Overexpression of tumor necrosis factor-α in the lungs alters immune response, matrix remodeling, and repair and maintenance pathways

American Journal of Pathology

Volumn 180, Issue 4, 2012, Pages 1413-1430

  Thomson, Errol M ^a   Williams, Andrew ^a   Yauk, Carole L ^a   Vincent, Renaud ^a  

^a HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPSIN; BLEOMYCIN; CALPONIN; CASPASE 4; CATHEPSIN B; CATHEPSIN D; CATHEPSIN K; CATHEPSIN S; CATHEPSIN X; CELL ADHESION MOLECULE; CONNECTIVE TISSUE GROWTH FACTOR; ENDOGLIN; GELATINASE A; GELATINASE B; GELSOLIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MACROPHAGE ELASTASE; MESSENGER RNA; PROTEIN LYSINE 6 OXIDASE; SURFACTANT PROTEIN C; T LYMPHOCYTE RECEPTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMPHYSEMA; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; HISTOPATHOLOGY; IMMUNOMODULATION; INFLAMMATION; LUNG ALVEOLUS; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PNEUMONIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; LUNG; MALE; MICE; MICE, TRANSGENIC; MYOFIBROBLASTS; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDE HYDROLASES; PEPTIDES; PNEUMONIA; PULMONARY EMPHYSEMA; REAL-TIME POLYMERASE CHAIN REACTION; REGENERATION; SIGNAL TRANSDUCTION; TRANSCRIPTOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84859041558     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.12.020     Document Type: Article

References (74)

1. C.A. Owen Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease Int J Chron Obstruct Pulmon Dis 3 2008 253 268
2. A. Churg, J.L. Wright Proteases and emphysema Curr Opin Pulm Med 11 2005 153 159
3. P.M. Henson, R.W. Vandivier, I.S. Douglas Cell death, remodeling, and repair in chronic obstructive pulmonary disease Proc Am Thorac Soc 3 2006 713 717
4. T. Tsuji, K. Aoshiba, A. Nagai Alveolar cell senescence in patients with pulmonary emphysema Am J Respir Crit Care Med 174 2006 886 893
5. Y. Kasahara, R.M. Tuder, L. Taraseviciene-Stewart, T.D. Le Cras, S. Abman, P.K. Hirth, J. Waltenberger, N.F. Voelkel Inhibition of VEGF receptors causes lung cell apoptosis and emphysema J Clin Invest 106 2000 1311 1319
6. J.L. Wright, A. Churg Current concepts in mechanisms of emphysema Toxicol Pathol 35 2007 111 115
7. C.C. Lewis, J.Y. Yang, X. Huang, S.K. Banerjee, M.R. Blackburn, P. Baluk, D.M. McDonald, T.S. Blackwell, V. Nagabhushanam, W. Peters, D. Voehringer, D.J. Erle Disease-specific gene expression profiling in multiple models of lung disease Am J Respir Crit Care Med 177 2008 376 387
8. A. Churg, R.D. Wang, H. Tai, X. Wang, C. Xie, J.L. Wright Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse Am J Respir Crit Care Med 170 2004 492 498
9. S. Mukhopadhyay, J.R. Hoidal, T.K. Mukherjee Role of TNFalpha in pulmonary pathophysiology Respir Res 7 2006 125
10. P.F. Piguet, M.A. Collart, G.E. Grau, A.P. Sappino, P. Vassalli Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis Nature 344 1990 245 247
11. Y. Miyazaki, K. Araki, C. Vesin, I. Garcia, Y. Kapanci, J.A. Whitsett, P.F. Piguet, P. Vassalli Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis: a mouse model of progressive pulmonary fibrosis J Clin Invest 96 1995 250 259
12. M. Fujita, J.M. Shannon, C.G. Irvin, K.A. Fagan, C. Cool, A. Augustin, R.J. Mason Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension Am J Physiol Lung Cell Mol Physiol 280 2001 L39 L49
13. L.K. Lundblad, J. Thompson-Figueroa, T. Leclair, M.J. Sullivan, M.E. Poynter, C.G. Irvin, J.H. Bates Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotype Am J Respir Crit Care Med 171 2005 1363 1370
