Engineering lubrication in articular cartilage

Tissue Engineering - Part B: Reviews

Volumn 18, Issue 2, 2012, Pages 88-100

  McNary, Sean M ^a   Athanasiou, Kyriacos A ^a,b   Reddi, A Hari ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICULAR CARTILAGES; BULK MECHANICAL PROPERTIES; CARTILAGE LUBRICATION; CARTILAGE SURFACES; CELL-BASED THERAPY; CRITICAL STEPS; ENGINEERED CARTILAGE; ENGINEERED TISSUES; LONG LASTING; MORPHOGENS; PIN-ON-DISK TRIBOMETERS; STEPPING STONE; SURFACE MECHANICAL PROPERTIES; SYNOVIAL JOINTS; TENSILE FORCES; TISSUE ENGINEERED CARTILAGE; TRIBOLOGICAL PROPERTIES; WEAR PROPERTIES;

BIOMECHANICS; BIOMIMETICS; FRICTION; HISTOLOGY; JOINTS (ANATOMY); KNOWLEDGE MANAGEMENT; MECHANICAL PROPERTIES; OPTIMIZATION; SCAFFOLDS (BIOLOGY); STEM CELLS; TISSUE; TRIBOLOGY;

CARTILAGE;

BIGLYCAN; BONE MORPHOGENETIC PROTEIN; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CD44V6 ANTIGEN; CHONDROITIN; DECORIN; ETANERCEPT; HYALURONIC ACID; HYALURONIDASE; INTERLEUKIN 1; INTERLEUKIN 1BETA; LUBRICATING AGENT; LUBRICIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; POLYETHERURETHAN; POLYURETHAN; PROTEOGLYCAN; SCAFFOLD PROTEIN; SOMATOMEDIN C; SUPERFICIAL ZONE PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTERIOR CRUCIATE LIGAMENT; ARTICLE; ARTICULAR CARTILAGE; ATOMIC FORCE MICROSCOPY; CARTILAGE; CARTILAGE CELL; CARTILAGE MATRIX; CELL DENSITY; ENZYMATIC DEGRADATION; EXTRACELLULAR MATRIX; FRICTION; HUMAN; HYDRODYNAMICS; HYDROSTATIC PRESSURE; JOINT DEGENERATION; KNEE MENISCUS; LUBRICATION; MECHANICAL STRESS; NONHUMAN; OSTEOARTHRITIS; OXYGEN TRANSPORT; PATELLOFEMORAL JOINT; PERICARDITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION; TISSUE ENGINEERING; WEIGHT BEARING;

CARTILAGE, ARTICULAR; HUMANS; PROTEOGLYCANS; SYNOVIAL FLUID; TISSUE ENGINEERING;

EID: 84858986640     PISSN: 19373368     EISSN: 19373376     Source Type: Journal    
DOI: 10.1089/ten.teb.2011.0394     Document Type: Article

References (116)

1. Lawrence, R.C., Felson, D.T., Helmick, C.G., Arnold, L.M., Choi, H., Deyo, R.A., et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 58, 26, 2008.
2. Hunter, D.J. Pharmacologic therapy for osteoarthritis-the era of disease modification. Nat Rev Rheumatol 7, 13, 2011.
3. Natoli, R.M., Revell, C.M., and Athanasiou, K.A. Chondroitinase ABC treatment results in greater tensile properties of self-assembled tissue-engineered articular cartilage. Tissue Eng Part A 15, 3119, 2009.
4. Elder, B.D., and Athanasiou, K.A. Synergistic and additive effects of hydrostatic pressure and growth factors on tissue formation. PLoS One 3, e2341, 2008.
5. Hu, J.C., and Athanasiou, K.A. A self-assembling process in articular cartilage tissue engineering. Tissue Eng 12, 969, 2006.
6. Marcelino, J., Carpten, J.D., Suwairi, W.M., Gutierrez, O.M., Schwartz, S., Robbins, C., et al. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathycoxa vara-pericarditis syndrome. Nat Genet 23, 319, 1999.
7. Jay, G.D., Torres, J.R., Rhee, D.K., Helminen, H.J., Hytinnen, M.M., Cha, C.J., et al. Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum 56, 3662, 2007.
8. Eleswarapu, S.V., Leipzig, N.D., and Athanasiou, K.A. Gene expression of single articular chondrocytes. Cell Tissue Res 327, 43, 2007.
