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Volumn 7, Issue 4, 2012, Pages 513-518

How Mycobacterium tuberculosis goes to sleep: The dormancy survival regulator DosR a decade later

Author keywords

dormancy; latency; Mycobacterium tuberculosis; nontuberculous mycobacteria; persistence

Indexed keywords

BEDAQUILINE; METRONIDAZOLE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DORMANCY SURVIVAL REGULATOR; UNCLASSIFIED DRUG;

EID: 84858955831     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.12.14     Document Type: Review
Times cited : (77)

References (64)
  • 1
    • 24944483644 scopus 로고    scopus 로고
    • Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A
    • Fujita M, Losick R. Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A. Genes Dev. 19(18), 2236-2244 (2005).
    • (2005) Genes Dev. , vol.19 , Issue.18 , pp. 2236-2244
    • Fujita, M.1    Losick, R.2
  • 3
    • 0036951936 scopus 로고    scopus 로고
    • Mycobacterium bovis BCG response regulator essential for hypoxic dormancy
    • Describes the discovery of DosR and its essential role in dormancy survival of Mycobacterium bovis BCG
    • Boon C, Dick T. Mycobacterium bovis BCG response regulator essential for hypoxic dormancy. J. Bacteriol. 184(24), 6760-6767 (2002). Describes the discovery of DosR and its essential role in dormancy survival of Mycobacterium bovis BCG.
    • (2002) J. Bacteriol. , vol.184 , Issue.24 , pp. 6760-6767
    • Boon, C.1    Dick, T.2
  • 4
    • 0034780485 scopus 로고    scopus 로고
    • Nonreplicating persistence of Mycobacterium tuberculosis
    • Gives a comprehensive overview of hypoxic dormancy in M. tuberculosis before interest in the field suddenly grew
    • Wayne LG, Sohaskey CD. Nonreplicating persistence of Mycobacterium tuberculosis. Annu. Rev. Microbiol. 55, 139-163 (2001). Gives a comprehensive overview of hypoxic dormancy in M. tuberculosis before interest in the field suddenly grew.
    • (2001) Annu. Rev. Microbiol. , vol.55 , pp. 139-163
    • Wayne, L.G.1    Sohaskey, C.D.2
  • 5
    • 0029976980 scopus 로고    scopus 로고
    • An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
    • Describes Wayne's hypoxia-dormancy culture model
    • Wayne LG, Hayes LG. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect. Immun. 64(6), 2062-2069 (1996). Describes Wayne's hypoxia-dormancy culture model.
    • (1996) Infect. Immun. , vol.64 , Issue.6 , pp. 2062-2069
    • Wayne, L.G.1    Hayes, L.G.2
  • 6
    • 70449705831 scopus 로고    scopus 로고
    • The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies
    • Barry CE 3rd, Boshoff HI, Dartois V et al. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nat. Rev. Microbiol. 7(12), 845-855 (2009).
    • (2009) Nat. Rev. Microbiol. , vol.7 , Issue.12 , pp. 845-855
    • Barry III, C.E.1    Boshoff, H.I.2    Dartois, V.3
  • 7
    • 77957946456 scopus 로고    scopus 로고
    • Letting sleeping Dos lie: Does dormancy play a role in tuberculosis?
    • Gives a comprehensive overview of the current state of research on various dormancies in M. tuberculosis
    • Chao MC, Rubin EJ. Letting sleeping Dos lie: does dormancy play a role in tuberculosis? Annu. Rev. Microbiol. 64, 293-311 (2010). Gives a comprehensive overview of the current state of research on various dormancies in M. tuberculosis.
    • (2010) Annu. Rev. Microbiol. , vol.64 , pp. 293-311
    • Chao, M.C.1    Rubin, E.J.2
  • 8
    • 0035182257 scopus 로고    scopus 로고
    • Dormant tubercle bacilli: The key to more effective TB chemotherapy?
    • Dick T. Dormant tubercle bacilli: the key to more effective TB chemotherapy? J. Antimicrob. Chemother. 47(1), 117-118 (2001).