14. P.F. Piguet, C. Ribaux, V. Karpuz, G.E. Grau, Y. Kapanci Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis Am J Pathol 143 1993 651 655
15. J.C. Grutters, R.M. du Bois Genetics of fibrosing lung diseases Eur Respir J 25 2005 915 927
16. P.F. Piguet, M.A. Collart, G.E. Grau, Y. Kapanci, P. Vassalli Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis J Exp Med 170 1989 655 663
17. M. Fujita, J.M. Shannon, O. Morikawa, J. Gauldie, N. Hara, R.J. Mason Overexpression of TNF-alpha diminishes pulmonary fibrosis induced by bleomycin or TGF-beta Am J Respir Cell Mol Biol 29 2003 669 676
18. E.M. Thomson, A. Williams, C.L. Yauk, R. Vincent Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation Part Fibre Toxicol 6 2009 6
19. Y.H. Yang, S. Dudoit, P. Luu, D.M. Lin, V. Peng, J. Ngai, T.P. Speed Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation Nucleic Acids Res 30 2002 e15
20. H. Wu, M.K. Kerr, X. Cui, G.A. Churchill MAANOVA: a software package for the analysis of spotted cDNA microarray experiments G. Parmigiani, E.S. Garrett, R.A. Irizarry, S. Zeger, The Analysis of Gene Expression Data: Methods and Software 2003 Springer-Verlag New York 313 431
21. X.G. Cui, J.T.G. Hwang, J. Qiu, N.J. Blades, G.A. Churchill Improved statistical tests for differential gene expression by shrinking variance components Biostatistics 6 2005 59 75
22. Y. Benjamini, Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J R Stat Soc 57 1995 289 300
23. G. Dennis Jr, B.T. Sherman, D.A. Hosack, J. Yang, W. Gao, H.C. Lane, R.A. Lempicki DAVID: Database for Annotation, Visualization, and Integrated Discovery Genome Biol 4 2003 P3
24. W. Huang da, B.T. Sherman, R.A. Lempicki Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat Protoc 4 2009 44 57
25. H.Y. Min, B.M. Spiegelman Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor Nucleic Acids Res 14 1986 8879 8892
26. P.M. Becker, A.A. Kazi, R. Wadgaonkar, D.B. Pearse, D. Kwiatkowski, J.G. Garcia Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice Am J Respir Cell Mol Biol 28 2003 478 484
27. C.J. Scotton, R.C. Chambers Molecular targets in pulmonary fibrosis: the myofibroblast in focus Chest 132 2007 1311 1321
28. S. Gao, K. Chen, Y. Zhao, C.B. Rich, L. Chen, S.J. Li, P. Toselli, P. Stone, W. Li Transcriptional and posttranscriptional inhibition of lysyl oxidase expression by cigarette smoke condensate in cultured rat fetal lung fibroblasts Toxicol Sci 87 2005 197 203
29. B.R. Vuillemenot, J.F. Rodriguez, G.W. Hoyle Lymphoid tissue and emphysema in the lungs of transgenic mice inducibly expressing tumor necrosis factor-alpha Am J Respir Cell Mol Biol 30 2004 438 448
30. J. Wang, M.J. Lenardo Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies J Cell Sci 113 Pt 5 2000 753 757
31. S. Ke, A.B. Rabson, J.F. Germino, M.A. Gallo, Y. Tian Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide J Biol Chem 276 2001 39638 39644
32. E. Mazzon, S. Cuzzocrea Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation Respir Res 8 2007 75
33. I. Rahman Regulation of glutathione in inflammation and chronic lung diseases Mutat Res 579 2005 58 80
34. R.D. Hautamaki, D.K. Kobayashi, R.M. Senior, S.D. Shapiro Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice Science 277 1997 2002 2004
35. S. Lanone, T. Zheng, Z. Zhu, W. Liu, C.G. Lee, B. Ma, Q. Chen, R.J. Homer, J. Wang, L.A. Rabach, M.E. Rabach, J.M. Shipley, S.D. Shapiro, R.M. Senior, J.A. Elias Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling J Clin Invest 110 2002 463 474
36. K.J. Leco, P. Waterhouse, O.H. Sanchez, K.L. Gowing, A.R. Poole, A. Wakeham, T.W. Mak, R. Khokha Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3) J Clin Invest 108 2001 817 829