9. Knobloch, T.J., Madhavan, S., Nam, J., Agarwal, S., Jr., and Agarwal, S. Regulation of chondrocytic gene expression by biomechanical signals. Crit Rev Eukaryot Gene Expr 18, 139, 2008.
10. Mow, V.C., Ratcliffe, A., and Poole, A.R. Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures. Biomaterials 13, 67, 1992.
11. Fitzgerald, J.B., Jin, M., and Grodzinsky, A.J. Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue. J Biol Chem 281, 24095, 2006.
12. Quinn, T.M., Hunziker, E.B., and Hauselmann, H.J. Variation of cell and matrix morphologies in articular cartilage among locations in the adult human knee. Osteoarthritis Cartilage 13, 672, 2005.
13. Almarza, A.J., and Athanasiou, K.A. Design characteristics for the tissue engineering of cartilaginous tissues. Ann Biomed Eng 32, 2, 2004.
14. Dunn, W., DuRaine, G., and Reddi, A.H. Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction. Arthritis Rheum 60, 2333, 2009.
15. Darling, E.M., Hu, J.C., and Athanasiou, K.A. Zonal and topographical differences in articular cartilage gene expression. J Orthop Res 22, 1182, 2004.
16. Becerra, J., Andrades, J.A., Guerado, E., Zamora-Navas, P., Lopez-Puertas, J.M., and Reddi, A.H. Articular cartilage: structure and regeneration. Tissue Eng Part BRev 16, 617, 2010.
17. Darling, E.M., and Athanasiou, K.A. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J Orthop Res 23, 425, 2005.
18. Lin, Z., Willers, C., Xu, J., and Zheng, M.H. The chondrocyte: biology and clinical application. Tissue Eng 12, 1971, 2006.
19. Athanasiou, K.A., Rosenwasser, M.P., Buckwalter, J.A., Malinin, T.I., and Mow, V.C. Interspecies comparisons of in situ intrinsic mechanical properties of distal femoral cartilage. J Orthop Res 9, 330, 1991.
20. Hodge, W.A., Fijan, R.S., Carlson, K.L., Burgess, R.G., Harris, W.H., and Mann, R.W. Contact pressures in the human hip joint measured in vivo. Proc Natl Acad Sci USA 83, 2879, 1986.
21. Mow, V.C., Kuei, S.C., Lai, W.M., and Armstrong, C.G. Biphasic creep and stress relaxation of articular cartilage in compression: Theory and experiments. J Biomech Eng 102, 73, 1980.
22. Dowson, D. History of Tribology, second ed. London: Professional Engineering Publishing, 1998.
23. Scherge, M., and Gorb, S.N. Biological Micro-and Nanotribology: Nature's Solutions. Germany: Springer-Verlag Berlin Heidelberg, 2001.
24. Neu, C.P., Komvopoulos, K., and Reddi, A.H. The interface of functional biotribology and regenerative medicine in synovial joints. Tissue Eng Part B Rev 14, 235, 2008.
25. Elwell, R. Hydrostatic lubrication. In: Booser, E.R., ed. CRC Handbook of Lubrication. New York: CRC Press, 1983, pp. 105-120.
26. Cheng, H. Elastohydrodynamic lubrication. In: Booser, E.R., ed. CRC Handbook of Lubrication. New York: CRC Press, 1983, pp. 139-162.
27. Gleghorn, J.P., and Bonassar, L.J. Lubrication mode analysis of articular cartilage using Stribeck surfaces. J Biomech 41, 1910, 2008.
28. Chan, S.M., Neu, C.P., Duraine, G., Komvopoulos, K., and Reddi, A.H. Atomic force microscope investigation of the boundary-lubricant layer in articular cartilage. Osteoarthritis Cartilage 18, 956, 2010.
29. Heshmat, H. Tribology of Interface Layers. New York: CRC Press, 2010.
30. Hsu, S.M. Boundary lubrication: current understanding. Tribology Letters 3, 1, 1997.
31. Chan, S.M., Neu, C.P., Komvopoulos, K., and Reddi, A.H. Dependence of nanoscale friction and adhesion properties of articular cartilage on contact load. J Biomech, 44, 1340, 2011.
32. Lewis, P.R., and McCutchen, C.W. Mechanism of animal joints: experimental evidence for weeping lubrication in mammalian joints. Nature 184, 1285, 1959.
33. McCutchen, C.W. Mechanism of animal joints: spongehydrostatic and weeping bearings. Nature 184, 1284, 1959.
34. Walker, P.S., Dowson, D., Longfield, M.D., and Wright, V. "Boosted lubrication" in synovial joints by fluid entrapment and enrichment. Ann Rheum Dis 27, 512, 1968.
