메뉴 건너뛰기




Volumn 106, Issue 5, 2011, Pages 835-842

Opioid-induced constipation: Challenges and therapeutic opportunities

Author keywords

[No Author keywords available]

Indexed keywords

17 METHYLNALTREXONE; ALVIMOPAN; IBUPROFEN; LUBIPROSTONE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NALOXONE; NALTREXONE; NKTR 118; OPIATE; OXYCODONE; PLACEBO; PRUCALOPRIDE; TAPENTADOL; TD 1211; UNCLASSIFIED DRUG;

EID: 79955578050     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2011.30     Document Type: Review
Times cited : (211)

References (76)
  • 1
    • 0032168726 scopus 로고    scopus 로고
    • Prevalence of chronic benign pain disorder among adults: A review of the literature
    • DOI 10.1016/S0304-3959(98)00117-1, PII S0304395998001171
    • Verhaak PF, Kerssens JJ, Dekker J et al. Prevalence of chronic benign pain disorder among adults: A review of the literature. Pain 1998; 77: 231-9. (Pubitemid 28451511)
    • (1998) Pain , vol.77 , Issue.3 , pp. 231-239
    • Verhaak, P.F.M.1    Kerssens, J.J.2    Dekker, J.3    Sorbi, M.J.4    Bensing, J.M.5
  • 3
    • 33645231857 scopus 로고    scopus 로고
    • Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
    • Breivik H, Collett B, Ventafridda V et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 2006; 10: 287-333.
    • (2006) Eur J Pain , vol.10 , pp. 287-333
    • Breivik, H.1    Collett, B.2    Ventafridda, V.3
  • 4
    • 58949087497 scopus 로고    scopus 로고
    • Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain
    • the American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
    • Chou R, Fanciullo GJ, Fine PG et al. and the American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain 2009; 10: 113-130.
    • (2009) J Pain , vol.10 , pp. 113-130
    • Chou, R.1    Fanciullo, G.J.2    Fine, P.G.3
  • 6
    • 25844526549 scopus 로고    scopus 로고
    • Trends in abuse of OxyContin® and other opioid analgesics in the United States: 2002-2004
    • DOI 10.1016/j.jpain.2005.05.004, PII S1526590005006565
    • Cicero TJ, Inciardi JA, Munoz A. Trends in abuse of oxycontin and other opioid analgesics in the United States: 2002-2004. J Pain 2005; 6: 662-672. (Pubitemid 41395058)
    • (2005) Journal of Pain , vol.6 , Issue.10 , pp. 662-672
    • Cicero, T.J.1    Inciardi, J.A.2    Munoz, A.3
  • 7
    • 0037337026 scopus 로고    scopus 로고
    • Oxycodone involvement in drug abuse deaths
    • Cone EJ, Fant RV, Rohay JM et al. Oxycodone involvement in drug abuse deaths. J Anal Toxicol 2003; 27: 57-67.
    • (2003) J Anal Toxicol , vol.27 , pp. 57-67
    • Cone, E.J.1    Fant, R.V.2    Rohay, J.M.3
  • 8
    • 34250891600 scopus 로고    scopus 로고
    • Substance Abuse and Mental Health Services Administration Office of Applied Studies National Admissions to Substance Abuse Treatment Services, DASIS Series: S-37 (DHHS Publication No. [SMA] 07-4234) Rockville, MD, SAMHSA
    • Substance Abuse and Mental Health Services Administration Office of Applied Studies. Treatment Episode Data Set (TEDS), 1995-2005. National Admissions to Substance Abuse Treatment Services, DASIS Series: S-37. (DHHS Publication No. [SMA] 07-4234) Rockville, MD, SAMHSA, 2007).
    • (2007) Treatment Episode Data Set (TEDS) 1995-2005
  • 9
    • 43649101761 scopus 로고    scopus 로고
    • Therapeutic opioids: A ten-year perspective on the complexities and complications of the escalating use, abuse, and non-medical use of opioids
    • Manchikanti L, Singh A. Therapeutic opioids: a ten-year perspective on the complexities and complications of the escalating use, abuse, and non-medical use of opioids. Pain Physician 2008; 11: S63-89.
