Risk factors, molecular epidemiology and outcomes of ertapenem-resistant, carbapenem-susceptible enterobacteriaceae: A case-case-control study

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Teo, Jocelyn ^a   Cai, Yiying ^a   Tang, Sarah ^a   Lee, Winnie ^a   Tan, Thean Yen ^b   Tan, Thuan Tong ^a   Kwa, Andrea Lay Hoon ^a  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b CHANGI GENERAL HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; BETA LACTAMASE AMPC; CARBAPENEM; CEFEPIME; CEFTRIAXONE; CEPHALOSPORIN; CIPROFLOXACIN; ERTAPENEM; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; PORIN; ANTIINFECTIVE AGENT; BETA LACTAM; CARBAPENEM DERIVATIVE;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; CARBAPENEM SUSCEPTIBLE ENTEROBACTERIACEAE; CASE CONTROL STUDY; CLONAL VARIATION; COMORBIDITY; CONTROLLED STUDY; DEMOGRAPHY; DRUG EXPOSURE; DRUG RESPONSE; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTION; ERTAPENEM RESISTANT ENTEROBACTERIACEAE; FEMALE; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; INDEPENDENT VARIABLE; INSTRUMENTATION; MAJOR CLINICAL STUDY; MALE; MOLECULAR EPIDEMIOLOGY; MORTALITY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; OUTCOME ASSESSMENT; RETROSPECTIVE STUDY; RISK FACTOR; SINGAPORE; TERTIARY HEALTH CARE; TREATMENT DURATION; ADOLESCENT; CROSS INFECTION; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; MICROBIOLOGY; MIDDLE AGED; MULTIDRUG RESISTANCE; MULTIVARIATE ANALYSIS; STATISTICAL MODEL; TREATMENT OUTCOME;

ENTEROBACTERIACEAE; NEGIBACTERIA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CARBAPENEMS; CASE-CONTROL STUDIES; CROSS INFECTION; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MULTIVARIATE ANALYSIS; RISK FACTORS; SINGAPORE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84858961621     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034254     Document Type: Article

References (37)