35. Jay, G.D., and Cha, C.J. The effect of phospholipase digestion upon the boundary lubricating ability of synovial fluid. J Rheumatol 26, 2454, 1999.
36. Krishnan, R., Caligaris, M., Mauck, R.L., Hung, C.T., Costa, K.D., and Ateshian, G.A. Removal of the superficial zone of bovine articular cartilage does not increase its frictional coefficient. Osteoarthritis Cartilage 12, 947, 2004.
37. Hills, B.A. Identity of the joint lubricant. J Rheumatol 29, 200, 2002.
38. Knudson, C.B., and Knudson, W. Hyaluronan and CD44: modulators of chondrocyte metabolism. Clin Orthop Relat Res 427 Suppl, S152, 2004.
39. Swann, D.A., Radin, E.L., Nazimiec, M., Weisser, P.A., Curran, N., and Lewinnek, G. Role of hyaluronic acid in joint lubrication. Ann Rheum Dis 33, 318, 1974.
40. Radin, E.L., Swann, D.A., and Weisser, P.A. Separation of a hyaluronate-free lubricating fraction from synovial fluid. Nature 228, 377, 1970.
41. Linn, F.C., and Radin, E.L. Lubrication of animal joints. 3. The effect of certain chemical alterations of the cartilage and lubricant. Arthritis Rheum 11, 674, 1968.
42. Chang, D.P., Abu-Lail, N.I., Guilak, F., Jay, G.D., and Zauscher, S. Conformational mechanics, adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfaces. Langmuir 24, 1183, 2008.
43. Tadmor, R., Chen, N., and Israelachvili, J.N. Thin film rheology and lubricity of hyaluronic acid solutions at a normal physiological concentration. J Biomed Mater Res 61, 514, 2002.
44. Schmidt, T.A., Gastelum, N.S., Nguyen, Q.T., Schumacher, B.L., and Sah, R.L. Boundary lubrication of articular cartilage: role of synovial fluid constituents. Arthritis Rheum 56, 882, 2007.
45. Benz, M., Chen, N., and Israelachvili, J. Lubrication and wear properties of grafted polyelectrolytes, hyaluronan and hylan, measured in the surface forces apparatus. J Biomed Mater Res A 71, 6, 2004.
46. Greene, G.W., Banquy, X., Lee, D.W., Lowrey, D.D., Yu, J., and Israelachvili, J.N. Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc Natl Acad Sci USA 108, 5255, 2011.
47. Hills, B.A., and Butler, B.D. Surfactants identified in synovial fluid and their ability to act as boundary lubricants. Ann Rheum Dis 43, 641, 1984.
48. Sarma, A.V., Powell, G.L., and LaBerge, M. Phospholipid composition of articular cartilage boundary lubricant. J Orthop Res 19, 671, 2001.
49. Schwarz, I.M., and Hills, B.A. Surface-active phospholipid as the lubricating component of lubricin. Br J Rheumatol 37, 21, 1998.
50. Swann, D.A., Slayter, H.S., and Silver, F.H. The molecular structure of lubricating glycoprotein-I, the boundary lubricant for articular cartilage. J Biol Chem 256, 5921, 1981.
51. Flannery, C.R., Hughes, C.E., Schumacher, B.L., Tudor, D., Aydelotte, M.B., Kuettner, K.E., et al. Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growthpromoting, cytoprotective, and lubricating properties in cartilage metabolism. Biochem Biophys Res Commun 254, 535, 1999.
52. Ikegawa, S., Sano, M., Koshizuka, Y., and Nakamura, Y. Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes. Cytogenet Cell Genet 90, 291, 2000.
53. Jay, G.D., Tantravahi, U., Britt, D.E., Barrach, H.J., and Cha, C.J. Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25. J Orthop Res 19, 677, 2001.
54. Liu, Y.J., Lu, S.H., Xu, B., Yang, R.C., Ren, Q., Liu, B., et al. Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. Blood 103, 4449, 2004.
55. Schumacher, B.L., Block, J.A., Schmid, T.M., Aydelotte, M.B., and Kuettner, K.E. A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage. Arch Biochem Biophys 311, 144, 1994.
56. Schmidt, T.A., Schumacher, B.L., Klein, T.J., Voegtline, M.S., and Sah, R.L. Synthesis of proteoglycan 4 by chondrocyte subpopulations in cartilage explants,monolayer cultures, and resurfaced cartilage cultures. Arthritis Rheum 50, 2849, 2004.