    • (2001) J. Antimicrob. Chemother. , vol.47 , Issue.1 , pp. 117-118
    • Dick, T.1
  • 9
    • 0032911198 scopus 로고    scopus 로고
    • Oxygen depletion-induced dormancy in Mycobacterium bovis BCG
    • Lim A, Eleuterio M, Hutter B, Murugasu-Oei B, Dick T. Oxygen depletion-induced dormancy in Mycobacterium bovis BCG. J. Bacteriol. 181(7), 2252-2256 (1999).
    • (1999) J. Bacteriol. , vol.181 , Issue.7 , pp. 2252-2256
    • Lim, A.1    Eleuterio, M.2    Hutter, B.3    Murugasu-Oei, B.4    Dick, T.5
  • 10
    • 0035094416 scopus 로고    scopus 로고
    • Proteins of Mycobacterium bovis BCG induced in the Wayne dormancy model
    • Boon C, Li R, Qi R, Dick T. Proteins of Mycobacterium bovis BCG induced in the Wayne dormancy model. J. Bacteriol. 183(8), 2672-2676 (2001).
    • (2001) J. Bacteriol. , vol.183 , Issue.8 , pp. 2672-2676
    • Boon, C.1    Li, R.2    Qi, R.3    Dick, T.4
  • 11
    • 46249108568 scopus 로고    scopus 로고
    • Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
    • Shows hypoxia and metronidazole activity in a rabbit model of TB
    • Via LE, Lin PL, Ray SM et al. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect. Immun. 76(6), 2333-2340 (2008). Shows hypoxia and metronidazole activity in a rabbit model of TB.
    • (2008) Infect. Immun. , vol.76 , Issue.6 , pp. 2333-2340
    • Via, L.E.1    Lin, P.L.2    Ray, S.M.3
  • 12
    • 35948964746 scopus 로고    scopus 로고
    • Location of persisting mycobacteria in a guinea pig model of tuberculosis revealed by r207910
    • Lenaerts AJ, Hoff D, Aly S et al. Location of persisting mycobacteria in a guinea pig model of tuberculosis revealed by r207910. Antimicrob. Agents Chemother. 51(9), 3338-3345 (2007).
    • (2007) Antimicrob. Agents Chemother. , vol.51 , Issue.9 , pp. 3338-3345
    • Lenaerts, A.J.1    Hoff, D.2    Aly, S.3
  • 13
    • 0032508046 scopus 로고    scopus 로고
    • Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
    • Cole ST, Brosch R, Parkhill J et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393(6685), 537-544 (1998).
    • (1998) Nature , vol.393 , Issue.6685 , pp. 537-544
    • Cole, S.T.1    Brosch, R.2    Parkhill, J.3
  • 14
    • 0033802744 scopus 로고    scopus 로고
    • Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis
    • Dasgupta N, Kapur V, Singh KK et al. Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis. Tuber. Lung Dis. 80(3), 141-159 (2000).
    • (2000) Tuber. Lung Dis. , vol.80 , Issue.3 , pp. 141-159
    • Dasgupta, N.1    Kapur, V.2    Singh, K.K.3
  • 15
    • 0043142536 scopus 로고    scopus 로고
    • Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment
    • Schnappinger D, Ehrt S, Voskuil MI et al. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment. J. Exp. Med. 198(5), 693-704 (2003).
    • (2003) J. Exp. Med. , vol.198 , Issue.5 , pp. 693-704
    • Schnappinger, D.1    Ehrt, S.2    Voskuil, M.I.3
  • 16
    • 0038349268 scopus 로고    scopus 로고
    • Rv3133c/DosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis
    • Park HD, Guinn KM, Harrell MI et al. Rv3133c/DosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol. Microbiol. 48(3), 833-843 (2003).
    • (2003) Mol. Microbiol. , vol.48 , Issue.3 , pp. 833-843
    • Park, H.D.1    Guinn, K.M.2    Harrell, M.I.3
  • 18
    • 0042140672 scopus 로고    scopus 로고
    • Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program
    • Voskuil MI, Schnappinger D, Visconti KC et al. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J. Exp. Med. 198(5), 705-713 (2003).