    • (2008) Pain Physician , vol.11
    • Manchikanti, L.1    Singh, A.2
  • 12
    • 78549264128 scopus 로고    scopus 로고
    • A flood of opioids, a rising tide of deaths
    • Okie S. A flood of opioids, a rising tide of deaths. N Engl J Med 2010; 363: 1981-1985.
    • (2010) N Engl J Med , vol.363 , pp. 1981-1985
    • Okie, S.1
  • 13
    • 74949083811 scopus 로고    scopus 로고
    • Opioid prescriptions for chronic pain and overdose: A cohort study
    • Dunn KM, Saunders KW, Rutter CM et al. Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med 2010; 152: 85-92.
    • (2010) Ann Intern Med , vol.152 , pp. 85-92
    • Dunn, K.M.1    Saunders, K.W.2    Rutter, C.M.3
  • 14
    • 9244233833 scopus 로고    scopus 로고
    • Opioids in chronic non-cancer pain: Systematic review of efficacy and safety
    • DOI 10.1016/j.pain.2004.09.019, PII S0304395904004476
    • Kalso E, Edwards JE, Moore A et al. Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain 2004; 112: 372-380. (Pubitemid 39550738)
    • (2004) Pain , vol.112 , Issue.3 , pp. 372-380
    • Kalso, E.1    Edwards, J.E.2    Moore, R.A.3    McQuay, H.J.4
  • 15
    • 0035695398 scopus 로고    scopus 로고
    • Incidence, prevalence and management of opioid bowel dysfunction
    • Papagallo M. Incidence, prevalence and management of opioid bowel dysfunction. Am J Surg 2001; 182 (November Suppl): S11-8.
    • (2001) Am J Surg , vol.182 , Issue.SUPPL.
    • Papagallo, M.1
  • 17
    • 0035695398 scopus 로고    scopus 로고
    • Incidence, prevalence, and management of opioid bowel dysfunction
    • PII S0002961001007826
    • Pappagallo M. Incidence, prevalence, and management of opioid bowel dysfunction. Am J Surg 2001; 182 (5A Suppl): 11S-8S. (Pubitemid 34072942)
    • (2001) American Journal of Surgery , vol.182 , Issue.5 SUPPL.
    • Pappagallo, M.1
  • 18
    • 77949290974 scopus 로고    scopus 로고
    • Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain
    • Tuteja AK, Biskupiak J, Stoddard GJ et al. Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain. Neurogastroenterol Motil 2010; 22: 424-430.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 424-430
    • Tuteja, A.K.1    Biskupiak, J.2    Stoddard, G.J.3
  • 19
    • 59649110657 scopus 로고    scopus 로고
    • The prevalence, severity, and impact of opioid-induced bowel dysfunction: Results of a US and European Patient Survey (PROBE 1)
    • Bell TJ, Panchal SJ, Miaskowski C et al. The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European Patient Survey (PROBE 1). Pain Med 2009; 10: 35-42.