37. A.J. Gearing, P. Beckett, M. Christodoulou, M. Churchill, J. Clements, A.H. Davidson, A.H. Drummond, W.A. Galloway, R. Gilbert, J.L. Gordon, T.M. Leber, M. Mangan, K. Miller, P. Nayee, K. Owen, S. Patel, W. Thomas, G. Wells, L.M. Wood, K. Woolley Processing of tumour necrosis factor-alpha precursor by metalloproteinases Nature 370 1994 555 557
38. A. Amour, P.M. Slocombe, A. Webster, M. Butler, C.G. Knight, B.J. Smith, P.E. Stephens, C. Shelley, M. Hutton, V. Knauper, A.J. Docherty, G. Murphy TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3 FEBS Lett 435 1998 39 44
39. D.S. Son, K.F. Roby, P.F. Terranova Tumor necrosis factor-alpha induces serum amyloid A3 in mouse granulosa cells Endocrinology 145 2004 2245 2252
40. R. Vallon, F. Freuler, N. Desta-Tsedu, A. Robeva, J. Dawson, P. Wenner, P. Engelhardt, L. Boes, J. Schnyder, C. Tschopp, R. Urfer, G. Baumann Serum amyloid A (apoSAA) expression is up-regulated in rheumatoid arthritis and induces transcription of matrix metalloproteinases J Immunol 166 2001 2801 2807
41. P.J. Wolters, H.A. Chapman Importance of lysosomal cysteine proteases in lung disease Respir Res 1 2000 170 177
42. B.M. Steiglitz, D.R. Keene, D.S. Greenspan PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1 J Biol Chem 277 2002 49820 49830
43. A.H. Baker, D.R. Edwards, G. Murphy Metalloproteinase inhibitors: biological actions and therapeutic opportunities J Cell Sci 115 2002 3719 3727
44. C.M. Overall, R.A. Dean Degradomics: systems biology of the protease web: pleiotropic roles of MMPs in cancer Cancer Metastasis Rev 25 2006 69 75
45. N.F. Voelkel, I.S. Douglas, M. Nicolls Angiogenesis in chronic lung disease Chest 131 2007 874 879
46. M. Fujita, R.J. Mason, C. Cool, J.M. Shannon, N. Hara, K.A. Fagan Pulmonary hypertension in TNF-alpha-overexpressing mice is associated with decreased VEGF gene expression J Appl Physiol 93 2002 2162 2170
47. M. Fujita, S. Ikegame, Q. Ye, E. Harada, H. Ouchi, I. Inoshima, K. Watanabe, R.J. Mason, Y. Nakanishi Attenuation of pulmonary hypertension, but not emphysematous change, by breeding emphysema model mice at sea level Cytokine 41 2008 286 292
48. D. Gao, D.J. Nolan, A.S. Mellick, K. Bambino, K. McDonnell, V. Mittal Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis Science 319 2008 195 198
49. A. Chaouat, R. Naeije, E. Weitzenblum Pulmonary hypertension in COPD Eur Respir J 32 2008 1371 1385
50. D.E. Niewoehner, J.R. Hoidal Lung fibrosis and emphysema: divergent responses to a common injury Science 217 1982 359 360
51. F.E. Sirianni, A. Milaninezhad, F.S. Chu, D.C. Walker Alteration of fibroblast architecture and loss of Basal lamina apertures in human emphysematous lung Am J Respir Crit Care Med 173 2006 632 638
52. F. Yu, C.W. Chou, C.C. Chen TNF-alpha suppressed TGF-beta-induced CTGF expression by switching the binding preference of p300 from Smad4 to p65 Cell Signal 21 2009 867 872
53. X. Liu, R.J. Kelm Jr, A.R. Strauch Transforming growth factor beta1-mediated activation of the smooth muscle alpha-actin gene in human pulmonary myofibroblasts is inhibited by tumor necrosis factor-alpha via mitogen-activated protein kinase kinase 1-dependent induction of the Egr-1 transcriptional repressor Mol Biol Cell 20 2009 2174 2185
54. J. Wicks, H.M. Haitchi, S.T. Holgate, D.E. Davies, R.M. Powell Enhanced upregulation of smooth muscle related transcripts by TGF beta2 in asthmatic (myo) fibroblasts Thorax 61 2006 313 319
55. N. Oikonomou, A. Thanasopoulou, A. Tzouvelekis, V. Harokopos, T. Paparountas, I. Nikitopoulou, W. Witke, A. Karameris, A. Kotanidou, D. Bouros, V. Aidinis Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis Thorax 64 2009 467 475
