Road traffic accident risk related to prescriptions of the hypnotics zopiclone, zolpidem, flunitrazepam and nitrazepam

Sleep Medicine

Volumn 9, Issue 8, 2008, Pages 818-822

  Gustavsen, Ingebjørg ^a   Bramness, Jørgen G ^a   Skurtveit, Svetlana ^a,b   Engeland, Anders ^a,c   Neutel, Ineke ^d   Mørland, Jørg ^a,e  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

^c UNIVERSITY OF BERGEN   (Norway)

^d UNIVERSITY OF OTTAWA   (Canada)

^e UNIVERSITY OF OSLO   (Norway)

Author keywords

Flunitrazepam; Hypnotics; Nitrazepam; Pharmacoepidemiology; Traffic accident risk; Zolpidem; Zopiclone

Indexed keywords

FLUNITRAZEPAM; NITRAZEPAM; ZOLPIDEM; ZOPICLONE;

ADULT; AGED; ARTICLE; DISEASE ASSOCIATION; DRUG EXPOSURE; DRUG UTILIZATION; FEMALE; HIGH RISK POPULATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; NORWAY; PHARMACOEPIDEMIOLOGY; PRESCRIPTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; TRAFFIC ACCIDENT;

ACCIDENTS, TRAFFIC; ADOLESCENT; ADULT; AGED; AZABICYCLO COMPOUNDS; FEMALE; FLUNITRAZEPAM; FOLLOW-UP STUDIES; HUMANS; HYPNOTICS AND SEDATIVES; INCIDENCE; MALE; MIDDLE AGED; NITRAZEPAM; NORWAY; PIPERAZINES; PYRIDINES; RISK FACTORS; SLEEP INITIATION AND MAINTENANCE DISORDERS; YOUNG ADULT;

EID: 46249131714     PISSN: 13899457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sleep.2007.11.011     Document Type: Article

References (31)