    • (2009) Pain Med , vol.10 , pp. 35-42
    • Bell, T.J.1    Panchal, S.J.2    Miaskowski, C.3
  • 21
    • 0037249711 scopus 로고    scopus 로고
    • Opioid-induced bowel dysfunction: Pathophysiology and potential new therapies
    • DOI 10.2165/00003495-200363070-00003
    • Kurz A, Sessler DI. Opioid-induced bowel dysfunction: pathophysiology and potential new therapies. Drugs 2003; 63: 649-671. (Pubitemid 36408072)
    • (2003) Drugs , vol.63 , Issue.7 , pp. 649-671
    • Kurz, A.1    Sessler, D.I.2
  • 23
    • 0031559923 scopus 로고    scopus 로고
    • Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract
    • DOI 10.1016/S0306-4522(97)00227-3, PII S0306452297002273
    • Bagnol D, Mansour A, Akil H et al. Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract. Neuroscience 1997; 81: 579-591. (Pubitemid 27382009)
    • (1997) Neuroscience , vol.81 , Issue.2 , pp. 579-591
    • Bagnol, D.1    Mansour, A.2    Akil, H.3    Watson, S.J.4
  • 24
    • 0019349861 scopus 로고
    • Influence of opiates on ion transport across rabbit ileal mucosa
    • McKay JS, Linaker BD, Turnberg LA. Influence of opiates on ion transport across rabbit ileal mucosa. Gastroenterology 1981; 80: 279-284. (Pubitemid 11217520)
    • (1981) Gastroenterology , vol.80 , Issue.2 , pp. 279-284
    • McKay, J.S.1    Linaker, B.N.2    Turnberg, L.A.3
  • 25
    • 0030953721 scopus 로고    scopus 로고
    • Opioid receptor expression in the rat gastrointestinal tract: A quantitative study with comparison to the brain
    • DOI 10.1016/S0169-328X(96)00266-5, PII S0169328X96002665
    • Fickel J, Bagnol D, Watson SJ et al. Opioid receptor expression in the rat gastrointestinal tract: a quantitative study with comparison to the brain. Brain Res Mol Brain Res 1997; 46: 1-8. (Pubitemid 27214349)
    • (1997) Molecular Brain Research , vol.46 , Issue.1-2 , pp. 1-8
    • Fickel, J.1    Bagnol, D.2    Watson, S.J.3    Akil, H.4
  • 27
    • 7944230640 scopus 로고    scopus 로고
    • Function of opioids in the enteric nervous system
    • DOI 10.1111/j.1743-3150.2004.00554.x
    • Wood JD, Galligan JJ. Function of opioids in the enteric nervous system. Neurogastroenterol Motil 2004; 16 (Suppl 2): 17-28. (Pubitemid 39468863)
    • (2004) Neurogastroenterology and Motility , vol.16 , Issue.SUPPL. 2 , pp. 17-28
    • Wood, J.D.1    Galligan, J.J.2
  • 28
    • 0037249711 scopus 로고    scopus 로고
    • Opioid-induced bowel dysfunction: Pathophysiology and potential new therapies
    • DOI 10.2165/00003495-200363070-00003
    • Kurz A, Sessler DI. Opioid-induced bowel dysfunction: pathophysiology and potential new therapies. Drugs 2003; 63: 649-671. (Pubitemid 36408072)
    • (2003) Drugs , vol.63 , Issue.7 , pp. 649-671
    • Kurz, A.1    Sessler, D.I.2
  • 29
    • 0029940621 scopus 로고    scopus 로고
    • Insights into opioid action in the intestinal tract
    • DOI 10.1016/0163-7258(95)02053-5
    • De Luca A, Coupar IM. Insights into opioid action in the intestinal tract. Pharmacol Ther 1996; 69: 103-115. (Pubitemid 26111425)
    • (1996) Pharmacology and Therapeutics , vol.69 , Issue.2 , pp. 103-115
    • De Luca, A.1    Coupar, I.M.2
  • 30
    • 77956057791 scopus 로고    scopus 로고
    • Tapentadol and its two mechanisms of action: Is there a new pharmacological class of centrally-acting analgesics on the horizon?
    • Kress HG. Tapentadol and its two mechanisms of action: is there a new pharmacological class of centrally-acting analgesics on the horizon? Eur J Pain 2010; 14: 781-3.
    • (2010) Eur J Pain , vol.14 , pp. 781-783
    • Kress, H.G.1
  • 31
    • 78650417906 scopus 로고    scopus 로고
    • Mu-opioid and noradrenergic ( 2)-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats
    • Bee LA, Bannister K, Rahman W et al. Mu-opioid and noradrenergic (2)-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats. Pain 2011; 152: 131-9.
    • (2011) Pain , vol.152 , pp. 131-139
    • Bee, L.A.1    Bannister, K.2    Rahman, W.3
  • 33
    • 0035658427 scopus 로고    scopus 로고
    • Effects of an alpha(2)-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans
    • Viramontes BE, Malcolm A, Camilleri M et al. Effects of an alpha(2)-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans. Am J Physiol Gastroint Liver Physiol 2001; 281: G1468-76.
