Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells

Pathology International

Volumn 62, Issue 4, 2012, Pages 232-245

  Kashiwagi, Korehito ^a,b   Ishii, Jun ^a,b   Sakaeda, Masashi ^a,b   Arimasu, Yuu ^a,b   Shimoyamada, Hiroaki ^b   Sato, Hanako ^c   Miyata, Chie ^c   Kamma, Hiroshi ^b   Aoki, Ichiro ^a   Yazawa, Takuya ^b  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

ASCL1; Chromogranin A; Lung neuroendocrine tumor (LNET); NCAM1; NeuroD1; Synaptophysin

Indexed keywords

CHROMOGRANIN A; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NERVE CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE 1; NEUROGENIC DIFFERENTIATION FACTOR; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR MASH1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MOLECULAR MECHANICS; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

ANTIGENS, CD56; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, NEUROENDOCRINE; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CHROMOGRANIN A; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; NADH DEHYDROGENASE; NEOPLASM PROTEINS; REPRESSOR PROTEINS; TRANSFECTION; VESICULAR TRANSPORT PROTEINS;

EID: 84859002379     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2011.02781.x     Document Type: Article

References (57)

1. Travis WB, Nicholson S, Hirsch FR etal. Small cell carcinoma. Travis WB, Brambilla E, Muller-Hermelink HK, Harris CC, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus, and Heart. Lyon: IARC Press, 2004; 31-4.
2. Brambilla E, Pugatch B, Geisinger K etal. Large cell carcinoma. Travis WB, Brambilla E, Muller-Hermelink HK, Harris CC, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus, and Heart. Lyon: IARC Press, 2004; 45-50.
3. Beasley MB, Thunnissen FB, Hasleton PHS etal. Carcinoid tumour. Travis WB, Brambilla E, Muller-Hermelink HK, Harris CC, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus, and Heart. Lyon: IARC Press, 2004; 59-62.
4. Colby TV, Koss MN, Travis WD. Small cell carcinoma and large cell neuroendocrine carcinoma. Rosai J, ed. Atlas of Tumor Pathology. Tumors of the Lower Respiratory Tract. Washington, DC: Armed Forced Institute of Pathology, 1995; 235-57.
5. Colby TV, Koss MN, Travis WD. Carcinoid and other neuroendocrine tumors. Rosai J, ed. Atlas of Tumor Pathology. Tumors of the Lower Respiratory Tract. Washington, DC: Armed Forced Institute of Pathology, 1995; 287-317.
6. Hammar SP. Neuroendocrine tumors. Tomashefski JF, ed. Dail and Hammar's Pulmonary Pathology. Volume II: Neoplastic Lung Disease, 3rd edn. New York: Springer, 2006; 308-74.
7. Lantuejoul S, Moro D, Michalides R, Brambilla C, Brambilla E. Neural cell adhesion molecule (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors. Am J Surg Pathol 1998; 22: 1367-76.
8. Shy SW, Lee WH, Chou MC, Lai YS, Tu YC. Small cell lung carcinoma: Clinicopathological, immunohistochemical, and ultrastructural study. J Surg Oncol 1990; 45: 146-61.
9. Hiroshima K, Iyoda A, Shida T etal. Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: A morphological, immunohistochemical, and molecular analysis. Mod Pathol 2006; 19: 1358-68.
10. Gollard R, Jhatakia S, Elliott M, Kosty M. Large cell/neuroendocrine carcinoma. Lung Cancer 2010; 69: 13-8.
11. Jensen SM, Gazdar AF, Cuttitta F, Russell EK, Linnoila RI. A comparison of synaptophysin, chromogranin, and L-dopa decarboxylase as markers for neuroendocrine differentiation. Cancer Res 1990; 50: 6068-74.
12. Bertrand N, Castro DS, Guillemot F. Proneural genes and the specification of neural cell types. Nat Rev Neurosci 2002; 3: 517-30.
