE;

EID: 84859083891     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.03.004     Document Type: Article
Times cited : (29)

References (53)
  • 1
    • 0002977005 scopus 로고    scopus 로고
    • Maple syrup urine disease (branched-chain ketoaciduria)
    • McGraw-Hill, New York, C.R. Scriver, A.L. Beaudt, W.L. Sly, D. Valle (Eds.)
    • Chuang D.T., Shih V.E. Maple syrup urine disease (branched-chain ketoaciduria). The metabolic and molecular bases of inherited disease 2001, 1971-2005. McGraw-Hill, New York. C.R. Scriver, A.L. Beaudt, W.L. Sly, D. Valle (Eds.).
    • (2001) The metabolic and molecular bases of inherited disease , pp. 1971-2005
    • Chuang, D.T.1    Shih, V.E.2
  • 2
    • 0026553444 scopus 로고
    • Maple syrup urine disease: interrelationship between branched-chain amino-, oxo- and hydroxyacids; implications for treatment; associations with CNS dysmyelination
    • Treacy E., Clow C.L., Reade T.R., Chitayat D., Mamer O.A., Scriver C.R. Maple syrup urine disease: interrelationship between branched-chain amino-, oxo- and hydroxyacids; implications for treatment; associations with CNS dysmyelination. J Inherit Metab Dis 1992, 15:121-135.
    • (1992) J Inherit Metab Dis , vol.15 , pp. 121-135
    • Treacy, E.1    Clow, C.L.2    Reade, T.R.3    Chitayat, D.4    Mamer, O.A.5    Scriver, C.R.6
  • 3
    • 1942425094 scopus 로고    scopus 로고
    • Dysmyelination in the brain of adolescents and young adults with maple syrup urine disease
    • Schonberger S., Schweiger B., Schwahn B., Schwarz M., Wendel U. Dysmyelination in the brain of adolescents and young adults with maple syrup urine disease. Mol Genet Metab 2004, 82:69-75.
    • (2004) Mol Genet Metab , vol.82 , pp. 69-75
    • Schonberger, S.1    Schweiger, B.2    Schwahn, B.3    Schwarz, M.4    Wendel, U.5
  • 4
    • 0026660006 scopus 로고
    • Glutamate and (-aminobutyric acid neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinemia encephalopathies in newborn calves
    • Dodd P.R., Williams S.H., Gundlach A.L., Harper P.A., Healy P.J., Dennis J.A., et al. Glutamate and (-aminobutyric acid neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinemia encephalopathies in newborn calves. J Neurochem 1992, 59:582-590.
    • (1992) J Neurochem , vol.59 , pp. 582-590
    • Dodd, P.R.1    Williams, S.H.2    Gundlach, A.L.3    Harper, P.A.4    Healy, P.J.5    Dennis, J.A.6
  • 5
    • 0014039598 scopus 로고
    • Changes in the amino acid composition of proteolipids of white matter during maturation of the human nervous system
    • Prensky A.L., Moser H.W. Changes in the amino acid composition of proteolipids of white matter during maturation of the human nervous system. J Neurochem 1967, 14:117-121.
    • (1967) J Neurochem , vol.14 , pp. 117-121
    • Prensky, A.L.1    Moser, H.W.2
  • 6
    • 0034547976 scopus 로고    scopus 로고
    • Inhibition of glutamate uptake into synaptic vesicles of rat brain by the metabolites accumulating in maple syrup urine disease
    • Tavares R.G., Santos C.E.F., Tasca C., Wajner M., Souza D.O., Dutra-Filho C.S. Inhibition of glutamate uptake into synaptic vesicles of rat brain by the metabolites accumulating in maple syrup urine disease. J Neurol Sci 2000, 181:44-49.
    • (2000) J Neurol Sci , vol.181 , pp. 44-49
    • Tavares, R.G.1    Santos, C.E.F.2    Tasca, C.3    Wajner, M.4    Souza, D.O.5    Dutra-Filho, C.S.6
  • 7
    • 0028006431 scopus 로고
    • Interrelationships of leucine and glutamate metabolism in cultured astrocyts
    • Yudkoff M., Daikhin Y., Lin Z.P., Nissim I., Stern J., Pleasure D., et al. Interrelationships of leucine and glutamate metabolism in cultured astrocyts. J Neurochem 1994, 62:1192-1202.