    • (2003) J. Exp. Med. , vol.198 , Issue.5 , pp. 705-713
    • Voskuil, M.I.1    Schnappinger, D.2    Visconti, K.C.3
  • 19
    • 49649095474 scopus 로고    scopus 로고
    • Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon
    • Kumar A, Deshane JS, Crossman DK et al. Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon. J. Biol. Chem. 283(26), 18032-18039 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.26 , pp. 18032-18039
    • Kumar, A.1    Deshane, J.S.2    Crossman, D.K.3
  • 20
    • 43049170080 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection
    • Shiloh MU, Manzanillo P, Cox JS. Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection. Cell Host Microbe 3(5), 323-330 (2008).
    • (2008) Cell Host Microbe , vol.3 , Issue.5 , pp. 323-330
    • Shiloh, M.U.1    Manzanillo, P.2    Cox, J.S.3
  • 21
    • 78649647277 scopus 로고    scopus 로고
    • DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon
    • Honaker RW, Dhiman RK, Narayanasamy P, Crick DC, Voskuil MI. DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon. J. Bacteriol. 192(24), 6447-6455 (2010).
    • (2010) J. Bacteriol. , vol.192 , Issue.24 , pp. 6447-6455
    • Honaker, R.W.1    Dhiman, R.K.2    Narayanasamy, P.3    Crick, D.C.4    Voskuil, M.I.5
  • 22
    • 67651202584 scopus 로고    scopus 로고
    • Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
    • Honaker RW, Leistikow RL, Bartek IL, Voskuil MI. Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy. Infect. Immun. 77(8), 3258-3263 (2009).
    • (2009) Infect. Immun. , vol.77 , Issue.8 , pp. 3258-3263
    • Honaker, R.W.1    Leistikow, R.L.2    Bartek, I.L.3    Voskuil, M.I.4
  • 24
    • 2542475060 scopus 로고    scopus 로고
    • Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis
    • Roberts DM, Liao RP, Wisedchaisri G, Hol WG, Sherman DR. Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis. J. Biol. Chem. 279(22), 23082-23087 (2004).
    • (2004) J. Biol. Chem. , vol.279 , Issue.22 , pp. 23082-23087
    • Roberts, D.M.1    Liao, R.P.2    Wisedchaisri, G.3    Hol, W.G.4    Sherman, D.R.5
  • 25
    • 77956519362 scopus 로고    scopus 로고
    • Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis
    • Chao JD, Papavinasasundaram KG, Zheng X et al. Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis. J. Biol. Chem. 285(38), 29239-29246 (2010).
    • (2010) J. Biol. Chem. , vol.285 , Issue.38 , pp. 29239-29246
    • Chao, J.D.1    Papavinasasundaram, K.G.2    Zheng, X.3
  • 26
    • 79959815079 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis uses host triacylglycerol to accumulate lipid droplets and acquires a dormancy-like phenotype in lipid-loaded macrophages
    • Daniel J, Maamar H, Deb C, Sirakova TD, Kolattukudy PE. Mycobacterium tuberculosis uses host triacylglycerol to accumulate lipid droplets and acquires a dormancy-like phenotype in lipid-loaded macrophages. PLoS Pathog. 7(6), E1002093 (2011).
    • (2011) PLoS Pathog. , vol.7 , Issue.6
    • Daniel, J.1    Maamar, H.2    Deb, C.3    Sirakova, T.D.4    Kolattukudy, P.E.5
  • 27
    • 77954380461 scopus 로고    scopus 로고
    • Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin
    • Low KL, Shui G, Natter K et al. Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin. J. Biol. Chem. 285(28), 21662-21670 (2010).
    • (2010) J. Biol. Chem. , vol.285 , Issue.28 , pp. 21662-21670
    • Low, K.L.1    Shui, G.2    Natter, K.3
  • 28
    • 0036729047 scopus 로고    scopus 로고
    • Can a biologist fix a radio? - Or, what I learned while studying apoptosis
    • Lazebnik Y. Can a biologist fix a radio? - Or, what I learned while studying apoptosis. Cancer Cell 2(3), 179-182 (2002).