1. Ohayon M.M., and Zulley J. Correlates of global sleep dissatisfaction in the German population. Sleep 24 (2001) 780-787
2. Stewart R., Besset A., Bebbington P., Brugha T., Lindesay J., Jenkins R., et al. Insomnia comorbidity and impact and hypnotic use by age group in a national survey population aged 16 to 74 years. Sleep 29 (2006) 1391-1397
3. Mellinger G.D., Balter M.B., and Uhlenhuth E.H. Insomnia and its treatment. Prevalence and correlates. Arch Gen Psychiatry 42 (1985) 225-232
4. Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomnia. National Institute for Clinical Excellence; 2004.
5. Woods J.H., Katz J.L., and Winger G. Benzodiazepines: use, abuse, and consequences. Pharmacol Rev 44 (1992) 151-347
6. Nowell P.D., Mazumdar S., Buysse D.J., Dew M.A., Reynolds III C.F., and Kupfer D.J. Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy. JAMA 278 (1997) 2170-2177
7. Kassam A., Carter B., and Patten S.B. Sedative hypnotic use in Alberta. Can J Psychiatry 51 (2006) 287-294
8. Antai-Otong D. The art of prescribing. Risks and benefits of non-benzodiazepine receptor agonists in the treatment of acute primary insomnia in older adults. Perspect Psychiatr Care 42 (2006) 196-200
9. Hajak G., Muller W.E., Wittchen H.U., Pittrow D., and Kirch W. Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data. Addiction 98 (2003) 1371-1378
10. Busto U.E., Sproule B.A., Knight K., and Herrmann N. Use of prescription and nonprescription hypnotics in a Canadian elderly population. Can J Clin Pharmacol 8 (2001) 213-221
11. Norwegian prescription database [Norwegian Institute of Public Health] [updated 2007 Sep 20]. Available from: http://www.reseptregisteret.no/.
12. Neutel C.I. Risk of traffic accident injury after prescription for a benzodiazepine. AEP 5 (1995) 239-244
13. Neutel I. Benzodiazepine-related traffic accidents in young and elderly drivers. Hum Psychopharmacol Clin Exp 13 (1998) 115-123
14. Ray W.A., Fought R.L., and Decker M.D. Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. Am J Epidemiol 136 (1992) 873-883
15. Hemmelgarn B., Suissa S., Huang A., Boivin J.F., and Pinard G. Benzodiazepine use and the risk of motor vehicle crash in the elderly. JAMA 278 (1997) 27-31
16. Barbone F., McMahon A.D., Davey P.G., Morris A.D., Reid I.C., McDevitt D.G., et al. Association of road-traffic accidents with benzodiazepine use. Lancet 352 (1998) 1331-1336
17. Engeland A., Skurtveit S., and Morland J. Risk of road traffic accidents associated with the prescription of drugs: a registry-based cohort study. Ann Epidemiol 17 (2007) 597-602
18. Bramness J.G., Skurtveit S., Morland J., and Engeland A. The risk of traffic accidents after prescriptions of carisoprodol. Accid Anal Prev 39 (2007) 1050-1055
19. Road traffic accidents [Statistics Norway] [updated 2007 Sep 20]. Available from: http://www.ssb.no/english/subjects/10/12/20/vtu_en/.
20. Gambi F., Conti C.M., Grimaldi M.R., Giampietro L., De Bernardis B., and Ferro F.M. Flunitrazepam a benzodiazepine most used among drug abusers. Int J Immunopathol Pharmacol 12 (1999) 157-159
21. Verster J.C., Veldhuijzen D.S., and Volkerts E.R. Residual effects of sleep medication on driving ability. Sleep Med Rev 8 (2004) 309-325
22. Kuitunen T., Mattila M.J., Seppala T., Aranko K., and Mattila M.E. Actions of zopiclone and carbamazepine, alone and in combination, on human skilled performance in laboratory and clinical tests. Br J Clin Pharmacol 30 (1990) 453-461
23. Kuitunen T., Mattila M.J., and Seppala T. Actions and interactions of hypnotics on human performance: single doses of zopiclone, triazolam and alcohol. Int Clin Psychopharmacol 5 Suppl 2 (1990) 115-130
24. Griffiths A.N., Jones D.M., and Richens A. Zopiclone produces effects on human performance similar to flurazepam, lormetazepam and triazolam. Br J Clin Pharmacol 21 (1986) 647-653
25. Berlin I., Warot D., Hergueta T., Molinier P., Bagot C., and Puech A.J. Comparison of the effects of zolpidem and triazolam on memory functions, psychomotor performances, and postural sway in healthy subjects. J Clin Psychopharmacol 13 (1993) 100-106
26. Verster J.C., Volkerts E.R., Schreuder A.H.C.M., Eijken E.J.E., van Heucklum J.H.G., Veldhuijzen D.S., et al. Residual effects of middle of-the-night administration of zaleplon and zolpidem on driving ability, memory functions and psychomotor performance. J Clin Psychopharmacol 22 (2002) 576-583
27. Partinen M., Hirvonen K., Hublin C., Halavaara M., and Hiltunen H. Effects of after-midnight intake of zolpidem and temazepam on driving ability in women with non-organic insomnia. Sleep Med 4 (2003) 553-561
28. Staner L., Ertle S., Boeijinga P., Rinaudo G., Arnal M.A., Muzet A., et al. Next-day residual effects of hypnotics in DSM-IV primary insomnia: a driving simulator study with simultaneous electroencephalogram monitoring. Psychopharmacology (Berl) 181 (2005) 790-798
29. Vermeeren A., Riedel W.J., van Boxtel M.P., Darwish M., Paty I., and Patat A. Differential residual effects of zaleplon and zopiclone on actual driving: a comparison with a low dose of alcohol. Sleep 25 (2002) 224-231
30. Berthelon C., Bocca M.L., Denise P., and Pottier A. Do zopiclone, zolpidem and flunitrazepam have residual effects on simulated task of collision anticipation?. J Psychopharmacol 17 (2003) 324-331
31. Montplaisir J., Hawa R., Moller H., Morin C., Fortin M., Matte J., et al. Zopiclone and zaleplon vs benzodiazepines in the treatment of insomnia: Canadian consensus statement. Hum Psychopharmacol 18 (2003) 29-38