Inhibition of glutamate uptake into synaptic vesicles of rat brain by the metabolites accumulating in maple syrup urine disease

Journal of the Neurological Sciences

Volumn 181, Issue 1-2, 2000, Pages 44-49

  Tavares, Rejane G ^a   Santos, Candice E S ^a   Tasca, Carla I ^b   Wajner, Moacir ^a   Souza, Diogo O ^a   Dutra Filho, Carlos S ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Branched chain amino acids; Branched chain organic acids; Glutamate; Maple syrup urine disease; Rat brain; Synaptic vesicle

Indexed keywords

2 OXOISOCAPROIC ACID; 3 METHYL 2 OXOVALERIC ACID; BRANCHED CHAIN AMINO ACID; GLUTAMIC ACID; ISOLEUCINE; LEUCINE; UNCLASSIFIED DRUG; VALINE;

ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN; COMPETITIVE INHIBITION; CONTROLLED STUDY; MALE; MAPLE SYRUP URINE DISEASE; NEUROPATHOLOGY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; SYNAPSE VESICLE; TISSUE LEVEL;

ANIMALS; BRAIN; GLUTAMIC ACID; ISOLEUCINE; KETO ACIDS; LEUCINE; MALE; MAPLE SYRUP URINE DISEASE; NEURONS; RATS; RATS, WISTAR; SYNAPTIC VESICLES; SYNAPTOSOMES; VALINE;

EID: 0034547976     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(00)00402-0     Document Type: Article

References (41)

1. Disorders of branched chain amino acid and keto acid metabolism
2. The mammalian 2-oxoacid dehydrogenase: A complex family
3. Maple syrup urine disease: Interrelationship between branched chain amino-, oxo-, and hydroxyacids; implications for treatment; association with CNS dysmyelination
4. Roitman B Maple syrup urine disease, with particular reference to dietotherapy
5. Disorders of branched chain amino acid and keto acid metabolism
6. Inhibition of mitochondrial pyruvate transport by phenylpyruvate and α-ketoisocaproate
7. Influence of alpha-ketoacids on the respiration of brain in vitro
8. Control of pyruvate and β-hydroxybutyrate utilization in rat brain mitochondria and its relevance to phenylketonuria and maple syrup urine disease
9. Inhibition of brain glutamic acid decarboxylase by phenylalanine, valine, and leucine derivatives: A suggestion concerning the etiology of the neurological defect in phenylketonuria and branched-chain ketonuria
10. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate
11. Aging, energy, and oxidative stress in neurodegenerative diseases
12. Glutamate receptors in the mammalian central nervous system
13. Excitatory amino acids as a final common pathway for neurologic disorders
14. New order from neurologic disorders
15. The glutamatergic nerve terminal
16. Quisqualate-sensitive, chlorine-dependent transport of glutamate into rat brain synaptosomes
17. Characterization of glutamate uptake into synaptic vesicles
18. Glutamate: A neurotransmitter in mammalian brain
19. Amino acid neurotransmission: Dynamics of vesicular uptake
20. Uptake of gamma-aminobutyric acid by a synaptic vesicle fraction isolated from rat brain
21. +-ATPase in rat brain synaptic vesicles
22. A study of the uptake of glutamate, γ-aminobutyric acid (GABA), glycine and β-alanine in synaptic brain vesicles from fish and avians
23. Bioenergetics of neurotransmitter transport
24. Protein measurement with the Folin phenol reagent
25. Regulation of glutamate transport into synaptic vesicles by chloride and proton gradient
26. Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain
27. The relationship between the branched chain amino acids and their α-ketoacids in maple syrup urine disease
28. Kinetics of neutral amino acid transport across the blood-brain barrier
29. Blood-brain barrier transport of the alpha-keto acid analogs of amino acids
30. Chronic early leucine administration induces behavioral deficits in rats
31. Glutamate and γ-aminobutyric acid neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinemia encephalopathies in newborn calves
32. Brain lipids, proteolipids, and free amino acids in maple syrup urine disease
33. Interrelationships of leucine and glutamate metabolism in cultured astrocytes
34. Elevation of amino acids in the interstitial space of the rat brain following infusion of large neutral amino and keto acids by microdialysis: Leucine infusion
35. Inhibition of glutamate uptake and proton pumping in synaptic vesicles by S-nitrosylation
36. Synaptic vesicular glutamate uptake: Modulation by a synaptosomal cytosolic factor
37. Comparison of the properties of gamma aminobutyric acid and L-glutamate uptake into synaptic vesicles isolated from rat brain
38. Uptake of L-glutamate into rat brain synaptic vesicles: Effect of inhibitors that bind specifically to the glutamate transporter
39. Dithiocarbamate pesticides affect glutamate transport in brain synaptic vesicles
40. Inhibition of L-glutamate uptake into synaptic vesicles