1. Winokur PL, Canton R, Casellas JM, Legakis N, (2001) Variations in the prevalence of strains expressing an extended-spectrum beta-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific region. Clin Infect Dis 2001 32 (Suppl 2): S94-103.
2. Endimiani A, Luzzaro F, Perilli M, Lombardi G, Colì A, et al. (2004) Bacteremia due to Klebsiella pneumoniae isolates producing the TEM-52 extended-spectrum beta-lactamase: treatment outcome of patients receiving imipenem or ciprofloxacin. Clin Infect Dis 38: 243-51.
3. Mackenzie FM, Forbes KJ, Dorai-John T, Amyes SG, Gould IM, (1997) Emergence of a carbapenem-resistant Klebsiella pneumoniae. Lancet 350 (9080): 783.
4. Tan TY, Hsu LY, Koh TH, Ng LS, Tee NW, et al. (2008) Antibiotic resistance in gram-negative bacilli: a Singapore perspective. Ann Acad Med Singapore 37 (10): 819-25.
5. Hsu LY, Tan TY, Tam VH, Kwa A, Fisher DA, et al. (2010) Surveillance and correlation of antibiotic prescription and resistance of Gram-negative bacteria in Singaporean hospitals. Antimicrob Agents Chemother 54 (3): 1173-8.
6. Walsh TR, (2010) Emerging carbapenemases: a global perspective. Int J Antimicrob Agents 36 (S3): 8-14.
7. Doumith M, Ellington MJ, Livermore DM, Woodford N, (2009) Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK. J Antimicrob Chemother 63: 659-667.
8. Jacoby GA, Mills DM, Chow N, (2004) Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae. Antimicrob Agents Chemother 48 (8): 3203-6.
9. Szabó D, Silveira F, Hujer AM, Bonomo RA, Hujer KM, et al. (2006) Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae. Antimicrob Agents Chemother 50 (8): 2833-5.
10. Leavitt A, Chmelnitsky I, Colodner R, Ofek I, Carmeli Y, et al. (2009) Ertapenem resistance among extended-spectrum-β-lactamase-producing Klebsiella isolates. J Clin Microbiol 47 (4): 969-74.
11. Wu JJ, Wang LR, Liu YF, Chen HM, Yan JJ, (2011) Prevalence and characteristics of ertapenem-resistant Klebsiella pneumoniae isolates in a Taiwanese university hospital. Microb Drug Resist 17 (2): 259-66.
12. García-Fernández A, Miriagou V, Papagiannitsis CC, Giordano A, Venditti M, et al. (2010) An ertapenem-resistant ESBL-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. Antimicrob Agents Chemother 54: 4178-4184.
13. Falagas ME, Rafailidis PI, Kofteridis D, Virtzili S, Chelvatzoglou FC, et al. (2007) Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case control study. J Antimicrob Chemother 60 (5): 1124-30.
14. Schwaber MJ, Klarfeld-Lidji S, Navon-Venezia S, Schwartz D, Leavitt A, et al. (2008) Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality. Antimicrob Agents Chemother 52 (3): 1028-1033.
15. Jeon MH, Choi SH, Kwak YG, Chung JW, Lee SO, et al. (2008) Risk factors for the acquisition of carbapenem-resistant Escherichia coli among hospitalized patients. Diagn Microbiol Infect Dis 62 (4): 402-6.
16. Hussein K, Sprecher H, Mashiach T, Oren I, Kassis I, et al. (2009) Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns. Infect Control Hosp Epidemiol 30 (7): 666-71.
17. Mouloudi E, Protonotariou E, Zagorianou A, Iosifidis E, Karapanagiotou A, et al. (2010) Bloodstream infections caused by metallo-β-lactamase/Klebsiella pneumoniae carbapenemase-producing K. pneumoniae among intensive care unit patients in Greece: risk factors for infection and impact of type of resistance on outcomes. Infect Control Hosp Epidemiol 31 (12): 1250-6.
18. Patel, Harrington S, Dihmess A, Woo B, Masoud R, et al. (2011) Clinical epidemiology of carbapenem-intermediate or-resistant Enterobacteriaceae. J Antimicrob Chemother 66 (7): 1600-8.
19. Kritsotakis EI, Tsioutis C, Roumbelaki M, Christidou A, Gikas A, (2011) Antibiotic use and the risk of carbapenem-resistant extended-spectrum-β-lactamase-producing Klebsiella pneumoniae infection in hospitalized patients: results of a double case-control study. J Antimicrob Chemother 66 (6): 1383-91.
20. Hyle EP, Ferraro MJ, Silver M, Lee H, Hooper DC, (2010) Ertapenem-resistant Enterobacteriaceae: risk factors for acquisition and outcomes. Infect Control Hosp Epidemiol 31 (12): 1242-9.
21. Orsi GB, García-Fernández A, Giordano A, Venditti C, Bencardino A, et al. (2011) Risk factors and clinical significance of ertapenem-resistant Klebsiella pneumoniae in hospitalised patients. J Hosp Infect 78 (1): 54-8.
22. Kaye KS, Harris AD, Samore M, Carmeli Y, (2005) The case-case-control study design: addressing the limitations of risk factor studies for antimicrobial resistance. Infect Control Hosp Epidemiol 26 (4): 346-51.
23. Harris AD, Karchmer TB, Carmeli Y, Samore MH, (2001) Methodological principles of case-control studies that analyze risk factors for antibiotic resistance: a systematic review. Clin Infect Dis 32: 1055-1061.
24. Clinical and Laboratory Standards Institute (CLSI) (2009) Performance standards for antimicrobial susceptibility testing - 19th informational supplement Wayne, PA CLSI; CLSI document M100-S19.
25. Dombek PE, Johnson LK, Zimmerley ST, Sadowsky MJ, (2000) Use of repetitive DNA sequences and the PCR to differentiate Escherichia coli isolates from human and animal sources. Appl Environ Microbiol 66 (6): 2572-7.
26. Monstein HJ, Ostholm-Balkhed A, Nilsson MV, Nilsson M, Dornbusch K, et al. (2007) Multiplex PCR amplification assay for the detection of blaSHV, blaTEM and blaCTX-M genes in Enterobacteriaceae. APMIS 115 (12): 1400-8.
27. Hindiyeh M, Smollen G, Grossman Z, Ram D, Davidson Y, et al. (2008) Rapid detection of blaKPC carbapenemase genes by real-time PCR. J Clin Microbiol 2008;46 (9): 2879-83.
28. Ellington MJ, Kistler J, Livermore DM, Woodford N, (2007) Multiplex PCR for rapid detection of genes encoding acquired metallo-β-lactamases. J Antimicrob Chemother 59 (2): 321-2.
29. Woodford N, Fagan EJ, Ellington MJ, (2006) Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum β-lactamases. J Antimicrob Chemother 57: 154-5.
30. Perez-Perez FJ, Hanson ND, (2002) Detection of plasmid-mediated AmpC β-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 40: 2153-62.
31. Schwaber MJ, Carmeli Y, (2008) Carbapenem-resistant Enterobacteriaceae: a potential threat. JAMA 300: 2911-3.
32. Eagye KJ, Kuti JL, Nicolau DP, (2009) Risk factors and outcomes associated with isolation of meropenem high-level-resistant Pseudomonas aeruginosa. Infect Control Hosp Epidemiol 30 (8): 746-52.
33. Baran G, Erbay A, Bodur H, Ongürü P, Akinci E, et al. (2008) Risk factors for nosocomial imipenem-resistant Acinetobacter baumannii infections. Int J Infect Dis 12 (1): 16-21.
34. Ikonomidis A, Tokatlidou D, Kristo I, Sofianou D, Tsakris A, et al. (2005) Outbreaks in distinct regions due to a single Klebsiella pneumoniae clone carrying a bla VIM-1 metallo β-lactamase gene. J Clin Microbiol 43 (10): 5344-7.
35. Bradford PA, Bratu S, Urban C, Visalli M, Mariano N, et al. (2004) Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 β-lactamases in New York City. Clin Infect Dis 39: 55-60.
36. Bratu S, Landman D, Haag R, Recco R, Eramo A, et al. (2005) Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch Intern Med 165: 1430-1435.
37. Woodford N, Tierno PM Jr, Young K, Tysall L, Palepou MF, et al. (2004) Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A β-lactamase, KPC-3, in a New York Medical Center. Antimicrob Agents Chemother 48 (12): 4793-9.