    • (2002) Cancer Cell , vol.2 , Issue.3 , pp. 179-182
    • Lazebnik, Y.1
  • 29
    • 81755177792 scopus 로고    scopus 로고
    • Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis
    • Arnvig KB, Comas I, Thomson NR et al. Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis. PLoS Pathog. 7(11), E1002342 (2011).
    • (2011) PLoS Pathog. , vol.7 , Issue.11
    • Arnvig, K.B.1    Comas, I.2    Thomson, N.R.3
  • 30
    • 77949356979 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy
    • Confirms the essential role of DosR in dormancy survival of M. tuberculosis
    • Leistikow RL, Morton RA, Bartek IL, Frimpong I, Wagner K, Voskuil MI. The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy. J. Bacteriol. 192(6), 1662-1670 (2010). Confirms the essential role of DosR in dormancy survival of M. tuberculosis.
    • (2010) J. Bacteriol. , vol.192 , Issue.6 , pp. 1662-1670
    • Leistikow, R.L.1    Morton, R.A.2    Bartek, I.L.3    Frimpong, I.4    Wagner, K.5    Voskuil, M.I.6
  • 31
    • 50149113470 scopus 로고    scopus 로고
    • The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
    • Rao SP, Alonso S, Rand L, Dick T, Pethe K. The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 105(33), 11945-11950 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.33 , pp. 11945-11950
    • Rao, S.P.1    Alonso, S.2    Rand, L.3    Dick, T.4    Pethe, K.5
  • 32
    • 78149425904 scopus 로고    scopus 로고
    • Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses
    • Tan MP, Sequeira P, Lin WW et al. Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses. PLoS ONE 5(10), E13356 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.10
    • Tan, M.P.1    Sequeira, P.2    Lin, W.W.3
  • 33
    • 66649090346 scopus 로고    scopus 로고
    • The diarylquinoline TMC207 for multidrug-resistant tuberculosis
    • Describes the dramatic efficacy of a new drug candidate that has dual activity against growing and hypoxic-dormant bacilli in vitro
    • Diacon AH, Pym A, Grobusch M et al. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N. Engl. J. Med. 360(23), 2397-2405 (2009). Describes the dramatic efficacy of a new drug candidate that has dual activity against growing and hypoxic-dormant bacilli in vitro.
    • (2009) N. Engl. J. Med. , vol.360 , Issue.23 , pp. 2397-2405
    • Diacon, A.H.1    Pym, A.2    Grobusch, M.3
  • 34
    • 19944429772 scopus 로고    scopus 로고
    • A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
    • Andries K, Verhasselt P, Guillemont J et al. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307(5707), 223-227 (2005).
    • (2005) Science , vol.307 , Issue.5707 , pp. 223-227
    • Andries, K.1    Verhasselt, P.2    Guillemont, J.3
  • 35
    • 76849095708 scopus 로고    scopus 로고
    • Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability
    • Gengenbacher M, Rao SP, Pethe K, Dick T. Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability. Microbiology 156(Pt 1), 81-87 (2010).
    • (2010) Microbiology , vol.156 , Issue.PART 1 , pp. 81-87
    • Gengenbacher, M.1    Rao, S.P.2    Pethe, K.3    Dick, T.4
  • 36
    • 80055079575 scopus 로고    scopus 로고
    • Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis
    • Watanabe S, Zimmermann M, Goodwin MB, Sauer U, Barry CE 3rd, Boshoff HI. Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis. PLoS Pathog. 7(10), E1002287 (2011).
    • (2011) PLoS Pathog. , vol.7 , Issue.10
    • Watanabe, S.1    Zimmermann, M.2    Goodwin, M.B.3    Sauer, U.4    Barry III, C.E.5    Boshoff, H.I.6
  • 37
    • 67249131526 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-binding: Requirement for establishing chronic persistent infection
    • Drumm JE, Mi K, Bilder P et al. Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-binding: requirement for establishing chronic persistent infection.PLoS Pathog. 5(5), E1000460 (2009).
