Older adults and withdrawal from benzodiazepine hypnotics in general practice: Effects on cognitive function, sleep, mood and quality of life

Psychological Medicine

Volumn 33, Issue 7, 2003, Pages 1223-1237

  Curran, H Valerie ^a,b   Collins, R ^a,b   Fletcher, S ^a,b   Kee, S C Y ^a,b   Woods, B ^a,b   Iliffe, S ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b BANGOR UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE; DIAZEPAM; HYPNOTIC AGENT; LOPRAZOLAM; NITRAZEPAM; PLACEBO; TEMAZEPAM;

AGED; ARTICLE; CLINICAL PRACTICE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG WITHDRAWAL; ELDERLY CARE; FEMALE; GENERAL PRACTICE; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MOOD; PSYCHOLOGIC ASSESSMENT; PSYCHOMOTOR ACTIVITY; PSYCHOMOTOR PERFORMANCE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SLEEP DISORDER; TASK PERFORMANCE; WITHDRAWAL SYNDROME;

AFFECT; AGED; BENZODIAZEPINES; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FAMILY PRACTICE; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; LONDON; LONG-TERM CARE; MALE; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; QUALITY OF LIFE; SLEEP; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

EID: 0142094179     PISSN: 00332917     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0033291703008213     Document Type: Article

References (49)