    • (2001) Am J Physiol Gastroint Liver Physiol , vol.281
    • Viramontes, B.E.1    Malcolm, A.2    Camilleri, M.3
  • 34
    • 62449290346 scopus 로고    scopus 로고
    • Pharmacogenetics of low dose clonidine in irritable bowel syndrome
    • Camilleri M, Busciglio I, Carlson P et al. Pharmacogenetics of low dose clonidine in irritable bowel syndrome. Neurogastroenterol Motil 2009; 21: 399-410.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 399-410
    • Camilleri, M.1    Busciglio, I.2    Carlson, P.3
  • 36
    • 77953577261 scopus 로고    scopus 로고
    • Review of the effect of opioid-related side effects on the undertreatment of moderate to severe chronic noncancer pain: Tapentadol, a step toward a solution?
    • Candiotti KA, Gitlin MC. Review of the effect of opioid-related side effects on the undertreatment of moderate to severe chronic noncancer pain: tapentadol, a step toward a solution? Curr Med Res Opin 2010; 26: 1677-1684.
    • (2010) Curr Med Res Opin , vol.26 , pp. 1677-1684
    • Candiotti, K.A.1    Gitlin, M.C.2
  • 38
    • 77954211482 scopus 로고    scopus 로고
    • Efficacy and safety of tapentadol extended release compared with oxycodone controlled release for the management of moderate to severe chronic pain related to osteoarthritis of the knee: Results of a randomized, double-blind, placebo-and activecontrolled phase 3 study
    • Afilalo M, Etropolski MS, Kuperwasser B et al. Efficacy and safety of tapentadol extended release compared with oxycodone controlled release for the management of moderate to severe chronic pain related to osteoarthritis of the knee: results of a randomized, double-blind, placebo-and activecontrolled phase 3 study. Clinical Drug Invest 2010; 30: 489-505.
    • (2010) Clinical Drug Invest , vol.30 , pp. 489-505
    • Afilalo, M.1    Etropolski, M.S.2    Kuperwasser, B.3
  • 39
    • 77954776260 scopus 로고    scopus 로고
    • Efficacy and safety of tapentadol extended release for the management of chronic low back pain: Results of a prospective, randomized, double-blind, placebo-and active-controlled phase III study
    • Buynak R, Shapiro DY, Okamoto A et al. Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo-and active-controlled phase III study. Expert Opin Pharmacother 2010; 11: 1787-804.
    • (2010) Expert Opin Pharmacother , vol.11 , pp. 1787-1804
    • Buynak, R.1    Shapiro, D.Y.2    Okamoto, A.3
  • 40
    • 0023228264 scopus 로고
    • Oral naloxone antagonizes loperamide-induced delay of orocecal transit
    • Basilisco G, Camboni G, Bozzani A et al. Oral naloxone antagonizes loperamide-induced delay of orocecal transit. Dig Dis Sci 1987; 32: 829-832. (Pubitemid 17135284)
    • (1987) Digestive Diseases and Sciences , vol.32 , Issue.8 , pp. 829-832
    • Basilisco, G.1    Camboni, G.2    Bozzani, A.3
  • 41
    • 0023949974 scopus 로고
    • Role of opiate receptors in the regulation of colonic transit
    • Kaufman PN, Krevsky B, Malmud LS et al. Role of opiate receptors in the regulation of colonic transit. Gastroenterology 1988; 94: 1351-1356.
    • (1988) Gastroenterology , vol.94 , pp. 1351-1356
    • Kaufman, P.N.1    Krevsky, B.2    Malmud, L.S.3
  • 42
    • 0033991826 scopus 로고    scopus 로고
    • Oral naloxone reverses opioidassociated constipation
    • Meissner W, Schmidt U, Hartmann M et al. Oral naloxone reverses opioidassociated constipation. Pain 2000; 84: 105-9.