    • (2009) PLoS Pathog. , vol.5 , Issue.5
    • Drumm, J.E.1    Mi, K.2    Bilder, P.3
  • 38
    • 31844449080 scopus 로고    scopus 로고
    • Deletion of the Mycobacterium tuberculosis alpha-crystallin-like hspX gene causes increased bacterial growth in vivo
    • Hu Y, Movahedzadeh F, Stoker NG, Coates AR. Deletion of the Mycobacterium tuberculosis alpha-crystallin-like hspX gene causes increased bacterial growth in vivo. Infect. Immun. 74(2), 861-868 (2006).
    • (2006) Infect. Immun. , vol.74 , Issue.2 , pp. 861-868
    • Hu, Y.1    Movahedzadeh, F.2    Stoker, N.G.3    Coates, A.R.4
  • 39
    • 77950492841 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis conserved hypothetical protein rRv2626c modulates macrophage effector functions
    • Bashir N, Kounsar F, Mukhopadhyay S, Hasnain SE. Mycobacterium tuberculosis conserved hypothetical protein rRv2626c modulates macrophage effector functions. Immunology 130(1), 34-45 (2010).
    • (2010) Immunology , vol.130 , Issue.1 , pp. 34-45
    • Bashir, N.1    Kounsar, F.2    Mukhopadhyay, S.3    Hasnain, S.E.4
  • 40
    • 33750934574 scopus 로고    scopus 로고
    • Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection
    • Sharma D, Bose A, Shakila H, Das TK, Tyagi JS, Ramanathan VD. Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection. FEMS Immunol. Med. Microbiol. 48(3), 329-336 (2006).
    • (2006) FEMS Immunol. Med. Microbiol. , vol.48 , Issue.3 , pp. 329-336
    • Sharma, D.1    Bose, A.2    Shakila, H.3    Das, T.K.4    Tyagi, J.S.5    Ramanathan, V.D.6
  • 41
    • 68149132300 scopus 로고    scopus 로고
    • Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa
    • Black GF, Thiel BA, Ota MO et al. Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa. Clin. Vaccine Immunol. 16(8), 1203-1212 (2009).
    • (2009) Clin. Vaccine Immunol. , vol.16 , Issue.8 , pp. 1203-1212
    • Black, G.F.1    Thiel, B.A.2    Ota, M.O.3
  • 42
    • 80053193189 scopus 로고    scopus 로고
    • Double- and monofunctional CD4 and CD8 T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals
    • Commandeur S, Lin MY, Van Meijgaarden KE et al. Double- and monofunctional CD4 and CD8 T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals. Eur. J. Immunol. 41(10), 2925-2936 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , Issue.10 , pp. 2925-2936
    • Commandeur, S.1    Lin, M.Y.2    Van Meijgaarden, K.E.3
  • 43
    • 65949089610 scopus 로고    scopus 로고
    • Identification of T-cell antigens specific for latent Mycobacterium tuberculosis infection
    • Schuck SD, Mueller H, Kunitz F et al. Identification of T-cell antigens specific for latent Mycobacterium tuberculosis infection. PLoS ONE 4(5), E5590 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.5
    • Schuck, S.D.1    Mueller, H.2    Kunitz, F.3
  • 44
    • 33748194116 scopus 로고    scopus 로고
    • Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis
    • Leyten EM, Lin MY, Franken KL et al. Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis. Microbes Infect. 8(8), 2052-2060 (2006).
    • (2006) Microbes Infect. , vol.8 , Issue.8 , pp. 2052-2060
    • Leyten, E.M.1    Lin, M.Y.2    Franken, K.L.3
  • 45
    • 43249101747 scopus 로고    scopus 로고
    • Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum
    • Garton NJ, Waddell SJ, Sherratt AL et al. Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Med. 5(4), E75 (2008).
    • (2008) PLoS Med. , vol.5 , Issue.4
    • Garton, N.J.1    Waddell, S.J.2    Sherratt, A.L.3
  • 46
    • 0037371176 scopus 로고    scopus 로고
    • Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis
    • Parish T, Smith DA, Kendall S, Casali N, Bancroft GJ, Stoker NG. Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis. Infect. Immun. 71(3), 1134-1140 (2003).
