Opiate-induced constipation related to activation of small intestine opioid μ2-receptors

World Journal of Gastroenterology

Volumn 18, Issue 12, 2012, Pages 1391-1396

  Chen, Wency ^a   Chung, Hsien Hui ^b   Cheng, Juei Tang ^c  

^a E DA HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

Author keywords

Isometric tension; Loperamide; Opioid receptors; Small intestine

Indexed keywords

ACETYLCHOLINE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYPRODIME; GLIBENCLAMIDE; LOPERAMIDE; MU OPIATE RECEPTOR; NALOXONAZINE; STEVIOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONSTIPATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ILEUM; INTESTINE CONTRACTION; INTESTINE TRANSIT TIME; MALE; MOUSE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; MUSCLE TONE; NONHUMAN; OPIATE INDUCED CONSTIPATION; SMALL INTESTINE;

EID: 84859061037     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v18.i12.1391     Document Type: Article

References (38)

1. Camilleri M. Opioid-induced constipation: challenges and therapeutic opportunities. Am J Gastroenterol 2011; 106: 835-842; quiz 843
2. Holzer P. New approaches to the treatment of opioid-induced constipation. Eur Rev Med Pharmacol Sci 2008; 12 Suppl 1: 119-127
3. Holzer P. Opioid receptors in the gastrointestinal tract. Regul Pept 2009; 155: 11-17
4. Hanauer SB. The role of loperamide in gastrointestinal disorders. Rev Gastroenterol Disord 2008; 8: 15-20
5. Corazziari E. Role of opioid ligands in the irritable bowel syndrome. Can J Gastroenterol 1999; 13 Suppl A: 71A-75A
6. Baker DE. Loperamide: a pharmacological review. Rev Gastroenterol Disord 2007; 7 Suppl 3: S11-S18
7. Nozaki-Taguchi N, Yaksh TL. Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide. Anesthesiology 1999; 90: 225-234
8. Tagaya E, Tamaoki J, Chiyotani A, Konno K. Stimulation of opioid mu-receptors potentiates beta adrenoceptor-mediated relaxation of canine airway smooth muscle. J Pharmacol Exp Ther 1995; 275: 1288-1292
9. Ozdem SS, Batu O, Tayfun F, Yalcin O, Meiselman HJ, Baskurt OK. The effect of morphine in rat small mesenteric arteries. Vascul Pharmacol 2005; 43: 56-61
10. Raimundo JM, Sudo RT, Pontes LB, Antunes F, Trachez MM, Zapata-Sudo G. In vitro and in vivo vasodilator activity of racemic tramadol and its enantiomers in Wistar rats. Eur J Pharmacol 2006; 530: 117-123
11. Stefano GB. Endogenous morphine: a role in wellness medicine. Med Sci Monit 2004; 10: ED5
12. Liu IM, Liou SS, Chen WC, Chen PF, Cheng JT. Signals in the activation of opioid mu-receptors by loperamide to enhance glucose uptake into cultured C2C12 cells. Horm Metab Res 2004; 36: 210-214
13. Unno T, Matsuyama H, Okamoto H, Sakamoto T, Yamamoto M, Tanahashi Y, Yan HD, Komori S. Muscarinic cationic current in gastrointestinal smooth muscles: signal transduction and role in contraction. Auton Autacoid Pharmacol 2006; 26: 203-217
14. Cheng TC, Lu CC, Chung HH, Hsu CC, Kakizawa N, Yamada S, Cheng JT. Activation of muscarinic M-1 cholinoceptors by curcumin to increase contractility in urinary bladder isolated from Wistar rats. Neurosci Lett 2010; 473: 107-109
15. Choi S, Parajuli SP, Yeum CH, Park CG, Kim MY, Kim YD, Cha KH, Park YB, Park JS, Jeong HS, Jun JY. Calcitonin gene-related peptide suppresses pacemaker currents by nitric oxide/cGMP-dependent activation of ATP-sensitive K(+) channels in cultured interstitial cells of Cajal from the mouse small intestine. Mol Cells 2008; 26: 181-185
16. + current in regulating membrane potential and current in rat aorta. Cardiovasc Res 1999; 44: 429-435