    • (2000) Pain , vol.84 , pp. 105-109
    • Meissner, W.1    Schmidt, U.2    Hartmann, M.3
  • 43
    • 0029878393 scopus 로고    scopus 로고
    • An investigation of the ability of oral naloxone to correct opioid-related constipation in patients with advanced cancer
    • Sykes NP. An investigation of the ability of oral naloxone to correct opioid-related constipation in patients with advanced cancer. Palliat Med 1996; 10: 135-144. (Pubitemid 26110994)
    • (1996) Palliative Medicine , vol.10 , Issue.2 , pp. 135-144
    • Sykes, N.P.1
  • 44
    • 56349136276 scopus 로고    scopus 로고
    • Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain
    • Vondrackova D, Leyendecker P, Meissner W et al. Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain. J Pain 2008; 9: 1144-1154.
    • (2008) J Pain , vol.9 , pp. 1144-1154
    • Vondrackova, D.1    Leyendecker, P.2    Meissner, W.3
  • 45
    • 58149178876 scopus 로고    scopus 로고
    • A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation
    • Meissner W, Leyendecker P, Mueller-Lissner S et al. A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation. Eur J Pain 2009; 13: 56-64.
    • (2009) Eur J Pain , vol.13 , pp. 56-64
    • Meissner, W.1    Leyendecker, P.2    Mueller-Lissner, S.3
  • 46
    • 77950641718 scopus 로고    scopus 로고
    • Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain
    • Sandner-Kiesling A, Leyendecker P, Hopp M et al. Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain. Int J Clin Pract 2010; 64: 763-774.
    • (2010) Int J Clin Pract , vol.64 , pp. 763-774
    • Sandner-Kiesling, A.1    Leyendecker, P.2    Hopp, M.3
  • 47
    • 78349272369 scopus 로고    scopus 로고
    • Long-term safety and efficacy of morphine sulfate and naltrexone hydrochloride extended release capsules, a novel formulation containing morphine and sequestered naltrexone, in patients with chronic, moderate to severe pain
    • Webster LR, Brewer R, Wang C et al. Long-term safety and efficacy of morphine sulfate and naltrexone hydrochloride extended release capsules, a novel formulation containing morphine and sequestered naltrexone, in patients with chronic, moderate to severe pain. J Pain Symptom Manage 2010; 40: 734-746.
    • (2010) J Pain Symptom Manage , vol.40 , pp. 734-746
    • Webster, L.R.1    Brewer, R.2    Wang, C.3
  • 48
    • 0035690146 scopus 로고    scopus 로고
    • A review of the potential role of methylnaltrexone in opioid bowel dysfunction
    • PII S0002961001007838
    • Foss JF. A review of the potential role of methyl-naltrexone in opioid bowel dysfunction. Am J Surg 2001; 182 (5A Suppl): 19S-26S. (Pubitemid 34072943)
    • (2001) American Journal of Surgery , vol.182 , Issue.5 SUPPL.
    • Foss, J.F.1
  • 49
    • 34250192178 scopus 로고    scopus 로고
    • Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects
    • Yuan CS. Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects. Ann Pharmacother 2007; 41: 984-993.
    • (2007) Ann Pharmacother , vol.41 , pp. 984-993
    • Yuan, C.S.1
  • 52
    • 0029971436 scopus 로고    scopus 로고
    • Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: A double-blind randomized placebo-controlled trial
    • DOI 10.1016/S0009-9236(96)90117-4
    • Yuan CS, Foss JF, O'Connor M et al. Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial. Clin Pharmacol Ther 1996; 59: 469-475. (Pubitemid 26151630)
    • (1996) Clinical Pharmacology and Therapeutics , vol.59 , Issue.4 , pp. 469-475
    • Yuan, C.-S.1    Foss, J.F.2    O'Connor, M.3    Toledano, A.4    Roizen, M.F.5    Moss, J.6
  • 53
    • 0032752321 scopus 로고    scopus 로고
    • Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: A pilot study
    • Yuan CS, Foss JF, O'Connor M et al. Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot study. Pain 1999; 83: 631-5.