13. Ito T, Udaka N, Yazawa T etal. Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development 2000; 127: 3913-21.
14. Naptune ER, Podowski M, Calvi C etal. Role of NeuroD in airway and airspace morphogenesis. J Biol Chem 2008; 283: 21160-9.
15. Chu K, Nemoz-Gaillard E, Tsai MJ. BETA2 and pancreatic islet development. Recent Prog Horm Res 2001; 56: 23-46.
16. Morrow EM, Furukawa T, Lee JE, Cepko CL. NeuroD regulates multiple functions in the developing neural retina in rodent. Development 1999; 126: 23-36.
17. Miyata T, Maeda T, Lee JE. NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev 1999; 13: 1647-52.
18. Kim WY, Fritzsch B, Serls A etal. NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development 2001; 128: 417-26.
19. Mutoh H, Fung BP, Naya FJ, Tsai MJ, Nishitani J, Leiter AB. The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression. Proc Natl Acad Sci U S A 1997; 94: 3560-4.
20. Naya FJ, Huang HP, Qiu Y etal. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 1997; 11: 2323-34.
21. Johnson JE, Birren SJ, Anderson DJ. Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Nature 1990; 346: 858-61.
22. Lee JE, Hollenberg SM, Snider L, Turner DL, Lipnick N, Weintraub H. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 1995; 268: 836-44.
23. Kageyama R, Nakanishi S. Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system. Curr Opin Genet Dev 1997; 7: 659-65.
24. Messager M, Carriere C, Bertagna X, De Keyzer Y. RT-PCR analysis of corticotroph-associated genes expression in carcinoid tumours in the ectopic-ACTH syndrome. Eur J Endocrinol 2006; 154: 159-66.
25. Ball DW, Azzoli CG, Baylin SB etal. Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. Proc Natl Acad Sci U S A 1993; 90: 5648-562.
26. Jiang SX, Kameya T, Asamura H etal. hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors. Mod Pathol 2004; 17: 222-9.
27. Schoenherr CJ, Anderson DJ. The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science 1995; 267: 1360-3.
28. Chong JA, Tapia-Ramirez J, Kim S etal. REST: A mammalian silencer protein that restricts sodium channel gene expression to neuron. Cell 1995; 80: 949-57.
29. Schoenherr CJ, Paquette AJ, Anderson DJ. Identification of potential target genes for the neuron-restrictive silencer factor. Proc Natl Acad Sci U S A 1996; 93: 9881-6.
30. Bruce AW, Donaldson IJ, Wood IC etal. Gene-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci U S A 2004; 101: 10458-63.
31. Ching GY, Kiem RKH. REST is involved in regulating neuron-specific expression of α-internexin and neurofilament genes. J Neurochem 2009; 109: 1610-23.
32. Bollas N, Grunseich C, Lu DD, Speh JC, Mandel G. REST and its correpressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 2005; 121: 645-57.
33. Grimes JA, Nielsen SJ, Battaglioli E etal. The co-repressor mSin3A is a functional component of the REST-coREST repressor complex. J Biol Chem 2000; 275: 9461-7.
34. Roopra A, Huang Y, Dingeldine R. Neurological disease: Listening to gene silencers. Mol Interv 2001; 1: 219-28.
35. Westbrook TF, Hu G, Ang XL etal. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 2008; 452: 370-4.
36. Gurrola-Diaz C, Lacroix J, Dihlmann S, Becker CM, Doeberitz MK. Reduced expression of the neuron restrictive silencer factor permits transcription of glycine receptor α1 subunit in small-cell lung cancer cells. Oncogene 2003; 22: 5636-45.
37. Neumann SB, Seitz R, Gorzella A, Heister A, Doeberitz MK, Becker CM. Relaxation of glycine receptor and onconeural gene transcription control in NRSF deficient small cell lung cancer cell lines. Brain Res Mol Brain Res 2004; 120: 173-81.
