Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 β-lactamases in New York City

Clinical Infectious Diseases

Volumn 39, Issue 1, 2004, Pages 55-60

  Bradford, Patricia A ^a   Bratu, Simona ^b   Urban, Carl ^d   Visalli, Melissa ^a   Mariano, Noriel ^d   Landman, David ^b   Rahal, James J ^d   Brooks, Steven ^c   Cebular, Sanda ^b   Quale, John ^b  

^a PFIZER INC   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c KINGSBROOK JEWISH MEDICAL CENTER   (United States)

^d NEW YORK HOSPITAL QUEENS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; CARBAPENEM;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; ENZYME ANALYSIS; HYDROLYSIS; KLEBSIELLA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RIBOTYPING; SPECIES ENDEMICITY;

BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; DRUG RESISTANCE, BACTERIAL; HUMANS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; NEW YORK CITY;

EID: 3042835910     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/421495     Document Type: Article

References (33)

1. Rahal JJ, Urban C, Horn D, et al. Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. JAMA 1998; 280:1233-7.
2. Saurina G, Quale JM, Manikal VM, Oydna E, Landman D. Antimicrobial resistance in Enterobacteriaceae in Brooklyn, NY: epidemiology and relation to antibiotic usage patterns. J Antimicrob Chemother 2000; 45:895-8.
3. Quale JM, Landman D, Bradford PA, et al. Molecular epidemiology of a citywide outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae infection. Clin Infect Dis 2002; 35:834-41.
4. Wiener J, Quinn JP, Bradford PA, et al. Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes. J Am Med Assoc 1999; 281:517-23.
5. Bradford PA, Urban C, Mariano N, Projan SJ, Rahal JJ, Bush K. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC β-lactamase, and the loss of an outer membrane protein. Antimicrob Agents Chemother 1997; 41:563-9.
6. Martinez-Martinez L, Pascual A, Hernandez-Alles S, et al. Roles of β-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae. Antimicrob Agents Chemother 1999; 43:1669-73.
7. Cao VTB, Arlet G, Ericsson BM, Tammelin A, Courvalin P, Lambert T. Emergence of imipenem resistance in Klebsiella pneumoniae owing to combination of plasmid-mediated CMY-4 and permeability alteration. J Antimicrob Chemother 2000; 46:895-900.
8. Chow JW, Shlaes DM. Imipenem resistance associated with the loss of a 40 kDa outer membrane protein in Enterobacter aerogenes. J Antimicrob Chemother 1991; 28:499-504.
9. Raimondi A, Traverso A, Nikaido H. Imipenem- and meropenem-resistant mutants of Enterobacter cloacae and Proteus rettgeri lack porins. Antimicrob Agents Chemother 1991; 35:1174-80.
10. Yan JJ, Ko WC, Tsai SH, Wu HM, Wu JJ. Outbreak of infection with multidrug-resistant Klebsiella pneumoniae carrying bla(IMP-8) in a university medical center in Taiwan. J Clin Microbiol 2001; 39:4433-9.
11. Queenan AM, Torres-Viera C, Gold HS, et al. SME-type carbapenem- hydrolyzing class A beta-lactamases from geographically diverse Serratia marcescens strains. Antimicrob Agents Chemother 2000; 44:3035-9.
12. Poirel L, Weldhagen GF, Naas T, De Champs C, Dove MG, Nordmann P. GES-2, a class A β-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem. Antimicrob Agents Chemother 2001; 45:2598-603.
13. Rasmussen BA, Bush K, Keeney D, et al. Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae. Antimicrob Agents Chemother 1996; 40:2080-6.
14. Nordmann P, Mariotte S, Naas T, Labia R, Nicolas MH. Biochemical properties of a carbapenem-hydrolyzing β-lactamase from Enterobacter cloacae and cloning of the gene into Escherichia coli. Antimicrob Agents Chemother 1994; 38:1262-70.
15. Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 2001; 45:1151-61.