    • (1994) J Neurochem , vol.62 , pp. 1192-1202
    • Yudkoff, M.1    Daikhin, Y.2    Lin, Z.P.3    Nissim, I.4    Stern, J.5    Pleasure, D.6
  • 9
    • 0000299656 scopus 로고
    • Disorders of branched chain amino acid and keto acid metabolism
    • McGraw-Hill, New York, C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds.)
    • Danner D.J., Elsas L.J. Disorders of branched chain amino acid and keto acid metabolism. The metabolic basis of inherited disease 1989, 671-692. McGraw-Hill, New York. C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds.).
    • (1989) The metabolic basis of inherited disease , pp. 671-692
    • Danner, D.J.1    Elsas, L.J.2
  • 10
    • 0016259467 scopus 로고
    • Inhibition of mitochondrial pyruvate transport by phenylpyruvate and a-ketoisocaproate
    • Halestrap A.P., Brand M.D., Denton R.M. Inhibition of mitochondrial pyruvate transport by phenylpyruvate and a-ketoisocaproate. Biochem Biophys Acta 1974, 367:102-108.
    • (1974) Biochem Biophys Acta , vol.367 , pp. 102-108
    • Halestrap, A.P.1    Brand, M.D.2    Denton, R.M.3
  • 11
    • 0017258183 scopus 로고
    • Control of pyruvate and h-hydroxybutyrate utilization in rat brain mitochondria and its relevance to phenylketonuria and maple syrup urine disease
    • Land J.M., Mowbray J., Clark J.B. Control of pyruvate and h-hydroxybutyrate utilization in rat brain mitochondria and its relevance to phenylketonuria and maple syrup urine disease. J Neurochem 1976, 26:823-830.
    • (1976) J Neurochem , vol.26 , pp. 823-830
    • Land, J.M.1    Mowbray, J.2    Clark, J.B.3
  • 13
    • 0042122354 scopus 로고    scopus 로고
    • Induction of oxidative stress in rat brain by the metabolites accumulating in maple syrup urine disease
    • Bridi R., Araldi J., Sgarbi M.B., Testa C.G., Durigon K., Wajner M., et al. Induction of oxidative stress in rat brain by the metabolites accumulating in maple syrup urine disease. Int J Dev Neurosci 2003, 21:327-332.
    • (2003) Int J Dev Neurosci , vol.21 , pp. 327-332
    • Bridi, R.1    Araldi, J.2    Sgarbi, M.B.3    Testa, C.G.4    Durigon, K.5    Wajner, M.6
  • 14
    • 20044390955 scopus 로고    scopus 로고
    • Alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats
    • Bridi R., Braun C.A., Zorzi G.K., Wannmacher C.M., Wajner M., Lissi E.G., et al. Alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats. Met Brain Dis 2005, 20:155-167.
    • (2005) Met Brain Dis , vol.20 , pp. 155-167
    • Bridi, R.1    Braun, C.A.2    Zorzi, G.K.3    Wannmacher, C.M.4    Wajner, M.5    Lissi, E.G.6
  • 15
    • 14644442394 scopus 로고    scopus 로고
    • Evaluation of the mechanisms involved in leucine induced oxidative damage in cerebral cortex of young rats
    • Bridi R., Latini A., Braun C.A., Zorzi G.K., Wajner M., Lissi E.G., et al. Evaluation of the mechanisms involved in leucine induced oxidative damage in cerebral cortex of young rats. Free Radic Res 2005, 39:71-79.
    • (2005) Free Radic Res , vol.39 , pp. 71-79
    • Bridi, R.1    Latini, A.2    Braun, C.A.3    Zorzi, G.K.4    Wajner, M.5    Lissi, E.G.6
  • 16
    • 0036186148 scopus 로고    scopus 로고
    • Stimulation of lipid peroxidation in vitro in rat brain by the metabolites accumulating in maple syrup urine disease
    • Fontella F.U., Gassen E., Pulrolni V., Wannmacher C.M.D., Klein A.B., Wajner M., et al. Stimulation of lipid peroxidation in vitro in rat brain by the metabolites accumulating in maple syrup urine disease. Metab Brain Dis 2002, 17:47-54.