57. Sun, Y., Berger, E.J., Zhao, C., Jay, G.D., An, K.N., and Amadio, P.C. Expression and mapping of lubricin in canine flexor tendon. J Orthop Res 24, 1861, 2006.
58. Lee, S.Y., Nakagawa, T., and Reddi, A.H. Induction of chondrogenesis and expression of superficial zone protein (SZP)/lubricin by mesenchymal progenitors in the infrapatellar fat pad of the knee joint treated with TGF-beta1 and BMP-7. Biochem Biophys Res Commun 376, 148, 2008.
59. Schumacher, B.L., Schmidt, T.A., Voegtline, M.S., Chen, A.C., and Sah, R.L. Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus. J Orthop Res 23, 562, 2005.
60. Rees, S.G., Davies, J.R., Tudor, D., Flannery, C.R., Hughes, C.E., Dent, C.M., et al. Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon. Matrix Biol 21, 593, 2002.
61. Neu, C.P., Khalafi, A., Komvopoulos, K., Schmid, T.M., and Reddi, A.H. Mechanotransduction of bovine articular cartilage superficial zone protein by transforming growth factor beta signaling. Arthritis Rheum 56, 3706, 2007.
62. Rhee, D.K., Marcelino, J., Al-Mayouf, S., Schelling, D.K., Bartels, C.F., Cui, Y., et al. Consequences of diseasecausing mutations on lubricin protein synthesis, secretion, and post-translational processing. J Biol Chem 280, 31325, 2005.
63. Coles, J.M., Zhang, L., Blum, J.J., Warman, M.L., Jay, G.D., Guilak, F., et al. Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis Rheum 62, 1666, 2010.
64. Rhee, D.K., Marcelino, J., Baker, M., Gong, Y., Smits, P., Lefebvre, V., et al. The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest 115, 622, 2005.
65. Teeple, E., Elsaid, K.A., Fleming, B.C., Jay, G.D., Aslani, K., Crisco, J.J., et al. Coefficients of friction, lubricin, and cartilage damage in the anterior cruciate ligament-deficient guinea pig knee. J Orthop Res 26, 231, 2008.
66. Wei, L., Fleming, B.C., Sun, X., Teeple, E., Wu, W., Jay, G.D., et al. Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model. J Orthop Res 28, 900, 2010.
67. Young, A.A., McLennan, S., Smith, M.M., Smith, S.M., Cake, M.A., Read, R.A., et al. Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Res Ther 8, R41, 2006.
68. Elsaid, K.A., Jay, G.D., Warman, M.L., Rhee, D.K., and Chichester, C.O. Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis. Arthritis Rheum 52, 1746, 2005.
69. DuRaine, G., Neu, C.P., Chan, S.M., Komvopoulos, K., June, R.K., and Reddi, A.H. Regulation of the friction coefficient of articular cartilage by TGF-beta1 and IL-1beta. J Orthop Res 27, 249, 2009.
70. Bahabri, S.A., Suwairi, W.M., Laxer, R.M., Polinkovsky, A., Dalaan, A.A., and Warman, M.L. The camptodactylyarthropathy-coxavara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. Arthritis Rheum 41, 730, 1998.
71. Englert, C., McGowan, K.B., Klein, T.J., Giurea, A., Schumacher, B.L., and Sah, R.L. Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fluid. Arthritis Rheum 52, 1091, 2005.
72. Niikura, T., and Reddi, A.H. Differential regulation of lubricin/superficial zone protein by transforming growth factor beta/bone morphogenetic protein superfamily members in articular chondrocytes and synoviocytes. Arthritis Rheum 56, 2312, 2007.
73. Jones, A.R., and Flannery, C.R. Bioregulation of lubricin expression by growth factors and cytokines. Eur Cell Mater 13, 40, 2007.
74. Schmidt, T.A., Gastelum, N.S., Han, E.H., Nugent-Derfus, G.E., Schumacher, B.L., and Sah, R.L. Differential regulation of proteoglycan 4 metabolism in cartilage by IL-1alpha, IGF-I, and TGF-beta1. Osteoarthritis Cartilage 16, 90, 2008.
75. Khalafi, A., Schmid, T.M., Neu, C., and Reddi, A.H. Increased accumulation of superficial zone protein (SZP) in articular cartilage in response to bone morphogenetic protein-7 and growth factors. J Orthop Res 25, 293, 2007.