17. Quayle JM, Standen NB. KATP channels in vascular smooth muscle. Cardiovasc Res 1994; 28: 797-804
18. Held B, Tsvilovskyy V, Meissner M, Kaestner L, Ludwig A, Mossmang S, Lipp P, Freichel M, Flockerzi V. Ca2+ channel currents and contraction in CaVbeta3-deficient ileum smooth muscle from mouse. Cell Calcium 2007; 42: 477-487
19. Menozzi A, Pozzoli C, Poli E, Passeri B, Gianelli P, Bertini S. Diazoxide attenuates indomethacin-induced small intestinal damage in the rat. Eur J Pharmacol 2011; 650: 378-383
20. Ramabadran K, Bansinath M, Turndorf H, Puig MM. Stereospecific inhibition of gastrointestinal transit by kappa opioid agonists in mice. Eur J Pharmacol 1988; 155: 329-331
21. Yang PS, Lee JJ, Tsao CW, Wu HT, Cheng JT. Stimulatory effect of stevioside on peripheral mu opioid receptors in animals. Neurosci Lett 2009; 454: 72-75
22. + currents by CGRP in gallbladder smooth muscle. Am J Physiol 1994; 267: G494-G499
23. Uder M, Heinrich M, Jansen A, Humke U, Utz J, Trautwein W, Kramann B. CAMP and cGMP do not mediate the vasorelaxation induced by iodinated radiographic contrast media in isolated swine renal arteries. Acta Radiol 2002; 43: 104-110
24. + channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle. J Physiol 1998; 507 (Pt 1): 117-129
25. Liu IM, Chi TC, Chen YC, Lu FH, Cheng JT. Activation of opioid mu-receptor by loperamide to lower plasma glucose in streptozotocin-induced diabetic rats. Neurosci Lett 1999; 265: 183-186
26. Chen JC, Smith ER, Cahill M, Cohen R, Fishman JB. The opioid receptor binding of dezocine, morphine, fentanyl, butorphanol and nalbuphine. Life Sci 1993; 52: 389-396
27. Kristensen K, Christensen CB, Christrup LL. The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine. Life Sci 1995; 56: PL45-PL50
28. Cadet P. Mu opiate receptor subtypes. Med Sci Monit 2004; 10: MS28-MS32
29. Mizoguchi H, Watanabe H, Hayashi T, Sakurada W, Sawai T, Fujimura T, Sakurada T, Sakurada S. Possible involvement of dynorphin A-(1-17) release via mu1-opioid receptors in spinal antinociception by endomorphin-2. J Pharmacol Exp Ther 2006; 317: 362-368
30. Sakurada S, Sawai T, Mizoguchi H, Watanabe H, Watanabe C, Yonezawa A, Morimoto M, Sato T, Komatsu T, Sakurada T. Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2. Peptides 2008; 29: 1554-1560
31. Bova S, Trevisi L, Cima L, Luciani S, Golovina V, Cargnelli G. Signaling mechanisms for the selective vasoconstrictor effect of norbormide on the rat small arteries. J Pharmacol Exp Ther 2001; 296: 458-463
32. Stefano GB, Hartman A, Bilfinger TV, Magazine HI, Liu Y, Casares F, Goligorsky MS. Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation. J Biol Chem 1995; 270: 30290-30293
33. Gintzler AR, Pasternak GW. Multiple mu receptors: evidence for mu2 sites in the guinea pig ileum. Neurosci Lett 1983; 39: 51-56
34. Matsumoto K, Hatori Y, Murayama T, Tashima K, Wongseripipatana S, Misawa K, Kitajima M, Takayama H, Horie S. Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa. Eur J Pharmacol 2006; 549: 63-70
35. Sternini C, Patierno S, Selmer IS, Kirchgessner A. The opioid system in the gastrointestinal tract. Neurogastroenterol Motil 2004; 16 Suppl 2: 3-16
36. + channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport. J Biol Chem 2010; 285: 7165-7175
37. Costagliola A, Van Nassauw L, Snyders D, Adriaensen D, Timmermans JP. Voltage-gated delayed rectifier Kv1-subunits may serve as distinctive markers for enteroglial cells with different phenotypes in the murine ileum. Neurosci Lett 2009; 461: 80-84
38. Mannhold R. KATP channel openers: structure-activity relationships and therapeutic potential. Med Res Rev 2004; 24: 213-266