Practical method for parallel synthesis of diversely substituted 1-phenylpiperazines

Letters in Organic Chemistry

Volumn 8, Issue 9, 2011, Pages 628-630

  Konstantinova, Igor ^a   Bukhryakov, Konstantin ^a   Gezentsvey, Yuri ^a   Krasavin, Mikhail ^a,b,c  

^a Chemical Diversity Research Institute   (Russian Federation)

^b YAROSLAVL STATE PEDAGOGICAL UNIVERSITY   (Russian Federation)

^c GRIFFITH UNIVERSITY   (Australia)

Author keywords

Bis alkylation; N arylpiperazines; Nitrogen mustard; Parallel synthesis; Solvent free synthesis

Indexed keywords

EID: 84858974978     PISSN: 15701786     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017811799304386     Document Type: Article

References (10)

1. Duarte, C. D.; Barreiro, E. J.; Fraga, C. A. Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev. Med. Chem., 2007, 7, 1108-1119. (Pubitemid 350200217)
2. Dyck, B.; Parker J.; Phillips, T.; Carter, L.; Murphy, B.; Summers, R.; Hermann, J.; Baker, T.; Cismowski, M.; Goodfellow, V. Aryl piperazine melanocortin MC4 receptor agonists. Bioorg. Med. Chem. Lett., 2003, 13, 3793-3796. (Pubitemid 37206509)
3. 1A receptor antagonist of the 1-arylpiperazine class of ligands. Eur. J. Med. Chem., 1995, 30, 587-592.
4. 2 Affinity as Potential Atypical Antipsychotics. J. Med. Chem., 1998, 41, 2010-2018. (Pubitemid 28308618)
5. Lyon, R. A.; Titeler, M.; McKenney, J. D.; Magee, P. S.; Glennon, R. A. Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J. Med. Chem., 1986, 29, 630-634. (Pubitemid 16034667)
6. Lee, M.; Rangisetty, J. B.; Pullagurla, M. R.; Dukat, M.; Setola, V.; Roth, B. L.; Glennon, R. A. 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorg. Med. Chem. Lett., 2005, 15, 1707-1711. (Pubitemid 40312557)
7. Tominaga, M.; Yo, E.; Ogawa, H.; Yamashita, S.; Yabuuchi, Y.; Nakagawa, K. Synthesis of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperizinyl]-2(1H)- quinolone and related compounds. Chem. Pharm. Bull., 1984, 32, 2100-2110.
8. Favor, D. A.; Johnson, D. S.; Powers, J. J.; Li, T.; Madabattula, R. Synthesis of chromanyl and dihydrobenzofuranyl piperazines. Tetrahedron Lett., 2007, 48, 3039-3041. (Pubitemid 46505156)
9. 3 Receptor Subtype. J. Med. Chem., 2001, 44, 3175-3186. (Pubitemid 32862348)
10. Koppe, V.; Poetsch, E.; Schulte, K. Substituted 4-phenyl-1-(3- pyrazolylalkyl)piperazines. Eur. J. Med. Chem., 1975, 10, 154-161.