76. Lee, S.Y., Niikura, T., and Reddi, A.H. Superficial zone protein (lubricin) in the different tissue compartments of the knee joint: modulation by transforming growth factor beta 1 and interleukin-1 beta. Tissue Eng Part A 14, 1799, 2008.
77. Nugent-Derfus, G.E., Takara, T., O'Neill J K, Cahill, S.B., Gortz, S., Pong, T., et al. Continuous passive motion applied to whole joints stimulates chondrocyte biosynthesis of PRG4. Osteoarthritis Cartilage 15, 566, 2007.
78. Nugent, G.E., Schmidt, T.A., Schumacher, B.L., Voegtline, M.S., Bae, W.C., Jadin, K.D., et al. Static and dynamic compression regulate cartilage metabolism of PRoteoGlycan 4 (PRG4). Biorheology 43, 191, 2006.
79. Grad, S., Gogolewski, S., Alini, M., and Wimmer, M.A. Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds. Tissue Eng 12, 3171, 2006.
80. Das, R.H., Jahr, H., Verhaar, J.A., van der Linden, J.C., van Osch, G.J., and Weinans, H. In vitro expansion affects the response of chondrocytes to mechanical stimulation. Osteoarthritis Cartilage 16, 385, 2008.
81. Hayman, D.M., Blumberg, T.J., Scott, C.C., and Athanasiou, K.A. The effects of isolation on chondrocyte gene expression. Tissue Eng 12, 2573, 2006.
82. Wong, M., Siegrist, M., and Goodwin, K. Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes. Bone 33, 685, 2003.
83. Nugent, G.E., Aneloski, N.M., Schmidt, T.A., Schumacher, B.L., Voegtline, M.S., and Sah, R.L. Dynamic shear stimulation of bovine cartilage biosynthesis of proteoglycan 4. Arthritis Rheum 54, 1888, 2006.
84. Flannery, C.R., Zollner, R., Corcoran, C., Jones, A.R., Root, A., Rivera-Bermudez, M.A., et al. Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum 60, 840, 2009.
85. Jay, G.D., Fleming, B.C., Watkins, B.A., McHugh, K.A., Anderson, S.C., Zhang, L.X., et al. Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum 62, 2382, 2010.
86. Elsaid, K.A., Fleming, B.C., Oksendahl, H.L., Machan, J.T., Fadale, P.D., Hulstyn, M.J., et al. Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum 58, 1707, 2008.
87. Jones, A.R., Chen, S., Chai, D.H., Stevens, A.L., Gleghorn, J.P., Bonassar, L.J., et al. Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis Rheum 60, 133, 2009.
88. Elsaid, K.A., Jay, G.D., and Chichester, C.O. Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigeninduced arthritis. Arthritis Rheum 56, 108, 2007.
89. Neu, C.P., Reddi, A.H., Komvopoulos, K., Schmid, T.M., and Di Cesare, P.E. Increased friction coefficient and superficial zone protein expression in patients with advanced osteoarthritis. Arthritis Rheum 62, 2680, 2010.
90. Gleghorn, J.P., Jones, A.R., Flannery, C.R., and Bonassar, L.J. Alteration of articular cartilage frictional properties by transforming growth factor beta, interleukin-1beta, and oncostatin M. Arthritis Rheum 60, 440, 2009.
91. Goldberg, V.M., and Buckwalter, J.A. Hyaluronans in the treatment of osteoarthritis of the knee: evidence for diseasemodifying activity. Osteoarthritis Cartilage 13, 216, 2005.
92. Balazs, E.A., and Denlinger, J.L. Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol Suppl 39, 3, 1993.
93. Jay, G.D., Torres, J.R., Warman, M.L., Laderer, M.C., and Breuer, K.S. The role of lubricin in the mechanical behavior of synovial fluid. Proc Natl Acad Sci USA 104, 6194, 2007.
94. Chawla, K., Ham, H.O., Nguyen, T., and Messersmith, P.B. Molecular resurfacing of cartilage with proteoglycan 4. Acta Biomater 6, 3388, 2010.
95. Katta, J., Jin, Z., Ingham, E., and Fisher, J. Chondroitin sulphate: an effective joint lubricant? Osteoarthritis Cartilage 17, 1001, 2009.
96. Sivan, S., Schroeder, A., Verberne, G., Merkher, Y., Diminsky, D., Priev, A., et al. Liposomes act as effective biolubricants for friction reduction in human synovial joints. Langmuir 26, 1107, 2010.