56. I.Y. Adamson, C. Hedgecock, D.H. Bowden Epithelial cell-fibroblast interactions in lung injury and repair Am J Pathol 137 1990 385 392
57. A. Churg, S. Zhou, X. Wang, R. Wang, J.L. Wright The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling Am J Respir Cell Mol Biol 40 2009 482 490
58. X. Lian, C. Yan, Y. Qin, L. Knox, T. Li, H. Du Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice Am J Pathol 167 2005 813 821
59. L.L. Koth, C.J. Cambier, A. Ellwanger, M. Solon, L. Hou, L.L. Lanier, C.L. Abram, J.A. Hamerman, P.G. Woodruff DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2 J Immunol 184 2010 6522 6528
60. P. Bonniaud, G. Martin, P.J. Margetts, K. Ask, J. Robertson, J. Gauldie, M. Kolb Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs Am J Respir Cell Mol Biol 31 2004 510 516
61. K. Tang, H.B. Rossiter, P.D. Wagner, E.C. Breen Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice J Appl Physiol 97 2004 1559 1566
62. J.M. Maki, R. Sormunen, S. Lippo, R. Kaarteenaho-Wiik, R. Soininen, J. Myllyharju Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues Am J Pathol 167 2005 927 936
63. S. Sonnylal, X. Shi-Wen, P. Leoni, K. Naff, C.S. Van Pelt, H. Nakamura, A. Leask, D. Abraham, G. Bou-Gharios, B. de Crombrugghe Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis Arthritis Rheum 62 2010 1523 1532
64. T. Nishida, H. Kawaki, R.M. Baxter, R.A. Deyoung, M. Takigawa, K.M. Lyons CCN2 (connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in chondrocytes J Cell Commun Signal 1 2007 45 58
65. A. Spira, J. Beane, V. Pinto-Plata, A. Kadar, G. Liu, V. Shah, B. Celli, J.S. Brody Gene expression profiling of human lung tissue from smokers with severe emphysema Am J Respir Cell Mol Biol 31 2004 601 610
66. V.M. Keatings, P.D. Collins, D.M. Scott, P.J. Barnes Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma Am J Respir Crit Care Med 153 1996 530 534
67. K. Ohnishi, M. Takagi, Y. Kurokawa, S. Satomi, Y.T. Konttinen Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema Lab Invest 78 1998 1077 1087
68. S. Molet, C. Belleguic, H. Lena, N. Germain, C.P. Bertrand, S.D. Shapiro, J.M. Planquois, P. Delaval, V. Lagente Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease Inflamm Res 54 2005 31 36
69. Y. Kasahara, R.M. Tuder, C.D. Cool, D.A. Lynch, S.C. Flores, N.F. Voelkel Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema Am J Respir Crit Care Med 163 2001 737 744
70. M. Fujita, Q. Ye, H. Ouchi, N. Nakashima, N. Hamada, N. Hagimoto, K. Kuwano, R.J. Mason, Y. Nakanishi Retinoic acid fails to reverse emphysema in adult mouse models Thorax 59 2004 224 230
71. P.F. Piguet, C. Vesin Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice Eur Respir J 7 1994 515 518
72. W.D. Hardie, S.W. Glasser, J.S. Hagood Emerging concepts in the pathogenesis of lung fibrosis Am J Pathol 175 2009 3 16
73. V. Cottin, H. Nunes, P.Y. Brillet, P. Delaval, G. Devouassoux, I. Tillie-Leblond, D. Israel-Biet, Court-Fortune, D. Valeyre, J.F. Cordier Groupe D'Etude et de Recherche sur les Maladies Orphelines Pulmonaires (GERM O P) Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity Eur Respir J 26 2005 586 593
74. G.R. Washko, G.M. Hunninghake, I.E. Fernandez, M. Nishino, Y. Okajima, T. Yamashiro, J.C. Ross, R.S. Estepar, D.A. Lynch, J.M. Brehm, K.P. Andriole, A.A. Diaz, R. Khorasani, K. D'Aco, F.C. Sciurba, E.K. Silverman, H. Hatabu, I.O. Rosas Lung volumes and emphysema in smokers with interstitial lung abnormalities N Engl J Med 364 2011 897 906