38. Moss AC, Jacobson GM, Walker LE, Blake NW, Marshall E, Coulson JM. SCG3 transcript in peripheral blood is a prognostic biomarker for REST-deficient small cell lung cancer. Clin Cancer Res 2009; 15: 274-83.
39. Kreisler A, Strissel PL, Strick R, Neumann SB, Schumacher U, Becker CM. Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer. Oncogene 2010; 29: 5828-38.
40. Coulson JM, Edgson JL, Woll PJ, Quinn JP. A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: A potential role in derepression of neuroendocrine genes and a useful clinical marker. Cancer Res 2000; 60: 1840-4.
41. Lietz M, Hohl M, Thiel G. RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. Eur J Biochem 2003; 270: 2-9.
42. Canaff L, Bevan S, Wheeler DG etal. Analysis of molecular mechanisms controlling neuroendocrine cell specific transcription of the chromogranin A gene. Endocrinology 1998; 139: 1184-96.
43. Yazawa T, Sato H, Shimoyamada H etal. Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer. Am J Pathol 2009; 175: 976-87.
44. Yazawa T, Ito T, Kamma H etal. Complicated mechanisms of class II transactivator transcription deficiency in small cell lung cancer and neuroblastoma. Am J Pathol 2002; 161: 291-300.
45. Yazawa T, Kamma H, Fujiwara M etal. Lack of class II transactivator causes severe deficiency of HLA-DR expression in small cell lung cancer. J Pathol 1999; 187: 191-9.
46. Barton CH, Mann DA, Walsh FS. Characterization of the human N-CAM promoter. Biochem J 1990; 268: 161-8.
47. Nicholson SA, Beasley MB, Brambilla E etal. Small cell lung carcinoma (SCLC). A clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol 2002; 26: 1184-97.
48. Jones FS, Holst BD, Minowa O, De Robertis EM, Edelman GM. Binding and transcriptional activation of the promoter for the neural cell adhesion molecule by HoxC6 (Hox-3.3). Proc Natl Acad Sci U S A 1993; 90: 6557-61.
49. Jones FS, Prediger EA, Bittner DA, De Robertis EM, Edelman GM. Cell adhesion molecules as targets for Hox genes: Neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4. Proc Natl Acad Sci U S A 1992; 89: 2086-90.
50. Hirsch MR, Valarche I, Deagostini-Bazin H, Pernelle C, Joliot A, Goridis C. An upstream regulatory element of the NCAM promoter contains a binding site for homeodomains. FEBS Lett 1991; 287: 197-202.
51. Holst BD, Goomer RS, Wood IC, Edelman GM, Jones FS. Binding and activation of the promoter for the neural cell adhesion molecule by Pax-8. J Biol Chem 1994; 269: 22245-52.
52. Westerman BA, Murre C, Oudejans CBM. The cellular Pax-Hox-Helix connection. Biochim Biophys Acta 2003; 1629: 1-7.
53. Yang C, Bolotin E, Jiang T, Sladek FM, Martinez E. Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in huan TATA-less core promoters. Gene 2007; 389: 52-65.
54. Travis WB. The concept of pulmonary neuroendocrine tumours. Travis WB, Brambilla E, Muller-Hermelink HK, Harris CC, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus, and Heart. Lyon: IARC Press, 2004; 19-20.
55. Sorhang S, Steinshamn S, Haaverstad R, Nordrum IS, Martinsen TC, Waldum HL. Expression of neuroendocrine markers in non-small cell lung cancer. APMIS 2007; 115: 152-63.
56. Ionescu DN, Treaba D, Gilks CB etal. Nonsmall cell lung carcinoma with neuroendocrine differentiation - an entity of no clinical or prognostic significance. Am J Surg Pathol 2007; 31: 26-32.
57. Osada H, Tomida S, Yatabe Y etal. Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer. Cancer Res 2008; 68: 1647-55.