97. Elsaid, K.A., Machan, J.T., Waller, K., Fleming, B.C., and Jay, G.D. The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model. Arthritis Rheum 60, 2997, 2009.
98. Klein, T.J., Schumacher, B.L., Blewis, M.E., Schmidt, T.A., Voegtline, M.S., Thonar, E.J., et al. Tailoring secretion of proteoglycan 4 (PRG4) in tissue-engineered cartilage. Tissue Eng 12, 1429, 2006.
99. Gleghorn, J.P., Jones, A.R., Flannery, C.R., and Bonassar, L.J. Boundary mode frictional properties of engineered cartilaginous tissues. Eur Cell Mater 14, 20, 2007.
100. Grad, S., Lee, C.R., Gorna, K., Gogolewski, S., Wimmer, M.A., and Alini, M. Surface motion upregulates superficial zone protein and hyaluronan production in chondrocyteseeded three-dimensional scaffolds. Tissue Eng 11, 249, 2005.
101. Morita, Y., Tomita, N., Aoki, H., Sonobe, M., Wakitani, S., Tamada, Y., et al. Frictional properties of regenerated cartilage in vitro. J Biomech 39, 103, 2006.
102. Moutos, F.T., and Guilak, F. Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering. Tissue Eng Part A 16, 1291, 2010.
103. Lee, S.Y., Nakagawa, T., and Reddi, A.H. Mesenchymal progenitor cells derived from synovium and infrapatellar fat pad as a source for superficial zone cartilage tissue engineering: analysis of superficial zone protein/lubricin expression. Tissue Eng Part A 16, 317, 2010.
104. Li, Z., Yao, S., Alini, M., and Grad, S. Different response of articular chondrocyte subpopulations to surface motion. Osteoarthritis Cartilage 15, 1034, 2007.
105. Swann, D.A., Hendren, R.B., Radin, E.L., Sotman, S.L., and Duda, E.A. The lubricating activity of synovial fluid glycoproteins. Arthritis Rheum 24, 22, 1981.
106. Jay, G.D., Elsaid, K.A., Zack, J., Robinson, K., Trespalacios, F., Cha, C.J., et al. Lubricating ability of aspirated synovial fluid from emergency department patients with knee joint synovitis. J Rheumatol 31, 557, 2004.
107. Schmidt, T.A., and Sah, R.L. Effect of synovial fluid on boundary lubrication of articular cartilage. Osteoarthritis Cartilage 15, 35, 2007.
108. Israelachvili, J., Min, Y., Akbulut, M., Alig, A., Carver, G., Greene, W., et al. Recent advances in the surface forces apparatus (SFA) technique. Rep Prog Phys 73, 2010.
109. Chang, D.P., Abu-Lail, N.I., Coles, J.M., Guilak, F., Jay, G.D., and Zauscher, S. Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfaces. Soft Matter 5, 3438, 2009.
110. Park, S., Costa, K.D., and Ateshian, G.A. Microscale frictional response of bovine articular cartilage from atomic force microscopy. J Biomech 37, 1679, 2004.
111. Hansma, P.K., Elings, V.B., Marti, O., and Bracker, C.E. Scanning tunneling microscopy and atomic force microscopy: application to biology and technology. Science 242, 209, 1988.
112. Graindorge, S., Ferrandez, W., Ingham, E., Jin, Z., Twigg, P., and Fisher, J. The role of the surface amorphous layer of articular cartilage in joint lubrication. Proc Inst Mech Eng H 220, 597, 2006.
113. Katta, J., Jin, Z., Ingham, E., and Fisher, J. Effect of nominal stress on the long term friction, deformation and wear of native and glycosaminoglycan deficient articular cartilage. Osteoarthritis Cartilage 17, 662, 2009.
114. Blewis, M.E., Lao, B.J., Schumacher, B.L., Bugbee, W.D., Sah, R.L., and Firestein, G.S. Interactive cytokine regulation of synoviocyte lubricant secretion. Tissue Eng Part A 16, 1329, 2010.
115. Blewis, M.E., Lao, B.J., Jadin, K.D., McCarty, W.J., Bugbee, W.D., Firestein, G.S., et al. Semi-permeable membrane retention of synovial fluid lubricants hyaluronan and proteoglycan 4 for a biomimetic bioreactor. Biotechnol Bioeng 106, 149, 2010.
116. Kamiya, T., Tanimoto, K., Tanne, Y., Lin, Y.Y., Kunimatsu, R., Yoshioka, M., et al. Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes. J Biomed Mater Res A 92, 801, 2009.