16. Moland ES, Black JA, Ourada J, Reisbig MD, Hanson ND, Thomson KS. Occurrence of newer β-lactamases in Klebsiella pneumoniae isolates from 24 US hospitals. Antimicrob Agents Chemother 2002; 46:3837-42.
17. Moland ES, Hanson ND, Herrera VL, et al. Plasmid-mediated, carbapenem-hydrolysing β-lactamase, KPC-2, in Klebsiella pneumoniae isolates. J Antimicrob Chemother 2003; 51:711-4.
18. Yigit H, Queenan AM, Rasheed JK, et al. Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing β-lactamase KPC-2. Antimicrob Agents Chemother 2003; 47:3881-9.
19. Miriagou V, Tzouvelekis LS, Rossiter S, Tzelepi E, Angulo FJ, Whichard JM. Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2. Antimicrob Agents Chemother 2003; 47:1297-300.
20. Hossain A, Ferraro MJ, Pino RM, et al. First report of plasmid-encoded carbapenem hydrolyzing enzyme KPC-2 in Enterobacter cloacae [abstract C1-264]. In: Program and abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (Chicago). Washington, DC: American Society for Microbiology, 2003:75.
21. Hong T, Moland ES, Abdalhamid B, et al. E. coli producing KPC-3 carbapenem hydrolyzing enzyme [abstract C1-265]. In: Program and abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (Chicago). Washington, DC: American Society for Microbiology, 2003:75.
22. Young K, Tierno P Jr, Tysall L, et al. Outbreak caused by Klebsiella pneumoniae with a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3 [abstract C2-20]. In: Program and abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (Chicago). Washington, DC: American Society for Microbiology, 2003: 75.
23. NCCLS. Performance standards for antimicrobial susceptibility testing. 11th informational supplement. NCCLS document M100-S11. Wayne, PA: NCCLS, 2001.
24. Matthew M, Harris AM. Identification of β-lactamases by analytical isoelectric focusing: correlation and bacterial taxonomy. J Gen Microbiol 1976; 94:55-67.
25. Livermore DM, Williams JD. β-Lactams: mode of action and mechanisms of bacterial resistance. In: Lorian V, ed. Antibiotics in laboratory medicine. 4th ed. Baltimore: Lippincott Williams & Wilkins, 1996: 502-78.
26. Sambrook J, Russell DW. Molecular cloning. 3rd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2001.
27. Bradford PA. Automated thermal cycling is superior to traditional methods for nucleotide sequencing for blaSHV genes. Antimicrob Agents Chemother 1999; 43:2960-3.
28. Centers for Disease Control and Prevention. National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992-June 2001. Am J Infect Control 2001; 29:404-21.
29. Toleman M, Rolston K, Jones RN, et al. Molecular characterization of VIM-4, a novel metallo-beta-lactamase from Texas: report form CANCER surveillance program [abstract C1-2851]. In: Program and abstracts of the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy (Chicago). Washington, DC: American Society for Microbiology, 2002:80.
30. Domenech-Sanchez A, Hernandez-Alles S, Martinez-Martinez L, Benedi VJ, Alberti S. Identification and characterization of a new porin gene of Klebsiella pneumoniae: its role in β-lactam antibiotic resistance. J Bacteriol 1999; 181:2726-32.
31. Okamoto K, Gotoh N, Nishino T. Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics: penem resistance mechanisms and their interplay. Antimicrob Agents Chemother 2001; 45:1964-71.
32. Villar HE, Danel F, Livermore DM. Permeability to carbapenems of Proteus mirabilis mutants selected for resistance to imipenem or other β-lactams. J Antimicrob Chemother 1997; 40:365-70.
33. Chaibi EB, Sirot D, Labia R. Inhibitor-resistant TEM β-lactamases: phenotypic, genetic and biochemical characteristics. J Antimicrob Chemother 1999; 43:447-58.