1. Andresen, E. M., Patrick, D. L., Carter, W. B. & Malmgren, J. A. (1995). Comparing the performance of health status measures for healthy older adults. Journal of the American Geriatric Society 43, 1030-1034.
2. Baddeley, A., Emslie, H. & Nimmo-Smith, I. (1992). The Speed and Capacity of Language Processing. Thames Valley Test Company: Reading.
3. Barbone, F., McMahon, A. D., Davey, P. G., Morris, A. D., Reid, I. C., McDevitt, D. G. & MacDonald, T. M. (1998). Association of road-traffic accidents with benzodiazepine use. Lancet 352, 1331-1336.
4. Barbui, C., Gregis, M. & Zappa, M. (1998). A cross-sectional audit of benzodiazepine use among general practice patients. Acta Psychiatrica Scandinavica 97, 153-156.
5. Bond, A. J. & Lader, M. H. (1974). The use of analogue scales in rating subjective feelings. British Journal of Medical Psychology 47, 211-218.
6. Bowling, A. (1991). Measuring Health: A Review of Quality of Life Measurement Scales. Open University Press: Buckingham.
7. Campbell, A. (1991). Drug treatment as a cause of falls in old age. Drugs and Aging 1, 289-302.
8. Colenda, C. C., Mickus, M. A., Marcus, S. C., Tanielian, T. L. & Pincus, H. A. (2002). Comparison of adult and geriatric psychiatric practice patterns: findings from the American Psychiatric Association's Practice Research Network. American Journal of Geriatric Psychiatry 10, 609-617.
9. Cummings, S. R., Nevitt, M. C., Browner, W. S., Stone, K., Fox, K. M., Ensrud, K. E., Cauley, J., Black, D. & Vogt, T. M. (1995 . Risk factors for hip fracture in white women. New England Journal of Medicine 332, 767-773.
10. Curran, H. V. (1991). Benzodiazepines, memory and mood: a review. Psychopharmacology 105, 1-8.
11. Curran, H. V. (2000). The psychopharmacology of memory. In The Oxford Handbook of Memory (ed. E. Tulving and F. Craik), pp. 539-556. Oxford University Press: New York.
12. Curran, H. V., Bond, A., O'Sullivan, G., Bruce, M., Marks, I., Lelliot, P., Shine, P. & Lader, M. (1994). Memory functions, alprazolam and exposure therapy: a controlled longitudinal trial of agoraphobia with panic disorder. Psychological Medicine 24, 969-976.
13. D'Ath, P., Katona, P., Mullan, E., Evans, S. & Katona, C. (1994). Screening, detection and management of depression in elderly primary care attenders: the acceptability and performance of the 15 item geriatric Depression Scale (GDS15) and the development of short versions. Family Practice 11, 260-266.
14. Egan, M., Moride, Y., Wolfson, C. & Monette, J. (2000). Long-term continous use of benzodiazepines by older adults in Quebec: prevalence, incidence and risk factors. Journal of the American Geriatric Society 48, 811-816.
15. Golombok, S., Moodley, P. & Lader, M. (1988). Cognitive impairment in long-term benzodiazepines users. Psychological Medicine 18, 365-374.
16. Gorenstein, C., Bernik, M. A. & Pompeia, S. (1994). Differential acute psychomotor and cognitive effects of diazepam on long-term benzodiazepine users. International Clinical Psychopharmacology 9, 145-153.
17. Gray, S. L., Lai, K. V. & Larson, E. B. (1999). Drug-induced cognition disorders in the elderly: incidence, prevention and management. Drug Safety 21, 101-122.
18. Greenblatt, D., Harmatz, J. S., Shapiro, L., Engelhardt, N., Gouthro, T. A. & Shader, R. I. (1991). Sensitivity to triazolam in the elderly. New England Journal of Medicine 324, 1326-1331.
19. Griffiths, R. R. (1995). Commentary - Benzodiazepines: long-term use among patients is a concern. Psychopharmacology 118, 116-117.
20. Hayes, V., Morris, J., Wolfe, C. & Morgan, M. (1995). The SF-36 Health Survey Questionnaire: is it suitable for older adults? Age and Ageing 24, 120-125.
21. Hinrichs, S. & Ghoneim, M. M. (1987). Diazepam, behavior and ageing. Psychopharmacology 92, 100-105.
22. Hemmelgarn, B., Suissa, S., Huang, A., Boivin, J. F. & Pinard, G. (1997). Benzodiazepine use and the risk of motor vehicle crash in the elderly. Journal of the American Medical Association 278, 27-31.
23. Holden, J. D., Hughes, I. M. & Tree, A. (1994). Benzodiazepine prescribing and withdrawal for 3234 patients in 15 general practices. Family Practice 11, 358-362.
24. Iliffe, S., Curran, H. V., Collins, R., Kee, S. C. H., Fletcher, S. & Woods, B. (2003). Attitudes to long-term use of benzodiazepine hypnotics by older people in general practice: findings from interviews with service users and providers. Ageing and Mental Health (in the press).
25. Jorm, A. F., Grayson, D., Creasey, H., Waite, L. & Broe, G. A. (2000). Long-term benzodiazepine use by elderly people living in the community. Australian and New Zealand Journal of Public Health 24, 7-10.
26. Kiliç, C., Curran, H. V., Noshirvani, H., Marks, I. M. & Başoǧlu, M. (1999). Long-term effects of alprazolam on memory: a 3.5 year follow-up of agoraphobial panic patients. Psychological Medicine 29, 225-231.
27. Lader, M. H. (1992). The Medical Management of Insomnia in General Practice. Royal Society of Medicine Round Table Series, 28. Royal Society of Medicine: London.
28. Leipzig, R. M., Cumming, R. G. & Tinetti, M. E. (1999). Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. Journal of the American Geriatric Society 47, 30-39.
29. Lyons, R., Perry, H. M. & Littlepage, B. N. (1994). Evidence for the validity of the short-form 36 questionnaire (SF-36) in an elderly population. Age and Aging 23, 182-184.
30. Marczynski, T. J. (1995). GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease; pharmacologic profile of the benzodiazepine antagonist, flumazenil. Review of Neuroscience 6, 221-258.
31. Mattila, M. J., Vanakoski, J., Kalska, H. & Seppala, T. (1998). Effects of alcohol, zolpidem, and some other sedatives and hypnotics on human performance and memory. Pharmacology, Biochemistry and Behaviour 59, 917-923.
32. Morgan, K. (1994). Hypnotic drugs, psychomotor performance and ageing. Journal of Sleep Reviews 3, 1-15.
33. Morgan, K. & Clarke, J. (1995). Longitudinal Trends in Late-Life Insomnia. Sleep Disorders Assessment and Treatment: Proceedings of the British Sleep Society Conference. St Georges Hospital Mental Health Science Conference Unit: London.
34. Morgan, K. & Gledhill, K. (1991). Managing Sleep and Insomnia in the Older Person. Winslow Press: Bicester.
35. Nikaido, A. M., Ellinwood, E. H., Heatherly, D. G. & Gupta, S. K. (1990). Age-related increase in CNS sensitivity to benzodiazepines as assessed by task difficulty. Psychopharmacology 100, 90-97.
36. Pomara, N., Stanley, B., Block, R., Berchou, R. C., Stanley, B., Greenblatt, D. J., Newton, R. E. & Gershon, S. (1985). Increased sensitivity of the elderly to the effects of diazepam. Journal of Clinical Psychiatry 46, 185-187.
37. Robertson, I. H., Ward, T., Ridgeway, V. & Nimmo-Smith, I. (1996). The structure of normal human attention: the Test of Everyday Attention. Journal of the International Neuropsychological Society 6, 525-534.
38. Rumble, R. H. & Morgan, K. (1994). Longitudinal trends in prescribing for elderly patients: two surveys four years apart. British Journal of General Practice 44, 571-575.
39. Salzman, C., Fisher, J., Nobel, K., Glassman, R., Wolfson, A. & Kelley, M. (1992). Cognitive improvement following benzodiazepine discontinuation in elderly nursing home residents. International Journal of Geriatric Psychiatry 7, 89-93.
40. Shorr, R. & Robin, D. (1994). Rational use of benzodiazepines in the elderly. Drugs and Aging 4, 9-20.
41. Tata, P. R., Rollings, J., Collins, M., Pickering, A. & Jacobson, R. R. (1994). Lack of cognitive recovery following withdrawal from long-term benzodiazepine use. Psychological Medicine 24, 203-213.
42. Thomas, R. E. (1998). Benzodiazepine use and motor vehicle accidents. Systematic review of reported association. Canadian Family Physician 44, 799-808.
43. Ticehurst, S. (1995). Alcohol and drug abuse. In Neurotic Disorders in the Elderly (ed. J. Linsey), pp. 56-71. Oxford University Press: Oxford.
44. Tyrer, P., Murphy, S. & Riley, P. (1990). The Benzodiazepine Withdrawal Symptoms Questionnaire. Journal of Affective Disorders 19, 53-61.
45. Wechsler, D. (1955). Manual for the Wechsler Adult Intelligence Scale. Psychological Corporation: New York.
46. Wesnes, K. A., Ward, T., McGinty, A. & Petrini, O. (2000). The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle aged volunteers. Psychopharmacology 152, 353-361.
47. Wilson, B., Cockburn, J. & Baddeley, A. (1985). The Rivermead Behavioural Memory Test. Thames Valley Test Company: Reading.
48. Woods, J. H. & Winger, G. (1995). Current benzodiazepine issues. Psychopharmacology 118, 107-115.
49. Woods, J. H., Katz, J. L. & Winger, G. (1992). Benzodiazepine use, abuse and consequences. Pharmacology Review 44, 151-347.