Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1(A)/D2 affinity as potential atypical antipsychotics

Journal of Medicinal Chemistry

Volumn 41, Issue 12, 1998, Pages 2010-2018

  Taverne, Thierry ^a   Diouf, Ousmane ^a   Depreux, Patrick ^a   Poupaert, Jacques H ^b   Lesieur, Daniel ^a   Guardiola Lemaître, Béatrice ^c   Renard, Pierre ^c   Rettori, Marie Claire ^c   Caignard, Daniel Henri ^c   Pfeiffer, Bruno ^c  

^a Institut de Chimie Pharmaceutique   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c ADIR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BENZOXAZIN 3 ONE DERIVATIVE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 METHYL 6 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]BENZOTHIAZOLIN 2 ONE; 3 METHYL 6 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL]BENZOTHIAZOLIN 2 ONE; 3 METHYL 6 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL]BENZOTHIAZOLIN 2 ONE; 5 HYDROXYTRYPTOPHAN; 7 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL] 4 METHYL 3 OXO 2,3 DIHYDRO[1,4]BENZOXAZINE; 7 [4 [4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL]BUTYL] 4 METHYL 3 OXO 2,3 DIHYDRO[1,4]BENZOXAZINE; ALPHA 1 ADRENERGIC RECEPTOR; APOMORPHINE; BARBITAL; BENZOTHIAZOLIN 2 ONE DERIVATIVE; CLOZAPINE; DEXAMPHETAMINE; DOPAMINE 2 RECEPTOR; MAZAPERTINE; MESCALINE; N ALLYLNORMETAZOCINE; NEUROLEPTIC AGENT; OLANZAPINE; PHENYLEPHRINE; PIPERAZINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PRAZOSIN; RACLOPRIDE; RISPERIDONE; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CATALEPSY; CATTLE; CHOROID PLEXUS; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EXTRAPYRAMIDAL SYMPTOM; FRONTAL CORTEX; HEAD TWITCH; HIPPOCAMPUS; HYPERACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALS; ANTIPSYCHOTIC AGENTS; AVOIDANCE LEARNING; CATALEPSY; CATTLE; CORPUS STRIATUM; DOPAMINE AGENTS; FRONTAL LOBE; HIPPOCAMPUS; HYPERKINESIS; MICE; OXAZINES; PIPERAZINES; RABBITS; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGENTS; SLEEP; STEREOTYPED BEHAVIOR; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; THIAZOLES;

EID: 15644363705     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970298c     Document Type: Article

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