    • (2002) Metab Brain Dis , vol.17 , pp. 47-54
    • Fontella, F.U.1    Gassen, E.2    Pulrolni, V.3    Wannmacher, C.M.D.4    Klein, A.B.5    Wajner, M.6
  • 17
    • 79955091150 scopus 로고    scopus 로고
    • In vivo neuroprotective effect of l-carnitine against oxidative stress in maple syrup urine disease
    • Mescka C., Moraes T., Rosa A., Mazzola P., Piccoli B., Jacques C., et al. In vivo neuroprotective effect of l-carnitine against oxidative stress in maple syrup urine disease. Metab Brain Dis 2011, 26:21-28.
    • (2011) Metab Brain Dis , vol.26 , pp. 21-28
    • Mescka, C.1    Moraes, T.2    Rosa, A.3    Mazzola, P.4    Piccoli, B.5    Jacques, C.6
  • 18
    • 77957723200 scopus 로고    scopus 로고
    • The intra-hippocampal leucine administration impairs memory consolidation and LTP generation in rats
    • Glaser V., Carlini V.P., Gabach L., Ghersi M., de Barioglio S.R., Ramirez O.A., et al. The intra-hippocampal leucine administration impairs memory consolidation and LTP generation in rats. Cell Mol Neurobiol 2010, 30:1067-1075.
    • (2010) Cell Mol Neurobiol , vol.30 , pp. 1067-1075
    • Glaser, V.1    Carlini, V.P.2    Gabach, L.3    Ghersi, M.4    de Barioglio, S.R.5    Ramirez, O.A.6
  • 19
    • 17844388567 scopus 로고    scopus 로고
    • Intrahippocampal administration of the branched-chain alpha-hydroxy acids accumulating in maple syrup urine disease compromises rat performance in aversive and non-aversive behavioral tasks
    • Vasques Vde C., Brinco F., Wajner M. Intrahippocampal administration of the branched-chain alpha-hydroxy acids accumulating in maple syrup urine disease compromises rat performance in aversive and non-aversive behavioral tasks. J Neurol Sci 2005, 232:11-21.
    • (2005) J Neurol Sci , vol.232 , pp. 11-21
    • Vasques, V.C.1    Brinco, F.2    Wajner, M.3
  • 20
    • 0033575298 scopus 로고    scopus 로고
    • Chronic early leucine administration induces behavioral deficits in rats
    • Mello C.F., Feksa L., Brusque A.M., Wannmacher C.M., Wajner M. Chronic early leucine administration induces behavioral deficits in rats. Life Sci 1999, 65:747-755.
    • (1999) Life Sci , vol.65 , pp. 747-755
    • Mello, C.F.1    Feksa, L.2    Brusque, A.M.3    Wannmacher, C.M.4    Wajner, M.5
  • 21
    • 0023029952 scopus 로고
    • Lung protection by a thiol-containing antioxidant: N-acetylcysteine
    • Moldeus P., Cotgreave I.A., Berggren M. Lung protection by a thiol-containing antioxidant: N-acetylcysteine. Respiration 1986, 50:31-32.
    • (1986) Respiration , vol.50 , pp. 31-32
    • Moldeus, P.1    Cotgreave, I.A.2    Berggren, M.3
  • 22
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • Aruoma O.I., Halliwell B., Hoey B.M., Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989, 6:593-597.
    • (1989) Free Radic Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3    Butler, J.4
  • 24
    • 1242342767 scopus 로고    scopus 로고
    • Treatment with n-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis
    • Ritter C., Andrades M.E., Reinke A., Menna-Barreto S., Moreira J.C., Dal-Pizzol F. Treatment with n-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis. Crit Care Med 2004, 32:342-349.
    • (2004) Crit Care Med , vol.32 , pp. 342-349
    • Ritter, C.1    Andrades, M.E.2    Reinke, A.3    Menna-Barreto, S.4    Moreira, J.C.5    Dal-Pizzol, F.6
  • 26
    • 40649115646 scopus 로고    scopus 로고
    • Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration
    • Di-Pietro P.B., Dias M.L., Scaini G., Burigo M., Constantino L., Machado R.A., et al. Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration. Neurosci Lett 2008, 434:139-143.
