A combined DNA-affinic molecule and N-mustard alkylating agent has an anti-cancer effect and induces autophagy in oral cancer cells

International Journal of Molecular Sciences

Volumn 13, Issue 3, 2012, Pages 3277-3290

  Lo, Wen Liang ^a,b   Chu, Pen Yuan ^a   Lee, Tsung Heng ^b   Su, Tsann Long ^c   Chien, Yueh ^a,b   Chen, Yi Wei ^a,b   Huang, Pin I ^a,b   Tseng, Ling Ming ^a,b   Tu, Pang Hsien ^c   Kao, Shou Yen ^a,b   Lo, Jeng Fan ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Autophagy; AVO; BO 1051; Cell cycle; Checkpoint kinases

Indexed keywords

ALKYLATING AGENT; ATM PROTEIN; ATR PROTEIN; BMI1 PROTEIN; BO 1051; CHECKPOINT KINASE 2; DNA; MUSTARD GAS DERIVATIVE; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; BO-1051; CHECKPOINT KINASE 1; CHLORMETHINE DERIVATIVE; LIGHT CHAIN 3, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL CYCLE ARREST; CELL VACUOLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; FEMALE; FIBROBLAST; FLOW CYTOMETRY; GENE; GENE EXPRESSION REGULATION; GINGIVA; IC 50; IMMUNOCOMPROMISED PATIENT; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MOUTH CANCER; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEMNESS GENE; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CYCLE CHECKPOINT; CELL LINE; CELL SURVIVAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; METABOLISM; MOUTH NEOPLASMS; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; AUTOPHAGY; CELL CYCLE CHECKPOINTS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CHECKPOINT KINASE 2; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GINGIVA; HUMANS; MICE; MICE, NUDE; MICROTUBULE-ASSOCIATED PROTEINS; MOUTH NEOPLASMS; NITROGEN MUSTARD COMPOUNDS; PHOSPHORYLATION; PROTEIN KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84858988475     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13033277     Document Type: Article

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