    • (2003) Infect. Immun. , vol.71 , Issue.3 , pp. 1134-1140
    • Parish, T.1    Smith, D.A.2    Kendall, S.3    Casali, N.4    Bancroft, G.J.5    Stoker, N.G.6
  • 47
    • 67650588768 scopus 로고    scopus 로고
    • The DosR regulon of M. tuberculosis and antibacterial tolerance
    • Bartek IL, Rutherford R, Gruppo V et al. The DosR regulon of M. tuberculosis and antibacterial tolerance. Tuberculosis (Edinb.) 89(4), 310-316 (2009).
    • (2009) Tuberculosis (Edinb.) , vol.89 , Issue.4 , pp. 310-316
    • Bartek, I.L.1    Rutherford, R.2    Gruppo, V.3
  • 48
    • 43049182981 scopus 로고    scopus 로고
    • The enduring hypoxic response of Mycobacterium tuberculosis
    • Rustad TR, Harrell MI, Liao R, Sherman DR. The enduring hypoxic response of Mycobacterium tuberculosis. PLoS ONE 3(1), E1502 (2008).
    • (2008) PLoS ONE , vol.3 , Issue.1
    • Rustad, T.R.1    Harrell, M.I.2    Liao, R.3    Sherman, D.R.4
  • 49
    • 62449219456 scopus 로고    scopus 로고
    • Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models
    • Converse PJ, Karakousis PC, Klinkenberg LG et al. Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models. Infect. Immun. 77(3), 1230-1237 (2009).
    • (2009) Infect. Immun. , vol.77 , Issue.3 , pp. 1230-1237
    • Converse, P.J.1    Karakousis, P.C.2    Klinkenberg, L.G.3
  • 50
    • 10744233580 scopus 로고    scopus 로고
    • Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis
    • Malhotra V, Sharma D, Ramanathan VD et al. Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. FEMS Microbiol. Lett. 231(2), 237-245 (2004).
    • (2004) FEMS Microbiol. Lett. , vol.231 , Issue.2 , pp. 237-245
    • Malhotra, V.1    Sharma, D.2    Ramanathan, V.D.3
  • 51
    • 70349427123 scopus 로고    scopus 로고
    • Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model
    • Lin PL, Rodgers M, Smith L et al. Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infect. Immun. 77(10), 4631-4642 (2009).
    • (2009) Infect. Immun. , vol.77 , Issue.10 , pp. 4631-4642
    • Lin, P.L.1    Rodgers, M.2    Smith, L.3
  • 52
    • 0024759118 scopus 로고
    • Role of metronidazole in improving response and specific drug sensitivity in advanced pulmonary tuberculosis
    • Desai CR, Heera S, Patel A, Babrekar AB, Mahashur AA, Kamat SR. Role of metronidazole in improving response and specific drug sensitivity in advanced pulmonary tuberculosis. J. Assoc. Physicians India 37(11), 694-697 (1989).
    • (1989) J. Assoc. Physicians India , vol.37 , Issue.11 , pp. 694-697
    • Desai, C.R.1    Heera, S.2    Patel, A.3    Babrekar, A.B.4    Mahashur, A.A.5    Kamat, S.R.6
  • 53
    • 33847050904 scopus 로고    scopus 로고
    • An official ATS/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
    • Griffith DE, Aksamit T, Brown-Elliott BA et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am. J. Respir. Crit. Care Med. 175(4), 367-416 (2007).
    • (2007) Am. J. Respir. Crit. Care Med. , vol.175 , Issue.4 , pp. 367-416
    • Griffith, D.E.1    Aksamit, T.2    Brown-Elliott, B.A.3
  • 54
    • 79952320659 scopus 로고    scopus 로고
    • Nontuberculous mycobacteria from household plumbing of patients with nontuberculous mycobacteria disease
    • Falkinham JO 3rd. Nontuberculous mycobacteria from household plumbing of patients with nontuberculous mycobacteria disease. Emerg. Infect. Dis. 17(3), 419-424 (2011).
    • (2011) Emerg. Infect. Dis. , vol.17 , Issue.3 , pp. 419-424
    • Falkinham III, J.O.1
  • 55
    • 77449132090 scopus 로고    scopus 로고
    • Mycobacterium abscessus: A new player in the mycobacterial field
    • Medjahed H, Gaillard JL, Reyrat JM. Mycobacterium abscessus: a new player in the mycobacterial field. Trends Microbiol. 18(3), 117-123 (2010).