    • (2008) Neurosci Lett , vol.434 , pp. 139-143
    • Di-Pietro, P.B.1    Dias, M.L.2    Scaini, G.3    Burigo, M.4    Constantino, L.5    Machado, R.A.6
  • 27
    • 33747204835 scopus 로고    scopus 로고
    • A chemically-induced acute model of maple syrup urine disease in rats for neurochemical studies
    • Bridi R., Fontella F.U., Pulrolnik V., Braun C.A., Zorzi G.K., Coelho D., et al. A chemically-induced acute model of maple syrup urine disease in rats for neurochemical studies. J Neurosci Methods 2006, 155:224-230.
    • (2006) J Neurosci Methods , vol.155 , pp. 224-230
    • Bridi, R.1    Fontella, F.U.2    Pulrolnik, V.3    Braun, C.A.4    Zorzi, G.K.5    Coelho, D.6
  • 28
    • 0031255352 scopus 로고    scopus 로고
    • Functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment
    • Rogers D.C., Fisher E.M., Brown S.D., Peters J., Hunter A.J., Behavioral Martin J.E. functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm Genome 1997, 8:711-713.
    • (1997) Mamm Genome , vol.8 , pp. 711-713
    • Rogers, D.C.1    Fisher, E.M.2    Brown, S.D.3    Peters, J.4    Hunter, A.J.5    Behavioral, M.J.E.6
  • 30
    • 0030890688 scopus 로고    scopus 로고
    • Sequential role of hippocampus and amygdala, entorhinal cortex and parietal cortex in formation and retrieval of memory for inhibitory avoidance in rats
    • Izquierdo I., Quillfeldt J.A., Zanatta M.S., Quevedo J., Schaeffer E., Schmitz P.K., et al. Sequential role of hippocampus and amygdala, entorhinal cortex and parietal cortex in formation and retrieval of memory for inhibitory avoidance in rats. Eur J Neurosci 1997, 9:786-793.
    • (1997) Eur J Neurosci , vol.9 , pp. 786-793
    • Izquierdo, I.1    Quillfeldt, J.A.2    Zanatta, M.S.3    Quevedo, J.4    Schaeffer, E.5    Schmitz, P.K.6
  • 31
    • 0033402904 scopus 로고    scopus 로고
    • Two time windows of anisomycin-induced amnesia for inhibitory avoidance training in rats: protection from amnesia by pretraining but not pre-exposure to the task apparatus
    • Quevedo J., Vianna M.R., Roesler R., De-Paris F., Izquierdo I., Rose S.P. Two time windows of anisomycin-induced amnesia for inhibitory avoidance training in rats: protection from amnesia by pretraining but not pre-exposure to the task apparatus. Learn Mem 1999, 6:600-607.
    • (1999) Learn Mem , vol.6 , pp. 600-607
    • Quevedo, J.1    Vianna, M.R.2    Roesler, R.3    De-Paris, F.4    Izquierdo, I.5    Rose, S.P.6
  • 34
    • 0034626947 scopus 로고    scopus 로고
    • Alpha-ketoisocaproate increases the in vitro 32P incorporation into intermediate filaments in cerebral cortex of rats
    • Branco T., Meirelles R., da Rocha B.B., de Mattos-Dutra A., Wajner M., Pessoa-Pureur R. Alpha-ketoisocaproate increases the in vitro 32P incorporation into intermediate filaments in cerebral cortex of rats. Neuroreport 2000, 11:3545-4350.
    • (2000) Neuroreport , vol.11 , pp. 3545-4350
    • Branco, T.1    Meirelles, R.2    da Rocha, B.B.3    de Mattos-Dutra, A.4    Wajner, M.5    Pessoa-Pureur, R.6
  • 35
    • 0037115295 scopus 로고    scopus 로고
    • Alpha-ketoisocaproic acid regulates phosphorylation of intermediate filaments in postnatal rat cortical slices through ionotropic glutamatergic receptors
    • Funchal C., de Lima Pelaez P., Loureiro S.O., Vivian L., Dall Bello Pessutto F., de Almeida L.M., et al. Alpha-ketoisocaproic acid regulates phosphorylation of intermediate filaments in postnatal rat cortical slices through ionotropic glutamatergic receptors. Brain Res Dev Brain Res 2002, 139:267-276.