    • (1999) Pain , vol.83 , pp. 631-635
    • Yuan, C.S.1    Foss, J.F.2    O'Connor, M.3
  • 56
    • 46049098356 scopus 로고    scopus 로고
    • The Food and Drug Administration Approves Methylnaltrexone Bromide for Opioid-Induced Constipation
    • DOI 10.1053/j.gastro.2008.06.003, PII S0016508508009608
    • Lang L. The food and drug administration approves methylnaltrexone bromide for opioid-induced constipation. Gastroenterology 2008; 135: 6. (Pubitemid 351899040)
    • (2008) Gastroenterology , vol.135 , Issue.1 , pp. 6
    • Lang, L.1
  • 57
    • 79955571650 scopus 로고    scopus 로고
    • MICROMEDEX: Physician's Desk Reference: methylnaltrexone
    • http://www.thomsonhc.com/hcs/librarian/MICROMEDEX: Physician's Desk Reference: methylnaltrexone.
  • 58
    • 77956408794 scopus 로고    scopus 로고
    • The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health
    • Wong BS, Rao AS, Camilleri M et al. The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health. Aliment Pharmacol Ther 2010; 32: 884-893.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 884-893
    • Wong, B.S.1    Rao, A.S.2    Camilleri, M.3
  • 59
    • 0035543168 scopus 로고    scopus 로고
    • Alvimopan*(ADL 8-2698) is a novel peripheral opioid antagonist
    • PII S000296100100784X
    • Schmidt WK. Alvimopan (ADL 8-298) is a novel peripheral opioid antagonist. Am J Surg 2001; 182: 27S-38S. (Pubitemid 34072944)
    • (2001) American Journal of Surgery , vol.182 , Issue.5 SUPPL.
    • Schmidt, W.K.1
  • 60
    • 16444366557 scopus 로고    scopus 로고
    • Alvimopan, a selective peripherally acting μ-opioid antagonist
    • DOI 10.1111/j.1365-2982.2005.00640.x
    • Camilleri M. Alvimopan, a selective peripherally acting mu-opioid antagonist. Neurogastroenterol Motil 2005; 17: 157-165. (Pubitemid 40476675)
    • (2005) Neurogastroenterology and Motility , vol.17 , Issue.2 , pp. 157-165
    • Camilleri, M.1
  • 61
    • 79955614038 scopus 로고    scopus 로고
    • MICROEDEX: Physician's Desk Reference: Alvimopan
    • http://www.thomsonhc.com/hcs/librarian/MICROEDEX: Physician's Desk Reference: Alvimopan.
  • 63
    • 45549109284 scopus 로고    scopus 로고
    • Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioidinduced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain
    • Webster L, Jansen JP, Peppin J et al. Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioidinduced bowel dysfunction: results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain. Pain 2008; 137: 428-440.
    • (2008) Pain , vol.137 , pp. 428-440
    • Webster, L.1    Jansen, J.P.2    Peppin, J.3
  • 66
    • 79955603843 scopus 로고    scopus 로고
    • Comparative bioavailability of NKTR-118 tablets and solution: A case of bioequivalence between dosage forms for a rapidly absorbed drug
    • abstract
    • Odinecs A, Gadiraju R, Sisco J et al. Comparative bioavailability of NKTR-118 tablets and solution: a case of bioequivalence between dosage forms for a rapidly absorbed drug. J Clin Pharmacol 2009; 49: 1123 (abstract).
    • (2009) J Clin Pharmacol , vol.49 , pp. 1123
    • Odinecs, A.1    Gadiraju, R.2    Sisco, J.3
  • 68
    • 50249107478 scopus 로고    scopus 로고
    • Efficacy and safety of mu-opioid antagonists in the treatment of opioid-induced bowel dysfunction: Systematic review and meta-analysis of randomized controlled trials
    • McNicol E, Boyce DB, Schumann R et al. Efficacy and safety of mu-opioid antagonists in the treatment of opioid-induced bowel dysfunction: systematic review and meta-analysis of randomized controlled trials. Pain Med 2008; 9: 634-659.