    • (2010) Trends Microbiol. , vol.18 , Issue.3 , pp. 117-123
    • Medjahed, H.1    Gaillard, J.L.2    Reyrat, J.M.3
  • 56
    • 79951837354 scopus 로고    scopus 로고
    • Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease
    • Jarand J, Levin A, Zhang L, Huitt G, Mitchell JD, Daley CL. Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease. Clin. Infect. Dis. 52(5), 565-571 (2011).
    • (2011) Clin. Infect. Dis. , vol.52 , Issue.5 , pp. 565-571
    • Jarand, J.1    Levin, A.2    Zhang, L.3    Huitt, G.4    Mitchell, J.D.5    Daley, C.L.6
  • 57
    • 79951824945 scopus 로고    scopus 로고
    • The talking Mycobacterium abscessus blues
    • Griffith DE. The talking Mycobacterium abscessus blues. Clin. Infect. Dis. 52(5), 572-574 (2011).
    • (2011) Clin. Infect. Dis. , vol.52 , Issue.5 , pp. 572-574
    • Griffith, D.E.1
  • 59
    • 70350458719 scopus 로고    scopus 로고
    • Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria
    • Lin MY, Reddy TB, Arend SM et al. Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria. Infect. Immun. 77(11), 5071-5079 (2009).
    • (2009) Infect. Immun. , vol.77 , Issue.11 , pp. 5071-5079
    • Lin, M.Y.1    Reddy, T.B.2    Arend, S.M.3
  • 60
    • 0032526681 scopus 로고    scopus 로고
    • Oxygen depletion induced dormancy in Mycobacterium smegmatis
    • Dick T, Lee BH, Murugasu-Oei B. Oxygen depletion induced dormancy in Mycobacterium smegmatis. FEMS Microbiol. Lett. 163(2), 159-164 (1998).
    • (1998) FEMS Microbiol. Lett. , vol.163 , Issue.2 , pp. 159-164
    • Dick, T.1    Lee, B.H.2    Murugasu-Oei, B.3
  • 61
    • 0037373063 scopus 로고    scopus 로고
    • A two-component regulator of universal stress protein expression and adaptation to oxygen starvation in Mycobacterium smegmatis
    • O'Toole R, Smeulders MJ, Blokpoel MC, Kay EJ, Lougheed K, Williams HD. A two-component regulator of universal stress protein expression and adaptation to oxygen starvation in Mycobacterium smegmatis. J. Bacteriol. 185(5), 1543-1554 (2003).
    • (2003) J. Bacteriol. , vol.185 , Issue.5 , pp. 1543-1554
    • O'Toole, R.1    Smeulders, M.J.2    Blokpoel, M.C.3    Kay, E.J.4    Lougheed, K.5    Williams, H.D.6
  • 62
    • 0037018884 scopus 로고    scopus 로고
    • Molecular analysis of the dormancy response in Mycobacterium smegmatis: Expression analysis of genes encoding the DevR-DevS two-component system, Rv3134c and chaperone alpha-crystallin homologues
    • Mayuri, Bagchi G, Das TK, Tyagi JS. Molecular analysis of the dormancy response in Mycobacterium smegmatis: expression analysis of genes encoding the DevR-DevS two-component system, Rv3134c and chaperone alpha-crystallin homologues. FEMS Microbiol. Lett. 211(2), 231-237 (2002).
    • (2002) FEMS Microbiol. Lett. , vol.211 , Issue.2 , pp. 231-237
    • Mayuri, B.G.1    Das, T.K.2    Tyagi, J.S.3
  • 63
    • 81555212286 scopus 로고    scopus 로고
    • Microbiology. Antioxidant strategies to tolerate antibiotics
    • Belenky P, Collins JJ. Microbiology. Antioxidant strategies to tolerate antibiotics.Science 334(6058), 915-916 (2011).
    • (2011) Science , vol.334 , Issue.6058 , pp. 915-916
    • Belenky, P.1    Collins, J.J.2


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