    • (2002) Brain Res Dev Brain Res , vol.139 , pp. 267-276
    • Funchal, C.1    de Lima Pelaez, P.2    Loureiro, S.O.3    Vivian, L.4    Dall Bello Pessutto, F.5    de Almeida, L.M.6
  • 36
    • 0346219384 scopus 로고    scopus 로고
    • Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system
    • Funchal C., Dall Bello Pessutto F., de Almeida L.M., de Lima Pelaez P., Loureiro S.O., Vivian L., et al. Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system. J Neurol Sci 2004, 217:17-24.
    • (2004) J Neurol Sci , vol.217 , pp. 17-24
    • Funchal, C.1    Dall Bello Pessutto, F.2    de Almeida, L.M.3    de Lima Pelaez, P.4    Loureiro, S.O.5    Vivian, L.6
  • 37
    • 1842455649 scopus 로고    scopus 로고
    • Reduction of glutamate uptake into cerebral cortex of developing rats by the branched-chain alpha-keto acids accumulating in maple syrup urine disease
    • Funchal C., Rosa A.M., Wajner M., Wofchuk S., Pureur R.P. Reduction of glutamate uptake into cerebral cortex of developing rats by the branched-chain alpha-keto acids accumulating in maple syrup urine disease. Neurochem Res 2004, 29:747-753.
    • (2004) Neurochem Res , vol.29 , pp. 747-753
    • Funchal, C.1    Rosa, A.M.2    Wajner, M.3    Wofchuk, S.4    Pureur, R.P.5
  • 38
    • 0035987827 scopus 로고    scopus 로고
    • Effect of the branched-chain alpha-ketoacids accumulating in maple syrup urine disease on the high molecular weight neurofilament subunit (NF-H) in rat cerebral cortex
    • Pessoa-Pureur R., Funchal C., de Lima Pelaez P., Vivian L., Oliveira Loureiro S., de Freitas Miranda R., et al. Effect of the branched-chain alpha-ketoacids accumulating in maple syrup urine disease on the high molecular weight neurofilament subunit (NF-H) in rat cerebral cortex. Metab Brain Dis 2002, 17:65-75.
    • (2002) Metab Brain Dis , vol.17 , pp. 65-75
    • Pessoa-Pureur, R.1    Funchal, C.2    de Lima Pelaez, P.3    Vivian, L.4    Oliveira Loureiro, S.5    de Freitas Miranda, R.6
  • 39
    • 0242543265 scopus 로고    scopus 로고
    • Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease
    • Sgaravatti A.M., Rosa R.B., Schuck P.F., Ribeiro C.A., Wannmacher C.M., Wyse A.T., et al. Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease. Biochim Biophys Acta 2003, 1639:232-238.
    • (2003) Biochim Biophys Acta , vol.1639 , pp. 232-238
    • Sgaravatti, A.M.1    Rosa, R.B.2    Schuck, P.F.3    Ribeiro, C.A.4    Wannmacher, C.M.5    Wyse, A.T.6
  • 40
    • 0000819855 scopus 로고
    • Inhibition of brain-glutamic decarboxylase by phenylalanine, valine, and leucine derivatives: a suggestion concerning the etiology of the neurological defect in phenylketonuria and branched chain ketonuria
    • Tashian R.E. Inhibition of brain-glutamic decarboxylase by phenylalanine, valine, and leucine derivatives: a suggestion concerning the etiology of the neurological defect in phenylketonuria and branched chain ketonuria. Metabolism 1961, 10:393-402.
    • (1961) Metabolism , vol.10 , pp. 393-402
    • Tashian, R.E.1
  • 41
    • 0034108632 scopus 로고    scopus 로고
    • Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: implications for neurological impairment associated with maple syrup urine disease
    • Jouvet P., Rustin P., Taylor D.L., Pocock J.M., Felderhoff-Mueser U., Mazarakis N.D., et al. Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: implications for neurological impairment associated with maple syrup urine disease. Mol Biol Cell 2000, 11:1919-1932.
    • (2000) Mol Biol Cell , vol.11 , pp. 1919-1932
    • Jouvet, P.1    Rustin, P.2    Taylor, D.L.3    Pocock, J.M.4    Felderhoff-Mueser, U.5    Mazarakis, N.D.6
  • 42
    • 0031282249 scopus 로고    scopus 로고
    • Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures
    • Izquierdo I., Medina J.H. Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiol Learn Mem 1997, 68:285-316.