    • (2008) Pain Med , vol.9 , pp. 634-659
    • McNicol, E.1    Boyce, D.B.2    Schumann, R.3
  • 69
    • 35548962696 scopus 로고    scopus 로고
    • Peripherally Acting Opioid Antagonists in the Treatment of Opiate-Related Constipation: A Systematic Review
    • DOI 10.1016/j.jpainsymman.2006.12.018, PII S088539240700509X
    • Becker G, Galandi D, Blum HE. Peripherally acting opioid antagonists in the treatment of opiate-related constipation: a systematic review. J Pain Symptom Manage 2007; 34: 547-565. (Pubitemid 350001379)
    • (2007) Journal of Pain and Symptom Management , vol.34 , Issue.5 , pp. 547-565
    • Becker, G.1    Galandi, D.2    Blum, H.E.3
  • 70
    • 77953733383 scopus 로고    scopus 로고
    • Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse
    • Fei G, Raehal K, Liu S et al. Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. J Pharmacol Exp Ther 2010; 334: 333-340.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 333-340
    • Fei, G.1    Raehal, K.2    Liu, S.3
  • 71
    • 79955596996 scopus 로고    scopus 로고
    • A Phase 3, randomized, double-blind, placebo-controlled clinical trial of lubiprostone for the treatment of opioidinduced bowel dysfunction in patients with chronic, non-cancer pain
    • Cryer BL, Katz S, Vallejo R et al. A Phase 3, randomized, double-blind, placebo-controlled clinical trial of lubiprostone for the treatment of opioidinduced bowel dysfunction in patients with chronic, non-cancer pain. Gastroenterology 2010; 138 (Suppl 1): S-129.
    • (2010) Gastroenterology , vol.138 , Issue.SUPPL. 1
    • Cryer, B.L.1    Katz, S.2    Vallejo, R.3
  • 72
    • 77954211482 scopus 로고    scopus 로고
    • Efficacy and safety of tapentadol extended release compared with oxycodone controlled release for the management of moderate to severe chronic pain related to osteoarthritis of the knee: Results of a randomized, double-blind, placebo-and active controlled phase 3 study
    • Afilalo M, Etropolski MS, Kuperwasser B et al. Efficacy and safety of tapentadol extended release compared with oxycodone controlled release for the management of moderate to severe chronic pain related to osteoarthritis of the knee: results of a randomized, double-blind, placebo-and active controlled phase 3 study. Clin Drug Invest 2010; 30: 489-505.
    • (2010) Clin Drug Invest , vol.30 , pp. 489-505
    • Afilalo, M.1    Etropolski, M.S.2    Kuperwasser, B.3
  • 73
    • 32844474925 scopus 로고    scopus 로고
    • Validation of the PAC-SYM questionnaire for opioid-induced constipation in patients with chronic low back pain
    • DOI 10.1016/j.ejpain.2005.03.008, PII S1090380105000431
    • Slappendel R, Simpson K, Dubois D et al. Development of the PAC-SYM questionnaire for opioid-induced constipation in patients with chronic low back pain. Eur J Pain 2006; 10: 209-217. (Pubitemid 43255207)
    • (2006) European Journal of Pain , vol.10 , Issue.3 , pp. 209-217
    • Slappendel, R.1    Simpson, K.2    Dubois, D.3    Keininger, D.L.4
  • 74
    • 77957924970 scopus 로고    scopus 로고
    • Efficacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation
    • Sloots CE, Rykx A, Cools M et al. Efficacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation. Dig Dis Sci 2010; 55: 2912-2921.
    • (2010) Dig Dis Sci , vol.55 , pp. 2912-2921
    • Sloots, C.E.1    Rykx, A.2    Cools, M.3
  • 75
    • 72749092412 scopus 로고    scopus 로고
    • Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation
    • Rentz AM, Yu R, Müller-Lissner S et al. Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation. J Med Econ 2009; 12: 371-383.
    • (2009) J Med Econ , vol.12 , pp. 371-383
    • Rentz, A.M.1    Yu, R.2    Müller-Lissner, S.3
  • 76
    • 79952360501 scopus 로고    scopus 로고
    • Validation of a bowel function diary for assessing opioid-induced constipation
    • Camilleri M, Rothman M, Ho KF et al. Validation of a bowel function diary for assessing opioid-induced constipation. Am J Gastroenterol 2011; 106: 497-506.
    • (2011) Am J Gastroenterol , vol.106 , pp. 497-506
    • Camilleri, M.1    Rothman, M.2    Ho, K.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.