    • (1997) Neurobiol Learn Mem , vol.68 , pp. 285-316
    • Izquierdo, I.1    Medina, J.H.2
  • 43
    • 0037294435 scopus 로고    scopus 로고
    • Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task
    • Bevilaqua L.R., Kerr D.S., Medina J.H., Izquierdo I., Cammarota M. Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task. Eur J Neurosci 2003, 17:897-902.
    • (2003) Eur J Neurosci , vol.17 , pp. 897-902
    • Bevilaqua, L.R.1    Kerr, D.S.2    Medina, J.H.3    Izquierdo, I.4    Cammarota, M.5
  • 44
    • 0028919098 scopus 로고
    • Correlation between the pharmacology of longterm potentiation and the pharmacology of memory
    • Izquierdo I., Medina J.H. Correlation between the pharmacology of longterm potentiation and the pharmacology of memory. Neurobiol Learn Mem 1995, 63:19-32.
    • (1995) Neurobiol Learn Mem , vol.63 , pp. 19-32
    • Izquierdo, I.1    Medina, J.H.2
  • 45
    • 0032726599 scopus 로고    scopus 로고
    • Effects of aging on cerebellar noradrenergic function and motor learning: nutritional interventions
    • Bickford P.C., Shukitt-Hale B., Joseph J. Effects of aging on cerebellar noradrenergic function and motor learning: nutritional interventions. Mech Ageing Dev 1999, 111:141-154.
    • (1999) Mech Ageing Dev , vol.111 , pp. 141-154
    • Bickford, P.C.1    Shukitt-Hale, B.2    Joseph, J.3
  • 47
    • 8444227821 scopus 로고    scopus 로고
    • Reactive oxygen species and synaptic plasticity in the aging hippocampus
    • Serrano F., Klann E. Reactive oxygen species and synaptic plasticity in the aging hippocampus. Ageing Res Rev 2004, 3:431-443.
    • (2004) Ageing Res Rev , vol.3 , pp. 431-443
    • Serrano, F.1    Klann, E.2
  • 48
    • 0025832844 scopus 로고
    • Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone
    • Carney J.M., Starke-Reed P.E., Oliver C.N., Landum R.W., Cheng M.S., Wu J.F., et al. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. Proc Natl Acad Sci USA 1991, 88:3633-3636.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3633-3636
    • Carney, J.M.1    Starke-Reed, P.E.2    Oliver, C.N.3    Landum, R.W.4    Cheng, M.S.5    Wu, J.F.6
  • 49
    • 0027193175 scopus 로고
    • The optimal dosage of (-) deprenyl for increasing superoxide dismutase activities in several brain regions decreases with age in male Fischer 344 rats
    • Carrillo M.C., Kanai S., Sato Y., Nokubo M., Ivy G.O., Kitani K. The optimal dosage of (-) deprenyl for increasing superoxide dismutase activities in several brain regions decreases with age in male Fischer 344 rats. Life Sci 1993, 52:1925-1934.
    • (1993) Life Sci , vol.52 , pp. 1925-1934
    • Carrillo, M.C.1    Kanai, S.2    Sato, Y.3    Nokubo, M.4    Ivy, G.O.5    Kitani, K.6
  • 50
    • 0028197308 scopus 로고
    • Sexually low performing male rats die earlier than their high performing peers and (-)deprenyl treatment eliminates this difference
    • Knoll J., Yen T.T., Miklya I. Sexually low performing male rats die earlier than their high performing peers and (-)deprenyl treatment eliminates this difference. Life Sci 1994, 54:1047-1057.
    • (1994) Life Sci , vol.54 , pp. 1047-1057
    • Knoll, J.1    Yen, T.T.2    Miklya, I.3
  • 51
    • 0035500510 scopus 로고    scopus 로고
    • An antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease
    • Amyloid-beta Kontush A. an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease. Free Radic Biol Med 2001, 31:1120-1131.
    • (2001) Free Radic Biol Med , vol.31 , pp. 1120-1131
    • Amyloid-beta, K.A.1
  • 52
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 1997, 23:134-147.
    • (1997) Free Radic Biol Med , vol.23 , pp. 134-147
    • Markesbery, W.R.1
  • 53
    • 0032571732 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease, current approaches and promising developments
    • Small G.W. Treatment of Alzheimer's disease, current approaches and promising developments. Am J Med 1998, 104:32S-38S.
    • (1998) Am J Med , vol.104
    • Small, G.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.